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The map label for this gene is livH [H]

Identifier: 66045444

GI number: 66045444

Start: 2560701

End: 2561603

Strand: Reverse

Name: livH [H]

Synonym: Psyr_2204

Alternate gene names: 66045444

Gene position: 2561603-2560701 (Counterclockwise)

Preceding gene: 66045445

Following gene: 66045443

Centisome position: 42.04

GC content: 61.35

Gene sequence:

>903_bases
ATGACTCTCGATACGCTGGTAATGCAAGTCTTCAGCGGGTTCTCGCTGTTTTCCGTGCTGGTGCTGATGGCACTCGGGCT
GACCATCGTGTTCGGCCTGATGGGCGTGATCAACATGGCGCACGGCGAACTGATGGCGATGGGCTCATACATGACCTACG
TCACCTCCGTGGTGTTTCAGCGCTACTTTCCCGAGCTCATGGACTGGTATTTCATCATCGGCATCGGGATGGCCTTTGTG
GTGACCTTTGCCTTCGGTCTACTGCTGGAACGCTGCTTCATCCGCTTCATGTACAACCGGCCGCTCGACACCCTGCTGGC
GACCTGGGGGCTGTCTCTGGTCCTGCAGCAGCTGTTCCGCCAGGTCTTCGGCCCCAAGGAAGTCAGCGTGCCCACCGTGC
AGTGGTTGCAGGGCGCATGGAAAATCAGCGACGGGCTGGAGCTGCCCCTCAACCGGATTTTCATCATCGGTCTGACCTTC
GTGATAGCCGCTGCGGTGTTCCTGTTTCTCTACCGCAGCCGCTGGGGCCTGCGCATTCGCGCCGTGACCCAGAACCGCGC
CATGGCCGGTGCAGCCGGGATCAACACTGCGCGGGTCGACTCGGTGACCTTCGCGCTGGGCTGTGGCCTTGCGGGCATTG
CCGGCAGTTCGTTCACCATGCTTGCGTCCACCGGCCCGGTCAGCGGTCAGCAGTACCTGGTGGACACCTTCATCGTCGTC
GTGTTCGGCGGCGTGGAAAGCCTGCTGGGCACCTTCCTTTCGGCGTTCGCCATTGGCCAGACCCAGGTTTCGCTGGAATA
CCTGACCACCGGTTCCATGGCCAAGGCGATCACCCTGCTGGTGGTCATCGTGCTGCTGTTCTTCCGCCCCAACGGCCTGT
TCGCCACGAAAGTGAGACGTTGA

Upstream 100 bases:

>100_bases
ACCGATCGAGCCCAACCCCTTTCCCAAACTCTGATTCCGGCCCGGGCGCGATCCGCTTCGCGCCCGCTTTCGTCAATGTG
CAGCAACAGGTAGCGACGGC

Downstream 100 bases:

>100_bases
GATGAATGACATGACTGAAAAGCCGACGCTGCGGCCGCAGGCCTCGGTGTCCGGCGCCGGCAAGCCAGCGGGTGGCTGGT
TGACGCTGATCGAGCGCTAC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTLDTLVMQVFSGFSLFSVLVLMALGLTIVFGLMGVINMAHGELMAMGSYMTYVTSVVFQRYFPELMDWYFIIGIGMAFV
VTFAFGLLLERCFIRFMYNRPLDTLLATWGLSLVLQQLFRQVFGPKEVSVPTVQWLQGAWKISDGLELPLNRIFIIGLTF
VIAAAVFLFLYRSRWGLRIRAVTQNRAMAGAAGINTARVDSVTFALGCGLAGIAGSSFTMLASTGPVSGQQYLVDTFIVV
VFGGVESLLGTFLSAFAIGQTQVSLEYLTTGSMAKAITLLVVIVLLFFRPNGLFATKVRR

Sequences:

>Translated_300_residues
MTLDTLVMQVFSGFSLFSVLVLMALGLTIVFGLMGVINMAHGELMAMGSYMTYVTSVVFQRYFPELMDWYFIIGIGMAFV
VTFAFGLLLERCFIRFMYNRPLDTLLATWGLSLVLQQLFRQVFGPKEVSVPTVQWLQGAWKISDGLELPLNRIFIIGLTF
VIAAAVFLFLYRSRWGLRIRAVTQNRAMAGAAGINTARVDSVTFALGCGLAGIAGSSFTMLASTGPVSGQQYLVDTFIVV
VFGGVESLLGTFLSAFAIGQTQVSLEYLTTGSMAKAITLLVVIVLLFFRPNGLFATKVRR
>Mature_299_residues
TLDTLVMQVFSGFSLFSVLVLMALGLTIVFGLMGVINMAHGELMAMGSYMTYVTSVVFQRYFPELMDWYFIIGIGMAFVV
TFAFGLLLERCFIRFMYNRPLDTLLATWGLSLVLQQLFRQVFGPKEVSVPTVQWLQGAWKISDGLELPLNRIFIIGLTFV
IAAAVFLFLYRSRWGLRIRAVTQNRAMAGAAGINTARVDSVTFALGCGLAGIAGSSFTMLASTGPVSGQQYLVDTFIVVV
FGGVESLLGTFLSAFAIGQTQVSLEYLTTGSMAKAITLLVVIVLLFFRPNGLFATKVRR

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=297, Percent_Identity=27.6094276094276, Blast_Score=89, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 32946; Mature: 32815

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDTLVMQVFSGFSLFSVLVLMALGLTIVFGLMGVINMAHGELMAMGSYMTYVTSVVFQ
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
RYFPELMDWYFIIGIGMAFVVTFAFGLLLERCFIRFMYNRPLDTLLATWGLSLVLQQLFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
QVFGPKEVSVPTVQWLQGAWKISDGLELPLNRIFIIGLTFVIAAAVFLFLYRSRWGLRIR
HHCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
AVTQNRAMAGAAGINTARVDSVTFALGCGLAGIAGSSFTMLASTGPVSGQQYLVDTFIVV
EEECCCHHHCCCCCCHHHHHHHHHHHHCCHHHCCCCCEEEEECCCCCCCHHHHHHHHHHH
VFGGVESLLGTFLSAFAIGQTQVSLEYLTTGSMAKAITLLVVIVLLFFRPNGLFATKVRR
HHHHHHHHHHHHHHHHHHCCHHEEHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TLDTLVMQVFSGFSLFSVLVLMALGLTIVFGLMGVINMAHGELMAMGSYMTYVTSVVFQ
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
RYFPELMDWYFIIGIGMAFVVTFAFGLLLERCFIRFMYNRPLDTLLATWGLSLVLQQLFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
QVFGPKEVSVPTVQWLQGAWKISDGLELPLNRIFIIGLTFVIAAAVFLFLYRSRWGLRIR
HHCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
AVTQNRAMAGAAGINTARVDSVTFALGCGLAGIAGSSFTMLASTGPVSGQQYLVDTFIVV
EEECCCHHHCCCCCCHHHHHHHHHHHHCCHHHCCCCCEEEEECCCCCCCHHHHHHHHHHH
VFGGVESLLGTFLSAFAIGQTQVSLEYLTTGSMAKAITLLVVIVLLFFRPNGLFATKVRR
HHHHHHHHHHHHHHHHHHCCHHEEHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]