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The map label for this gene is guaD [H]

Identifier: 66045056

GI number: 66045056

Start: 2085204

End: 2086538

Strand: Reverse

Name: guaD [H]

Synonym: Psyr_1812

Alternate gene names: 66045056

Gene position: 2086538-2085204 (Counterclockwise)

Preceding gene: 66045057

Following gene: 66045053

Centisome position: 34.24

GC content: 61.2

Gene sequence:

>1335_bases
ATGAGTCACAACGAGAGTGCCATGAGTTCAGTTTCCCGCCGTAAAGCCTACCGCGCCGCCATCGTTCACAGCCTAGCCGA
CCCGGCCGAAGTGGCGCTGGAGGCATCCTGTGAATACTTTGCCGACGGCTTGCTGCTGGTCGAGGACGGCAAGATCGTTT
CGGTGGGTCACGCTGCCGATCTGCTGGGGCGGCTCGACGACGATGTCGAGTTGATCGAGTACACGGACGCACTGATAACA
CCGGGGTTCATCGACACCCATATTCACTTGCCGCAAACCGGCATGATCGGCTCCTACGGCGAGCAATTGCTGGACTGGCT
CAACACCTACACCTTCCCCTGCGAAAGTCAGTTCGCCGACCCCGCGCATTCGGCGCAGGTGGCCGACATCTTCATCAAGG
AGCTGCTGCGCAACGGCACCACCACGGCGCTGGTGTTCGGCAGCGTGCACAAGGAATCGGTCGAGGCGTTTTTCAGCGCG
GCCCAGGCACTTGATCTGCGCATGATCGCCGGCAAGGTGATGATGGACCGCAATGCGCCGGATTATCTGGTCGATACGCC
AGAATCCGGGTATGCCGACAGCAAGGCACTGATCGAGCGCTGGCATGGCAAAGGTCGTTTGAGTTACGCAGTGACGCCGC
GATTCGCGCCGACCAGCAGCCCGGAGCAATTGAGCCTGGCCGGCCAGTTGCTCACCGAGTATCCCGGCCTGTACCTGCAG
ACCCACATCAGCGAGAACCTTCAGGAGATCGAGTGGGTCAAGGCGCTGTTCCCGGAGCGCAAGCATTACCTGGACGTCTA
CGATCACTTCAACCTGCTAGGCGAGCGCTCGGTGTTCGCCCATGGCGTTCACCTGTGCGACGAACAATGCGCCCGACTGG
CGCAGGCCGGTTCGGCGATTGCCTTCTGCCCGACCTCCAACCTGTTTTTGGGCAGCGGCCTGTTCAACCTGCCGATGGCC
GAGAAGCACAAGGTGAATGTCGGTCTGGGCACCGACGTGGGCGGCGGCACCAGCTTTTCGATTCTGCAGACCCTGAACGA
GGCCTACAAGGTCATGCAGATGCAGGGCGCACGGCTCAATCCGTTCAAGTCACTGTACCTGGCAACGCTGGGCGGCGCGC
GGGCGCTGCGTCTGGAAGACAAGGTCGGCAGCCTGAAGCCCGGCAACGAGGCCGACTTCCTGGTGCTCGACTACAACGCC
ACCCCACTGCTGTCGTATCGCTTGAAGCAGGCGAAGACTATCGAAGAGATTCTGTTCGTGCTGATGACCATCGGTGACGA
CCGGACGGTGAAGCAGACCTGGTCGGGTGGGCGATTGGTGCATGACAGAGGCTAG

Upstream 100 bases:

>100_bases
CGGAAATAATCGCCACTTACAATGTCAGCTTTGGCCAACACACCGCCAATGCCGAACCTATCGCCAGACTGCTGCCTGTA
TCGCGCCGCAGTCGGTCGCA

Downstream 100 bases:

>100_bases
CACCTCGTTCCTCACGCCCCAGCGTGCCAAGAGGACGCAGAGCGTCCGGAACGGCATGCCGACGCGGAGCGTCGCACGAT
AGTTGAATTACGACGCAGAG

Product: guanine deaminase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSHNESAMSSVSRRKAYRAAIVHSLADPAEVALEASCEYFADGLLLVEDGKIVSVGHAADLLGRLDDDVELIEYTDALIT
PGFIDTHIHLPQTGMIGSYGEQLLDWLNTYTFPCESQFADPAHSAQVADIFIKELLRNGTTTALVFGSVHKESVEAFFSA
AQALDLRMIAGKVMMDRNAPDYLVDTPESGYADSKALIERWHGKGRLSYAVTPRFAPTSSPEQLSLAGQLLTEYPGLYLQ
THISENLQEIEWVKALFPERKHYLDVYDHFNLLGERSVFAHGVHLCDEQCARLAQAGSAIAFCPTSNLFLGSGLFNLPMA
EKHKVNVGLGTDVGGGTSFSILQTLNEAYKVMQMQGARLNPFKSLYLATLGGARALRLEDKVGSLKPGNEADFLVLDYNA
TPLLSYRLKQAKTIEEILFVLMTIGDDRTVKQTWSGGRLVHDRG

Sequences:

>Translated_444_residues
MSHNESAMSSVSRRKAYRAAIVHSLADPAEVALEASCEYFADGLLLVEDGKIVSVGHAADLLGRLDDDVELIEYTDALIT
PGFIDTHIHLPQTGMIGSYGEQLLDWLNTYTFPCESQFADPAHSAQVADIFIKELLRNGTTTALVFGSVHKESVEAFFSA
AQALDLRMIAGKVMMDRNAPDYLVDTPESGYADSKALIERWHGKGRLSYAVTPRFAPTSSPEQLSLAGQLLTEYPGLYLQ
THISENLQEIEWVKALFPERKHYLDVYDHFNLLGERSVFAHGVHLCDEQCARLAQAGSAIAFCPTSNLFLGSGLFNLPMA
EKHKVNVGLGTDVGGGTSFSILQTLNEAYKVMQMQGARLNPFKSLYLATLGGARALRLEDKVGSLKPGNEADFLVLDYNA
TPLLSYRLKQAKTIEEILFVLMTIGDDRTVKQTWSGGRLVHDRG
>Mature_443_residues
SHNESAMSSVSRRKAYRAAIVHSLADPAEVALEASCEYFADGLLLVEDGKIVSVGHAADLLGRLDDDVELIEYTDALITP
GFIDTHIHLPQTGMIGSYGEQLLDWLNTYTFPCESQFADPAHSAQVADIFIKELLRNGTTTALVFGSVHKESVEAFFSAA
QALDLRMIAGKVMMDRNAPDYLVDTPESGYADSKALIERWHGKGRLSYAVTPRFAPTSSPEQLSLAGQLLTEYPGLYLQT
HISENLQEIEWVKALFPERKHYLDVYDHFNLLGERSVFAHGVHLCDEQCARLAQAGSAIAFCPTSNLFLGSGLFNLPMAE
KHKVNVGLGTDVGGGTSFSILQTLNEAYKVMQMQGARLNPFKSLYLATLGGARALRLEDKVGSLKPGNEADFLVLDYNAT
PLLSYRLKQAKTIEEILFVLMTIGDDRTVKQTWSGGRLVHDRG

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=446, Percent_Identity=35.2017937219731, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI1789249, Length=440, Percent_Identity=52.9545454545455, Blast_Score=495, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6319963, Length=395, Percent_Identity=32.9113924050633, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24643849, Length=439, Percent_Identity=35.7630979498861, Blast_Score=228, Evalue=5e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 48807; Mature: 48676

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHNESAMSSVSRRKAYRAAIVHSLADPAEVALEASCEYFADGLLLVEDGKIVSVGHAAD
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHCCEEEEECCCEEEECHHHH
LLGRLDDDVELIEYTDALITPGFIDTHIHLPQTGMIGSYGEQLLDWLNTYTFPCESQFAD
HHHCCCCCHHHHHHHHHHHCCCCEECEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
PAHSAQVADIFIKELLRNGTTTALVFGSVHKESVEAFFSAAQALDLRMIAGKVMMDRNAP
CCCCHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
DYLVDTPESGYADSKALIERWHGKGRLSYAVTPRFAPTSSPEQLSLAGQLLTEYPGLYLQ
CCEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEE
THISENLQEIEWVKALFPERKHYLDVYDHFNLLGERSVFAHGVHLCDEQCARLAQAGSAI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEE
AFCPTSNLFLGSGLFNLPMAEKHKVNVGLGTDVGGGTSFSILQTLNEAYKVMQMQGARLN
EECCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
PFKSLYLATLGGARALRLEDKVGSLKPGNEADFLVLDYNATPLLSYRLKQAKTIEEILFV
HHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
LMTIGDDRTVKQTWSGGRLVHDRG
HHHCCCCCCHHHHCCCCEEECCCC
>Mature Secondary Structure 
SHNESAMSSVSRRKAYRAAIVHSLADPAEVALEASCEYFADGLLLVEDGKIVSVGHAAD
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHCCEEEEECCCEEEECHHHH
LLGRLDDDVELIEYTDALITPGFIDTHIHLPQTGMIGSYGEQLLDWLNTYTFPCESQFAD
HHHCCCCCHHHHHHHHHHHCCCCEECEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
PAHSAQVADIFIKELLRNGTTTALVFGSVHKESVEAFFSAAQALDLRMIAGKVMMDRNAP
CCCCHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
DYLVDTPESGYADSKALIERWHGKGRLSYAVTPRFAPTSSPEQLSLAGQLLTEYPGLYLQ
CCEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEE
THISENLQEIEWVKALFPERKHYLDVYDHFNLLGERSVFAHGVHLCDEQCARLAQAGSAI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEE
AFCPTSNLFLGSGLFNLPMAEKHKVNVGLGTDVGGGTSFSILQTLNEAYKVMQMQGARLN
EECCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
PFKSLYLATLGGARALRLEDKVGSLKPGNEADFLVLDYNATPLLSYRLKQAKTIEEILFV
HHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
LMTIGDDRTVKQTWSGGRLVHDRG
HHHCCCCCCHHHHCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]