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The map label for this gene is sstT [H]

Identifier: 62391875

GI number: 62391875

Start: 3204359

End: 3205612

Strand: Reverse

Name: sstT [H]

Synonym: cg3356

Alternate gene names: 62391875

Gene position: 3205612-3204359 (Counterclockwise)

Preceding gene: 62391877

Following gene: 62391872

Centisome position: 97.65

GC content: 56.06

Gene sequence:

>1254_bases
ATGGACATAAAGAGCATGAGCTCGTCGCTGCTGTTCCGAGTGATCGTTGCCATCATCCTCGGAATCATCTGCAGCCTCTT
CTTCCCGGTGTGGCTCGCTGAGATCTTCACCACCTTCAACGGCCTATTCAGCAACTTTCTGGGCTTCTTCATCCCAGTGC
TGATCTTCTCCCTCATCGCCCCCGCCATTGCAGGGCTCGGCCGAGGCGCTGGCAAATGGCTCGGCATTGTTGCAGCAATC
GCCTACGCGTCCACCGTCTTCTCCGGTCTGATCGCCTACGGAGCATCCCAAGCGCTCTACCCATGGCTGCTGAAAGACCA
CCAAAGCGTCACCGAAATCGACCTTGATGCAGGTGCCCTCCAGCCCTACTTCAACATCGAGATGCCACCACCATTTGAAG
TGATGACCGCACTGCTGCTGGCATTCTGCCTCGGCCTGGGCATGGCTGTAATTAAATCAGACACCCTGTTCAAGGTAACC
CGCGAACTCGAGCGCGTAGTCATGAAGACCATCACCGCCTTTGTCATCCCACTGCTGCCACTCTTCATCTTCGGCATCTT
CCTCGGCATGGGCATGAACGGTGGCCTCCTGGAGATCATGTCCGCCTTTGGCAAGGTACTGATTCTCGCCGTCGTGGGAA
CCCTGCTCTTCCTAGCCATCCAGTTCATTATCGCTGGTGCAGTATCCAAGAAGAACCCATGGAAACTGTTCAAAAACATG
CTCCCTGCATACTTCACTGCACTGGGCACCTCCTCTTCAGCGGCAACCATCCCAGTGACCTACCAGCAGACCCTGAAAAA
CGATGTTGATGTCAACGTCGCAGGCTTTGTTGTCCCACTGTGCGCCACCATCCACCTAGCTGGATCGATGATGAAGATCG
GCCTCTTCACCTTCGCTGTTGTCTTCATGTACGACATGGAAGTAGGCGTCGGCCTCTCCATCGGATTCCTCCTCATGCTG
GGCATCACCATGATCGCCGCACCAGGCGTTCCCGGCGGAGCCATCATGGCAGCAACCGGCATGCTGGCCTCCATGCTCGG
ATTCAACACCGAACAAGTCGCCCTCATGATCGCCGCTTACATCGCGATTGACTCCTTCGGCACCGCAGCAAACGTCACCG
GCGACGGCGCAATCGCAGTCATCGTGAACAAATTCGCCAAGGGCCAGCTGCACACCACTTCCCCAGATGAAATCGAAGAA
GACGACCGCGTTGCCTTCGACATCACTCCATCGGATGTGGAACATCACAAGTAG

Upstream 100 bases:

>100_bases
GCTGTCCTTGTGACCCGTCACTTCCAAGCCGCACACAAAATTCCATCACGCGCTGCCGAGCATTGCTCAGACAGCACCTG
ATTAGAAATAAGGAACAACC

Downstream 100 bases:

