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The map label for this gene is hlyB [H]

Identifier: 66045299

GI number: 66045299

Start: 2405242

End: 2406717

Strand: Reverse

Name: hlyB [H]

Synonym: Psyr_2059

Alternate gene names: 66045299

Gene position: 2406717-2405242 (Counterclockwise)

Preceding gene: 66045300

Following gene: 66045298

Centisome position: 39.5

GC content: 62.87

Gene sequence:

>1476_bases
ATGGCCTCATGGCTTGGCAACCTGTCACTGAAATACAAGTTCTGGGCCGTCAACGCGGTCGCTTTCGTCACCACCCTGTT
GCTGGTGCTGTACGCCATGCAGACAGAGCAACAAGCGCGGACCGATGTGTCGCGTCAGGCAGCACAAGCGCAGGCGCGCC
TGCTGGCCGCCTGGCCCGTCGACGCAGCACTGCCCTCCAGCGATACAATACTGACTTACCGCCAGGGTCAGACACCGGTT
GTCGATGGCCTGGCGCTGCCGGAACTGGCTGACGCCCGCAACTGGGTGGCGCTGGACAAACCCGTCGGCGATCGATGGCT
GAGCGGTGCGCAGATCATCACTCGCGGCGCCGAGCAACGGATTGCGCTACTGGCATTCACCCCGACCTTCATGCACATCC
TGCTGGATCGCTTCACGCATTACGCGGTCGCGGTTTTCGTGCTGATGCTGTTGATGCTCTGTGCCTCGCAGCTGCTGATC
CGCTTTCTGCTCAGCCAGCTCAACGCGCTCAAGGATGTGATGCTGCACGTCGAAAAAAGCGGCGACCTGGCGGCCCGTGT
TCCCAACCGCAGTGACGATGAGGTCGGACAGATGGCCAAGGCCTTCAATGCCATGCAGGCCGGTTACCAGCGGGTGGTCA
ACACCGTTTCGCAAACTGCCGGGCGCCTCGATCAGGGCGCCGCGCATCTGGCGGCAGGCATGAAGGAGGTGCGCCAGGGC
ATGCTCGGCCAGCAAAGCGAAACCGACCAAGTGGCCACGGCCATCAACGAGATGACTGCCACGGTCCATCACATTGCCCA
GCACGCCACGGCCACCCGTGATCAGTCGCAGACCGCCGACGCACTGGCGGGCAGTGGCAAGGTGGTGGTCGACCGCGTGC
AAGTGTCCATCGCCGGGCTTTCCAGCGGCGTGCAGCAAACGGCGGAAATGATCCAGCGCATGGCCGAAGACAGCCAGAAG
ATCAACGGCGTGGTCAACGTCATCCACAGCATTGCCGAACAAACCAATCTGCTCGCCCTCAACGCAGCCATCGAGGCCGC
ACGCGCCGGGGAAATGGGTCGGGGTTTTGCCGTGGTCGCCGATGAGGTACGCAATCTGGCGAAGCGGGTGCAGACCTCCA
CCGATGAAATCACCACGATGGTCTCGACCCTGCAAAGCGGCACCCGCGATGCCGTGGATTTCATGCAGGAAAGCTCGCAC
AAGGCTGAAGAATGCCTGCAGCAGGCGCGGGAAGCGGGTGATGCGCTGGCGGCGATTGCCGGTGCCGTGGCACAGATGCG
CGAAAGCAATACGCAGATCGCCGTGGCGGCCCAGCAGCAAAGCCAGGTCGCCGAGGAGATGAACCGTGCGGTGGTGAGTA
TCCGCGATGTCACCGAACGCACGGTGATCCAGACGGTTGACTCGGCCAGCACCAGTGACGAGCTGGCTACGCTGGCAGGC
GAACTGAATGCCGCCATTGGCCAGCTCAAGCTGTAA

Upstream 100 bases:

>100_bases
TCTGCGGCTTTGTTGACCCGTATCAAAGGGCTCTTCGGTGGTTGAGGCACAGTGATGGCATCTTGCTGCTACTTCAACCG
ATTACCGAAGAAGACCCCTC

Downstream 100 bases:

>100_bases
CAGGCTATCGCCGCGATAGACAGGCTTGACTCGTCAGCCCTCTGCGCGCGGGCCTATCCTTCAGGCATTGAACGACGCTT
TACGCGTTGCCTGAAGAGGA

Product: histidine kinase, HAMP region: chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MASWLGNLSLKYKFWAVNAVAFVTTLLLVLYAMQTEQQARTDVSRQAAQAQARLLAAWPVDAALPSSDTILTYRQGQTPV
VDGLALPELADARNWVALDKPVGDRWLSGAQIITRGAEQRIALLAFTPTFMHILLDRFTHYAVAVFVLMLLMLCASQLLI
RFLLSQLNALKDVMLHVEKSGDLAARVPNRSDDEVGQMAKAFNAMQAGYQRVVNTVSQTAGRLDQGAAHLAAGMKEVRQG
MLGQQSETDQVATAINEMTATVHHIAQHATATRDQSQTADALAGSGKVVVDRVQVSIAGLSSGVQQTAEMIQRMAEDSQK
INGVVNVIHSIAEQTNLLALNAAIEAARAGEMGRGFAVVADEVRNLAKRVQTSTDEITTMVSTLQSGTRDAVDFMQESSH
KAEECLQQAREAGDALAAIAGAVAQMRESNTQIAVAAQQQSQVAEEMNRAVVSIRDVTERTVIQTVDSASTSDELATLAG
ELNAAIGQLKL

Sequences:

>Translated_491_residues
MASWLGNLSLKYKFWAVNAVAFVTTLLLVLYAMQTEQQARTDVSRQAAQAQARLLAAWPVDAALPSSDTILTYRQGQTPV
VDGLALPELADARNWVALDKPVGDRWLSGAQIITRGAEQRIALLAFTPTFMHILLDRFTHYAVAVFVLMLLMLCASQLLI
RFLLSQLNALKDVMLHVEKSGDLAARVPNRSDDEVGQMAKAFNAMQAGYQRVVNTVSQTAGRLDQGAAHLAAGMKEVRQG
MLGQQSETDQVATAINEMTATVHHIAQHATATRDQSQTADALAGSGKVVVDRVQVSIAGLSSGVQQTAEMIQRMAEDSQK
INGVVNVIHSIAEQTNLLALNAAIEAARAGEMGRGFAVVADEVRNLAKRVQTSTDEITTMVSTLQSGTRDAVDFMQESSH
KAEECLQQAREAGDALAAIAGAVAQMRESNTQIAVAAQQQSQVAEEMNRAVVSIRDVTERTVIQTVDSASTSDELATLAG
ELNAAIGQLKL
>Mature_490_residues
ASWLGNLSLKYKFWAVNAVAFVTTLLLVLYAMQTEQQARTDVSRQAAQAQARLLAAWPVDAALPSSDTILTYRQGQTPVV
DGLALPELADARNWVALDKPVGDRWLSGAQIITRGAEQRIALLAFTPTFMHILLDRFTHYAVAVFVLMLLMLCASQLLIR
FLLSQLNALKDVMLHVEKSGDLAARVPNRSDDEVGQMAKAFNAMQAGYQRVVNTVSQTAGRLDQGAAHLAAGMKEVRQGM
LGQQSETDQVATAINEMTATVHHIAQHATATRDQSQTADALAGSGKVVVDRVQVSIAGLSSGVQQTAEMIQRMAEDSQKI
NGVVNVIHSIAEQTNLLALNAAIEAARAGEMGRGFAVVADEVRNLAKRVQTSTDEITTMVSTLQSGTRDAVDFMQESSHK
AEECLQQAREAGDALAAIAGAVAQMRESNTQIAVAAQQQSQVAEEMNRAVVSIRDVTERTVIQTVDSASTSDELATLAGE
LNAAIGQLKL

Specific function: May form a pore through which the hemolysin can be exported [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=320, Percent_Identity=31.25, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1787690, Length=353, Percent_Identity=29.1784702549575, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788195, Length=310, Percent_Identity=32.5806451612903, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788194, Length=312, Percent_Identity=28.525641025641, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789453, Length=362, Percent_Identity=27.6243093922652, Blast_Score=92, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR000727 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 52760; Mature: 52628

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASWLGNLSLKYKFWAVNAVAFVTTLLLVLYAMQTEQQARTDVSRQAAQAQARLLAAWPV
CCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DAALPSSDTILTYRQGQTPVVDGLALPELADARNWVALDKPVGDRWLSGAQIITRGAEQR
CCCCCCCCCEEEEECCCCCCCCCCCCCHHHCCCCCEEECCCCCHHHHCCHHHHHCCHHHH
IALLAFTPTFMHILLDRFTHYAVAVFVLMLLMLCASQLLIRFLLSQLNALKDVMLHVEKS
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GDLAARVPNRSDDEVGQMAKAFNAMQAGYQRVVNTVSQTAGRLDQGAAHLAAGMKEVRQG
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLGQQSETDQVATAINEMTATVHHIAQHATATRDQSQTADALAGSGKVVVDRVQVSIAGL
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEHHHHHHHHHH
SSGVQQTAEMIQRMAEDSQKINGVVNVIHSIAEQTNLLALNAAIEAARAGEMGRGFAVVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
DEVRNLAKRVQTSTDEITTMVSTLQSGTRDAVDFMQESSHKAEECLQQAREAGDALAAIA
HHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
GAVAQMRESNTQIAVAAQQQSQVAEEMNRAVVSIRDVTERTVIQTVDSASTSDELATLAG
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ELNAAIGQLKL
HHHHHHHHCCC
>Mature Secondary Structure 
ASWLGNLSLKYKFWAVNAVAFVTTLLLVLYAMQTEQQARTDVSRQAAQAQARLLAAWPV
CCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DAALPSSDTILTYRQGQTPVVDGLALPELADARNWVALDKPVGDRWLSGAQIITRGAEQR
CCCCCCCCCEEEEECCCCCCCCCCCCCHHHCCCCCEEECCCCCHHHHCCHHHHHCCHHHH
IALLAFTPTFMHILLDRFTHYAVAVFVLMLLMLCASQLLIRFLLSQLNALKDVMLHVEKS
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GDLAARVPNRSDDEVGQMAKAFNAMQAGYQRVVNTVSQTAGRLDQGAAHLAAGMKEVRQG
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLGQQSETDQVATAINEMTATVHHIAQHATATRDQSQTADALAGSGKVVVDRVQVSIAGL
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEHHHHHHHHHH
SSGVQQTAEMIQRMAEDSQKINGVVNVIHSIAEQTNLLALNAAIEAARAGEMGRGFAVVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
DEVRNLAKRVQTSTDEITTMVSTLQSGTRDAVDFMQESSHKAEECLQQAREAGDALAAIA
HHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
GAVAQMRESNTQIAVAAQQQSQVAEEMNRAVVSIRDVTERTVIQTVDSASTSDELATLAG
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ELNAAIGQLKL
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2162464; 10952301 [H]