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The map label for this gene is gltP [H]

Identifier: 66043444

GI number: 66043444

Start: 188229

End: 189560

Strand: Direct

Name: gltP [H]

Synonym: Psyr_0174

Alternate gene names: 66043444

Gene position: 188229-189560 (Clockwise)

Preceding gene: 66043443

Following gene: 66043445

Centisome position: 3.09

GC content: 58.03

Gene sequence:

>1332_bases
ATGAAGAAGGCAAAGCTGAGTCTGGCCTGGCAGATTCTGATCGGACTGGTACTGGGTATCGCTGTGGGGGCGCTACTCAA
TCATTTCAGCGCAGAAAAGGCCTGGTGGATCACCAACATCCTGCAGCCCGCAGGCGATATCTTCATTCGTCTGATCAAGA
TGATCGTTATTCCCATCGTTGTCGCCTCGCTGATCGTCGGCATCGCGGGCGTGGGCGATGCCAAGAAGCTGGGACGTATC
GGTCTCAAGACCATTCTCTATTTTGAAGTCGTGACCACTATCGCGATTCTGGTGGGGCTGGTGCTGGCCAACGTGTTCCA
TCCGGGCACCGGCATCGACATGAGCACACTGGGCACCGTCGATATTTCCAAGTATCAGCAGACGACGGCTGAAGTTCAGC
ACGATCATGCGTTTATCGCGACCATTCTCAACCTGATCCCGTCCAACATCTTCGCCGCCATGGCGCGTGGCGAGATGCTG
CCGATCATCTTCTTTTCGGTGTTGTTCGGCCTGGGGCTTTCCAGTCTGCAAGCCGAGGTCCGTGAGCCGCTGGTGAAGCT
GTTTCAGGGCGTCTCGGAGACCATGTTCAAGGTCACTCACATGATCATGAACTACGCGCCGATTGGTGTGTTTGCCCTGA
TTGCGGTGACTGTCGCCAACTTCGGCTTCGCCTCCCTGCTGCCGCTCGCCAAGCTGGTGATTCTGGTTTACGTGGCCATC
GCCTTCTTCGCCTTCGTGGTGCTGGGGCTGATCGCTCGTGCATTCGGCTTTTCGGTCATCAGGCTGATGCGTATCTTCAA
GGACGAGCTGATTCTGTCCTACTCCACGGCCAGCTCTGAAACCGTGCTGCCACGGGTGATCCAGAAGATGGAAGCCTATG
GCGCACCGAAGGCGATTTGCAGTTTCGTGGTGCCCACGGGCTACTCGTTCAACCTTGACGGTTCGACGCTCTATCAGAGC
ATCGCAGCCATCTTCATCGCTCAGTTGTACGGCATCGACCTGTCGATTGGCGCGCAATTGATGTTGGTGCTGACCCTGAT
GGTCACCTCCAAAGGCATCGCGGGCGTACCGGGCGTTTCCTTCGTTGTGCTGCTGGCGACCCTGGGCAGCGCCGGTATTC
CACTGGAAGGCCTGGCGTTCATCGCTGGCGTCGACCGCATCATGGACATGGCGCGTACCGCTTTGAACGTGATCGGCAAT
GCGCTGGCAGTGCTGGTTATCTCGCGCTGGGAGGGCATGTATGACGATGCCAAGGGCGAGCGCTACTGGAACTCCCTGCC
GCACTGGCGCAGCAAAGAGCCAGTGCCGATGGGGCAACCGACGGCGGACTGA

Upstream 100 bases:

>100_bases
CATTTCCAAAGGGAGCTCCTGCCTCGAAACTGCTGTGAAAAAGCATGCTCGGTGCACGGGTTTTGGACTTGCCCAAGCCA
CTTTGAACAAGGGTAATAAT

Downstream 100 bases:

>100_bases
TCTTCGCTATGTGCTGACAAGCCCCGGACCTCCGGGGTTTGTTGTTTTCAGGTCGCCGGTTAGACTGCCTGCCTTACCTG
AGGAGTGACCATGACCGACG

Product: glutamate/aspartate:proton symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MKKAKLSLAWQILIGLVLGIAVGALLNHFSAEKAWWITNILQPAGDIFIRLIKMIVIPIVVASLIVGIAGVGDAKKLGRI
GLKTILYFEVVTTIAILVGLVLANVFHPGTGIDMSTLGTVDISKYQQTTAEVQHDHAFIATILNLIPSNIFAAMARGEML
PIIFFSVLFGLGLSSLQAEVREPLVKLFQGVSETMFKVTHMIMNYAPIGVFALIAVTVANFGFASLLPLAKLVILVYVAI
AFFAFVVLGLIARAFGFSVIRLMRIFKDELILSYSTASSETVLPRVIQKMEAYGAPKAICSFVVPTGYSFNLDGSTLYQS
IAAIFIAQLYGIDLSIGAQLMLVLTLMVTSKGIAGVPGVSFVVLLATLGSAGIPLEGLAFIAGVDRIMDMARTALNVIGN
ALAVLVISRWEGMYDDAKGERYWNSLPHWRSKEPVPMGQPTAD

Sequences:

>Translated_443_residues
MKKAKLSLAWQILIGLVLGIAVGALLNHFSAEKAWWITNILQPAGDIFIRLIKMIVIPIVVASLIVGIAGVGDAKKLGRI
GLKTILYFEVVTTIAILVGLVLANVFHPGTGIDMSTLGTVDISKYQQTTAEVQHDHAFIATILNLIPSNIFAAMARGEML
PIIFFSVLFGLGLSSLQAEVREPLVKLFQGVSETMFKVTHMIMNYAPIGVFALIAVTVANFGFASLLPLAKLVILVYVAI
AFFAFVVLGLIARAFGFSVIRLMRIFKDELILSYSTASSETVLPRVIQKMEAYGAPKAICSFVVPTGYSFNLDGSTLYQS
IAAIFIAQLYGIDLSIGAQLMLVLTLMVTSKGIAGVPGVSFVVLLATLGSAGIPLEGLAFIAGVDRIMDMARTALNVIGN
ALAVLVISRWEGMYDDAKGERYWNSLPHWRSKEPVPMGQPTAD
>Mature_443_residues
MKKAKLSLAWQILIGLVLGIAVGALLNHFSAEKAWWITNILQPAGDIFIRLIKMIVIPIVVASLIVGIAGVGDAKKLGRI
GLKTILYFEVVTTIAILVGLVLANVFHPGTGIDMSTLGTVDISKYQQTTAEVQHDHAFIATILNLIPSNIFAAMARGEML
PIIFFSVLFGLGLSSLQAEVREPLVKLFQGVSETMFKVTHMIMNYAPIGVFALIAVTVANFGFASLLPLAKLVILVYVAI
AFFAFVVLGLIARAFGFSVIRLMRIFKDELILSYSTASSETVLPRVIQKMEAYGAPKAICSFVVPTGYSFNLDGSTLYQS
IAAIFIAQLYGIDLSIGAQLMLVLTLMVTSKGIAGVPGVSFVVLLATLGSAGIPLEGLAFIAGVDRIMDMARTALNVIGN
ALAVLVISRWEGMYDDAKGERYWNSLPHWRSKEPVPMGQPTAD

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=490, Percent_Identity=25.9183673469388, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI21314632, Length=439, Percent_Identity=27.1070615034169, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI169790839, Length=424, Percent_Identity=26.6509433962264, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI66773030, Length=455, Percent_Identity=28.3516483516484, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI5032093, Length=417, Percent_Identity=27.3381294964029, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4827012, Length=256, Percent_Identity=32.03125, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI223468564, Length=291, Percent_Identity=28.5223367697594, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI223468566, Length=291, Percent_Identity=28.5223367697594, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI262359914, Length=365, Percent_Identity=25.2054794520548, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI194239697, Length=257, Percent_Identity=29.5719844357977, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI301601644, Length=203, Percent_Identity=30.5418719211823, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1790514, Length=423, Percent_Identity=73.9952718676123, Blast_Score=622, Evalue=1e-179,
Organism=Escherichia coli, GI1789947, Length=431, Percent_Identity=38.9791183294664, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI1788024, Length=384, Percent_Identity=25.5208333333333, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71983099, Length=483, Percent_Identity=26.7080745341615, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71983106, Length=451, Percent_Identity=26.8292682926829, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71996953, Length=461, Percent_Identity=27.765726681128, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17537407, Length=424, Percent_Identity=27.122641509434, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI193206505, Length=464, Percent_Identity=28.0172413793103, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI193206654, Length=460, Percent_Identity=25.8695652173913, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17541374, Length=407, Percent_Identity=25.3071253071253, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24583025, Length=467, Percent_Identity=25.2676659528908, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI17137668, Length=467, Percent_Identity=25.2676659528908, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24583023, Length=467, Percent_Identity=25.2676659528908, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI281360481, Length=472, Percent_Identity=27.5423728813559, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI281360483, Length=471, Percent_Identity=26.963906581741, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17137666, Length=471, Percent_Identity=26.963906581741, Blast_Score=102, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 47695; Mature: 47695

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAKLSLAWQILIGLVLGIAVGALLNHFSAEKAWWITNILQPAGDIFIRLIKMIVIPIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VASLIVGIAGVGDAKKLGRIGLKTILYFEVVTTIAILVGLVLANVFHPGTGIDMSTLGTV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCH
DISKYQQTTAEVQHDHAFIATILNLIPSNIFAAMARGEMLPIIFFSVLFGLGLSSLQAEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHH
REPLVKLFQGVSETMFKVTHMIMNYAPIGVFALIAVTVANFGFASLLPLAKLVILVYVAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AFFAFVVLGLIARAFGFSVIRLMRIFKDELILSYSTASSETVLPRVIQKMEAYGAPKAIC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCHHHHH
SFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSIGAQLMLVLTLMVTSKGIAGVPGVS
HHHCCCCCEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
FVVLLATLGSAGIPLEGLAFIAGVDRIMDMARTALNVIGNALAVLVISRWEGMYDDAKGE
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
RYWNSLPHWRSKEPVPMGQPTAD
HHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKAKLSLAWQILIGLVLGIAVGALLNHFSAEKAWWITNILQPAGDIFIRLIKMIVIPIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VASLIVGIAGVGDAKKLGRIGLKTILYFEVVTTIAILVGLVLANVFHPGTGIDMSTLGTV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCH
DISKYQQTTAEVQHDHAFIATILNLIPSNIFAAMARGEMLPIIFFSVLFGLGLSSLQAEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHH
REPLVKLFQGVSETMFKVTHMIMNYAPIGVFALIAVTVANFGFASLLPLAKLVILVYVAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AFFAFVVLGLIARAFGFSVIRLMRIFKDELILSYSTASSETVLPRVIQKMEAYGAPKAIC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCHHHHH
SFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSIGAQLMLVLTLMVTSKGIAGVPGVS
HHHCCCCCEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
FVVLLATLGSAGIPLEGLAFIAGVDRIMDMARTALNVIGNALAVLVISRWEGMYDDAKGE
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
RYWNSLPHWRSKEPVPMGQPTAD
HHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]