>100_bases
AAACCCGCATTTTCTGTAGTTTTTACTGCGGTTTGATCGCACCAGCTCGATGCGGCTGGTGCGATCTTTTCTGTCTTGAG
GGTTCGTGGGGGCTGTGGAA

Product: Na+/H+-dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: Na(+)/serine-threonine symporter [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MDIKSMSSSLLFRVIVAIILGIICSLFFPVWLAEIFTTFNGLFSNFLGFFIPVLIFSLIAPAIAGLGRGAGKWLGIVAAI
AYASTVFSGLIAYGASQALYPWLLKDHQSVTEIDLDAGALQPYFNIEMPPPFEVMTALLLAFCLGLGMAVIKSDTLFKVT
RELERVVMKTITAFVIPLLPLFIFGIFLGMGMNGGLLEIMSAFGKVLILAVVGTLLFLAIQFIIAGAVSKKNPWKLFKNM
LPAYFTALGTSSSAATIPVTYQQTLKNDVDVNVAGFVVPLCATIHLAGSMMKIGLFTFAVVFMYDMEVGVGLSIGFLLML
GITMIAAPGVPGGAIMAATGMLASMLGFNTEQVALMIAAYIAIDSFGTAANVTGDGAIAVIVNKFAKGQLHTTSPDEIEE
DDRVAFDITPSDVEHHK

Sequences:

>Translated_417_residues
MDIKSMSSSLLFRVIVAIILGIICSLFFPVWLAEIFTTFNGLFSNFLGFFIPVLIFSLIAPAIAGLGRGAGKWLGIVAAI
AYASTVFSGLIAYGASQALYPWLLKDHQSVTEIDLDAGALQPYFNIEMPPPFEVMTALLLAFCLGLGMAVIKSDTLFKVT
RELERVVMKTITAFVIPLLPLFIFGIFLGMGMNGGLLEIMSAFGKVLILAVVGTLLFLAIQFIIAGAVSKKNPWKLFKNM
LPAYFTALGTSSSAATIPVTYQQTLKNDVDVNVAGFVVPLCATIHLAGSMMKIGLFTFAVVFMYDMEVGVGLSIGFLLML
GITMIAAPGVPGGAIMAATGMLASMLGFNTEQVALMIAAYIAIDSFGTAANVTGDGAIAVIVNKFAKGQLHTTSPDEIEE
DDRVAFDITPSDVEHHK
>Mature_417_residues
MDIKSMSSSLLFRVIVAIILGIICSLFFPVWLAEIFTTFNGLFSNFLGFFIPVLIFSLIAPAIAGLGRGAGKWLGIVAAI
AYASTVFSGLIAYGASQALYPWLLKDHQSVTEIDLDAGALQPYFNIEMPPPFEVMTALLLAFCLGLGMAVIKSDTLFKVT
RELERVVMKTITAFVIPLLPLFIFGIFLGMGMNGGLLEIMSAFGKVLILAVVGTLLFLAIQFIIAGAVSKKNPWKLFKNM
LPAYFTALGTSSSAATIPVTYQQTLKNDVDVNVAGFVVPLCATIHLAGSMMKIGLFTFAVVFMYDMEVGVGLSIGFLLML
GITMIAAPGVPGGAIMAATGMLASMLGFNTEQVALMIAAYIAIDSFGTAANVTGDGAIAVIVNKFAKGQLHTTSPDEIEE
DDRVAFDITPSDVEHHK

Specific function: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=196, Percent_Identity=31.1224489795918, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI66773030, Length=262, Percent_Identity=29.7709923664122, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI40254478, Length=203, Percent_Identity=32.0197044334975, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI194239697, Length=166, Percent_Identity=33.1325301204819, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4827012, Length=165, Percent_Identity=28.4848484848485, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71983106, Length=340, Percent_Identity=27.6470588235294, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71983099, Length=341, Percent_Identity=27.8592375366569, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193206654, Length=286, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17541374, Length=201, Percent_Identity=29.8507462686567, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71996953, Length=165, Percent_Identity=28.4848484848485, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17537407, Length=274, Percent_Identity=27.7372262773723, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193206505, Length=263, Percent_Identity=26.9961977186312, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583025, Length=255, Percent_Identity=24.3137254901961, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17137668, Length=255, Percent_Identity=24.3137254901961, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24583023, Length=255, Percent_Identity=24.3137254901961, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR023025 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44475; Mature: 44475

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCC
>Mature Secondary Structure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HHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA