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The map label for this gene is pdxB [H]

Identifier: 66045072

GI number: 66045072

Start: 2108925

End: 2110067

Strand: Direct

Name: pdxB [H]

Synonym: Psyr_1828

Alternate gene names: 66045072

Gene position: 2108925-2110067 (Clockwise)

Preceding gene: 66045071

Following gene: 66045074

Centisome position: 34.61

GC content: 64.39

Gene sequence:

>1143_bases
ATGCGCATTGTTGCCGACGAAAATATTCCCCTGCTCGACGCCTTTTTTGCTCATTTTGGTGAAATCCATCGCTTGCCGGG
CCGCGCCATGGATCGCGCCGCGGTGGCGGATGCCGACATCCTGCTGGTTCGCTCGGTCACCGCAGTGACCCGCGAACTGC
TTGAAGGCAGCCCGGTACGTTTTGTCGGGACCTGCACCATCGGCACCGATCACCTGGATCTGGACTGGTTTCAGCAAGCC
GGTATCCAGTGGGCCAGTGCTCCGGGCTGCAATGCGCGTGGCGTGGTGGACTACGTGCTCGGCAGCCTGCTGACCCTGGC
TGAAATCGAAGGTGTCGACCTTGCGCAGCGCACCTACGGAGTGGTCGGTGCAGGGCAGGTGGGTGCTCGGCTGATCAGCG
TATTGAAGGCCCTGGGCTGGAACGTGCTGGTCTGCGATCCGCCACGCCAGGCTGCCGAAGGCGGCGATTTCGTCAGCCTC
GACGAGATCCTGCAGCGCTGTGACGTCATCAGCCTGCACACGCCGCTGAGCAAAACCGGAGCGTCACCGACCTGGCATCT
GCTTGACGACGCGCGCCTGCGTCAGCTTCGGCAAGGCGCCTGGCTGATCAATGCCAGCCGTGGCGCCGTGGTGGATAACG
CGGCGCTGCATGACGTCCTGCTTGAGCGGGAAGACCTGCAGGCCGTGCTGGATGTGTGGGAAGGCGAGCCGCAGGTCAAC
GTCGCACTCGCTGATCTGTGCATTCTGGGGACGCCGCATATCGCCGGCTACAGCCTGGATGGCAGGCAGCGCGGCACGGC
ACAGATCTATCAGGCGCTGTGCGGCTTTCTTGATCAGCCTGCGACGATCGAGCTGGACGATCTGCTGCCAAAACCCTGGC
TGGCCCAGGTCAGTCTCGACGCGGCCTGCGACCCGGTCTGGGCACTTAACATGCTGTGCCGCGGCGTGTATGACCCGCGA
CGTGACGATGCGGACTTCCGCCGCAGCCTGACCGGTGACACCGCCAGCCAGCGTCTGGCCTTTGATGCATTGCGCAAGCA
GTACCCGCCACGCCGGGAAATAGAAGGGCTGAAGGTGCGCCTGGAGGGCGAGTCCGAGGCGTTGGCGCAACTGGTGCGGG
CGCTGGGTGCGGTGCTGGTCTGA

Upstream 100 bases:

>100_bases
AGTCCGACTGATCGCCATATCGCTGCAACCCGCGCCTGTTCACGACACGCCTGTTCCCGATTCGAGCAGGTCCCTGTTCG
CCAGACCCAGAGAGTCTTCC

Downstream 100 bases:

>100_bases
TCGCCAGCCGGGCTGGCGGACAATAAAAAACCCGACCAAGTGGTCGGGTTTCAAATGTCTGGTACGGCTCGGTTTTATTT
TTCCGGGGTTACCCAGTTCT

Product: erythronate-4-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MRIVADENIPLLDAFFAHFGEIHRLPGRAMDRAAVADADILLVRSVTAVTRELLEGSPVRFVGTCTIGTDHLDLDWFQQA
GIQWASAPGCNARGVVDYVLGSLLTLAEIEGVDLAQRTYGVVGAGQVGARLISVLKALGWNVLVCDPPRQAAEGGDFVSL
DEILQRCDVISLHTPLSKTGASPTWHLLDDARLRQLRQGAWLINASRGAVVDNAALHDVLLEREDLQAVLDVWEGEPQVN
VALADLCILGTPHIAGYSLDGRQRGTAQIYQALCGFLDQPATIELDDLLPKPWLAQVSLDAACDPVWALNMLCRGVYDPR
RDDADFRRSLTGDTASQRLAFDALRKQYPPRREIEGLKVRLEGESEALAQLVRALGAVLV

Sequences:

>Translated_380_residues
MRIVADENIPLLDAFFAHFGEIHRLPGRAMDRAAVADADILLVRSVTAVTRELLEGSPVRFVGTCTIGTDHLDLDWFQQA
GIQWASAPGCNARGVVDYVLGSLLTLAEIEGVDLAQRTYGVVGAGQVGARLISVLKALGWNVLVCDPPRQAAEGGDFVSL
DEILQRCDVISLHTPLSKTGASPTWHLLDDARLRQLRQGAWLINASRGAVVDNAALHDVLLEREDLQAVLDVWEGEPQVN
VALADLCILGTPHIAGYSLDGRQRGTAQIYQALCGFLDQPATIELDDLLPKPWLAQVSLDAACDPVWALNMLCRGVYDPR
RDDADFRRSLTGDTASQRLAFDALRKQYPPRREIEGLKVRLEGESEALAQLVRALGAVLV
>Mature_380_residues
MRIVADENIPLLDAFFAHFGEIHRLPGRAMDRAAVADADILLVRSVTAVTRELLEGSPVRFVGTCTIGTDHLDLDWFQQA
GIQWASAPGCNARGVVDYVLGSLLTLAEIEGVDLAQRTYGVVGAGQVGARLISVLKALGWNVLVCDPPRQAAEGGDFVSL
DEILQRCDVISLHTPLSKTGASPTWHLLDDARLRQLRQGAWLINASRGAVVDNAALHDVLLEREDLQAVLDVWEGEPQVN
VALADLCILGTPHIAGYSLDGRQRGTAQIYQALCGFLDQPATIELDDLLPKPWLAQVSLDAACDPVWALNMLCRGVYDPR
RDDADFRRSLTGDTASQRLAFDALRKQYPPRREIEGLKVRLEGESEALAQLVRALGAVLV

Specific function: Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=297, Percent_Identity=26.9360269360269, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI61743967, Length=303, Percent_Identity=26.7326732673267, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI4557497, Length=303, Percent_Identity=26.7326732673267, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI145580578, Length=277, Percent_Identity=25.6317689530686, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4557499, Length=277, Percent_Identity=25.6317689530686, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI145580575, Length=277, Percent_Identity=25.6317689530686, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI6912396, Length=295, Percent_Identity=27.4576271186441, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1788660, Length=368, Percent_Identity=49.1847826086957, Blast_Score=316, Evalue=1e-87,
Organism=Escherichia coli, GI1787645, Length=206, Percent_Identity=27.6699029126214, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789279, Length=281, Percent_Identity=28.1138790035587, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87082289, Length=251, Percent_Identity=27.8884462151394, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=263, Percent_Identity=26.615969581749, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322116, Length=287, Percent_Identity=26.8292682926829, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=304, Percent_Identity=26.6447368421053, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=269, Percent_Identity=25.6505576208178, Blast_Score=99, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24646446, Length=268, Percent_Identity=27.9850746268657, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646448, Length=268, Percent_Identity=27.9850746268657, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646452, Length=268, Percent_Identity=27.9850746268657, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646450, Length=268, Percent_Identity=27.9850746268657, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI62472511, Length=268, Percent_Identity=27.9850746268657, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921140, Length=289, Percent_Identity=25.2595155709343, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR020921
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.290 [H]

Molecular weight: Translated: 41377; Mature: 41377

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVADENIPLLDAFFAHFGEIHRLPGRAMDRAAVADADILLVRSVTAVTRELLEGSPVR
CEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEE
FVGTCTIGTDHLDLDWFQQAGIQWASAPGCNARGVVDYVLGSLLTLAEIEGVDLAQRTYG
EEEEEEECCCCCCHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHC
VVGAGQVGARLISVLKALGWNVLVCDPPRQAAEGGDFVSLDEILQRCDVISLHTPLSKTG
CCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHCCCCEECHHHHHHHCCEEEECCCHHHCC
ASPTWHLLDDARLRQLRQGAWLINASRGAVVDNAALHDVLLEREDLQAVLDVWEGEPQVN
CCCCEEHHHHHHHHHHHCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VALADLCILGTPHIAGYSLDGRQRGTAQIYQALCGFLDQPATIELDDLLPKPWLAQVSLD
EEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHCCCCCCHHHEECC
AACDPVWALNMLCRGVYDPRRDDADFRRSLTGDTASQRLAFDALRKQYPPRREIEGLKVR
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCEEEE
LEGESEALAQLVRALGAVLV
ECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIVADENIPLLDAFFAHFGEIHRLPGRAMDRAAVADADILLVRSVTAVTRELLEGSPVR
CEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEE
FVGTCTIGTDHLDLDWFQQAGIQWASAPGCNARGVVDYVLGSLLTLAEIEGVDLAQRTYG
EEEEEEECCCCCCHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHC
VVGAGQVGARLISVLKALGWNVLVCDPPRQAAEGGDFVSLDEILQRCDVISLHTPLSKTG
CCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHCCCCEECHHHHHHHCCEEEECCCHHHCC
ASPTWHLLDDARLRQLRQGAWLINASRGAVVDNAALHDVLLEREDLQAVLDVWEGEPQVN
CCCCEEHHHHHHHHHHHCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VALADLCILGTPHIAGYSLDGRQRGTAQIYQALCGFLDQPATIELDDLLPKPWLAQVSLD
EEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHCCCCCCHHHEECC
AACDPVWALNMLCRGVYDPRRDDADFRRSLTGDTASQRLAFDALRKQYPPRREIEGLKVR
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCEEEE
LEGESEALAQLVRALGAVLV
ECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA