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The map label for this gene is folD1 [H]

Identifier: 66044988

GI number: 66044988

Start: 1980210

End: 1981064

Strand: Reverse

Name: folD1 [H]

Synonym: Psyr_1743

Alternate gene names: 66044988

Gene position: 1981064-1980210 (Counterclockwise)

Preceding gene: 66044989

Following gene: 66044981

Centisome position: 32.51

GC content: 64.09

Gene sequence:

>855_bases
ATGACTGCAAAACTAATCGACGGCAAGGCGATCGCCGCCAGCCTGCGCCAGCAGATCGCCAAACGTGTCGCCGAACGTAG
CCAGCAAGGTCTGCGTACGCCGGGCCTCGCGGTGATTCTGGTCGGCAGCGACCCCGCCTCCCAAGTCTATGTCTCTCACA
AGCGCAAGGACTGCGAGGAAGTCGGCTTTATCTCCCAGGCTTACGACTTGCCCGCTGATACCACTCAGGCAGCACTGACC
GATCTGATCGACCGCCTCAATGAAGATGCCGCCGTCGACGGCGTCCTGCTGCAACTGCCCTTGCCCGCGCACCTCGACGC
TTCGCTGCTGCTGGAGCGCATTCGCCCGGACAAGGACGTGGACGGCTTCCATCCTTATAACGTGGGTCGCCTCGCTCAAC
GCATTCCGCTGCTGCGCCCGTGCACTCCCAAAGGCATCATGACCCTGCTGGAAAGCACCGGTGTCGACCTGTACGGCCTG
GATGCCGTCGTCGTCGGCGCATCCAACATCGTCGGCCGCCCGATGGCAATGGAACTGCTGCTGGCGGGCTGCACCGTCAC
GGTGACCCATCGTTTCACCAGGGATCTGGCAGGCCACGTGGGTCGTGCCGATCTGGTGGTGGTTGCCGCCGGCAAGCCGG
GCCTTGTCAAAGGCGAATGGATCAAGCCGGGCGCGATCGTCATCGACGTCGGCATCAACCGCCAGGAAGACGGCAAGCTG
GTAGGCGATGTGGTTTACGAGACCGCCCTGCCCCGCGCTGGCTGGATCACTCCGGTTCCGGGCGGCGTCGGCCCCATGAC
CCGCGCCTGCCTGCTGGAAAACACGCTGTACGCGGCAGAAACCCTGCACGACTGA

Upstream 100 bases:

>100_bases
AGGAGTTAGCTGAATATGCAAAGCAATCGCCTTTGCCCTCGCGCCATGTCATGAGAGAATGCGCACTCATTTTTTTCCTC
TCGATGGTTAATCACGCGTC

Downstream 100 bases:

>100_bases
TCAGGCTGTTCTGCTCCCATAAAAAACGGCACCTGAGGTGCCGTTTTTTCATTCCCGAAAAAACTTACTTCCTGGCTGCT
TCCCAGCTTTTCAGCAAGTC

Product: bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MTAKLIDGKAIAASLRQQIAKRVAERSQQGLRTPGLAVILVGSDPASQVYVSHKRKDCEEVGFISQAYDLPADTTQAALT
DLIDRLNEDAAVDGVLLQLPLPAHLDASLLLERIRPDKDVDGFHPYNVGRLAQRIPLLRPCTPKGIMTLLESTGVDLYGL
DAVVVGASNIVGRPMAMELLLAGCTVTVTHRFTRDLAGHVGRADLVVVAAGKPGLVKGEWIKPGAIVIDVGINRQEDGKL
VGDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAETLHD

Sequences:

>Translated_284_residues
MTAKLIDGKAIAASLRQQIAKRVAERSQQGLRTPGLAVILVGSDPASQVYVSHKRKDCEEVGFISQAYDLPADTTQAALT
DLIDRLNEDAAVDGVLLQLPLPAHLDASLLLERIRPDKDVDGFHPYNVGRLAQRIPLLRPCTPKGIMTLLESTGVDLYGL
DAVVVGASNIVGRPMAMELLLAGCTVTVTHRFTRDLAGHVGRADLVVVAAGKPGLVKGEWIKPGAIVIDVGINRQEDGKL
VGDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAETLHD
>Mature_283_residues
TAKLIDGKAIAASLRQQIAKRVAERSQQGLRTPGLAVILVGSDPASQVYVSHKRKDCEEVGFISQAYDLPADTTQAALTD
LIDRLNEDAAVDGVLLQLPLPAHLDASLLLERIRPDKDVDGFHPYNVGRLAQRIPLLRPCTPKGIMTLLESTGVDLYGLD
AVVVGASNIVGRPMAMELLLAGCTVTVTHRFTRDLAGHVGRADLVVVAAGKPGLVKGEWIKPGAIVIDVGINRQEDGKLV
GDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAETLHD

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate [H]

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=292, Percent_Identity=44.1780821917808, Blast_Score=221, Evalue=5e-58,
Organism=Homo sapiens, GI222418558, Length=295, Percent_Identity=43.3898305084746, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI94721354, Length=295, Percent_Identity=44.0677966101695, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI36796743, Length=225, Percent_Identity=29.7777777777778, Blast_Score=85, Evalue=6e-17,
Organism=Escherichia coli, GI1786741, Length=284, Percent_Identity=67.2535211267606, Blast_Score=401, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17568735, Length=292, Percent_Identity=40.0684931506849, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6321643, Length=299, Percent_Identity=44.4816053511706, Blast_Score=236, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6319558, Length=285, Percent_Identity=43.5087719298246, Blast_Score=220, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6322933, Length=311, Percent_Identity=27.9742765273312, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136818, Length=297, Percent_Identity=47.1380471380471, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI17136816, Length=297, Percent_Identity=47.1380471380471, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI62472483, Length=287, Percent_Identity=44.5993031358885, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI45551871, Length=287, Percent_Identity=44.5993031358885, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24645718, Length=287, Percent_Identity=44.5993031358885, Blast_Score=212, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17137370, Length=287, Percent_Identity=44.5993031358885, Blast_Score=212, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020631 [H]

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C [H]

EC number: =1.5.1.5; =3.5.4.9 [H]

Molecular weight: Translated: 30285; Mature: 30154

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKLIDGKAIAASLRQQIAKRVAERSQQGLRTPGLAVILVGSDPASQVYVSHKRKDCEE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHCCHHH
VGFISQAYDLPADTTQAALTDLIDRLNEDAAVDGVLLQLPLPAHLDASLLLERIRPDKDV
HCCHHHHHCCCCCHHHHHHHHHHHHCCCCHHHCCEEEEECCCCCCCHHHHHHHHCCCCCC
DGFHPYNVGRLAQRIPLLRPCTPKGIMTLLESTGVDLYGLDAVVVGASNIVGRPMAMELL
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEECCEEEECCHHHCCCHHHHHHH
LAGCTVTVTHRFTRDLAGHVGRADLVVVAAGKPGLVKGEWIKPGAIVIDVGINRQEDGKL
HHCCEEEEHHHHHHHHHHCCCCCEEEEEECCCCCCEECCEECCCEEEEEECCCCCCCCCH
VGDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAETLHD
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TAKLIDGKAIAASLRQQIAKRVAERSQQGLRTPGLAVILVGSDPASQVYVSHKRKDCEE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHCCHHH
VGFISQAYDLPADTTQAALTDLIDRLNEDAAVDGVLLQLPLPAHLDASLLLERIRPDKDV
HCCHHHHHCCCCCHHHHHHHHHHHHCCCCHHHCCEEEEECCCCCCCHHHHHHHHCCCCCC
DGFHPYNVGRLAQRIPLLRPCTPKGIMTLLESTGVDLYGLDAVVVGASNIVGRPMAMELL
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEECCEEEECCHHHCCCHHHHHHH
LAGCTVTVTHRFTRDLAGHVGRADLVVVAAGKPGLVKGEWIKPGAIVIDVGINRQEDGKL
HHCCEEEEHHHHHHHHHHCCCCCEEEEEECCCCCCEECCEECCCEEEEEECCCCCCCCCH
VGDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAETLHD
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA