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The map label for this gene is nadC [H]

Identifier: 66044070

GI number: 66044070

Start: 919536

End: 920384

Strand: Reverse

Name: nadC [H]

Synonym: Psyr_0815

Alternate gene names: 66044070

Gene position: 920384-919536 (Counterclockwise)

Preceding gene: 66044074

Following gene: 66044069

Centisome position: 15.1

GC content: 61.84

Gene sequence:

>849_bases
ATGCCGAATTTACGAATTGCCGACCTGACCGCCGAGATCGAGGCCAATGTGCGTCGCGCGTTGCTGGAGGATGTCGGCAG
CGGCGATATCACTGCTCAATTGATTCCGGCAGAGCGACTGGCCAAGGCCACCATCATTTCCCGCGATACAGCGGTGATCG
CCGGTACTGCCTGGGTCGATGCGGTCTTTCGGCAACTGGACCCGCGCGTCGCCGTGCACTGGCAAGTGACCGATGGCGAT
CGCGTCAACCCGAATCAGGCCCTGTTTCATCTTGAAGGCCCGGCCCGCTCGCTGTTGACCGGCGAACGCAGCGCGCTCAA
TTTCCTGCAGATGCTCTCGGGAGTGGCCACGCGGGCGCAGTACTTCGCGGACATGGTCGCAGGCACTCAGGTCAAATTGC
TGGATACCCGCAAGACCCTGCCCGGTCTGCGCATGGCGCAGAAATACGCAGTCACCTGCGGCGGCTGTCATAACCACCGC
ATCGGGCTGTACGACGCGTTTCTGATCAAGGAAAACCACATCGCAGCCTGTGGCGGCATCGCCCAGGCAGTGGAAGCGGC
ACACCGGATTGCACCCGGCAAGCCTGTGGAAGTCGAGGTGGAGAGCCTGGGTGAACTCAAGCAGGCGCTGGACGCAGGCG
CCGACATCATCATGCTCGATGAATTGAGCCTTGATGACATGCGCGAGGCCGTGCGCCTCACCGCGGGCCGTGCCAGTCTG
GAAGCCAGCGGCGGCATCAACGACGATACCCTGCGGGTGATTGCCGAAACGGGTGTCGATTACATTTCCATCGGTGCGAT
GACCAAGGATGTGAAAGCCGTGGACCTGTCCATGCGCCTGAGCCTCTGA

Upstream 100 bases:

>100_bases
CCAACTGCACGTTCCCGGAGGTAACACCCTGGCATTGGCGCAGGTGGGTAAGCGGGATGCGGTGCCTTATACTCGAACGA
CTTTGCTACTGGAGCCCGCT

Downstream 100 bases:

>100_bases
CCCATCGCGCACAGCCAACTGTCACTATTCGCTCGGGAGTAGACGCTTTGGAACAATGGTTTGTAATGAACGCGGGCAAG
CAACTCGGCCCGATGGACGC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MPNLRIADLTAEIEANVRRALLEDVGSGDITAQLIPAERLAKATIISRDTAVIAGTAWVDAVFRQLDPRVAVHWQVTDGD
RVNPNQALFHLEGPARSLLTGERSALNFLQMLSGVATRAQYFADMVAGTQVKLLDTRKTLPGLRMAQKYAVTCGGCHNHR
IGLYDAFLIKENHIAACGGIAQAVEAAHRIAPGKPVEVEVESLGELKQALDAGADIIMLDELSLDDMREAVRLTAGRASL
EASGGINDDTLRVIAETGVDYISIGAMTKDVKAVDLSMRLSL

Sequences:

>Translated_282_residues
MPNLRIADLTAEIEANVRRALLEDVGSGDITAQLIPAERLAKATIISRDTAVIAGTAWVDAVFRQLDPRVAVHWQVTDGD
RVNPNQALFHLEGPARSLLTGERSALNFLQMLSGVATRAQYFADMVAGTQVKLLDTRKTLPGLRMAQKYAVTCGGCHNHR
IGLYDAFLIKENHIAACGGIAQAVEAAHRIAPGKPVEVEVESLGELKQALDAGADIIMLDELSLDDMREAVRLTAGRASL
EASGGINDDTLRVIAETGVDYISIGAMTKDVKAVDLSMRLSL
>Mature_281_residues
PNLRIADLTAEIEANVRRALLEDVGSGDITAQLIPAERLAKATIISRDTAVIAGTAWVDAVFRQLDPRVAVHWQVTDGDR
VNPNQALFHLEGPARSLLTGERSALNFLQMLSGVATRAQYFADMVAGTQVKLLDTRKTLPGLRMAQKYAVTCGGCHNHRI
GLYDAFLIKENHIAACGGIAQAVEAAHRIAPGKPVEVEVESLGELKQALDAGADIIMLDELSLDDMREAVRLTAGRASLE
ASGGINDDTLRVIAETGVDYISIGAMTKDVKAVDLSMRLSL

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=255, Percent_Identity=34.9019607843137, Blast_Score=141, Evalue=6e-34,
Organism=Escherichia coli, GI1786299, Length=278, Percent_Identity=56.8345323741007, Blast_Score=289, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6321162, Length=282, Percent_Identity=31.9148936170213, Blast_Score=137, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30292; Mature: 30161

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNLRIADLTAEIEANVRRALLEDVGSGDITAQLIPAERLAKATIISRDTAVIAGTAWVD
CCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHEECCCEEEEHHHHHH
AVFRQLDPRVAVHWQVTDGDRVNPNQALFHLEGPARSLLTGERSALNFLQMLSGVATRAQ
HHHHHCCCCEEEEEEECCCCCCCCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHH
YFADMVAGTQVKLLDTRKTLPGLRMAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGI
HHHHHHCCCEEEEEECHHCCCCHHHHHHHEEEECCCCCCCCCEEEEEEEECCCEEHHHHH
AQAVEAAHRIAPGKPVEVEVESLGELKQALDAGADIIMLDELSLDDMREAVRLTAGRASL
HHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCE
EASGGINDDTLRVIAETGVDYISIGAMTKDVKAVDLSMRLSL
ECCCCCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEECC
>Mature Secondary Structure 
PNLRIADLTAEIEANVRRALLEDVGSGDITAQLIPAERLAKATIISRDTAVIAGTAWVD
CCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHEECCCEEEEHHHHHH
AVFRQLDPRVAVHWQVTDGDRVNPNQALFHLEGPARSLLTGERSALNFLQMLSGVATRAQ
HHHHHCCCCEEEEEEECCCCCCCCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHH
YFADMVAGTQVKLLDTRKTLPGLRMAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGI
HHHHHHCCCEEEEEECHHCCCCHHHHHHHEEEECCCCCCCCCEEEEEEEECCCEEHHHHH
AQAVEAAHRIAPGKPVEVEVESLGELKQALDAGADIIMLDELSLDDMREAVRLTAGRASL
HHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCE
EASGGINDDTLRVIAETGVDYISIGAMTKDVKAVDLSMRLSL
ECCCCCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]