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The map label for this gene is dac [H]

Identifier: 66045351

GI number: 66045351

Start: 2467163

End: 2468629

Strand: Reverse

Name: dac [H]

Synonym: Psyr_2111

Alternate gene names: 66045351

Gene position: 2468629-2467163 (Counterclockwise)

Preceding gene: 66045353

Following gene: 66045347

Centisome position: 40.51

GC content: 61.01

Gene sequence:

>1467_bases
ATGATCAAGTCGCTACGTCCATTGTTGCTCGCGTCACTCCTTTTGCCCCTGGCCCTACCCTCCTACGCTGCCGTCATCAA
CACCACGCTGCCCCCCAAGGTTCAACAGGCCCTGAAAGCCAGCAAACTCGGCGATGACGCACTCTCGCTGGTGATGCTGC
CGCTCAACGGCCCAGGTACACCGACCGTGTTCAACGCCGACGTATCGGTCAATCCGGCGTCTACCATGAAGCTGATTACC
ACCTACGCGGCCCTTGAAATGCTCGGCCCGACCCACCAGTGGAAAACCGAATTCTTCACCGACGGCACCCTGAGCAACGG
CGTGCTGCGCGGCAACCTGTACCTCAAGGGCGGCGGCGATCCCAAGCTGAATATGGAAAAGCTCTGGCTGCTGATGCGTG
ACCTGCGCGCCAATGGTGTACAGCAGGTGACCGGCGATCTGGTTCTCGACCGCAGTCATTTTGTGCAACCGCAATTGCCG
GTGTTCAACGATGACGGCAATGACGACAACAAGCCGTTTCTGGTCAAGCCCGACGCGCTGATGGTCAACCTCAAGGCGCT
ACGCTTCGTGACCCGCAATGATGACGGCAGGATTCTGGTCTCGGTCGAGCCGCCGATTGCCAGCATTCGCATTGATAATC
AGGTCAAGGCAAGCGCCTCGAAACAATGCACCGGGGATGTGCGCTACAACCCGGTCACCCAGGCGGATGGCAGCGTCAAC
GTGACGGTCACCGGCCAGTTGGGCAATGGCTGCAACTCACAGACCTACCTGTCACTGCTGGACCACCCTACCTATGCGGC
CGGCGCAGTGCGAGCCATCTGGCAGGAACTGGGCGGTACCATTCAAGGCAAGGATCGCGTTGGCGTGCTGCCCGGCAATG
CCAAGCTGTTGGCCAAGGCCTTTTCTCCGGACCTGGTGGAAGTCATTCGTGACATCAACAAATTCAGCAACAACACCATG
GCTCAGCAACTGTTCCTGAGCCTGGGCGAAGAGTTCCGCAACGAAGCTGACGGTGACGACGGCAAGGCCGCCCAGCGTGT
CATCCGTCAGTGGCTGGCGAAGAAAGGCATCACCGCGCCGCATCTGGTCATGGAGAATGGCTCCGGGCTGTCGCGGGCCG
AGCGTGTCAGCGCGCGCGAGATGGCGGTGATCCTGCAAGCGGCCTGGCGCAGCCCCTATGCTGCGGAATTCATGAGCTCG
ATGCCGCTGGCCGGTCTCGACGGAACCATGCGCAAGCGACTCAAGCGCACTCCGCTGCTCGGCGAGGCGCACATCAAGAC
CGGCACCCTGAATACCGTGCGCGCGATTGCCGGCTTCAGCCGCGACAGCAACGGCAACACCTGGGCCGTCGTGGCGATCC
TCAACGACCCGCGTCCGTTCGGCGCATCCTCGATACTCGACGAAGTACTGGTCGATCTGTACCGGCAGCCCAAGCTGACC
AACACCACCGTCTCGATCCAGCAATAA

Upstream 100 bases:

>100_bases
ACTATAGTTATCGAAATCGAATCTACATTTGCAATAGTTACCGAGGGAATTCATCCATGCCCTCTTTTTCGTTTCCCTCT
TTGCAGTAGGGTTTTAGTCA

Downstream 100 bases:

>100_bases
CCAGCCGATACCGGCCATCGGCAGACCCGCTATCGCAGCGGGTCTGTCTGCATCAACCCTGCTCGGGCTCGACCCGGTCG
CGACCGGCCTGTTTGGCGGC

Product: peptidase S13, D-Ala-D-Ala carboxypeptidase C

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein; PBP [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MIKSLRPLLLASLLLPLALPSYAAVINTTLPPKVQQALKASKLGDDALSLVMLPLNGPGTPTVFNADVSVNPASTMKLIT
TYAALEMLGPTHQWKTEFFTDGTLSNGVLRGNLYLKGGGDPKLNMEKLWLLMRDLRANGVQQVTGDLVLDRSHFVQPQLP
VFNDDGNDDNKPFLVKPDALMVNLKALRFVTRNDDGRILVSVEPPIASIRIDNQVKASASKQCTGDVRYNPVTQADGSVN
VTVTGQLGNGCNSQTYLSLLDHPTYAAGAVRAIWQELGGTIQGKDRVGVLPGNAKLLAKAFSPDLVEVIRDINKFSNNTM
AQQLFLSLGEEFRNEADGDDGKAAQRVIRQWLAKKGITAPHLVMENGSGLSRAERVSAREMAVILQAAWRSPYAAEFMSS
MPLAGLDGTMRKRLKRTPLLGEAHIKTGTLNTVRAIAGFSRDSNGNTWAVVAILNDPRPFGASSILDEVLVDLYRQPKLT
NTTVSIQQ

Sequences:

>Translated_488_residues
MIKSLRPLLLASLLLPLALPSYAAVINTTLPPKVQQALKASKLGDDALSLVMLPLNGPGTPTVFNADVSVNPASTMKLIT
TYAALEMLGPTHQWKTEFFTDGTLSNGVLRGNLYLKGGGDPKLNMEKLWLLMRDLRANGVQQVTGDLVLDRSHFVQPQLP
VFNDDGNDDNKPFLVKPDALMVNLKALRFVTRNDDGRILVSVEPPIASIRIDNQVKASASKQCTGDVRYNPVTQADGSVN
VTVTGQLGNGCNSQTYLSLLDHPTYAAGAVRAIWQELGGTIQGKDRVGVLPGNAKLLAKAFSPDLVEVIRDINKFSNNTM
AQQLFLSLGEEFRNEADGDDGKAAQRVIRQWLAKKGITAPHLVMENGSGLSRAERVSAREMAVILQAAWRSPYAAEFMSS
MPLAGLDGTMRKRLKRTPLLGEAHIKTGTLNTVRAIAGFSRDSNGNTWAVVAILNDPRPFGASSILDEVLVDLYRQPKLT
NTTVSIQQ
>Mature_488_residues
MIKSLRPLLLASLLLPLALPSYAAVINTTLPPKVQQALKASKLGDDALSLVMLPLNGPGTPTVFNADVSVNPASTMKLIT
TYAALEMLGPTHQWKTEFFTDGTLSNGVLRGNLYLKGGGDPKLNMEKLWLLMRDLRANGVQQVTGDLVLDRSHFVQPQLP
VFNDDGNDDNKPFLVKPDALMVNLKALRFVTRNDDGRILVSVEPPIASIRIDNQVKASASKQCTGDVRYNPVTQADGSVN
VTVTGQLGNGCNSQTYLSLLDHPTYAAGAVRAIWQELGGTIQGKDRVGVLPGNAKLLAKAFSPDLVEVIRDINKFSNNTM
AQQLFLSLGEEFRNEADGDDGKAAQRVIRQWLAKKGITAPHLVMENGSGLSRAERVSAREMAVILQAAWRSPYAAEFMSS
MPLAGLDGTMRKRLKRTPLLGEAHIKTGTLNTVRAIAGFSRDSNGNTWAVVAILNDPRPFGASSILDEVLVDLYRQPKLT
NTTVSIQQ

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG2027

COG function: function code M; D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S13 family [H]

Homologues:

Organism=Escherichia coli, GI1789573, Length=405, Percent_Identity=28.3950617283951, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR000667 [H]

Pfam domain/function: PF02113 Peptidase_S13 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 52917; Mature: 52917

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKSLRPLLLASLLLPLALPSYAAVINTTLPPKVQQALKASKLGDDALSLVMLPLNGPGT
CCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCC
PTVFNADVSVNPASTMKLITTYAALEMLGPTHQWKTEFFTDGTLSNGVLRGNLYLKGGGD
CEEEECCEECCCHHHHHHHHHHHHHHHHCCCCHHCHHEECCCCCCCCEEEEEEEEECCCC
PKLNMEKLWLLMRDLRANGVQQVTGDLVLDRSHFVQPQLPVFNDDGNDDNKPFLVKPDAL
CCCCHHHHHHHHHHHHCCCHHHHHHHEEECHHHCCCCCCCEECCCCCCCCCCEEECCCHH
MVNLKALRFVTRNDDGRILVSVEPPIASIRIDNQVKASASKQCTGDVRYNPVTQADGSVN
EEEHHHHEEEEECCCCEEEEEECCCCEEEEECCCHHCCCCCCCCCCCCCCCCCCCCCEEE
VTVTGQLGNGCNSQTYLSLLDHPTYAAGAVRAIWQELGGTIQGKDRVGVLPGNAKLLAKA
EEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCEEECCCEEEECCCCHHHHHHH
FSPDLVEVIRDINKFSNNTMAQQLFLSLGEEFRNEADGDDGKAAQRVIRQWLAKKGITAP
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCC
HLVMENGSGLSRAERVSAREMAVILQAAWRSPYAAEFMSSMPLAGLDGTMRKRLKRTPLL
EEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCC
GEAHIKTGTLNTVRAIAGFSRDSNGNTWAVVAILNDPRPFGASSILDEVLVDLYRQPKLT
CCCEECCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCC
NTTVSIQQ
CCEEEEEC
>Mature Secondary Structure
MIKSLRPLLLASLLLPLALPSYAAVINTTLPPKVQQALKASKLGDDALSLVMLPLNGPGT
CCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCC
PTVFNADVSVNPASTMKLITTYAALEMLGPTHQWKTEFFTDGTLSNGVLRGNLYLKGGGD
CEEEECCEECCCHHHHHHHHHHHHHHHHCCCCHHCHHEECCCCCCCCEEEEEEEEECCCC
PKLNMEKLWLLMRDLRANGVQQVTGDLVLDRSHFVQPQLPVFNDDGNDDNKPFLVKPDAL
CCCCHHHHHHHHHHHHCCCHHHHHHHEEECHHHCCCCCCCEECCCCCCCCCCEEECCCHH
MVNLKALRFVTRNDDGRILVSVEPPIASIRIDNQVKASASKQCTGDVRYNPVTQADGSVN
EEEHHHHEEEEECCCCEEEEEECCCCEEEEECCCHHCCCCCCCCCCCCCCCCCCCCCEEE
VTVTGQLGNGCNSQTYLSLLDHPTYAAGAVRAIWQELGGTIQGKDRVGVLPGNAKLLAKA
EEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCEEECCCEEEECCCCHHHHHHH
FSPDLVEVIRDINKFSNNTMAQQLFLSLGEEFRNEADGDDGKAAQRVIRQWLAKKGITAP
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCC
HLVMENGSGLSRAERVSAREMAVILQAAWRSPYAAEFMSSMPLAGLDGTMRKRLKRTPLL
EEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCC
GEAHIKTGTLNTVRAIAGFSRDSNGNTWAVVAILNDPRPFGASSILDEVLVDLYRQPKLT
CCCEECCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCC
NTTVSIQQ
CCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1554361; 7305936 [H]