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The map label for this gene is betC [H]

Identifier: 66043300

GI number: 66043300

Start: 32731

End: 34236

Strand: Reverse

Name: betC [H]

Synonym: Psyr_0029

Alternate gene names: 66043300

Gene position: 34236-32731 (Counterclockwise)

Preceding gene: 66043303

Following gene: 66043299

Centisome position: 0.56

GC content: 60.03

Gene sequence:

>1506_bases
ATGAAGCGCAAAAATATTCTGTTCATCATGGCCGATCAAATGGCCGCGCCAATGTTGCCGTTTTACGCCCGGTCCCCGAT
TCTGATGCCGAACCTGAGCCGTCTCGCCGCCGACGGCGTAGTGTTCGATTCGGCGTACTGCAACAGCCCGCTATGCGCGC
CGTCGCGCTTCACCCTGGTCAGCGGCCAGTTGCCAAGCAGGATCGGCGCGTACGACAACGCAGCCGACTTCCCGGCCGAT
ATTCCGACCTATGCCCACTACCTGCGTGCGCTGGGCTACAAGACCGCCCTCGCAGGCAAGATGCATTTCTGCGGACCGGA
TCAACTGCACGGCTACGAAGAACGCCTGACCAGTGACATCTACCCGGCCGATTACGGCTGGTCGGTCAACTGGGACGAGC
CGGACGTGCGGCCAAGCTGGTATCACAACATGTCTTCGGTGTTGCAGGCCGGTCCGTGCATTCGCACCAACCAGCTGGAC
TTCGATGAAGAGGTGCTGTTCAAGTCCCAGCAATACCTCTACGACCATGTGCGCCAGGACGGTGATGCGCCGTTCTGCCT
GACCGTTTCAATGACTCACCCTCATGACCCGTACACCATCCCTCTGCCGTTCTGGGACCTGTACGCCGACGACGAAATAC
CGATGCCCACGCCGCACGCCAACCAGGCCGCGCTGGACCCGCATTCACAACGGCTGCTCAAGGTCTATGACCTGTGGGAC
AAGCCCATGCCGACCGACAAGATTCGTGATGCCCGCCGCGCCTACTTCGGTGCGTGCAGCTACATTGACCTCAACGTCGG
CAAACTGATGCAGACGCTCGATGAAGTCGGGTTGGCGGAAGACACCATCGTGGTGTTCTCCGGCGATCACGGCGACATGC
TGGGCGAGAAGGGCCTCTGGTACAAAATGCACTGGTTCGAAATGGCCGCCCGCGTGCCGCTGGTGGTGTACGCGCCGGGC
CAGTTCAAACCGGGACGGGTCAGTGCGTCGGTGTCGACTGCCGACTTGCTGCCGACCTTCGTCGAAATGGCCAAAGGCAA
ACTGGACGCCGGTTTGCCAATGGACGGACGTTCGCTGATGCCGCATTTGAAACGCAAGGGCGGGCACGATGAGGTGTTCG
GTGAGTACATGGCCGAAGGCACCACCAGCCCGCTGATGATGATCCGTCGTGGCGCGTACAAATTCATCTATTCGGAGCAG
GACCCGTGCCTGCTGTTCGATGTGAAAAAGGACCCGAAAGAGCAGAAGGACCTGAGCCAGTCACCCACCCATGAAAAGCT
GTTCAACGATTTCCTGGCCGAAGCTCGGGCCAAGTGGGACATCCCGGCGATACACCAACAGGTGCTCGCCAGCCAGCGCA
GAAGGCGCTTCGTCGCCAAATCGCTGGCAACCGGCAAGCTGAAGAGTTGGGATCACCAGCCACTGGTCGACGCCAGTCAG
CAGTACATGCGCAACCACATTGATCTGGACGATCTGGAGCGCAAGGCACGTTTTCCGCAACCTTGA

Upstream 100 bases:

>100_bases
CCTAGGCATTGCTGTGTATGGGCTTTACCCTGAAACTTATGGACTCCATCCTCATACCCGGCACTTTCGCATAACTTTTC
ACAATGGATATAGCGATTAC

Downstream 100 bases:

>100_bases
CCCTGCCCACACCAAAAAAACCAAAGGGGTACATCAATGAAGAAGTTATCCACAGCCGTTGCGGTCGCGGTCATGACCCT
CGGCAGCCTTGCAGCACAGG

Product: sulfatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MKRKNILFIMADQMAAPMLPFYARSPILMPNLSRLAADGVVFDSAYCNSPLCAPSRFTLVSGQLPSRIGAYDNAADFPAD
IPTYAHYLRALGYKTALAGKMHFCGPDQLHGYEERLTSDIYPADYGWSVNWDEPDVRPSWYHNMSSVLQAGPCIRTNQLD
FDEEVLFKSQQYLYDHVRQDGDAPFCLTVSMTHPHDPYTIPLPFWDLYADDEIPMPTPHANQAALDPHSQRLLKVYDLWD
KPMPTDKIRDARRAYFGACSYIDLNVGKLMQTLDEVGLAEDTIVVFSGDHGDMLGEKGLWYKMHWFEMAARVPLVVYAPG
QFKPGRVSASVSTADLLPTFVEMAKGKLDAGLPMDGRSLMPHLKRKGGHDEVFGEYMAEGTTSPLMMIRRGAYKFIYSEQ
DPCLLFDVKKDPKEQKDLSQSPTHEKLFNDFLAEARAKWDIPAIHQQVLASQRRRRFVAKSLATGKLKSWDHQPLVDASQ
QYMRNHIDLDDLERKARFPQP

Sequences:

>Translated_501_residues
MKRKNILFIMADQMAAPMLPFYARSPILMPNLSRLAADGVVFDSAYCNSPLCAPSRFTLVSGQLPSRIGAYDNAADFPAD
IPTYAHYLRALGYKTALAGKMHFCGPDQLHGYEERLTSDIYPADYGWSVNWDEPDVRPSWYHNMSSVLQAGPCIRTNQLD
FDEEVLFKSQQYLYDHVRQDGDAPFCLTVSMTHPHDPYTIPLPFWDLYADDEIPMPTPHANQAALDPHSQRLLKVYDLWD
KPMPTDKIRDARRAYFGACSYIDLNVGKLMQTLDEVGLAEDTIVVFSGDHGDMLGEKGLWYKMHWFEMAARVPLVVYAPG
QFKPGRVSASVSTADLLPTFVEMAKGKLDAGLPMDGRSLMPHLKRKGGHDEVFGEYMAEGTTSPLMMIRRGAYKFIYSEQ
DPCLLFDVKKDPKEQKDLSQSPTHEKLFNDFLAEARAKWDIPAIHQQVLASQRRRRFVAKSLATGKLKSWDHQPLVDASQ
QYMRNHIDLDDLERKARFPQP
>Mature_501_residues
MKRKNILFIMADQMAAPMLPFYARSPILMPNLSRLAADGVVFDSAYCNSPLCAPSRFTLVSGQLPSRIGAYDNAADFPAD
IPTYAHYLRALGYKTALAGKMHFCGPDQLHGYEERLTSDIYPADYGWSVNWDEPDVRPSWYHNMSSVLQAGPCIRTNQLD
FDEEVLFKSQQYLYDHVRQDGDAPFCLTVSMTHPHDPYTIPLPFWDLYADDEIPMPTPHANQAALDPHSQRLLKVYDLWD
KPMPTDKIRDARRAYFGACSYIDLNVGKLMQTLDEVGLAEDTIVVFSGDHGDMLGEKGLWYKMHWFEMAARVPLVVYAPG
QFKPGRVSASVSTADLLPTFVEMAKGKLDAGLPMDGRSLMPHLKRKGGHDEVFGEYMAEGTTSPLMMIRRGAYKFIYSEQ
DPCLLFDVKKDPKEQKDLSQSPTHEKLFNDFLAEARAKWDIPAIHQQVLASQRRRRFVAKSLATGKLKSWDHQPLVDASQ
QYMRNHIDLDDLERKARFPQP

Specific function: Converts choline-O-sulfate into choline [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4557659, Length=422, Percent_Identity=27.7251184834123, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI39930577, Length=449, Percent_Identity=23.8307349665924, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI5360208, Length=318, Percent_Identity=28.3018867924528, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI262118210, Length=345, Percent_Identity=27.536231884058, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI146229331, Length=482, Percent_Identity=25.3112033195021, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI146229329, Length=482, Percent_Identity=25.3112033195021, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI6005990, Length=482, Percent_Identity=25.3112033195021, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI146229324, Length=482, Percent_Identity=25.3112033195021, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI53831991, Length=113, Percent_Identity=35.3982300884956, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790112, Length=433, Percent_Identity=27.2517321016166, Blast_Score=142, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24647401, Length=382, Percent_Identity=26.9633507853403, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24666175, Length=410, Percent_Identity=24.8780487804878, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR017785
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.6 [H]

Molecular weight: Translated: 56910; Mature: 56910

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKNILFIMADQMAAPMLPFYARSPILMPNLSRLAADGVVFDSAYCNSPLCAPSRFTLV
CCCCCEEEEEECCCCCCCCHHHHCCCCCCCCHHHHHHCCEEEEHHHCCCCCCCCCCEEEE
SGQLPSRIGAYDNAADFPADIPTYAHYLRALGYKTALAGKMHFCGPDQLHGYEERLTSDI
CCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHCCC
YPADYGWSVNWDEPDVRPSWYHNMSSVLQAGPCIRTNQLDFDEEVLFKSQQYLYDHVRQD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
GDAPFCLTVSMTHPHDPYTIPLPFWDLYADDEIPMPTPHANQAALDPHSQRLLKVYDLWD
CCCCEEEEEEECCCCCCEEECCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
KPMPTDKIRDARRAYFGACSYIDLNVGKLMQTLDEVGLAEDTIVVFSGDHGDMLGEKGLW
CCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCE
YKMHWFEMAARVPLVVYAPGQFKPGRVSASVSTADLLPTFVEMAKGKLDAGLPMDGRSLM
EEHHHHHHHHCCCEEEECCCCCCCCCEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHH
PHLKRKGGHDEVFGEYMAEGTTSPLMMIRRGAYKFIYSEQDPCLLFDVKKDPKEQKDLSQ
HHHHHCCCCHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCCCEEEEECCCCCHHHHHCCC
SPTHEKLFNDFLAEARAKWDIPAIHQQVLASQRRRRFVAKSLATGKLKSWDHQPLVDASQ
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
QYMRNHIDLDDLERKARFPQP
HHHHHCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MKRKNILFIMADQMAAPMLPFYARSPILMPNLSRLAADGVVFDSAYCNSPLCAPSRFTLV
CCCCCEEEEEECCCCCCCCHHHHCCCCCCCCHHHHHHCCEEEEHHHCCCCCCCCCCEEEE
SGQLPSRIGAYDNAADFPADIPTYAHYLRALGYKTALAGKMHFCGPDQLHGYEERLTSDI
CCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHCCC
YPADYGWSVNWDEPDVRPSWYHNMSSVLQAGPCIRTNQLDFDEEVLFKSQQYLYDHVRQD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
GDAPFCLTVSMTHPHDPYTIPLPFWDLYADDEIPMPTPHANQAALDPHSQRLLKVYDLWD
CCCCEEEEEEECCCCCCEEECCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
KPMPTDKIRDARRAYFGACSYIDLNVGKLMQTLDEVGLAEDTIVVFSGDHGDMLGEKGLW
CCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCE
YKMHWFEMAARVPLVVYAPGQFKPGRVSASVSTADLLPTFVEMAKGKLDAGLPMDGRSLM
EEHHHHHHHHCCCEEEECCCCCCCCCEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHH
PHLKRKGGHDEVFGEYMAEGTTSPLMMIRRGAYKFIYSEQDPCLLFDVKKDPKEQKDLSQ
HHHHHCCCCHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCCCEEEEECCCCCHHHHHCCC
SPTHEKLFNDFLAEARAKWDIPAIHQQVLASQRRRRFVAKSLATGKLKSWDHQPLVDASQ
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
QYMRNHIDLDDLERKARFPQP
HHHHHCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141699; 11481430; 9736747 [H]