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The map label for this gene is moeB [H]

Identifier: 66044204

GI number: 66044204

Start: 1086802

End: 1087581

Strand: Direct

Name: moeB [H]

Synonym: Psyr_0951

Alternate gene names: 66044204

Gene position: 1086802-1087581 (Clockwise)

Preceding gene: 66044203

Following gene: 66044205

Centisome position: 17.83

GC content: 60.9

Gene sequence:

>780_bases
ATGCAAGCCGTGCTGAGTGATCAGGAACTGCTGCGCTACAGTCGCCAGATTCTGCTGCAACATGTTGATATCGATGGCCA
GCTAAGACTCAAGCAAAGTCGTGTGCTGGTCGTGGGCGTCGGCGGGCTTGGCTCGCCGGTGGCCCTGTATCTGGCCGCCG
CTGGGGTTGGTGAGCTGCATCTGGCGGATTTTGATCACGTCGACCTGACCAACCTGCAACGCCAGATCATCCACGACACT
CAGAGCATCGGGCAGGCCAAGGTAGATTCGGCCATCACCCGGCTCAATGCGATCAATCCCGAGATCACCCTTGTCGCTCA
TCGTGCAGCGCTGGATACCGACTCACTGGACGCGGCGGTACAGGCTGTCGATCTGGTGCTCGATTGCTCGGATAATTTCG
CCACTCGCGAAGCGGTCAATGCCGCCTGTGTCGTTGCCGGCAAGCCGTTGGTCAGTGGTGCGGCCATTCGGCTTGAAGGG
CAGTTGTCGGTGTTCGACCCGCGTCGTGCGGACAGCCCTTGTTACCATTGTCTGTACGGGCATGGCAGCGAAGCCGAACT
GACCTGCAGCGAGGCCGGTGTCATCGGGCCGCTGGTCGGTCTGGTTGGCAGCCTGCAAGCGCTGGAGGCGTTGAAACTGC
TGGCCGGCTTTGGCGAACCCATGGTCGGTCGACTGTTATTGATCGACGCCTTGAGCACGCGTTTCCGTGAACTGAAGGTC
AAGCGTGACCCGGCGTGCAGCGTCTGTGGTCCGGCCAGTGTGCAGCGCGAGCATGCTTGA

Upstream 100 bases:

>100_bases
ACGATCAGGGACCTGCGGTGCGTGAGCTGCTGATTCGCCAGGGCTTCGAGCGTATCCAGACGCGTCGTGATCTGGGCGAG
CATGAGCGCATCACGTTCGG

Downstream 100 bases:

>100_bases
CGTGCATATGAGCCATGGCGGCGATGCACCGGTCGGAATCTTCGATTCCGGGGTCGGTGGTCTGTCGGTGCTCAATGAAA
TCCGCCAGCTGTTGCCCAGC

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MQAVLSDQELLRYSRQILLQHVDIDGQLRLKQSRVLVVGVGGLGSPVALYLAAAGVGELHLADFDHVDLTNLQRQIIHDT
QSIGQAKVDSAITRLNAINPEITLVAHRAALDTDSLDAAVQAVDLVLDCSDNFATREAVNAACVVAGKPLVSGAAIRLEG
QLSVFDPRRADSPCYHCLYGHGSEAELTCSEAGVIGPLVGLVGSLQALEALKLLAGFGEPMVGRLLLIDALSTRFRELKV
KRDPACSVCGPASVQREHA

Sequences:

>Translated_259_residues
MQAVLSDQELLRYSRQILLQHVDIDGQLRLKQSRVLVVGVGGLGSPVALYLAAAGVGELHLADFDHVDLTNLQRQIIHDT
QSIGQAKVDSAITRLNAINPEITLVAHRAALDTDSLDAAVQAVDLVLDCSDNFATREAVNAACVVAGKPLVSGAAIRLEG
QLSVFDPRRADSPCYHCLYGHGSEAELTCSEAGVIGPLVGLVGSLQALEALKLLAGFGEPMVGRLLLIDALSTRFRELKV
KRDPACSVCGPASVQREHA
>Mature_259_residues
MQAVLSDQELLRYSRQILLQHVDIDGQLRLKQSRVLVVGVGGLGSPVALYLAAAGVGELHLADFDHVDLTNLQRQIIHDT
QSIGQAKVDSAITRLNAINPEITLVAHRAALDTDSLDAAVQAVDLVLDCSDNFATREAVNAACVVAGKPLVSGAAIRLEG
QLSVFDPRRADSPCYHCLYGHGSEAELTCSEAGVIGPLVGLVGSLQALEALKLLAGFGEPMVGRLLLIDALSTRFRELKV
KRDPACSVCGPASVQREHA

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=252, Percent_Identity=46.031746031746, Blast_Score=187, Evalue=8e-48,
Organism=Homo sapiens, GI4885649, Length=145, Percent_Identity=30.3448275862069, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI13376212, Length=256, Percent_Identity=29.296875, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI38327032, Length=221, Percent_Identity=28.9592760180996, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI23510338, Length=170, Percent_Identity=27.0588235294118, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI23510340, Length=170, Percent_Identity=27.0588235294118, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI38045948, Length=180, Percent_Identity=27.7777777777778, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787048, Length=248, Percent_Identity=54.4354838709677, Blast_Score=272, Evalue=2e-74,
Organism=Escherichia coli, GI87082356, Length=246, Percent_Identity=48.3739837398374, Blast_Score=211, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17540406, Length=251, Percent_Identity=40.6374501992032, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI193203301, Length=151, Percent_Identity=31.7880794701987, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17508819, Length=268, Percent_Identity=30.9701492537313, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321903, Length=253, Percent_Identity=36.7588932806324, Blast_Score=162, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6320598, Length=167, Percent_Identity=25.1497005988024, Blast_Score=73, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322639, Length=172, Percent_Identity=26.7441860465116, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24582879, Length=248, Percent_Identity=41.9354838709677, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24641311, Length=256, Percent_Identity=33.203125, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24660640, Length=152, Percent_Identity=33.5526315789474, Blast_Score=84, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 27500; Mature: 27500

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00116 DNA_POLYMERASE_B

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAVLSDQELLRYSRQILLQHVDIDGQLRLKQSRVLVVGVGGLGSPVALYLAAAGVGELH
CCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEECCCCHHHHHHHHHCCCCCEE
LADFDHVDLTNLQRQIIHDTQSIGQAKVDSAITRLNAINPEITLVAHRAALDTDSLDAAV
ECCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCHHHHHH
QAVDLVLDCSDNFATREAVNAACVVAGKPLVSGAAIRLEGQLSVFDPRRADSPCYHCLYG
HHHHHEEECCCCCHHHHHCCEEEEEECCCCCCCEEEEEECCEEEECCCCCCCCEEEEECC
HGSEAELTCSEAGVIGPLVGLVGSLQALEALKLLAGFGEPMVGRLLLIDALSTRFRELKV
CCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
KRDPACSVCGPASVQREHA
CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQAVLSDQELLRYSRQILLQHVDIDGQLRLKQSRVLVVGVGGLGSPVALYLAAAGVGELH
CCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEECCCCHHHHHHHHHCCCCCEE
LADFDHVDLTNLQRQIIHDTQSIGQAKVDSAITRLNAINPEITLVAHRAALDTDSLDAAV
ECCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCHHHHHH
QAVDLVLDCSDNFATREAVNAACVVAGKPLVSGAAIRLEGQLSVFDPRRADSPCYHCLYG
HHHHHEEECCCCCHHHHHCCEEEEEECCCCCCCEEEEEECCEEEECCCCCCCCEEEEECC
HGSEAELTCSEAGVIGPLVGLVGSLQALEALKLLAGFGEPMVGRLLLIDALSTRFRELKV
CCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
KRDPACSVCGPASVQREHA
CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]