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The map label for this gene is hutC [H]

Identifier: 66043635

GI number: 66043635

Start: 390409

End: 391230

Strand: Reverse

Name: hutC [H]

Synonym: Psyr_0366

Alternate gene names: 66043635

Gene position: 391230-390409 (Counterclockwise)

Preceding gene: 66043637

Following gene: 66043634

Centisome position: 6.42

GC content: 63.14

Gene sequence:

>822_bases
ATGGTTAGCGTGAGCGCTTTGCAGCGTCTGAATGCTCTCGAAAACACCGTCTCGAACAACAAGGACTCCCACGTGTCGAC
TCCGCCCGCCGCTTCTTCCCTGGCAGCCCAGATGGGCGAAAGTCCCGCACCCTTGTACGCCCGCGTGAAACAGATGATCG
CCTTGCAGATCCAGAACGGCACCTGGCCGCCGCACCATCGTGTGCCGTCGGAAAGCGAGCTGGTGACGCAACTGGGTTTT
AGCCGCATGACCATAAACCGGGCACTGCGCGAGCTGACCGCCGAGGGCCTGCTGGTGCGCATGCAGGGCGTCGGCACCTT
TGTCGCCGAGCCCAAGAGCCAGTCGGCGCTGTTCGAAGTGCACAACATTGCCGACGAGATCGCCGCACGCGGTCATCGCC
ACACCTGCAAGGTCATGGTCCTCAAGGAGGAAGCCGCTGGCTCCGAACGCGCCCTGGCGCTGGACATGCGCGAAGGCCAG
CGGGTCTTCCACTCGCTGATCGTGCATTACGAGAACGACATTCCAGTGCAGATCGAGGACCGCTTCGTGAACGCCCAGGT
CGCTCCGGACTACCTCCGGCAGGACTTCACCCTGCAGACGCCTTACGCCTACCTGTCGCAGGTTGCGCCACTCACCGAAG
GCGAGCACGTGGTCGAGGCGATTCTCGCCGAAGCCGATGAATGCAGGCTGTTGCAGATTGAGGCGGGAGAACCCTGCCTG
CTGATTCGCCGCCGTACCTGGTCAGGTCGTCAGCCGGTCACCGCTGCGCGCCTGATCCATCCCGGCTCCCGCCATCGCCT
GGAAGGACGCTTTACCAAATGA

Upstream 100 bases:

>100_bases
CTGACATTGACTTCACACCTCATCACTGTAATTTGTATATACATATACAGACGTTTAAGCGACCGGTAAACCTTCTGCAT
GCTTGCCGAGCAGCAGGTTA

Downstream 100 bases:

>100_bases
GCCAGACCCGCATTTTGCGCGCCGCAGACTACCCGCGCATGCCGTGGAAGAACGGCGGAGGCAGCACTGAAGAGATCGCT
CGCGACGCAGGCCAGGACCT

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MVSVSALQRLNALENTVSNNKDSHVSTPPAASSLAAQMGESPAPLYARVKQMIALQIQNGTWPPHHRVPSESELVTQLGF
SRMTINRALRELTAEGLLVRMQGVGTFVAEPKSQSALFEVHNIADEIAARGHRHTCKVMVLKEEAAGSERALALDMREGQ
RVFHSLIVHYENDIPVQIEDRFVNAQVAPDYLRQDFTLQTPYAYLSQVAPLTEGEHVVEAILAEADECRLLQIEAGEPCL
LIRRRTWSGRQPVTAARLIHPGSRHRLEGRFTK

Sequences:

>Translated_273_residues
MVSVSALQRLNALENTVSNNKDSHVSTPPAASSLAAQMGESPAPLYARVKQMIALQIQNGTWPPHHRVPSESELVTQLGF
SRMTINRALRELTAEGLLVRMQGVGTFVAEPKSQSALFEVHNIADEIAARGHRHTCKVMVLKEEAAGSERALALDMREGQ
RVFHSLIVHYENDIPVQIEDRFVNAQVAPDYLRQDFTLQTPYAYLSQVAPLTEGEHVVEAILAEADECRLLQIEAGEPCL
LIRRRTWSGRQPVTAARLIHPGSRHRLEGRFTK
>Mature_273_residues
MVSVSALQRLNALENTVSNNKDSHVSTPPAASSLAAQMGESPAPLYARVKQMIALQIQNGTWPPHHRVPSESELVTQLGF
SRMTINRALRELTAEGLLVRMQGVGTFVAEPKSQSALFEVHNIADEIAARGHRHTCKVMVLKEEAAGSERALALDMREGQ
RVFHSLIVHYENDIPVQIEDRFVNAQVAPDYLRQDFTLQTPYAYLSQVAPLTEGEHVVEAILAEADECRLLQIEAGEPCL
LIRRRTWSGRQPVTAARLIHPGSRHRLEGRFTK

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=223, Percent_Identity=26.457399103139, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786950, Length=199, Percent_Identity=26.1306532663317, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 30380; Mature: 30380

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSVSALQRLNALENTVSNNKDSHVSTPPAASSLAAQMGESPAPLYARVKQMIALQIQNG
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHEEEECCC
TWPPHHRVPSESELVTQLGFSRMTINRALRELTAEGLLVRMQGVGTFVAEPKSQSALFEV
CCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCCCHHHHHH
HNIADEIAARGHRHTCKVMVLKEEAAGSERALALDMREGQRVFHSLIVHYENDIPVQIED
HHHHHHHHHCCCCCEEEEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEC
RFVNAQVAPDYLRQDFTLQTPYAYLSQVAPLTEGEHVVEAILAEADECRLLQIEAGEPCL
EEECCCCCHHHHHCCCCEECCHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCCCEE
LIRRRTWSGRQPVTAARLIHPGSRHRLEGRFTK
EEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVSVSALQRLNALENTVSNNKDSHVSTPPAASSLAAQMGESPAPLYARVKQMIALQIQNG
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHEEEECCC
TWPPHHRVPSESELVTQLGFSRMTINRALRELTAEGLLVRMQGVGTFVAEPKSQSALFEV
CCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCCCHHHHHH
HNIADEIAARGHRHTCKVMVLKEEAAGSERALALDMREGQRVFHSLIVHYENDIPVQIED
HHHHHHHHHCCCCCEEEEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEC
RFVNAQVAPDYLRQDFTLQTPYAYLSQVAPLTEGEHVVEAILAEADECRLLQIEAGEPCL
EEECCCCCHHHHHCCCCEECCHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCCCEE
LIRRRTWSGRQPVTAARLIHPGSRHRLEGRFTK
EEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]