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The map label for this gene is emrA [H]

Identifier: 66044975

GI number: 66044975

Start: 1963800

End: 1965008

Strand: Direct

Name: emrA [H]

Synonym: Psyr_1730

Alternate gene names: 66044975

Gene position: 1963800-1965008 (Clockwise)

Preceding gene: 66044974

Following gene: 66044976

Centisome position: 32.23

GC content: 62.2

Gene sequence:

>1209_bases
ATGGCCACTGCTGCCGCTGAAAACACATCTGCCCCGGCTCCTGAACAGGAGCCGAAGTCCGGCAAGCGCACGTTCATGCT
GATCGGGCTTGCCATTGTCGTGGTGATCCTCGCACTGGGCATCTGGGCCTGGTACGAGATCTACGGCCAATGGAGCGAAG
AGACCGACGATGCCTATGTGAATGGCAACGTGGTCGAAATCACCCCGCTGGTCACCGGAACCGTCATCAGTATTGGTGCG
GACGATGGTGATCTGGTGCACGAAGGGCAGGTTCTGCTCAAGTTCGACCCGAGCGATGCCGAAGTCTCGCTGCAAAGCGC
CGAGGCCAATCTGGGCAAGGTCGTGCGCCAGGTGCGCGGCCTCTATAGCAATGTCGATGGCATGAAGGCGCAACTGGCCG
CGCAGCGTGCTGCTGTGCAGACCGCTCAGGACAACTATAACCGTCGTCGCAGCCTCGCAGCCGGCGGGGCGATTTCCCAG
GAAGAGCTGTCGCACGCCAGGGACAGCCTGACCAGCGCGCAGAGCGCCCTGAACAATATTCAGCAGCAATTGAGCACCAG
CGTGGCGCTGGTCGATGACACCGTTGTGTCCTCGCACCCGGACGTCAAGGCAGCGGCTGCGCAGTTGCGTCAGGCCTACC
TGACCAACGCACGTTCAACACTCGTGGCACCGGTCACCGGCTACGTGGCCAAGCGCACCGTGCAACTGGGGCAACGCATT
CAGCCGGGCACCGCTACCATGGCGGTCATCCCGCTGGATCAGTTGTGGATCGATGCCAACTTCAAGGAGACCCAGTTGGG
CAAGATGCGCATCGGTCAGCCGGTGGAGATCAGCTCCGACCTGTATGGCAGCGATGTGAAGTACAGCGGCACCATCGACA
GCCTGGGGGCCGGTACCGGCAGTGCCTTTGCGTTGCTGCCTGCGCAGAACGCCACCGGCAACTGGATCAAGATCGTCCAG
CGCGTGCCGGTGCGGGTGCATATCAACCCTGAAGAACTGGCGAAGTACCCATTGCGTATCGGCCTGTCGACCACGGTTGA
AGTCAACCTGCATGACCAGAGCGGTCCGGTCCTGGCGCAACAGCCGCGCAAGCAGGCCGCTTTCAGCACTCAGGTGTACA
CCGAGCAGCTGGCTGACGCCGACGCGCTGATCGCCCGCCTGATTCATGAGAACAGTGCGCCCGGTGGCAAGACTGCCGTT
CAGCGCTGA

Upstream 100 bases:

>100_bases
GAGCTTCAACCCCAAAGCTAAACGCTGAGCGGCCGACGTGTTGGCAGGCGTGAGCCTGATCGCCGTCGTTCCGTCGCTTC
GCTGATTAAAGGTAACTGCC

Downstream 100 bases:

>100_bases
ACCGCTAATCCGTGAGCCCCGGCCTGCTGGCCGGGGTGTCGCATTCGTCTTCAGGGATTCGCGATGAGCAACAACGCCCC
CGCTTCTTTTACCCCGCCAA

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MATAAAENTSAPAPEQEPKSGKRTFMLIGLAIVVVILALGIWAWYEIYGQWSEETDDAYVNGNVVEITPLVTGTVISIGA
DDGDLVHEGQVLLKFDPSDAEVSLQSAEANLGKVVRQVRGLYSNVDGMKAQLAAQRAAVQTAQDNYNRRRSLAAGGAISQ
EELSHARDSLTSAQSALNNIQQQLSTSVALVDDTVVSSHPDVKAAAAQLRQAYLTNARSTLVAPVTGYVAKRTVQLGQRI
QPGTATMAVIPLDQLWIDANFKETQLGKMRIGQPVEISSDLYGSDVKYSGTIDSLGAGTGSAFALLPAQNATGNWIKIVQ
RVPVRVHINPEELAKYPLRIGLSTTVEVNLHDQSGPVLAQQPRKQAAFSTQVYTEQLADADALIARLIHENSAPGGKTAV
QR

Sequences:

>Translated_402_residues
MATAAAENTSAPAPEQEPKSGKRTFMLIGLAIVVVILALGIWAWYEIYGQWSEETDDAYVNGNVVEITPLVTGTVISIGA
DDGDLVHEGQVLLKFDPSDAEVSLQSAEANLGKVVRQVRGLYSNVDGMKAQLAAQRAAVQTAQDNYNRRRSLAAGGAISQ
EELSHARDSLTSAQSALNNIQQQLSTSVALVDDTVVSSHPDVKAAAAQLRQAYLTNARSTLVAPVTGYVAKRTVQLGQRI
QPGTATMAVIPLDQLWIDANFKETQLGKMRIGQPVEISSDLYGSDVKYSGTIDSLGAGTGSAFALLPAQNATGNWIKIVQ
RVPVRVHINPEELAKYPLRIGLSTTVEVNLHDQSGPVLAQQPRKQAAFSTQVYTEQLADADALIARLIHENSAPGGKTAV
QR
>Mature_401_residues
ATAAAENTSAPAPEQEPKSGKRTFMLIGLAIVVVILALGIWAWYEIYGQWSEETDDAYVNGNVVEITPLVTGTVISIGAD
DGDLVHEGQVLLKFDPSDAEVSLQSAEANLGKVVRQVRGLYSNVDGMKAQLAAQRAAVQTAQDNYNRRRSLAAGGAISQE
ELSHARDSLTSAQSALNNIQQQLSTSVALVDDTVVSSHPDVKAAAAQLRQAYLTNARSTLVAPVTGYVAKRTVQLGQRIQ
PGTATMAVIPLDQLWIDANFKETQLGKMRIGQPVEISSDLYGSDVKYSGTIDSLGAGTGSAFALLPAQNATGNWIKIVQR
VPVRVHINPEELAKYPLRIGLSTTVEVNLHDQSGPVLAQQPRKQAAFSTQVYTEQLADADALIARLIHENSAPGGKTAVQ
R

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=390, Percent_Identity=43.5897435897436, Blast_Score=326, Evalue=1e-90,
Organism=Escherichia coli, GI1788711, Length=375, Percent_Identity=40.8, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1790519, Length=313, Percent_Identity=28.1150159744409, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI87081951, Length=312, Percent_Identity=27.2435897435897, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789637, Length=326, Percent_Identity=27.9141104294479, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790012, Length=258, Percent_Identity=22.8682170542636, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42960; Mature: 42829

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATAAAENTSAPAPEQEPKSGKRTFMLIGLAIVVVILALGIWAWYEIYGQWSEETDDAYV
CCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
NGNVVEITPLVTGTVISIGADDGDLVHEGQVLLKFDPSDAEVSLQSAEANLGKVVRQVRG
CCCEEEEEEEEECEEEEECCCCCCEEECCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHH
LYSNVDGMKAQLAAQRAAVQTAQDNYNRRRSLAAGGAISQEELSHARDSLTSAQSALNNI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
QQQLSTSVALVDDTVVSSHPDVKAAAAQLRQAYLTNARSTLVAPVTGYVAKRTVQLGQRI
HHHHHHHHEEEECHHHCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCC
QPGTATMAVIPLDQLWIDANFKETQLGKMRIGQPVEISSDLYGSDVKYSGTIDSLGAGTG
CCCCCEEEEEEHHHEEEECCCCCCCCCHHCCCCCCEECCCCCCCCEEECCCHHHCCCCCC
SAFALLPAQNATGNWIKIVQRVPVRVHINPEELAKYPLRIGLSTTVEVNLHDQSGPVLAQ
CEEEEEECCCCCCHHHHHHHHCCEEEEECHHHHHCCCEEECCEEEEEEEEECCCCCCCCC
QPRKQAAFSTQVYTEQLADADALIARLIHENSAPGGKTAVQR
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
ATAAAENTSAPAPEQEPKSGKRTFMLIGLAIVVVILALGIWAWYEIYGQWSEETDDAYV
CCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
NGNVVEITPLVTGTVISIGADDGDLVHEGQVLLKFDPSDAEVSLQSAEANLGKVVRQVRG
CCCEEEEEEEEECEEEEECCCCCCEEECCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHH
LYSNVDGMKAQLAAQRAAVQTAQDNYNRRRSLAAGGAISQEELSHARDSLTSAQSALNNI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
QQQLSTSVALVDDTVVSSHPDVKAAAAQLRQAYLTNARSTLVAPVTGYVAKRTVQLGQRI
HHHHHHHHEEEECHHHCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCC
QPGTATMAVIPLDQLWIDANFKETQLGKMRIGQPVEISSDLYGSDVKYSGTIDSLGAGTG
CCCCCEEEEEEHHHEEEECCCCCCCCCHHCCCCCCEECCCCCCCCEEECCCHHHCCCCCC
SAFALLPAQNATGNWIKIVQRVPVRVHINPEELAKYPLRIGLSTTVEVNLHDQSGPVLAQ
CEEEEEECCCCCCHHHHHHHHCCEEEEECHHHHHCCCEEECCEEEEEEEEECCCCCCCCC
QPRKQAAFSTQVYTEQLADADALIARLIHENSAPGGKTAVQR
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]