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The map label for this gene is gabT [H]

Identifier: 66043416

GI number: 66043416

Start: 158304

End: 159608

Strand: Reverse

Name: gabT [H]

Synonym: Psyr_0146

Alternate gene names: 66043416

Gene position: 159608-158304 (Counterclockwise)

Preceding gene: 66043419

Following gene: 66043415

Centisome position: 2.62

GC content: 62.38

Gene sequence:

>1305_bases
ATGAACAGCAAAGTCGACGAAACCCCTCATCTGCTCCGCCAGCGCGATCAATTCGTGCCGCGCGGGATTGTCACGGCTCA
CCCGCTGGTCATCGACCGCGCGCAGGGTTCTGAACTGTGGGACGTCGATGGCAAACGCTATCTGGATTTCGTCGGCGGTA
TCGGCGTGTTGAACATCGGCCACAACCACCCGAACGTGGTCAAGGCGATTCAGGCACAACTGACCAAAGTCACCCACGCC
TGCTTTCAGGTGGCGTCCTATCAGCCCTATCTGGATCTGGCCAAACGCCTGAGCCATCTCATTGCGGGGCAGAGCGGCAT
CGATCACAAGGCGGTGCTTTTCACTTCCGGCGCCGAAGCGGTCGAAAACGCGGTGAAAATCGCCCGCGCCCACACCAATC
GCCCGGCAATCATCTCGTTCCGAGGCGGCTTTCATGGCCGTACGCTGCTTGGCACCACGCTGACCGGCATGAGCCAGCCG
TACAAACAGAATTTCGGCCCCATGGCGCCTGAGGTGTTCCACACCCCGTACCCGAATGAGTATCGCGGCGTGACCACCGA
CGTGGCGCTGGCGGCGTTGCACGAGCTGTTGGCCACCCAGGTTGCCCCGGAGCGTGTGGCGGCGATCCTGATCGAGCCGA
TGCAGGGCGACGGCGGCTTCCTGACTGCGCCGGTCGAGTTCATGAAGGCCTTGCGTGCCCTCACCGAACAACACGGCATC
GTGCTGATTGCAGATGAAATCCAGTCCGGTTTCGGGCGTACCGGTAAATGGTTCGGCTTCGAGCATTCGGGCATCCAGCC
TGATCTGGTGACCGTGGCCAAGAGCCTCGCGGGCGGCATGCCGCTGTCGGGCGTGGTCGGGCGTGCCGAGATCATGGACG
CACCGCTTCCGGGCGGCCTGGGCGGCACCTACGGCGGTAATGCGCTGTCCTGCGCCGCGGCACTGGCAGTGATCGACACC
TATGAGCAGGAAAACCTGCTGGCACGTGGCGAACAGTTGGGCAACCAACTGCGCGCCGGTCTGCTCAAGCTCAAGGAACG
TTACAGCTGCATCGGCGACGTGCGCGGCACCGGTTTCATGCTCGCGATGGAGATGGTCAAGAATGACGCGGCACGCAGTC
CGGACGCTGATCTCAACCAGAAGGTGATCGATCAGGCGCGTCTTGGCGGCTTGCTGGTGATCAAGTGCGGCGTGTACCGC
AACGTCCTGCGCTTCCTGGCTCCGTTGGTGACTACCGAGCAGCAGATCGATGAAGCGCTGGGCATTCTCGACGCGGCGTT
GGCACGAGTATTGAAGTCCAGCTGA

Upstream 100 bases:

>100_bases
TCTGAGGGGGCAAGTTCGGCGTAGATCATTTCGCTGAACGCTTAACCTGAACAGCATCGCAGCCACCCCGCCGGCTGCCT
GGCCCACGACAGGTATAACC

Downstream 100 bases:

>100_bases
GCGCAAGCGTGGTCGCAGCTGTCGCGAGACGCTGCGATCACCCGCGCCGGGAATCATTGTTGAATGGAGACGTTGCCTGC
CATGGGGCTTATTGATTACC

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MNSKVDETPHLLRQRDQFVPRGIVTAHPLVIDRAQGSELWDVDGKRYLDFVGGIGVLNIGHNHPNVVKAIQAQLTKVTHA
CFQVASYQPYLDLAKRLSHLIAGQSGIDHKAVLFTSGAEAVENAVKIARAHTNRPAIISFRGGFHGRTLLGTTLTGMSQP
YKQNFGPMAPEVFHTPYPNEYRGVTTDVALAALHELLATQVAPERVAAILIEPMQGDGGFLTAPVEFMKALRALTEQHGI
VLIADEIQSGFGRTGKWFGFEHSGIQPDLVTVAKSLAGGMPLSGVVGRAEIMDAPLPGGLGGTYGGNALSCAAALAVIDT
YEQENLLARGEQLGNQLRAGLLKLKERYSCIGDVRGTGFMLAMEMVKNDAARSPDADLNQKVIDQARLGGLLVIKCGVYR
NVLRFLAPLVTTEQQIDEALGILDAALARVLKSS

Sequences:

>Translated_434_residues
MNSKVDETPHLLRQRDQFVPRGIVTAHPLVIDRAQGSELWDVDGKRYLDFVGGIGVLNIGHNHPNVVKAIQAQLTKVTHA
CFQVASYQPYLDLAKRLSHLIAGQSGIDHKAVLFTSGAEAVENAVKIARAHTNRPAIISFRGGFHGRTLLGTTLTGMSQP
YKQNFGPMAPEVFHTPYPNEYRGVTTDVALAALHELLATQVAPERVAAILIEPMQGDGGFLTAPVEFMKALRALTEQHGI
VLIADEIQSGFGRTGKWFGFEHSGIQPDLVTVAKSLAGGMPLSGVVGRAEIMDAPLPGGLGGTYGGNALSCAAALAVIDT
YEQENLLARGEQLGNQLRAGLLKLKERYSCIGDVRGTGFMLAMEMVKNDAARSPDADLNQKVIDQARLGGLLVIKCGVYR
NVLRFLAPLVTTEQQIDEALGILDAALARVLKSS
>Mature_434_residues
MNSKVDETPHLLRQRDQFVPRGIVTAHPLVIDRAQGSELWDVDGKRYLDFVGGIGVLNIGHNHPNVVKAIQAQLTKVTHA
CFQVASYQPYLDLAKRLSHLIAGQSGIDHKAVLFTSGAEAVENAVKIARAHTNRPAIISFRGGFHGRTLLGTTLTGMSQP
YKQNFGPMAPEVFHTPYPNEYRGVTTDVALAALHELLATQVAPERVAAILIEPMQGDGGFLTAPVEFMKALRALTEQHGI
VLIADEIQSGFGRTGKWFGFEHSGIQPDLVTVAKSLAGGMPLSGVVGRAEIMDAPLPGGLGGTYGGNALSCAAALAVIDT
YEQENLLARGEQLGNQLRAGLLKLKERYSCIGDVRGTGFMLAMEMVKNDAARSPDADLNQKVIDQARLGGLLVIKCGVYR
NVLRFLAPLVTTEQQIDEALGILDAALARVLKSS

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=438, Percent_Identity=32.4200913242009, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI4557809, Length=415, Percent_Identity=31.566265060241, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI37574042, Length=429, Percent_Identity=32.1678321678322, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI226442705, Length=423, Percent_Identity=31.9148936170213, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI226442709, Length=398, Percent_Identity=32.1608040201005, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI24119277, Length=414, Percent_Identity=28.743961352657, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI284507298, Length=324, Percent_Identity=32.0987654320988, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI188536080, Length=437, Percent_Identity=26.3157894736842, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI38679950, Length=437, Percent_Identity=26.3157894736842, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI38679946, Length=437, Percent_Identity=26.3157894736842, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1789016, Length=419, Percent_Identity=49.1646778042959, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1787560, Length=419, Percent_Identity=48.9260143198091, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1789759, Length=405, Percent_Identity=33.5802469135802, Blast_Score=227, Evalue=9e-61,
Organism=Escherichia coli, GI1788044, Length=406, Percent_Identity=32.2660098522167, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI145693181, Length=403, Percent_Identity=33.4987593052109, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1786349, Length=360, Percent_Identity=30, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1786991, Length=362, Percent_Identity=30.3867403314917, Blast_Score=127, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71992977, Length=430, Percent_Identity=32.3255813953488, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI32564660, Length=444, Percent_Identity=30.4054054054054, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25144271, Length=405, Percent_Identity=28.1481481481481, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI25144274, Length=292, Percent_Identity=28.0821917808219, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17541228, Length=435, Percent_Identity=25.9770114942529, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71981843, Length=160, Percent_Identity=26.875, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=405, Percent_Identity=31.6049382716049, Blast_Score=192, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6324432, Length=414, Percent_Identity=30.6763285024155, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6321456, Length=372, Percent_Identity=28.7634408602151, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324386, Length=313, Percent_Identity=26.8370607028754, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI161085790, Length=458, Percent_Identity=32.5327510917031, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI28574759, Length=455, Percent_Identity=32.7472527472527, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI21357415, Length=406, Percent_Identity=30.7881773399015, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI21356575, Length=423, Percent_Identity=31.9148936170213, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI281366494, Length=420, Percent_Identity=25, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24667139, Length=420, Percent_Identity=25, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24667143, Length=420, Percent_Identity=25, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 46625; Mature: 46625

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKVDETPHLLRQRDQFVPRGIVTAHPLVIDRAQGSELWDVDGKRYLDFVGGIGVLNIG
CCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEECCCCHHHHHHHCCCEEEEEC
HNHPNVVKAIQAQLTKVTHACFQVASYQPYLDLAKRLSHLIAGQSGIDHKAVLFTSGAEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHH
VENAVKIARAHTNRPAIISFRGGFHGRTLLGTTLTGMSQPYKQNFGPMAPEVFHTPYPNE
HHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCHHHCCCCCCCHHHCCCCCCC
YRGVTTDVALAALHELLATQVAPERVAAILIEPMQGDGGFLTAPVEFMKALRALTEQHGI
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCCEEECHHHHHHHHHHHHHHCCE
VLIADEIQSGFGRTGKWFGFEHSGIQPDLVTVAKSLAGGMPLSGVVGRAEIMDAPLPGGL
EEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHCCHHHHHCCCCCCCC
GGTYGGNALSCAAALAVIDTYEQENLLARGEQLGNQLRAGLLKLKERYSCIGDVRGTGFM
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LAMEMVKNDAARSPDADLNQKVIDQARLGGLLVIKCGVYRNVLRFLAPLVTTEQQIDEAL
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
GILDAALARVLKSS
HHHHHHHHHHHHCC
>Mature Secondary Structure
MNSKVDETPHLLRQRDQFVPRGIVTAHPLVIDRAQGSELWDVDGKRYLDFVGGIGVLNIG
CCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEECCCCHHHHHHHCCCEEEEEC
HNHPNVVKAIQAQLTKVTHACFQVASYQPYLDLAKRLSHLIAGQSGIDHKAVLFTSGAEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHH
VENAVKIARAHTNRPAIISFRGGFHGRTLLGTTLTGMSQPYKQNFGPMAPEVFHTPYPNE
HHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCHHHCCCCCCCHHHCCCCCCC
YRGVTTDVALAALHELLATQVAPERVAAILIEPMQGDGGFLTAPVEFMKALRALTEQHGI
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCCEEECHHHHHHHHHHHHHHCCE
VLIADEIQSGFGRTGKWFGFEHSGIQPDLVTVAKSLAGGMPLSGVVGRAEIMDAPLPGGL
EEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHCCHHHHHCCCCCCCC
GGTYGGNALSCAAALAVIDTYEQENLLARGEQLGNQLRAGLLKLKERYSCIGDVRGTGFM
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LAMEMVKNDAARSPDADLNQKVIDQARLGGLLVIKCGVYRNVLRFLAPLVTTEQQIDEAL
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
GILDAALARVLKSS
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]