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The map label for this gene is proC [H]

Identifier: 66043743

GI number: 66043743

Start: 514881

End: 515699

Strand: Reverse

Name: proC [H]

Synonym: Psyr_0476

Alternate gene names: 66043743

Gene position: 515699-514881 (Counterclockwise)

Preceding gene: 66043744

Following gene: 66043742

Centisome position: 8.46

GC content: 64.47

Gene sequence:

>819_bases
ATGAGCAAGACCCGTATTGCCTTCGTCGGTGCCGGTAACATGGCCGCCAGCCTGATCGGCGGCCTGCGCGCCCAGGGCGT
GGAGGCGGCACTGATCAGTGCCAGTGCGCCGGGTGCCGAAACCCGCGAACGCATTGCCAACGATCACGGCATCCAGGTAT
TCGCTGACAACGCTGACGCCATCAAGGGCGTCGACGTGGTGGTACTGGCAGTCAAGCCGCAGATGATGAAAACCGTCTGT
CAGGCCTTGAAGTCCGGTCTCGAACCTCACCAGCTGATTGTTTCGGTCGCGGCCGGCATCACCTGCGCCAGCCTGACGCA
ATGGCTGGGCGAGCAGCCGGTGGTGCGCTGCATGCCCAATACGCCCTCGCTGCTGCGTCAGGGTGCCAGCGGGCTGTACG
CGACCGACAACGTCACGCCCGAGCAGCGTGAGCAGGCCGAGGCGTTGCTGGCCGCGGTCGGCATCGCGGTCTGGGTCGAG
CAGGAAAAACACATGGACGCTGTCACGGCCGTTTCCGGCAGTGGCCCGGCGTATTTCTTTCTGATGATGGAAGCGATGAC
AGCGGCAGGCGTGAAACTGGGTCTGCCGGAGGACATCGCTAAAAAGCTGACCCTGCAGACAGCGCTGGGCTCGGCCCTGA
TCGCGACTGGCAGTGATGCAGGCGCGGGCGAGCTGCGTCGTCGTGTCACTTCGCCGGGCGGGACCACCGAGGCGGCTATC
AAGGCATTTCAGGCGGGCGGCTTCGAGGCACTGGTGGAAACGGCACTGACCGCCGCAGACCATCGTGCAGCCGAGCTGGC
TGAACAACTGGGCAAATAA

Upstream 100 bases:

>100_bases
AGCCGCCATTGCACAAGGCGCAACCTGGGTGCGCATCGGCACCGCTCTTTTTGGCGCCCGCGACTATGGCCAGCCATAAA
CTCTTCACAAGGACCCCTTC

Downstream 100 bases:

>100_bases
TTTTCGGGTTTTCTGGAGCAGATCGATGATCGGATTGAACACCGCTGCAATTTACGTCCTGCAGACGCTTGGCAGTCTTT
ACCTGCTGATCGTACTGTTG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSKTRIAFVGAGNMAASLIGGLRAQGVEAALISASAPGAETRERIANDHGIQVFADNADAIKGVDVVVLAVKPQMMKTVC
QALKSGLEPHQLIVSVAAGITCASLTQWLGEQPVVRCMPNTPSLLRQGASGLYATDNVTPEQREQAEALLAAVGIAVWVE
QEKHMDAVTAVSGSGPAYFFLMMEAMTAAGVKLGLPEDIAKKLTLQTALGSALIATGSDAGAGELRRRVTSPGGTTEAAI
KAFQAGGFEALVETALTAADHRAAELAEQLGK

Sequences:

>Translated_272_residues
MSKTRIAFVGAGNMAASLIGGLRAQGVEAALISASAPGAETRERIANDHGIQVFADNADAIKGVDVVVLAVKPQMMKTVC
QALKSGLEPHQLIVSVAAGITCASLTQWLGEQPVVRCMPNTPSLLRQGASGLYATDNVTPEQREQAEALLAAVGIAVWVE
QEKHMDAVTAVSGSGPAYFFLMMEAMTAAGVKLGLPEDIAKKLTLQTALGSALIATGSDAGAGELRRRVTSPGGTTEAAI
KAFQAGGFEALVETALTAADHRAAELAEQLGK
>Mature_271_residues
SKTRIAFVGAGNMAASLIGGLRAQGVEAALISASAPGAETRERIANDHGIQVFADNADAIKGVDVVVLAVKPQMMKTVCQ
ALKSGLEPHQLIVSVAAGITCASLTQWLGEQPVVRCMPNTPSLLRQGASGLYATDNVTPEQREQAEALLAAVGIAVWVEQ
EKHMDAVTAVSGSGPAYFFLMMEAMTAAGVKLGLPEDIAKKLTLQTALGSALIATGSDAGAGELRRRVTSPGGTTEAAIK
AFQAGGFEALVETALTAADHRAAELAEQLGK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=268, Percent_Identity=37.6865671641791, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI24797097, Length=268, Percent_Identity=37.6865671641791, Blast_Score=154, Evalue=6e-38,
Organism=Homo sapiens, GI21361454, Length=268, Percent_Identity=36.5671641791045, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI198041662, Length=272, Percent_Identity=32.7205882352941, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1786585, Length=272, Percent_Identity=34.1911764705882, Blast_Score=135, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17569021, Length=265, Percent_Identity=37.7358490566038, Blast_Score=153, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17540664, Length=287, Percent_Identity=30.6620209059233, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6320861, Length=227, Percent_Identity=33.0396475770925, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21358587, Length=269, Percent_Identity=35.6877323420074, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24648116, Length=276, Percent_Identity=32.2463768115942, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24647700, Length=170, Percent_Identity=37.0588235294118, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28005; Mature: 27874

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTRIAFVGAGNMAASLIGGLRAQGVEAALISASAPGAETRERIANDHGIQVFADNADA
CCCCEEEEEECCHHHHHHHHHHHHCCCHHEEEECCCCCHHHHHHHCCCCCEEEEECCCCC
IKGVDVVVLAVKPQMMKTVCQALKSGLEPHQLIVSVAAGITCASLTQWLGEQPVVRCMPN
CCCCEEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCC
TPSLLRQGASGLYATDNVTPEQREQAEALLAAVGIAVWVEQEKHMDAVTAVSGSGPAYFF
CHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHEECCHHHHHHHHEECCCCCHHHH
LMMEAMTAAGVKLGLPEDIAKKLTLQTALGSALIATGSDAGAGELRRRVTSPGGTTEAAI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHEECCCCCCHHHHHHHHCCCCCCHHHHH
KAFQAGGFEALVETALTAADHRAAELAEQLGK
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKTRIAFVGAGNMAASLIGGLRAQGVEAALISASAPGAETRERIANDHGIQVFADNADA
CCCEEEEEECCHHHHHHHHHHHHCCCHHEEEECCCCCHHHHHHHCCCCCEEEEECCCCC
IKGVDVVVLAVKPQMMKTVCQALKSGLEPHQLIVSVAAGITCASLTQWLGEQPVVRCMPN
CCCCEEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCC
TPSLLRQGASGLYATDNVTPEQREQAEALLAAVGIAVWVEQEKHMDAVTAVSGSGPAYFF
CHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHEECCHHHHHHHHEECCCCCHHHH
LMMEAMTAAGVKLGLPEDIAKKLTLQTALGSALIATGSDAGAGELRRRVTSPGGTTEAAI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHEECCCCCCHHHHHHHHCCCCCCHHHHH
KAFQAGGFEALVETALTAADHRAAELAEQLGK
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]