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The map label for this gene is lldD

Identifier: 66044163

GI number: 66044163

Start: 1029403

End: 1030545

Strand: Reverse

Name: lldD

Synonym: Psyr_0908

Alternate gene names: 66044163

Gene position: 1030545-1029403 (Counterclockwise)

Preceding gene: 66044167

Following gene: 66044162

Centisome position: 16.91

GC content: 58.88

Gene sequence:

>1143_bases
ATGATTATTTCTTCGGCATCCGACTACCGTGCAGCGGCCAAACGCAAACTCCCGCGTTTTCTGTTTGATTACATTGACGG
CGGTGCGTATGCAGAGCACACGCTGCGTGCCAATGGTTCGGACCTGGCCGATATCAGCCTGCGCCAGCGCGTCCTGAAAA
ATGTCGATAACGTGAGTCTTGAAACCAGACTGTTTGGCGAATCCCTGGCGATGCCGATTATCCTCAGCCCCGTAGGCCTG
AGCGGAATGTATGCGCGCCGCGGTGAAGTGCAGGTAGCCAGGGCCGCGGCGAACAAGCGGATTCCATTCTGTCTGTCGAC
GGTGTCGGTGTGTTCGATTGAAGAGGTAGCGTCGCAGAGCGATCAGGCGATCTGGTTTCAGCTCTACGTGCTCAAAGACC
GTGGCTTCATGAAAAACGCTCTGGAGCGTGCCAAGGCGGCGGGCGTCACGACGCTGGTCTTTACCGTCGACATGCCAACG
CCCGGCGCGCGTTATCGTGATGCGCACTCGGGCATGTCAGGGCCTTATGCCGCGCCTCGACGCATTCTGCAAGCCATGAC
CAAACCGGACTGGGCGCTGAATGTCGGCCTGCTCGGTCGCCCCCATGATCTGGGCAATATCTCCAGATACCTGGGCAAGG
CCACCACCCTGGAAGATTATGTGGGCTGGCTGGCGAACAACTTCGACCCGTCCATCAGCTGGAAGGATCTGGAGTGGATT
CGTGAGTTCTGGCAAGGCCCGATGATCATCAAGGGCATTCTCGATCCGCAGGATGCCAGAGATGCGCTGAGTTTTGGCGC
GGACGGCATTGTCGTATCCAACCACGGCGGACGTCAGCTGGATGGCGTGCTGTCCACCGCCAAGGCTTTGCCGCCGATTG
TTCAGGCGGTCGGCAGTGACCTGACAGTGCTGGCCGACTCCGGCATTCGCTCGGGTCTTGATGTGGTGCGCATGCTCGCC
CTCGGTGCCAAAGGCGTGTTGCTCGGACGCTCGATGGCCTATGCGCTGGGCGCCGATGGGCAGCGTGGCGTCGAGAATAT
GCTGGATATTTTTGCCAGGGAAATGCATGTGGCGATGACGTTGACCGGGGTGACATCGATTGAGCAGATCGACGCAAGCA
TTCTGGTTAAAGCAGTTGCTTGA

Upstream 100 bases:

>100_bases
GTATTAGTTGTTTTGATCATAGTCGGTTTTTCCGTAATCTGAACCTGCCGCTCTCCCTTGGCGGCCTCGCTTCGTAGATT
TATTCGCTCAGGAAAACGTC

Downstream 100 bases:

>100_bases
AGGCCGGGACTGGACGGAATCGTTATCCGGGTCGGCCTTTCGACGAACTGCATTTTTCACTCTGCATGCCTGGTCTATGC
TCGAAAGTGATGGCTCAAGA

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MIISSASDYRAAAKRKLPRFLFDYIDGGAYAEHTLRANGSDLADISLRQRVLKNVDNVSLETRLFGESLAMPIILSPVGL
SGMYARRGEVQVARAAANKRIPFCLSTVSVCSIEEVASQSDQAIWFQLYVLKDRGFMKNALERAKAAGVTTLVFTVDMPT
PGARYRDAHSGMSGPYAAPRRILQAMTKPDWALNVGLLGRPHDLGNISRYLGKATTLEDYVGWLANNFDPSISWKDLEWI
REFWQGPMIIKGILDPQDARDALSFGADGIVVSNHGGRQLDGVLSTAKALPPIVQAVGSDLTVLADSGIRSGLDVVRMLA
LGAKGVLLGRSMAYALGADGQRGVENMLDIFAREMHVAMTLTGVTSIEQIDASILVKAVA

Sequences:

>Translated_380_residues
MIISSASDYRAAAKRKLPRFLFDYIDGGAYAEHTLRANGSDLADISLRQRVLKNVDNVSLETRLFGESLAMPIILSPVGL
SGMYARRGEVQVARAAANKRIPFCLSTVSVCSIEEVASQSDQAIWFQLYVLKDRGFMKNALERAKAAGVTTLVFTVDMPT
PGARYRDAHSGMSGPYAAPRRILQAMTKPDWALNVGLLGRPHDLGNISRYLGKATTLEDYVGWLANNFDPSISWKDLEWI
REFWQGPMIIKGILDPQDARDALSFGADGIVVSNHGGRQLDGVLSTAKALPPIVQAVGSDLTVLADSGIRSGLDVVRMLA
LGAKGVLLGRSMAYALGADGQRGVENMLDIFAREMHVAMTLTGVTSIEQIDASILVKAVA
>Mature_380_residues
MIISSASDYRAAAKRKLPRFLFDYIDGGAYAEHTLRANGSDLADISLRQRVLKNVDNVSLETRLFGESLAMPIILSPVGL
SGMYARRGEVQVARAAANKRIPFCLSTVSVCSIEEVASQSDQAIWFQLYVLKDRGFMKNALERAKAAGVTTLVFTVDMPT
PGARYRDAHSGMSGPYAAPRRILQAMTKPDWALNVGLLGRPHDLGNISRYLGKATTLEDYVGWLANNFDPSISWKDLEWI
REFWQGPMIIKGILDPQDARDALSFGADGIVVSNHGGRQLDGVLSTAKALPPIVQAVGSDLTVLADSGIRSGLDVVRMLA
LGAKGVLLGRSMAYALGADGQRGVENMLDIFAREMHVAMTLTGVTSIEQIDASILVKAVA

