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The map label for this gene is copA [H]

Identifier: 66044816

GI number: 66044816

Start: 1765724

End: 1767502

Strand: Reverse

Name: copA [H]

Synonym: Psyr_1571

Alternate gene names: 66044816

Gene position: 1767502-1765724 (Counterclockwise)

Preceding gene: 66044817

Following gene: 66044815

Centisome position: 29.01

GC content: 62.28

Gene sequence:

>1779_bases
ATGCCCACCCGAACCTCAAGACGAACCTTTGTGAAAGGGCTGGCCGCCAGTGGCCTGCTCGGCGGCCTCGGGCTATGGCG
CAGCCCGGCGTGGGCGGTGGCCAACCCGGGTCAGCCCAACGGGTTGTCCGGCACCGAGTTCGATCTGTATATCGGCGAAA
CCCAGGTCAACATCACCGGCAATGCCAAGACCGCGCAGACCATCAACGGCGGCATTCCCGGCCCGCTGCTGCGCTGGCGC
GAAGGCGATACCGTGACCCTGAGGGTCAAGAACCGGCTCGACGAAGCCACATCCATCCATTGGCACGGCATCATCCTGCC
GGCCAACATGGACGGCGTGCCGGGGTTGAGCTTTGACGGCATCGCGCCGGACGGCATGTATGTCTACCGCTTCAAGGTCA
GGCAGCATGGCACCTACTGGTATCACAGCCACTCCGGCTTCCAGGAACAGTCGGGGGTCTACGGGCCACTGGTGATCGAC
CCGAAAGAGCCGGAGCCGTTCGAATACGACCGCGAACACGTGATCATGCTCAGCGACTGGACCGACGAAGAGCCGGTCCA
GCTGATGAAAACGCTCAAGAAACAGTCCGATTACTACAACAATAATCAGCGCACCGTCGGCGACTTCATCAACGACGTGG
GTGAAAAAGGCTGGAGCGAGACCACCCGTGATCGCTGGATGTGGGCGCAGATGAGGATGGACCCGACCGATCTCGCGGAT
GTCAGCGGCGCGACCTACACCTACCTGATGAACGGTCAGGCGCCGAACATGAACTGGACCGGGCTGTTCAAGCCTGGCGA
GCGGATCCGACTGCGGCTGATCAACGGCTCGGCAATGACGTACTTCGACGTGCGTATTCCGGGCCTGAAGATGACCGTAG
TGGCCAGCGACGGCCTGCACGTCAAGCCGGTGACCGTCGACGAGTTGCGCATCGCAGTGGCGGAAACCTTCGACGTGATT
GTCGAACCGGCGGAAGGTGCCTATACGCTGTTCGCCCAGTCGATGGACCGCACCGGTTATGCCCGCGGCACCCTGGCCAG
CAGGCCCGGCCTGCAGGCTGCCGTTCCGCCCCTCGATCCACGCCCGCTGTCGAGCATGGATGATATGGGCATGGCGGGCA
TGGAGCATGGCAGCATGAACCACGCCGCAGCCCCGGCAACGCACGACATGTCAGGCATGGACCACAGCAAGATGGGCCAC
GACGCGATGCCCGGAATGGACCACGCGCAGACGCCGGCCCAGAAAACGCCGACTCCGCAATCGCACCCCGAGAGCGAAAA
CAACAACCCGCTGGTCGACATGCAAGCCATGAGCACCTCGCCCAAGCTCGACGATCCGGGCATCGGCCTCAGGGGCAATG
GCCGCAGAGTCCTGACCTACGCTGACCTGCGCAGCACCTTCGAAGACCCGGACGGCCGTGAGCCCAGTCGCACGATCGAG
CTGCACCTGACCGGGCATATGGAAAAATACGCCTGGTCATTCGACGGTGTGAAGTTCTCGGACGCCAAACCGCTGATGCT
CAAATACGGTGAGCGGGTGCGTGTCGTGCTGGTCAACGACACGATGATGACCCACCCCATCCATCTGCATGGCATGTGGA
GCGACCTCGAAGACGAGAATGGACAGTTCATGGTGCGCAAACACACCATCGACATGCCACCGGGATCACGCCGCAGCTAT
CGCGTGACCGCCGATGCGCTGGGCCGTTGGGCTTATCACTGTCACATGCTGTACCACATGGAAATGGGCATGTTCCGCGA
AGTGCGGGTGGAAGAATGA

Upstream 100 bases:

>100_bases
AAAAGGACGAGTAACCTCGGCGCTTTCGACCAGCCACGCTCCCCTGCCCTACCCGCACTTCCCCTGGCCTGCGGCCACCC
GACCGACCGGATACTTTGTC

Downstream 100 bases:

>100_bases
GGACCTTGATGTTGAGCAGAACGCTGAATTCGCCCCGCCTGCCGATGCTGTTGCTGGCCGCCGGGCTGACCGCCACGCCG
TGGGCCTCGACCTTGGCCGC

Product: twin-arginine translocation pathway signal:copper-resistance protein CopA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 591

Protein sequence:

>592_residues
MPTRTSRRTFVKGLAASGLLGGLGLWRSPAWAVANPGQPNGLSGTEFDLYIGETQVNITGNAKTAQTINGGIPGPLLRWR
EGDTVTLRVKNRLDEATSIHWHGIILPANMDGVPGLSFDGIAPDGMYVYRFKVRQHGTYWYHSHSGFQEQSGVYGPLVID
PKEPEPFEYDREHVIMLSDWTDEEPVQLMKTLKKQSDYYNNNQRTVGDFINDVGEKGWSETTRDRWMWAQMRMDPTDLAD
VSGATYTYLMNGQAPNMNWTGLFKPGERIRLRLINGSAMTYFDVRIPGLKMTVVASDGLHVKPVTVDELRIAVAETFDVI
VEPAEGAYTLFAQSMDRTGYARGTLASRPGLQAAVPPLDPRPLSSMDDMGMAGMEHGSMNHAAAPATHDMSGMDHSKMGH
DAMPGMDHAQTPAQKTPTPQSHPESENNNPLVDMQAMSTSPKLDDPGIGLRGNGRRVLTYADLRSTFEDPDGREPSRTIE
LHLTGHMEKYAWSFDGVKFSDAKPLMLKYGERVRVVLVNDTMMTHPIHLHGMWSDLEDENGQFMVRKHTIDMPPGSRRSY
RVTADALGRWAYHCHMLYHMEMGMFREVRVEE

Sequences:

>Translated_592_residues
MPTRTSRRTFVKGLAASGLLGGLGLWRSPAWAVANPGQPNGLSGTEFDLYIGETQVNITGNAKTAQTINGGIPGPLLRWR
EGDTVTLRVKNRLDEATSIHWHGIILPANMDGVPGLSFDGIAPDGMYVYRFKVRQHGTYWYHSHSGFQEQSGVYGPLVID
PKEPEPFEYDREHVIMLSDWTDEEPVQLMKTLKKQSDYYNNNQRTVGDFINDVGEKGWSETTRDRWMWAQMRMDPTDLAD
VSGATYTYLMNGQAPNMNWTGLFKPGERIRLRLINGSAMTYFDVRIPGLKMTVVASDGLHVKPVTVDELRIAVAETFDVI
VEPAEGAYTLFAQSMDRTGYARGTLASRPGLQAAVPPLDPRPLSSMDDMGMAGMEHGSMNHAAAPATHDMSGMDHSKMGH
DAMPGMDHAQTPAQKTPTPQSHPESENNNPLVDMQAMSTSPKLDDPGIGLRGNGRRVLTYADLRSTFEDPDGREPSRTIE
LHLTGHMEKYAWSFDGVKFSDAKPLMLKYGERVRVVLVNDTMMTHPIHLHGMWSDLEDENGQFMVRKHTIDMPPGSRRSY
RVTADALGRWAYHCHMLYHMEMGMFREVRVEE
>Mature_591_residues
PTRTSRRTFVKGLAASGLLGGLGLWRSPAWAVANPGQPNGLSGTEFDLYIGETQVNITGNAKTAQTINGGIPGPLLRWRE
GDTVTLRVKNRLDEATSIHWHGIILPANMDGVPGLSFDGIAPDGMYVYRFKVRQHGTYWYHSHSGFQEQSGVYGPLVIDP
KEPEPFEYDREHVIMLSDWTDEEPVQLMKTLKKQSDYYNNNQRTVGDFINDVGEKGWSETTRDRWMWAQMRMDPTDLADV
SGATYTYLMNGQAPNMNWTGLFKPGERIRLRLINGSAMTYFDVRIPGLKMTVVASDGLHVKPVTVDELRIAVAETFDVIV
EPAEGAYTLFAQSMDRTGYARGTLASRPGLQAAVPPLDPRPLSSMDDMGMAGMEHGSMNHAAAPATHDMSGMDHSKMGHD
AMPGMDHAQTPAQKTPTPQSHPESENNNPLVDMQAMSTSPKLDDPGIGLRGNGRRVLTYADLRSTFEDPDGREPSRTIEL
HLTGHMEKYAWSFDGVKFSDAKPLMLKYGERVRVVLVNDTMMTHPIHLHGMWSDLEDENGQFMVRKHTIDMPPGSRRSYR
VTADALGRWAYHCHMLYHMEMGMFREVRVEE

Specific function: Could be involved in copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=624, Percent_Identity=24.8397435897436, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17539950, Length=347, Percent_Identity=24.4956772334294, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321067, Length=285, Percent_Identity=29.1228070175439, Blast_Score=90, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6323703, Length=280, Percent_Identity=28.9285714285714, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320714, Length=290, Percent_Identity=25.8620689655172, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28574104, Length=617, Percent_Identity=23.9870340356564, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24650186, Length=598, Percent_Identity=22.4080267558528, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18859919, Length=297, Percent_Identity=29.6296296296296, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281360167, Length=289, Percent_Identity=26.9896193771626, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24585842, Length=289, Percent_Identity=26.9896193771626, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI221330000, Length=289, Percent_Identity=26.9896193771626, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI221329998, Length=289, Percent_Identity=26.9896193771626, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 66228; Mature: 66097

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTRTSRRTFVKGLAASGLLGGLGLWRSPAWAVANPGQPNGLSGTEFDLYIGETQVNITG
CCCCCCHHHHHHHHHHHHHHHCCHHHCCCCEEECCCCCCCCCCCCEEEEEECCEEEEEEC
NAKTAQTINGGIPGPLLRWREGDTVTLRVKNRLDEATSIHWHGIILPANMDGVPGLSFDG
CCCEEEECCCCCCCCCEEECCCCEEEEEECCCCCCHHEEEEEEEEEECCCCCCCCCCCCC
IAPDGMYVYRFKVRQHGTYWYHSHSGFQEQSGVYGPLVIDPKEPEPFEYDREHVIMLSDW
CCCCCEEEEEEEEEECCEEEEECCCCCHHHCCCCCCEEECCCCCCCCCCCCCEEEEEECC
TDEEPVQLMKTLKKQSDYYNNNQRTVGDFINDVGEKGWSETTRDRWMWAQMRMDPTDLAD
CCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCHHHHEEEEEECCCCHHHHH
VSGATYTYLMNGQAPNMNWTGLFKPGERIRLRLINGSAMTYFDVRIPGLKMTVVASDGLH
CCCCEEEEEECCCCCCCCEEEEECCCCEEEEEEECCCEEEEEEEEECCEEEEEEECCCCE
VKPVTVDELRIAVAETFDVIVEPAEGAYTLFAQSMDRTGYARGTLASRPGLQAAVPPLDP
EECEEHHHHHHHHEEEEEEEEECCCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCC
RPLSSMDDMGMAGMEHGSMNHAAAPATHDMSGMDHSKMGHDAMPGMDHAQTPAQKTPTPQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCC
SHPESENNNPLVDMQAMSTSPKLDDPGIGLRGNGRRVLTYADLRSTFEDPDGREPSRTIE
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEHHHHHHCCCCCCCCCCEEEE
LHLTGHMEKYAWSFDGVKFSDAKPLMLKYGERVRVVLVNDTMMTHPIHLHGMWSDLEDEN
EEEECCCCHHEEEECCEEECCCCCHHEECCCEEEEEEEECCEEECCEEEEECCCCCCCCC
GQFMVRKHTIDMPPGSRRSYRVTADALGRWAYHCHMLYHMEMGMFREVRVEE
CCEEEEEEEECCCCCCCCEEEEEHHHHHHHHHHEEEEEECCCCCEEEEEECC
>Mature Secondary Structure 
PTRTSRRTFVKGLAASGLLGGLGLWRSPAWAVANPGQPNGLSGTEFDLYIGETQVNITG
CCCCCHHHHHHHHHHHHHHHCCHHHCCCCEEECCCCCCCCCCCCEEEEEECCEEEEEEC
NAKTAQTINGGIPGPLLRWREGDTVTLRVKNRLDEATSIHWHGIILPANMDGVPGLSFDG
CCCEEEECCCCCCCCCEEECCCCEEEEEECCCCCCHHEEEEEEEEEECCCCCCCCCCCCC
IAPDGMYVYRFKVRQHGTYWYHSHSGFQEQSGVYGPLVIDPKEPEPFEYDREHVIMLSDW
CCCCCEEEEEEEEEECCEEEEECCCCCHHHCCCCCCEEECCCCCCCCCCCCCEEEEEECC
TDEEPVQLMKTLKKQSDYYNNNQRTVGDFINDVGEKGWSETTRDRWMWAQMRMDPTDLAD
CCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCHHHHEEEEEECCCCHHHHH
VSGATYTYLMNGQAPNMNWTGLFKPGERIRLRLINGSAMTYFDVRIPGLKMTVVASDGLH
CCCCEEEEEECCCCCCCCEEEEECCCCEEEEEEECCCEEEEEEEEECCEEEEEEECCCCE
VKPVTVDELRIAVAETFDVIVEPAEGAYTLFAQSMDRTGYARGTLASRPGLQAAVPPLDP
EECEEHHHHHHHHEEEEEEEEECCCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCC
RPLSSMDDMGMAGMEHGSMNHAAAPATHDMSGMDHSKMGHDAMPGMDHAQTPAQKTPTPQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCC
SHPESENNNPLVDMQAMSTSPKLDDPGIGLRGNGRRVLTYADLRSTFEDPDGREPSRTIE
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEHHHHHHCCCCCCCCCCEEEE
LHLTGHMEKYAWSFDGVKFSDAKPLMLKYGERVRVVLVNDTMMTHPIHLHGMWSDLEDEN
EEEECCCCHHEEEECCEEECCCCCHHEECCCEEEEEEEECCEEECCEEEEECCCCCCCCC
GQFMVRKHTIDMPPGSRRSYRVTADALGRWAYHCHMLYHMEMGMFREVRVEE
CCEEEEEEEECCCCCCCCEEEEEHHHHHHHHHHEEEEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]