Click here to switch to the map view.

The map label for this gene is iscS [H]

Identifier: 66043404

GI number: 66043404

Start: 142016

End: 143203

Strand: Direct

Name: iscS [H]

Synonym: Psyr_0134

Alternate gene names: 66043404

Gene position: 142016-143203 (Clockwise)

Preceding gene: 66043401

Following gene: 66043405

Centisome position: 2.33

GC content: 62.54

Gene sequence:

>1188_bases
TTGATTTTGACTCGATTACAAAGCGAATTGCCCATGACCACCTCTGCGCTCTATCTGGATTACGCCGCTACCACACCTGT
CGACGGACAGGTCATCGAAGCCATGGTTGCCTGCATGGGGCGCGAAGGTCATTTCGGTAATCCGGCATCCAGCGGGCACG
GTTATGGGCAGGTGGCGCGGCAGGCCGTTGAACAGGCACGCGCGCAGGTGGCCGATGCGGTGGGTGCGCCTGTCGACACC
ATTGTCTGGACCTCCGGCGCTACCGAGTCCAACAACCTGGCGATCAAAGGCATCGCTCATGATGCCAGCGCGCCACGCCG
GCACATCATCACCAGCGTCCTGGAACACAAGGCCGTGCTCGACACCGTCAGCACGCTGGAGCGTCAGGGCTTTCCCGTCA
CCTGGCTGAAACCGGACGCTCAAGGCCTGATCCAGCCTCACGCGGTACAGGCTGCCTTGCGCGAAGACACGCTGCTGGTG
TCGCTGATGCTGGTGAACAATGAACTGGGTACGCTGACCGATATCGCCAGCATTGGCGCCCTGGTGCGCGAGCACGGTGC
GCTGTTTCATGTGGACGCTGCGCAGGGCGTCGGCAAGGTGAAGGTCGATCTGGCGAGTCTGGCCGTCGACCTGATGTCGT
TCTCGGCGCACAAGGCCTACGGCCCCAAGGGCATAGGCGCGCTGTACGTGGGCCCGCGTGCTCACTCGTTGTTGAAAGCG
CAGATTCACGGCGGCGGACATGAAGGTGGCTTTCGTTCGGGCACATTGGCCACCCATCAGATCGTCGGCATGGGGACGGC
CTTTGCGTTGGCGATCAGCCAGGCCGAAACTGAAAACCGTCGTATCGAAGAGCTGAGTCGTCACCTGCGCGAAGGCCTGT
TGAGTCTGCCGGATGTGCAACTCAACGGCTGTCCGCAACAACGCATCCCGCACACCCTGAACCTGTGCATCACCCGCAGT
GGCTTCACCAGCTCGCAGTTGTCCCACAGCCTGGCGTTGTCCTCGACGTCCGCGTGCAACTCGGCCAGCAATGCACCCTC
GCATGTGCTGCTTGCTCTGGGCATGGACTCTGCCAAGGCCCTGGCCAGCGTGCGCGTCAGCCTCGGCCGCTACACCACGC
AGGCAGATGTCGAGCGCGCCATCGAGGTGTTCAGCAAGGCGCTCAGCGCACCTGCTGCGTTCTGGTAA

Upstream 100 bases:

>100_bases
ATAATTTTTCGCATTGGCTGCCCATGTCCGTGTAAATATCAAAAAATTTTCGCGCGCGGATCAGTAATCTTTCAAGCAGT
CGGTCTGGTGATGCCAGCCC

Downstream 100 bases:

>100_bases
TTGACGATACCTACAGGCCGCCCGAATCCAGGGCGGCTCTTTCCCGGCGCACCCGCGCCAATCTGCCGAGTTGATACCCG
CCGGGGTCAGCGGCTGCGCC

Product: aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MILTRLQSELPMTTSALYLDYAATTPVDGQVIEAMVACMGREGHFGNPASSGHGYGQVARQAVEQARAQVADAVGAPVDT
IVWTSGATESNNLAIKGIAHDASAPRRHIITSVLEHKAVLDTVSTLERQGFPVTWLKPDAQGLIQPHAVQAALREDTLLV
SLMLVNNELGTLTDIASIGALVREHGALFHVDAAQGVGKVKVDLASLAVDLMSFSAHKAYGPKGIGALYVGPRAHSLLKA
QIHGGGHEGGFRSGTLATHQIVGMGTAFALAISQAETENRRIEELSRHLREGLLSLPDVQLNGCPQQRIPHTLNLCITRS
GFTSSQLSHSLALSSTSACNSASNAPSHVLLALGMDSAKALASVRVSLGRYTTQADVERAIEVFSKALSAPAAFW

Sequences:

>Translated_395_residues
MILTRLQSELPMTTSALYLDYAATTPVDGQVIEAMVACMGREGHFGNPASSGHGYGQVARQAVEQARAQVADAVGAPVDT
IVWTSGATESNNLAIKGIAHDASAPRRHIITSVLEHKAVLDTVSTLERQGFPVTWLKPDAQGLIQPHAVQAALREDTLLV
SLMLVNNELGTLTDIASIGALVREHGALFHVDAAQGVGKVKVDLASLAVDLMSFSAHKAYGPKGIGALYVGPRAHSLLKA
QIHGGGHEGGFRSGTLATHQIVGMGTAFALAISQAETENRRIEELSRHLREGLLSLPDVQLNGCPQQRIPHTLNLCITRS
GFTSSQLSHSLALSSTSACNSASNAPSHVLLALGMDSAKALASVRVSLGRYTTQADVERAIEVFSKALSAPAAFW
>Mature_395_residues
MILTRLQSELPMTTSALYLDYAATTPVDGQVIEAMVACMGREGHFGNPASSGHGYGQVARQAVEQARAQVADAVGAPVDT
IVWTSGATESNNLAIKGIAHDASAPRRHIITSVLEHKAVLDTVSTLERQGFPVTWLKPDAQGLIQPHAVQAALREDTLLV
SLMLVNNELGTLTDIASIGALVREHGALFHVDAAQGVGKVKVDLASLAVDLMSFSAHKAYGPKGIGALYVGPRAHSLLKA
QIHGGGHEGGFRSGTLATHQIVGMGTAFALAISQAETENRRIEELSRHLREGLLSLPDVQLNGCPQQRIPHTLNLCITRS
GFTSSQLSHSLALSSTSACNSASNAPSHVLLALGMDSAKALASVRVSLGRYTTQADVERAIEVFSKALSAPAAFW

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=388, Percent_Identity=43.298969072165, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI156713448, Length=412, Percent_Identity=33.495145631068, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI48994898, Length=373, Percent_Identity=51.4745308310992, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1789175, Length=405, Percent_Identity=26.1728395061728, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1787970, Length=418, Percent_Identity=28.9473684210526, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25143064, Length=376, Percent_Identity=43.8829787234042, Blast_Score=292, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17533177, Length=323, Percent_Identity=31.8885448916409, Blast_Score=137, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6319831, Length=386, Percent_Identity=42.7461139896373, Blast_Score=301, Evalue=1e-82,
Organism=Drosophila melanogaster, GI20129463, Length=364, Percent_Identity=43.956043956044, Blast_Score=281, Evalue=7e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41619; Mature: 41619

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILTRLQSELPMTTSALYLDYAATTPVDGQVIEAMVACMGREGHFGNPASSGHGYGQVAR
CCHHHHHHCCCCCCHHEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
QAVEQARAQVADAVGAPVDTIVWTSGATESNNLAIKGIAHDASAPRRHIITSVLEHKAVL
HHHHHHHHHHHHHHCCCCHHEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
DTVSTLERQGFPVTWLKPDAQGLIQPHAVQAALREDTLLVSLMLVNNELGTLTDIASIGA
HHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCHHEEEEEEECCCCCHHHHHHHHHH
LVREHGALFHVDAAQGVGKVKVDLASLAVDLMSFSAHKAYGPKGIGALYVGPRAHSLLKA
HHHHCCCEEEEEHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHH
QIHGGGHEGGFRSGTLATHQIVGMGTAFALAISQAETENRRIEELSRHLREGLLSLPDVQ
HCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LNGCPQQRIPHTLNLCITRSGFTSSQLSHSLALSSTSACNSASNAPSHVLLALGMDSAKA
CCCCCHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHH
LASVRVSLGRYTTQADVERAIEVFSKALSAPAAFW
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MILTRLQSELPMTTSALYLDYAATTPVDGQVIEAMVACMGREGHFGNPASSGHGYGQVAR
CCHHHHHHCCCCCCHHEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
QAVEQARAQVADAVGAPVDTIVWTSGATESNNLAIKGIAHDASAPRRHIITSVLEHKAVL
HHHHHHHHHHHHHHCCCCHHEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
DTVSTLERQGFPVTWLKPDAQGLIQPHAVQAALREDTLLVSLMLVNNELGTLTDIASIGA
HHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCHHEEEEEEECCCCCHHHHHHHHHH
LVREHGALFHVDAAQGVGKVKVDLASLAVDLMSFSAHKAYGPKGIGALYVGPRAHSLLKA
HHHHCCCEEEEEHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHH
QIHGGGHEGGFRSGTLATHQIVGMGTAFALAISQAETENRRIEELSRHLREGLLSLPDVQ
HCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LNGCPQQRIPHTLNLCITRSGFTSSQLSHSLALSSTSACNSASNAPSHVLLALGMDSAKA
CCCCCHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHH
LASVRVSLGRYTTQADVERAIEVFSKALSAPAAFW
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA