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The map label for this gene is gltA [H]

Identifier: 66045244

GI number: 66045244

Start: 2324521

End: 2325810

Strand: Reverse

Name: gltA [H]

Synonym: Psyr_2004

Alternate gene names: 66045244

Gene position: 2325810-2324521 (Counterclockwise)

Preceding gene: 66045254

Following gene: 66045234

Centisome position: 38.17

GC content: 59.53

Gene sequence:

>1290_bases
ATGGCTGACAAAAAAGCGCAGTTGATCATCGAGGGCGCTGCCCCCGTCGAGCTGCCAATTCTGACCGGTACAGTGGGTCC
GGACGTGATCGACGTACGCGGCCTGACCGCCACCGGCCGCTTCACATTTGACCCTGGTTTCATGTCCACGGCGTCTTGCG
ATTCGAAGATCACCTACATCGATGGTGACAATGGCATTCTGCTGCACCGCGGCTACCCGATCGAACAACTGGCCGAGCAG
TCCGACTACCTCGAAACCTGCTACCTGCTGCTCAACGGCGAACTGCCCACCGCCGAGCAGAAAGCCCAGTTCGTGGCCGT
GGTCAAGAACCACACGATGGTTCACGAGCAACTCAAGACCTTTTTCAACGGTTTCCGTCGCGACGCCCACCCGATGGCCG
TCATGTGTGGCGTAGTCGGTGCCCTGTCAGCGTTCTACCACGACTCGCTGGACATCAATAACCCGCAGCACCGCGAGATT
TCCGCGGTACGCCTGGTCGCCAAGATGCCGACCCTGGCAGCGATGGTCTACAAGTACTCCATGGGTCAGCCCATGATGTA
CCCGCGCAACGACCTCAGCTACGCGGAAAACTTCCTGCACATGATGTTCAACACCCCGTGCGAGATCAAACCGATCAGCC
CGGTGCTGGCCAAGGCGATGGACAAGATCTTCATCCTCCACGCCGATCACGAGCAGAACGCTTCGACCTCCACCGTGCGC
ATGGCAGGCTCTTCGGGCGCCAACCCGTTCGCCTGTATCGCAGCCGGCATCGCAGCGCTCTGGGGCCCTGCCCACGGCGG
CGCCAACGAAGCGGTACTGACCATGCTCGATGAAATCGGCGATGTGTCGAACATCGACACGTTCATTGCCAAGGCCAAGG
ACAAGAACGATCCGTTCAAGCTCATGGGCTTCGGTCACCGCGTCTACAAGAACCGTGACCCGCGCGCCACTGTAATGAAG
CAGACCTGCGACGAAGTACTGAAAGAGCTGGGCATCACCAACGATCCTCAACTCGAACTGGCCATGCGCCTCGAAGAGAT
CGCCCTGACCGATCCGTACTTCATCGAGCGCTCGCTGTACCCGAACGTCGACTTCTATTCGGGCATCATCCTCAAGGCCA
TCGGCATTCCGACCAGCATGTTCACCGTGATCTTCGCCCTGGCGCGGACTGTCGGCTGGATCTCGCACTGGAAAGAAATG
CTCTCCAGCCCTTACAAGATCGGTCGCCCTCGCCAGCTGTACACCGGCAACGTGCAACGCGACATCGTCGCCCTGCAAGA
CCGCAAGTAA

Upstream 100 bases:

>100_bases
CGACTTTAGGCAAATTGACTTTAGAATTTATCTCACTATAGTGATGCGGGCCCTGCGTGGGGGGCCTGTCTGATGATTTG
AAGCATAAATAGGAGGCCAC

Downstream 100 bases:

>100_bases
GCGCCACACGCAAAAAAAAGGGCTGCCATTGGCAGCCCTTTTTTTATGCGCGCTATCCGGTGCGGATCATTTGGTTTGCG
CGGCACGCTCCCTGAGCGCT

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MADKKAQLIIEGAAPVELPILTGTVGPDVIDVRGLTATGRFTFDPGFMSTASCDSKITYIDGDNGILLHRGYPIEQLAEQ
SDYLETCYLLLNGELPTAEQKAQFVAVVKNHTMVHEQLKTFFNGFRRDAHPMAVMCGVVGALSAFYHDSLDINNPQHREI
SAVRLVAKMPTLAAMVYKYSMGQPMMYPRNDLSYAENFLHMMFNTPCEIKPISPVLAKAMDKIFILHADHEQNASTSTVR
MAGSSGANPFACIAAGIAALWGPAHGGANEAVLTMLDEIGDVSNIDTFIAKAKDKNDPFKLMGFGHRVYKNRDPRATVMK
QTCDEVLKELGITNDPQLELAMRLEEIALTDPYFIERSLYPNVDFYSGIILKAIGIPTSMFTVIFALARTVGWISHWKEM
LSSPYKIGRPRQLYTGNVQRDIVALQDRK

Sequences:

>Translated_429_residues
MADKKAQLIIEGAAPVELPILTGTVGPDVIDVRGLTATGRFTFDPGFMSTASCDSKITYIDGDNGILLHRGYPIEQLAEQ
SDYLETCYLLLNGELPTAEQKAQFVAVVKNHTMVHEQLKTFFNGFRRDAHPMAVMCGVVGALSAFYHDSLDINNPQHREI
SAVRLVAKMPTLAAMVYKYSMGQPMMYPRNDLSYAENFLHMMFNTPCEIKPISPVLAKAMDKIFILHADHEQNASTSTVR
MAGSSGANPFACIAAGIAALWGPAHGGANEAVLTMLDEIGDVSNIDTFIAKAKDKNDPFKLMGFGHRVYKNRDPRATVMK
QTCDEVLKELGITNDPQLELAMRLEEIALTDPYFIERSLYPNVDFYSGIILKAIGIPTSMFTVIFALARTVGWISHWKEM
LSSPYKIGRPRQLYTGNVQRDIVALQDRK
>Mature_428_residues
ADKKAQLIIEGAAPVELPILTGTVGPDVIDVRGLTATGRFTFDPGFMSTASCDSKITYIDGDNGILLHRGYPIEQLAEQS
DYLETCYLLLNGELPTAEQKAQFVAVVKNHTMVHEQLKTFFNGFRRDAHPMAVMCGVVGALSAFYHDSLDINNPQHREIS
AVRLVAKMPTLAAMVYKYSMGQPMMYPRNDLSYAENFLHMMFNTPCEIKPISPVLAKAMDKIFILHADHEQNASTSTVRM
AGSSGANPFACIAAGIAALWGPAHGGANEAVLTMLDEIGDVSNIDTFIAKAKDKNDPFKLMGFGHRVYKNRDPRATVMKQ
TCDEVLKELGITNDPQLELAMRLEEIALTDPYFIERSLYPNVDFYSGIILKAIGIPTSMFTVIFALARTVGWISHWKEML
SSPYKIGRPRQLYTGNVQRDIVALQDRK

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=422, Percent_Identity=25.8293838862559, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1786939, Length=422, Percent_Identity=71.8009478672986, Blast_Score=655, Evalue=0.0,
Organism=Escherichia coli, GI1786527, Length=370, Percent_Identity=32.1621621621622, Blast_Score=158, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17555174, Length=405, Percent_Identity=26.1728395061728, Blast_Score=107, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6325257, Length=411, Percent_Identity=25.5474452554745, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6319850, Length=365, Percent_Identity=26.027397260274, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6324328, Length=339, Percent_Identity=26.2536873156342, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24640126, Length=423, Percent_Identity=26.4775413711584, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24640124, Length=423, Percent_Identity=26.4775413711584, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI21356863, Length=368, Percent_Identity=26.3586956521739, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 47534; Mature: 47403

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKKAQLIIEGAAPVELPILTGTVGPDVIDVRGLTATGRFTFDPGFMSTASCDSKITYI
CCCCCCEEEEECCCCEEEEEEECCCCCCEEEECCCEECCEEEECCCCCCCCCCCCEEEEE
DGDNGILLHRGYPIEQLAEQSDYLETCYLLLNGELPTAEQKAQFVAVVKNHTMVHEQLKT
ECCCCEEEECCCCHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FFNGFRRDAHPMAVMCGVVGALSAFYHDSLDINNPQHREISAVRLVAKMPTLAAMVYKYS
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MGQPMMYPRNDLSYAENFLHMMFNTPCEIKPISPVLAKAMDKIFILHADHEQNASTSTVR
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCEEEEEECCCCCCCCCCEEE
MAGSSGANPFACIAAGIAALWGPAHGGANEAVLTMLDEIGDVSNIDTFIAKAKDKNDPFK
ECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEE
LMGFGHRVYKNRDPRATVMKQTCDEVLKELGITNDPQLELAMRLEEIALTDPYFIERSLY
EEECCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCC
PNVDFYSGIILKAIGIPTSMFTVIFALARTVGWISHWKEMLSSPYKIGRPRQLYTGNVQR
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCHH
DIVALQDRK
EEEEECCCC
>Mature Secondary Structure 
ADKKAQLIIEGAAPVELPILTGTVGPDVIDVRGLTATGRFTFDPGFMSTASCDSKITYI
CCCCCEEEEECCCCEEEEEEECCCCCCEEEECCCEECCEEEECCCCCCCCCCCCEEEEE
DGDNGILLHRGYPIEQLAEQSDYLETCYLLLNGELPTAEQKAQFVAVVKNHTMVHEQLKT
ECCCCEEEECCCCHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FFNGFRRDAHPMAVMCGVVGALSAFYHDSLDINNPQHREISAVRLVAKMPTLAAMVYKYS
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MGQPMMYPRNDLSYAENFLHMMFNTPCEIKPISPVLAKAMDKIFILHADHEQNASTSTVR
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCEEEEEECCCCCCCCCCEEE
MAGSSGANPFACIAAGIAALWGPAHGGANEAVLTMLDEIGDVSNIDTFIAKAKDKNDPFK
ECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEE
LMGFGHRVYKNRDPRATVMKQTCDEVLKELGITNDPQLELAMRLEEIALTDPYFIERSLY
EEECCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCC
PNVDFYSGIILKAIGIPTSMFTVIFALARTVGWISHWKEMLSSPYKIGRPRQLYTGNVQR
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCHH
DIVALQDRK
EEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2507528; 10984043 [H]