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The map label for this gene is aroE [H]

Identifier: 66045372

GI number: 66045372

Start: 2492164

End: 2493018

Strand: Reverse

Name: aroE [H]

Synonym: Psyr_2132

Alternate gene names: 66045372

Gene position: 2493018-2492164 (Counterclockwise)

Preceding gene: 66045374

Following gene: 66045369

Centisome position: 40.91

GC content: 63.51

Gene sequence:

>855_bases
ATGACTCATGCTGAAAAACCCTCCATCCTCGCCGGCCTGATCGGCTCGGGCATCCAGGCCTCGCGGACACCTGCCATGCA
CGAGCATGAAGGCGATGCACAAGGCATGCGCTATCTGTATCGGCTGATCGATATCGACGCCCTGCAACTGGACATCCATG
CCCTGCCCCAACTGCTGGAAGGTGCCAGGCAGTGCGGCTTCACCGGCCTGAATATCACCTTCCCCTGCAAGCAGGCGGTC
ATCCCGTTACTGGACGAGCTGTCCGACGAAGCGCGCGGTATCGGCGCGGTGAATACGGTGGTGTTCAAGGACGGCAAGCG
TATCGGTCACAACACCGACTGCCTGGGCTTTGCCGAAGGCTTTCAGCGCGGCCTGGACAAGGCCCCACGCCAACAGGTAG
TGCAGATGGGTGCAGGTGGCGCGGGCGCTGCCGTGGCTCATGCGCTGCTGAGCGCAGGCGTCGAGCGCCTCAGCGTGTTT
GAGGTCGAGCCGCAACGCGCCCAGGGGCTGGTGGACAACCTCAACCAGCACTTCGGTGCCGGACGCGCGCAGGTGGGTAC
CGACCTGCCTGCAGCGATGGCCGAAGCCGACGGGCTGGTCAATACCACGCCGGTCGGCATGACCAAACTGCCGGGTACGC
CGTTGCCGGTCGAGTTGCTGCGGCCTGAACTGTGGGTGGCGGAAATCATTTACTTTCCGCTGGAAACCGAACTGCTCAGG
CATGCCCGCGCACTGGGCTGCCGCACCCTGGATGGCAGCACCATGGCGGTGTTTCAGGCGGTCAAGGCCTTCGAACTGTT
CAGTGGCCAGTCCGCCGATGCAGAGCGGATGATGGCGCACTTCCACACGTTGTAA

Upstream 100 bases:

>100_bases
GTAATCGACTCCTGCCTGCGGCACTATTAACCATCTGGTACATTCTGTTTAACACCTGCCGCCAACCGGGCAGTGACACA
AAAACAAGAGACGTATTTTT

Downstream 100 bases:

>100_bases
ACATCAGCGCTTGAGATAACGCAACACAGCGTCGCAGATCATTGCCTTGTGACGCTGTTTGACCTCCTCGCTCCACAGCT
CGATCTGAAAGATTTCGCTG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MTHAEKPSILAGLIGSGIQASRTPAMHEHEGDAQGMRYLYRLIDIDALQLDIHALPQLLEGARQCGFTGLNITFPCKQAV
IPLLDELSDEARGIGAVNTVVFKDGKRIGHNTDCLGFAEGFQRGLDKAPRQQVVQMGAGGAGAAVAHALLSAGVERLSVF
EVEPQRAQGLVDNLNQHFGAGRAQVGTDLPAAMAEADGLVNTTPVGMTKLPGTPLPVELLRPELWVAEIIYFPLETELLR
HARALGCRTLDGSTMAVFQAVKAFELFSGQSADAERMMAHFHTL

Sequences:

>Translated_284_residues
MTHAEKPSILAGLIGSGIQASRTPAMHEHEGDAQGMRYLYRLIDIDALQLDIHALPQLLEGARQCGFTGLNITFPCKQAV
IPLLDELSDEARGIGAVNTVVFKDGKRIGHNTDCLGFAEGFQRGLDKAPRQQVVQMGAGGAGAAVAHALLSAGVERLSVF
EVEPQRAQGLVDNLNQHFGAGRAQVGTDLPAAMAEADGLVNTTPVGMTKLPGTPLPVELLRPELWVAEIIYFPLETELLR
HARALGCRTLDGSTMAVFQAVKAFELFSGQSADAERMMAHFHTL
>Mature_283_residues
THAEKPSILAGLIGSGIQASRTPAMHEHEGDAQGMRYLYRLIDIDALQLDIHALPQLLEGARQCGFTGLNITFPCKQAVI
PLLDELSDEARGIGAVNTVVFKDGKRIGHNTDCLGFAEGFQRGLDKAPRQQVVQMGAGGAGAAVAHALLSAGVERLSVFE
VEPQRAQGLVDNLNQHFGAGRAQVGTDLPAAMAEADGLVNTTPVGMTKLPGTPLPVELLRPELWVAEIIYFPLETELLRH
ARALGCRTLDGSTMAVFQAVKAFELFSGQSADAERMMAHFHTL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=273, Percent_Identity=30.03663003663, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789675, Length=269, Percent_Identity=27.8810408921933, Blast_Score=75, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320332, Length=277, Percent_Identity=26.7148014440433, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR013708
- InterPro:   IPR022893 [H]

Pfam domain/function: PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 30411; Mature: 30280

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHAEKPSILAGLIGSGIQASRTPAMHEHEGDAQGMRYLYRLIDIDALQLDIHALPQLLE
CCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GARQCGFTGLNITFPCKQAVIPLLDELSDEARGIGAVNTVVFKDGKRIGHNTDCLGFAEG
HHHHCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCHHHHEEEECCCCCCCCCCHHHHHHH
FQRGLDKAPRQQVVQMGAGGAGAAVAHALLSAGVERLSVFEVEPQRAQGLVDNLNQHFGA
HHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCC
GRAQVGTDLPAAMAEADGLVNTTPVGMTKLPGTPLPVELLRPELWVAEIIYFPLETELLR
CCHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHCHHHHHHH
HARALGCRTLDGSTMAVFQAVKAFELFSGQSADAERMMAHFHTL
HHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
THAEKPSILAGLIGSGIQASRTPAMHEHEGDAQGMRYLYRLIDIDALQLDIHALPQLLE
CCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GARQCGFTGLNITFPCKQAVIPLLDELSDEARGIGAVNTVVFKDGKRIGHNTDCLGFAEG
HHHHCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCHHHHEEEECCCCCCCCCCHHHHHHH
FQRGLDKAPRQQVVQMGAGGAGAAVAHALLSAGVERLSVFEVEPQRAQGLVDNLNQHFGA
HHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCC
GRAQVGTDLPAAMAEADGLVNTTPVGMTKLPGTPLPVELLRPELWVAEIIYFPLETELLR
CCHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHCHHHHHHH
HARALGCRTLDGSTMAVFQAVKAFELFSGQSADAERMMAHFHTL
HHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12692562; 11572948 [H]