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The map label for this gene is ycdW [C]

Identifier: 66044810

GI number: 66044810

Start: 1761509

End: 1762441

Strand: Direct

Name: ycdW [C]

Synonym: Psyr_1565

Alternate gene names: 66044810

Gene position: 1761509-1762441 (Clockwise)

Preceding gene: 66044809

Following gene: 66044812

Centisome position: 28.91

GC content: 62.38

Gene sequence:

>933_bases
ATGCGCGTTCTGATTGCCGAGCACGATTACCACGTTTACACCCAATTGTTGCGCAAGGCTGCGCCTGATCTGGAAGTTTT
CAGCACTGGCGATTCTGCCGAATTGTCGCGCATGGCCAGCGACTGCCCGGTCTGGCTGGGGCAGCCGGACCTGATGGCCA
ACCTGTTGCGGCAGGGGCACAAGCCGCAATGGCTGCAATCCACCTGGGCGGGCATCACACCGCTGCTGGCCGACAGCCTG
TCGCGCGACTATCGCCTGACCCGTGCGGTCGGGATTTTCGGGCAGGTCATGGCCGAATTCGTTTTGACCTACATGCTTGG
CCATGAGCGCGAGGTGCTGGCGCGCCTGATGAGCCAGGTCGAGCGCAAGTGGGACAACCGCACCGGGCAGAGCCTGTCGG
GCCGCAAGGCATTGATCGTCGGTGCCGGTGATATCGGTCAGCGCGTTGCCGAGTTCCTCCTGCCGTTCGGCGTGCAGGTG
TACGGTGTGGCTTCCAGTGCGCGCACTCAGGAACCGTTCATCGAAGTGACGGCGTTGTCAGACATGACGCGTCTGCTCGG
CGAGATGGATTACGTCATCAACCTGCTGCCCAACACGCCCGAGACGCACGACCTGTACGACGCGAAGCTGTTCGCCGGCT
TCAAGCCCTCGGCGCTGTTCATCAACGTCGGACGCGGGGTGGCGGTCGTCGACGCAGATCTGGTCGAGGCGTTGAAGGAA
GGGCATCTGGCTGGCGCGGTGATTGACGTCTGCCGTCAGGAGCCTTTGCCGCAGCGGCATCCGTTCTGGACTGCCTACGG
TCTGCTGTTGACCGGTCACAGCTCGGCGCCTACCTCACCTGTGGCCATGACCGAGCTTTTCGTGCATAACCTGAACGCTT
TTCAGGCCGGAGAAACGCTGCGCGGCGAGGTCGATTTTTCGCGAGGTTACTGA

Upstream 100 bases:

>100_bases
GAGCTGCTGCGCCGCAACGATCCCATGTAATCGTTGCTCACGTTGTAAAGCGGCCCACATCGACGTGGGTTGCCTGTCCT
GTTTTTAAGGTTTTTGAAAC

Downstream 100 bases:

>100_bases
CGCCCTTGCCAGCGAGCCGACGTTTCAGGCGTCGGCTCGCAGGTATCGATCACCGCAAACAGTCGGTTACAGCGAAAAAT
CACCTTCGGCGGCCAGTTCT

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NADPH; glyoxylate; glycerate [C]

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRVLIAEHDYHVYTQLLRKAAPDLEVFSTGDSAELSRMASDCPVWLGQPDLMANLLRQGHKPQWLQSTWAGITPLLADSL
SRDYRLTRAVGIFGQVMAEFVLTYMLGHEREVLARLMSQVERKWDNRTGQSLSGRKALIVGAGDIGQRVAEFLLPFGVQV
YGVASSARTQEPFIEVTALSDMTRLLGEMDYVINLLPNTPETHDLYDAKLFAGFKPSALFINVGRGVAVVDADLVEALKE
GHLAGAVIDVCRQEPLPQRHPFWTAYGLLLTGHSSAPTSPVAMTELFVHNLNAFQAGETLRGEVDFSRGY

Sequences:

>Translated_310_residues
MRVLIAEHDYHVYTQLLRKAAPDLEVFSTGDSAELSRMASDCPVWLGQPDLMANLLRQGHKPQWLQSTWAGITPLLADSL
SRDYRLTRAVGIFGQVMAEFVLTYMLGHEREVLARLMSQVERKWDNRTGQSLSGRKALIVGAGDIGQRVAEFLLPFGVQV
YGVASSARTQEPFIEVTALSDMTRLLGEMDYVINLLPNTPETHDLYDAKLFAGFKPSALFINVGRGVAVVDADLVEALKE
GHLAGAVIDVCRQEPLPQRHPFWTAYGLLLTGHSSAPTSPVAMTELFVHNLNAFQAGETLRGEVDFSRGY
>Mature_310_residues
MRVLIAEHDYHVYTQLLRKAAPDLEVFSTGDSAELSRMASDCPVWLGQPDLMANLLRQGHKPQWLQSTWAGITPLLADSL
SRDYRLTRAVGIFGQVMAEFVLTYMLGHEREVLARLMSQVERKWDNRTGQSLSGRKALIVGAGDIGQRVAEFLLPFGVQV
YGVASSARTQEPFIEVTALSDMTRLLGEMDYVINLLPNTPETHDLYDAKLFAGFKPSALFINVGRGVAVVDADLVEALKE
GHLAGAVIDVCRQEPLPQRHPFWTAYGLLLTGHSSAPTSPVAMTELFVHNLNAFQAGETLRGEVDFSRGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=245, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI87081824, Length=314, Percent_Identity=27.3885350318471, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI87082289, Length=240, Percent_Identity=28.75, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789279, Length=161, Percent_Identity=31.6770186335404, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=174, Percent_Identity=31.6091954022989, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320925, Length=188, Percent_Identity=27.1276595744681, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28571528, Length=182, Percent_Identity=29.6703296703297, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28574286, Length=195, Percent_Identity=31.7948717948718, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45552429, Length=187, Percent_Identity=28.3422459893048, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24585514, Length=187, Percent_Identity=28.3422459893048, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28574282, Length=187, Percent_Identity=28.3422459893048, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28574284, Length=187, Percent_Identity=28.3422459893048, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45551003, Length=187, Percent_Identity=28.3422459893048, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24585516, Length=230, Percent_Identity=26.0869565217391, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: NA

Molecular weight: Translated: 34271; Mature: 34271

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLIAEHDYHVYTQLLRKAAPDLEVFSTGDSAELSRMASDCPVWLGQPDLMANLLRQGH
CEEEEECCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCEECCCHHHHHHHHHCCC
KPQWLQSTWAGITPLLADSLSRDYRLTRAVGIFGQVMAEFVLTYMLGHEREVLARLMSQV
CCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ERKWDNRTGQSLSGRKALIVGAGDIGQRVAEFLLPFGVQVYGVASSARTQEPFIEVTALS
HHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEHHHH
DMTRLLGEMDYVINLLPNTPETHDLYDAKLFAGFKPSALFINVGRGVAVVDADLVEALKE
HHHHHHHHHHHHHEECCCCCCCCCCHHHHHHCCCCCCEEEEECCCCEEEECHHHHHHHHH
GHLAGAVIDVCRQEPLPQRHPFWTAYGLLLTGHSSAPTSPVAMTELFVHNLNAFQAGETL
CCHHHHHHHHHHCCCCCCCCCCHHEEHEEEECCCCCCCCHHHHHHHHHHHCCHHHCCCCC
RGEVDFSRGY
CCCCCCCCCC
>Mature Secondary Structure
MRVLIAEHDYHVYTQLLRKAAPDLEVFSTGDSAELSRMASDCPVWLGQPDLMANLLRQGH
CEEEEECCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCEECCCHHHHHHHHHCCC
KPQWLQSTWAGITPLLADSLSRDYRLTRAVGIFGQVMAEFVLTYMLGHEREVLARLMSQV
CCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ERKWDNRTGQSLSGRKALIVGAGDIGQRVAEFLLPFGVQVYGVASSARTQEPFIEVTALS
HHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEHHHH
DMTRLLGEMDYVINLLPNTPETHDLYDAKLFAGFKPSALFINVGRGVAVVDADLVEALKE
HHHHHHHHHHHHHEECCCCCCCCCCHHHHHHCCCCCCEEEEECCCCEEEECHHHHHHHHH
GHLAGAVIDVCRQEPLPQRHPFWTAYGLLLTGHSSAPTSPVAMTELFVHNLNAFQAGETL
CCHHHHHHHHHHCCCCCCCCCCHHEEHEEEECCCCCCCCHHHHHHHHHHHCCHHHCCCCC
RGEVDFSRGY
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycolate; NADP; hydroxypyruvate; NADPH [C]

Specific reaction: glycolate + NADP = NADPH + glyoxylate hydroxypyruvate + NADPH = glycerate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]