Click here to switch to the map view.

The map label for this gene is hemB [H]

Identifier: 66043562

GI number: 66043562

Start: 310413

End: 311423

Strand: Direct

Name: hemB [H]

Synonym: Psyr_0292

Alternate gene names: 66043562

Gene position: 310413-311423 (Clockwise)

Preceding gene: 66043556

Following gene: 66043563

Centisome position: 5.09

GC content: 60.14

Gene sequence:

>1011_bases
GTGAGCTTTACCCCCGCTAACCGCCTGTTTCCTCTCACTCGTCTGCGCCGTAATCGCCGCGACGACTTTTCCCGTCGGCT
GGTGCGTGAAAACGTTGTCACTGTCGACGATCTGATTCTTCCGGTATTTGTACTCGATGGTGAAAACCGTCGTGAATCCA
TCGCCTCGATGCCTGGCGTCGAGCGCTTGAGCGTGGATCTGTTGCTCAAGGAAGCCGAGCACTGGGTCGCGCTGGGTATC
CCTGCGCTGGCGCTGTTCCCGGTGACACCACCGGAAAAGAAATCCCTCGACGGCGCCGAAGCCTGGAACCCGGACGGCAT
CGCCCAGCGCGCGACCCGCGCCCTGCGTGACCGTTTCCCGGAGCTGGGCGTCATCACTGATGTGGCGCTGGACCCGTTCA
CCACGCATGGTCAGGACGGCATCCTCGACGAAGAGGGCTATGTTCAGAACGACATCACTGTCGACGCGCTGGTGAAGCAG
GCGCTGTCGCACGCAGATGCCGGTGCTCAGGTGATCGCTCCGTCGGACATGATGGACGGTCGTATTCAGGCCATCCGCGA
GTCTCTGGAGCTGGCCGGGCATGTCAATGTCAGGATCATGGCCTATTCGGCCAAGTACGCCAGTGCCTACTACGGCCCGT
TCCGTGATGCGGTGGGTTCCTCCCTGAATCTGGGCAAGGCCAACAAGGCCTCCTATCAGATGGACCCGGCCAACAGCAAC
GAGGCCCTGCACGAAGTGGCGGCCGACCTTGCCGAAGGCGCCGACATGGTCATGGTCAAGCCAGGCATGCCTTATCTGGA
CATTCTGTACAGGGTCAAGGATGAGTTCAAAGTGCCGACCTTTGTTTATCAGGTCAGCGGTGAATACGCGATGCACATGG
CCGCAATCCAGAACGGTTGGCTGAGTGAAGGGGTGATTCTCGAATCCCTCACTGCCTTCAAACGCGCCGGCGCCGACGGC
ATCCTTACCTACTTTGCTGTTCGCGCCGCTCAACTGTTGAAGGGGCAATAG

Upstream 100 bases:

>100_bases
ACGTGCAGTCGCAGGTCGAACCATGACTGTCACACATTGGTCATAATGGCGGCTTATAACTGTCGCGCTTGCCCGCGTAA
GCGGGCTCAGGAGTCTCGCC

Downstream 100 bases:

>100_bases
CCTCACAGGAACATTCATGAATACCGAAGCACTCATCGAAGCCGCTGTTCAAGTCGATGTCCCGGAGGCAACGCCCGTGG
TCGAACCTGACATCGAAGTA

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSFTPANRLFPLTRLRRNRRDDFSRRLVRENVVTVDDLILPVFVLDGENRRESIASMPGVERLSVDLLLKEAEHWVALGI
PALALFPVTPPEKKSLDGAEAWNPDGIAQRATRALRDRFPELGVITDVALDPFTTHGQDGILDEEGYVQNDITVDALVKQ
ALSHADAGAQVIAPSDMMDGRIQAIRESLELAGHVNVRIMAYSAKYASAYYGPFRDAVGSSLNLGKANKASYQMDPANSN
EALHEVAADLAEGADMVMVKPGMPYLDILYRVKDEFKVPTFVYQVSGEYAMHMAAIQNGWLSEGVILESLTAFKRAGADG
ILTYFAVRAAQLLKGQ

Sequences:

>Translated_336_residues
MSFTPANRLFPLTRLRRNRRDDFSRRLVRENVVTVDDLILPVFVLDGENRRESIASMPGVERLSVDLLLKEAEHWVALGI
PALALFPVTPPEKKSLDGAEAWNPDGIAQRATRALRDRFPELGVITDVALDPFTTHGQDGILDEEGYVQNDITVDALVKQ
ALSHADAGAQVIAPSDMMDGRIQAIRESLELAGHVNVRIMAYSAKYASAYYGPFRDAVGSSLNLGKANKASYQMDPANSN
EALHEVAADLAEGADMVMVKPGMPYLDILYRVKDEFKVPTFVYQVSGEYAMHMAAIQNGWLSEGVILESLTAFKRAGADG
ILTYFAVRAAQLLKGQ
>Mature_335_residues
SFTPANRLFPLTRLRRNRRDDFSRRLVRENVVTVDDLILPVFVLDGENRRESIASMPGVERLSVDLLLKEAEHWVALGIP
ALALFPVTPPEKKSLDGAEAWNPDGIAQRATRALRDRFPELGVITDVALDPFTTHGQDGILDEEGYVQNDITVDALVKQA
LSHADAGAQVIAPSDMMDGRIQAIRESLELAGHVNVRIMAYSAKYASAYYGPFRDAVGSSLNLGKANKASYQMDPANSNE
ALHEVAADLAEGADMVMVKPGMPYLDILYRVKDEFKVPTFVYQVSGEYAMHMAAIQNGWLSEGVILESLTAFKRAGADGI
LTYFAVRAAQLLKGQ

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=307, Percent_Identity=43.6482084690554, Blast_Score=228, Evalue=8e-60,
Organism=Escherichia coli, GI87081728, Length=321, Percent_Identity=42.0560747663551, Blast_Score=239, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6321398, Length=307, Percent_Identity=36.8078175895765, Blast_Score=182, Evalue=6e-47,
Organism=Drosophila melanogaster, GI21358291, Length=291, Percent_Identity=40.2061855670103, Blast_Score=219, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36936; Mature: 36804

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTPANRLFPLTRLRRNRRDDFSRRLVRENVVTVDDLILPVFVLDGENRRESIASMPGV
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHEEEEEEECCCCHHHHHHHCCCH
ERLSVDLLLKEAEHWVALGIPALALFPVTPPEKKSLDGAEAWNPDGIAQRATRALRDRFP
HHHHHHHHHHHHHHEEEECCCHHEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
ELGVITDVALDPFTTHGQDGILDEEGYVQNDITVDALVKQALSHADAGAQVIAPSDMMDG
CCCEEHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHH
RIQAIRESLELAGHVNVRIMAYSAKYASAYYGPFRDAVGSSLNLGKANKASYQMDPANSN
HHHHHHHHHHHHCCCEEEEEEEECHHHHHHCCHHHHHCCCCCCCCCCCCCCEEECCCCCH
EALHEVAADLAEGADMVMVKPGMPYLDILYRVKDEFKVPTFVYQVSGEYAMHMAAIQNGW
HHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCC
LSEGVILESLTAFKRAGADGILTYFAVRAAQLLKGQ
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SFTPANRLFPLTRLRRNRRDDFSRRLVRENVVTVDDLILPVFVLDGENRRESIASMPGV
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHEEEEEEECCCCHHHHHHHCCCH
ERLSVDLLLKEAEHWVALGIPALALFPVTPPEKKSLDGAEAWNPDGIAQRATRALRDRFP
HHHHHHHHHHHHHHEEEECCCHHEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
ELGVITDVALDPFTTHGQDGILDEEGYVQNDITVDALVKQALSHADAGAQVIAPSDMMDG
CCCEEHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHH
RIQAIRESLELAGHVNVRIMAYSAKYASAYYGPFRDAVGSSLNLGKANKASYQMDPANSN
HHHHHHHHHHHHCCCEEEEEEEECHHHHHHCCHHHHHCCCCCCCCCCCCCCEEECCCCCH
EALHEVAADLAEGADMVMVKPGMPYLDILYRVKDEFKVPTFVYQVSGEYAMHMAAIQNGW
HHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCC
LSEGVILESLTAFKRAGADGILTYFAVRAAQLLKGQ
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9529530; 10984043; 10356331; 12079382 [H]