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain

Homologues:

Organism=Homo sapiens, GI11068137, Length=372, Percent_Identity=36.0215053763441, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI54234014, Length=376, Percent_Identity=33.7765957446808, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI7705393, Length=376, Percent_Identity=33.7765957446808, Blast_Score=210, Evalue=2e-54,
Organism=Escherichia coli, GI1790033, Length=379, Percent_Identity=71.7678100263852, Blast_Score=563, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI193208036, Length=368, Percent_Identity=33.695652173913, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI32566217, Length=284, Percent_Identity=33.4507042253521, Blast_Score=157, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6323587, Length=379, Percent_Identity=32.7176781002639, Blast_Score=183, Evalue=4e-47,
Organism=Drosophila melanogaster, GI78707188, Length=377, Percent_Identity=34.4827586206897, Blast_Score=218, Evalue=8e-57,
Organism=Drosophila melanogaster, GI281363140, Length=377, Percent_Identity=34.4827586206897, Blast_Score=218, Evalue=8e-57,
Organism=Drosophila melanogaster, GI78707190, Length=377, Percent_Identity=34.4827586206897, Blast_Score=218, Evalue=8e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LLDD_PSEU2 (Q4ZY06)

Other databases:

- EMBL:   CP000075
- RefSeq:   YP_234004.1
- ProteinModelPortal:   Q4ZY06
- SMR:   Q4ZY06
- STRING:   Q4ZY06
- GeneID:   3366400
- GenomeReviews:   CP000075_GR
- KEGG:   psb:Psyr_0908
- NMPDR:   fig|205918.4.peg.1229
- eggNOG:   COG1304
- HOGENOM:   HBG517781
- OMA:   WIREFWE
- ProtClustDB:   PRK11197
- BioCyc:   PSYR205918:PSYR_0908-MONOMER
- HAMAP:   MF_01559
- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000138

Pfam domain/function: PF01070 FMN_dh

EC number: =1.1.2.3

Molecular weight: Translated: 41126; Mature: 41126

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH_1; PS51349 FMN_HYDROXY_ACID_DH_2

Important sites: ACT_SITE 275-275 BINDING 24-24 BINDING 106-106 BINDING 127-127 BINDING 129-129 BINDING 155-155 BINDING 164-164 BINDING 251-251 BINDING 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISSASDYRAAAKRKLPRFLFDYIDGGAYAEHTLRANGSDLADISLRQRVLKNVDNVSL
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCCCHHHHHHHHHHHHCCCCCCH
ETRLFGESLAMPIILSPVGLSGMYARRGEVQVARAAANKRIPFCLSTVSVCSIEEVASQS
HHHHHHHHHCCCEEECCCCCCCCHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
DQAIWFQLYVLKDRGFMKNALERAKAAGVTTLVFTVDMPTPGARYRDAHSGMSGPYAAPR
CCEEEEEEEEEECCCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCHHHCCCCCCCHHHH
RILQAMTKPDWALNVGLLGRPHDLGNISRYLGKATTLEDYVGWLANNFDPSISWKDLEWI
HHHHHHCCCCCEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
REFWQGPMIIKGILDPQDARDALSFGADGIVVSNHGGRQLDGVLSTAKALPPIVQAVGSD
HHHCCCCEEEEECCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
LTVLADSGIRSGLDVVRMLALGAKGVLLGRSMAYALGADGQRGVENMLDIFAREMHVAMT
EEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEE
LTGVTSIEQIDASILVKAVA
EECCHHHHHHHHHHHHEECC
>Mature Secondary Structure
MIISSASDYRAAAKRKLPRFLFDYIDGGAYAEHTLRANGSDLADISLRQRVLKNVDNVSL
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCCCHHHHHHHHHHHHCCCCCCH
ETRLFGESLAMPIILSPVGLSGMYARRGEVQVARAAANKRIPFCLSTVSVCSIEEVASQS
HHHHHHHHHCCCEEECCCCCCCCHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
DQAIWFQLYVLKDRGFMKNALERAKAAGVTTLVFTVDMPTPGARYRDAHSGMSGPYAAPR
CCEEEEEEEEEECCCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCHHHCCCCCCCHHHH
RILQAMTKPDWALNVGLLGRPHDLGNISRYLGKATTLEDYVGWLANNFDPSISWKDLEWI
HHHHHHCCCCCEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
REFWQGPMIIKGILDPQDARDALSFGADGIVVSNHGGRQLDGVLSTAKALPPIVQAVGSD
HHHCCCCEEEEECCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
LTVLADSGIRSGLDVVRMLALGAKGVLLGRSMAYALGADGQRGVENMLDIFAREMHVAMT
EEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEE
LTGVTSIEQIDASILVKAVA
EECCHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA