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The map label for this gene is trpA [H]

Identifier: 66043304

GI number: 66043304

Start: 37192

End: 38001

Strand: Reverse

Name: trpA [H]

Synonym: Psyr_0033

Alternate gene names: 66043304

Gene position: 38001-37192 (Counterclockwise)

Preceding gene: 66043305

Following gene: 66043303

Centisome position: 0.62

GC content: 64.57

Gene sequence:

>810_bases
ATGAGCCGTCTAGAACATCGTTTCGCCCAGCTTAAAACCGAAGGTCGTGCGGCGCTGGTCACCTTCATCACCGCCGGTGA
CCCTGGCTACGACACCTCGCTGAAAGTCCTGAAGGGCCTGCCTGCGGCGGGTGCTGACGTGATCGAGCTGGGCATGCCGT
TCACCGATCCGATGGCCGACGGTGTGGCGATTCAGCTGGCGACTCTGCGTGCTCTGGACGCTGGCCAGACTCTGCAGAAA
ACCCTGCAGATGGTCAGCGAATTTCGTGTCGACGATCAGACCACACCGATTGTGCTGATGGGTTACTACAACCCGATCCA
CCGCTTTGGCGTCGAAGCCTTCGTGGCGCAGGCAAAGGAAGCAGGCGTTGACGGTCTGATCATCGTTGACCTGCCACCCG
AGCACGACGCCGAGCTGGCGACGCCTGCACAGGCGTCCGGCATCGACTTCATCCGCCTGACCACACCGACCACTGACGAT
GCGCGTCTGCCGCGTGTGCTGGAGCGCAGCTCCGGGTTCGTCTACTACGTGTCGGTTGCCGGTGTGACCGGTGCAGGCTC
GGCCACCACCGAGCACGTCACCGAAGCCATCGCTCGCTTGCGCCGCCACACCGATCTGCCGATCAGCGTCGGTTTCGGTA
TCCGCACCCCCGAGCAGGCCGCGGCGATTGCGCGTCTGGCTGACGGTGTGGTCGTGGGCTCGGCCTTCGTCGACAAGATC
GCCAGCGCCGAGTCGCCGGAGCATGCCATCGACGGCGTGCTGACGCTGTGCGCGGCACTGGCCGAGGGCGTACGTAGCGC
TCGTCGCTGA

Upstream 100 bases:

>100_bases
ATCACCTGATGGTCGTGTGCCTGTCCGGGCGCGGCGACAAAGACATGCAAACCGTCATGAACCACATGGCCGCCGCCGAA
CACACTCAGGAGCAGCTGGT

Downstream 100 bases:

>100_bases
GGGTAAAGTTTCTGATACAGAGGAATCAAAGCCTGAGCAGCGGCTCTATGTAGCAAGACACAAGGGGTTCATGACCAACG
TCATGAACCCCTTTTTGCTG

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MSRLEHRFAQLKTEGRAALVTFITAGDPGYDTSLKVLKGLPAAGADVIELGMPFTDPMADGVAIQLATLRALDAGQTLQK
TLQMVSEFRVDDQTTPIVLMGYYNPIHRFGVEAFVAQAKEAGVDGLIIVDLPPEHDAELATPAQASGIDFIRLTTPTTDD
ARLPRVLERSSGFVYYVSVAGVTGAGSATTEHVTEAIARLRRHTDLPISVGFGIRTPEQAAAIARLADGVVVGSAFVDKI
ASAESPEHAIDGVLTLCAALAEGVRSARR

Sequences:

>Translated_269_residues
MSRLEHRFAQLKTEGRAALVTFITAGDPGYDTSLKVLKGLPAAGADVIELGMPFTDPMADGVAIQLATLRALDAGQTLQK
TLQMVSEFRVDDQTTPIVLMGYYNPIHRFGVEAFVAQAKEAGVDGLIIVDLPPEHDAELATPAQASGIDFIRLTTPTTDD
ARLPRVLERSSGFVYYVSVAGVTGAGSATTEHVTEAIARLRRHTDLPISVGFGIRTPEQAAAIARLADGVVVGSAFVDKI
ASAESPEHAIDGVLTLCAALAEGVRSARR
>Mature_268_residues
SRLEHRFAQLKTEGRAALVTFITAGDPGYDTSLKVLKGLPAAGADVIELGMPFTDPMADGVAIQLATLRALDAGQTLQKT
LQMVSEFRVDDQTTPIVLMGYYNPIHRFGVEAFVAQAKEAGVDGLIIVDLPPEHDAELATPAQASGIDFIRLTTPTTDDA
RLPRVLERSSGFVYYVSVAGVTGAGSATTEHVTEAIARLRRHTDLPISVGFGIRTPEQAAAIARLADGVVVGSAFVDKIA
SAESPEHAIDGVLTLCAALAEGVRSARR

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=219, Percent_Identity=39.7260273972603, Blast_Score=160, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6321412, Length=264, Percent_Identity=43.9393939393939, Blast_Score=212, Evalue=5e-56,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 28450; Mature: 28319

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLEHRFAQLKTEGRAALVTFITAGDPGYDTSLKVLKGLPAAGADVIELGMPFTDPMAD
CCHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHCCCCCCCHHHCCCCCCCCCCCC
GVAIQLATLRALDAGQTLQKTLQMVSEFRVDDQTTPIVLMGYYNPIHRFGVEAFVAQAKE
CEEEEHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
AGVDGLIIVDLPPEHDAELATPAQASGIDFIRLTTPTTDDARLPRVLERSSGFVYYVSVA
CCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEEEC
GVTGAGSATTEHVTEAIARLRRHTDLPISVGFGIRTPEQAAAIARLADGVVVGSAFVDKI
CCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHCCCEEHHHHHHHH
ASAESPEHAIDGVLTLCAALAEGVRSARR
HCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRLEHRFAQLKTEGRAALVTFITAGDPGYDTSLKVLKGLPAAGADVIELGMPFTDPMAD
CHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHCCCCCCCHHHCCCCCCCCCCCC
GVAIQLATLRALDAGQTLQKTLQMVSEFRVDDQTTPIVLMGYYNPIHRFGVEAFVAQAKE
CEEEEHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
AGVDGLIIVDLPPEHDAELATPAQASGIDFIRLTTPTTDDARLPRVLERSSGFVYYVSVA
CCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEEEC
GVTGAGSATTEHVTEAIARLRRHTDLPISVGFGIRTPEQAAAIARLADGVVVGSAFVDKI
CCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHCCCEEHHHHHHHH
ASAESPEHAIDGVLTLCAALAEGVRSARR
HCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA