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The map label for this gene is pth [H]

Identifier: 66044195

GI number: 66044195

Start: 1077613

End: 1078197

Strand: Reverse

Name: pth [H]

Synonym: Psyr_0942

Alternate gene names: 66044195

Gene position: 1078197-1077613 (Counterclockwise)

Preceding gene: 66044196

Following gene: 66044194

Centisome position: 17.69

GC content: 60.17

Gene sequence:

>585_bases
GTGACCGCCATACAACTGATCGTGGGCCTGGGAAATCCAGGCGCCGAATACGAACAGACCCGGCATAACGCAGGGGCTTT
TTTTGTTGAGCGTATTGCTGCGGCGCAACGAGTTGACCTCGTTCCCGAGCGCAAATTCTTTGGCCTGACCGGGCGCTTCA
CGCACCAGGGTCAGGATGTTCGTCTGCTGATTCCCACCACTTACATGAATCGCAGCGGCCAGGCTGTCGCGGCACTCGCG
GGCTTTTATCGCATCCCGGTCGAGTCGATTCTGGTGGCGCATGACGAACTGGACCTGCCTCCGGGCGTTGCCAAACTCAA
AGTGGGTGGCGGCCATGGCGGTCATAACGGGCTGCGCGACATCATTGCGCAGCTCGGCAACCAGAACACATTCCATCGCT
TGCGGCTTGGCATTGGCCACCCGGGCGATGCCAGCAAGGTATCCGGCTTTGTCCTGGGTCGAGCGCCACGCGCCGAACAG
GAAAAACTGGACGCCAGTATCGACTTTGCCCTCGGCGTGCTGCCGGATATCTTCGCCGGTGAATGGAACCGGGCGATGAA
AAACCTGCACAGCCAGAAGGCCTGA

Upstream 100 bases:

>100_bases
GAGATCGCTGAGTTTACATCATGGTAAATGAGCAGTTTTCGTCCACATTGCCGCTGTCGTCAGCGGTTCAACCCTCAACT
CCAAAGGAAGAGCCCCTGTC

Downstream 100 bases:

>100_bases
CATCACTCGAGGGGAAACACCATGGGATTCAATTGCGGCATCGTCGGCCTGCCTAACGTCGGCAAGTCCACCCTGTTCAA
CGCCCTGACCAAATCTGGTA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MTAIQLIVGLGNPGAEYEQTRHNAGAFFVERIAAAQRVDLVPERKFFGLTGRFTHQGQDVRLLIPTTYMNRSGQAVAALA
GFYRIPVESILVAHDELDLPPGVAKLKVGGGHGGHNGLRDIIAQLGNQNTFHRLRLGIGHPGDASKVSGFVLGRAPRAEQ
EKLDASIDFALGVLPDIFAGEWNRAMKNLHSQKA

Sequences:

>Translated_194_residues
MTAIQLIVGLGNPGAEYEQTRHNAGAFFVERIAAAQRVDLVPERKFFGLTGRFTHQGQDVRLLIPTTYMNRSGQAVAALA
GFYRIPVESILVAHDELDLPPGVAKLKVGGGHGGHNGLRDIIAQLGNQNTFHRLRLGIGHPGDASKVSGFVLGRAPRAEQ
EKLDASIDFALGVLPDIFAGEWNRAMKNLHSQKA
>Mature_193_residues
TAIQLIVGLGNPGAEYEQTRHNAGAFFVERIAAAQRVDLVPERKFFGLTGRFTHQGQDVRLLIPTTYMNRSGQAVAALAG
FYRIPVESILVAHDELDLPPGVAKLKVGGGHGGHNGLRDIIAQLGNQNTFHRLRLGIGHPGDASKVSGFVLGRAPRAEQE
KLDASIDFALGVLPDIFAGEWNRAMKNLHSQKA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=184, Percent_Identity=34.7826086956522, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1787455, Length=192, Percent_Identity=61.4583333333333, Blast_Score=212, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6321983, Length=167, Percent_Identity=32.3353293413174, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 20966; Mature: 20835

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAIQLIVGLGNPGAEYEQTRHNAGAFFVERIAAAQRVDLVPERKFFGLTGRFTHQGQDV
CCCEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEECCCCEEECCCCCE
RLLIPTTYMNRSGQAVAALAGFYRIPVESILVAHDELDLPPGVAKLKVGGGHGGHNGLRD
EEEEEEHCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHH
IIAQLGNQNTFHRLRLGIGHPGDASKVSGFVLGRAPRAEQEKLDASIDFALGVLPDIFAG
HHHHHCCCCCEEEEEECCCCCCCCHHHCEEEECCCCCCHHHHHCCHHHHHHHHHHHHHHC
EWNRAMKNLHSQKA
CHHHHHHHHHHCCC
>Mature Secondary Structure 
TAIQLIVGLGNPGAEYEQTRHNAGAFFVERIAAAQRVDLVPERKFFGLTGRFTHQGQDV
CCEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEECCCCEEECCCCCE
RLLIPTTYMNRSGQAVAALAGFYRIPVESILVAHDELDLPPGVAKLKVGGGHGGHNGLRD
EEEEEEHCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHH
IIAQLGNQNTFHRLRLGIGHPGDASKVSGFVLGRAPRAEQEKLDASIDFALGVLPDIFAG
HHHHHCCCCCEEEEEECCCCCCCCHHHCEEEECCCCCCHHHHHCCHHHHHHHHHHHHHHC
EWNRAMKNLHSQKA
CHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA