Click here to switch to the map view.

The map label for this gene is cobB3 [H]

Identifier: 66045598

GI number: 66045598

Start: 2739782

End: 2740627

Strand: Reverse

Name: cobB3 [H]

Synonym: Psyr_2362

Alternate gene names: 66045598

Gene position: 2740627-2739782 (Counterclockwise)

Preceding gene: 66045600

Following gene: 66045596

Centisome position: 44.97

GC content: 63.0

Gene sequence:

>846_bases
ATGCTCGACAGCCCAATCCGAGATCTGCTCGACACGCTATGCCAGGTAATGGCCGACAAACCGTTTCTGGTGGTGACCGG
CGCAGGGATCAGCACCGCATCCGGCATTCCGGACTACCGCGACAAGAATGGCGTGCGGCGCGGCAAGCAGCCGATGATGT
ATCAGGAATTTCTCGGCAACCCTGCAGCGCGCCAGCGCTACTGGGCACGCGCCATGCTCGGCTGGCCGCGGATCCGCGCG
GCACAGGCCAATGCCGCGCATCTGGCCCTGGCTGCGCTGCAGGCTGAACACGCCATTACCGGACTGATCACCCAGAACGT
CGATGCACTGCACACACAGGCCGGAAGCCGGGACGTCATCGAACTTCACGGCAGCCTGCACCGGGTGCTGTGTCTGGATT
GCCAGCAGCGCAGCGACCGTGCAGGAATTCAAGAGCAGATGCTGGCGCACAACCTTTATCTGATCGGCGTCCACGCGACA
CAGGCACCGGACGGCGATACCCTGCTAGACCCGGCGTTCGAAGCCAGTTTCGAGGTGCCCCGCTGTCCGCACTGTGGAGG
CGACAGGCTCAAGCCGGACGTCGTGTTCTTCGGTGAAAACGTCGCCGCGCAGACCGCTGCCAGGGCTACGCAAAGTGTCG
AGGACGCAGAAGGTCTGCTGGTGGTGGGCACGTCATTGATGGCCTGGTCGGCATTCCGCCTGTGCAAGGCCATGGCCGAA
CAGGGCAAACCGGTCATCGCCATCAACCATGGCAAGACCCGGGCGGACGAGCTGCTTGAAATGAAGATCGAAGCGTCCTG
TGAGCAGGCCTTGCCGTGGCTGGCCGAACAGTTGGTTTCGCCTTAG

Upstream 100 bases:

>100_bases
GTCGGCCACGGCGGCTCACAGCTGTGGCAGTCGCAACGCTACCTGCATGCCAGATGATAATGTGTCCAGTCACAAGAGGC
AGGCCACCCGAGGTTCAAAC

Downstream 100 bases:

>100_bases
AACAACCCCAGTTGCCCGCCGATCAGGGTGCTGAAATCGTCGTCCACAAACGGCAGGATCGCGTCAGCCAGCGGTTGTAA
CTGACGAGTCACGTAGTGAT

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 3 [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MLDSPIRDLLDTLCQVMADKPFLVVTGAGISTASGIPDYRDKNGVRRGKQPMMYQEFLGNPAARQRYWARAMLGWPRIRA
AQANAAHLALAALQAEHAITGLITQNVDALHTQAGSRDVIELHGSLHRVLCLDCQQRSDRAGIQEQMLAHNLYLIGVHAT
QAPDGDTLLDPAFEASFEVPRCPHCGGDRLKPDVVFFGENVAAQTAARATQSVEDAEGLLVVGTSLMAWSAFRLCKAMAE
QGKPVIAINHGKTRADELLEMKIEASCEQALPWLAEQLVSP

Sequences:

>Translated_281_residues
MLDSPIRDLLDTLCQVMADKPFLVVTGAGISTASGIPDYRDKNGVRRGKQPMMYQEFLGNPAARQRYWARAMLGWPRIRA
AQANAAHLALAALQAEHAITGLITQNVDALHTQAGSRDVIELHGSLHRVLCLDCQQRSDRAGIQEQMLAHNLYLIGVHAT
QAPDGDTLLDPAFEASFEVPRCPHCGGDRLKPDVVFFGENVAAQTAARATQSVEDAEGLLVVGTSLMAWSAFRLCKAMAE
QGKPVIAINHGKTRADELLEMKIEASCEQALPWLAEQLVSP
>Mature_281_residues
MLDSPIRDLLDTLCQVMADKPFLVVTGAGISTASGIPDYRDKNGVRRGKQPMMYQEFLGNPAARQRYWARAMLGWPRIRA
AQANAAHLALAALQAEHAITGLITQNVDALHTQAGSRDVIELHGSLHRVLCLDCQQRSDRAGIQEQMLAHNLYLIGVHAT
QAPDGDTLLDPAFEASFEVPRCPHCGGDRLKPDVVFFGENVAAQTAARATQSVEDAEGLLVVGTSLMAWSAFRLCKAMAE
QGKPVIAINHGKTRADELLEMKIEASCEQALPWLAEQLVSP

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912662, Length=260, Percent_Identity=43.8461538461538, Blast_Score=216, Evalue=1e-56,
Organism=Homo sapiens, GI6912664, Length=261, Percent_Identity=28.3524904214559, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI300795542, Length=263, Percent_Identity=27.7566539923954, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI13787215, Length=250, Percent_Identity=29.6, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI300797577, Length=259, Percent_Identity=25.8687258687259, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI308199517, Length=269, Percent_Identity=28.996282527881, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71990482, Length=256, Percent_Identity=40.625, Blast_Score=195, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71990487, Length=258, Percent_Identity=40.3100775193798, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17567771, Length=256, Percent_Identity=37.5, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17541892, Length=241, Percent_Identity=27.3858921161826, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28571445, Length=274, Percent_Identity=41.970802919708, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI28571443, Length=221, Percent_Identity=41.1764705882353, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI28571441, Length=221, Percent_Identity=41.1764705882353, Blast_Score=168, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 30571; Mature: 30571

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSPIRDLLDTLCQVMADKPFLVVTGAGISTASGIPDYRDKNGVRRGKQPMMYQEFLGN
CCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCC
PAARQRYWARAMLGWPRIRAAQANAAHLALAALQAEHAITGLITQNVDALHTQAGSRDVI
HHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHH
ELHGSLHRVLCLDCQQRSDRAGIQEQMLAHNLYLIGVHATQAPDGDTLLDPAFEASFEVP
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCEEEEEEEECCCCCCCCCCCCHHHCCCCCC
RCPHCGGDRLKPDVVFFGENVAAQTAARATQSVEDAEGLLVVGTSLMAWSAFRLCKAMAE
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHH
QGKPVIAINHGKTRADELLEMKIEASCEQALPWLAEQLVSP
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDSPIRDLLDTLCQVMADKPFLVVTGAGISTASGIPDYRDKNGVRRGKQPMMYQEFLGN
CCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCC
PAARQRYWARAMLGWPRIRAAQANAAHLALAALQAEHAITGLITQNVDALHTQAGSRDVI
HHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHH
ELHGSLHRVLCLDCQQRSDRAGIQEQMLAHNLYLIGVHATQAPDGDTLLDPAFEASFEVP
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCEEEEEEEECCCCCCCCCCCCHHHCCCCCC
RCPHCGGDRLKPDVVFFGENVAAQTAARATQSVEDAEGLLVVGTSLMAWSAFRLCKAMAE
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHH
QGKPVIAINHGKTRADELLEMKIEASCEQALPWLAEQLVSP
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]