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The map label for this gene is clpB [H]

Identifier: 62391615

GI number: 62391615

Start: 2936909

End: 2939467

Strand: Reverse

Name: clpB [H]

Synonym: cg3079

Alternate gene names: 62391615

Gene position: 2939467-2936909 (Counterclockwise)

Preceding gene: 62391616

Following gene: 62391614

Centisome position: 89.54

GC content: 55.88

Gene sequence:

>2559_bases
ATGAGTTCATTCAATCCAACTACCAAAACCAATGAAGCCATGCAGGCTGCTCTTCAGCAGGCATCCTCGGCTGGCAACCC
TGATATTCGTCCAGCTCACCTGTTGGCTGCCATCTTGGAGCAAACTGATGGCGTAGCAGCGCCAGTCCTCATGGCTACTG
GTGTGGATCCTAAGGAGATCCTCGCAGAGGCCAAGAAGTTGGTTGCTTCTTACCCCAAGGCTTCTGGCGCCAATATGGCT
AATCCAAACTTCAACCGGGATGCCCTCAATGCGTTCACTGCAGCTCAGGAGCTTGCCGGTGAGTTGGGCGATGAGTACGT
CTCAACCGAAGTACTTCTTGCCGGTATCGCTCGCGGAAAGTCTGATGCTGCGGATCTGTTGACCAACAAGGGTGCAACCT
ATGACGCCATCAAAGAGGCTTTCCCTTCGGTTCGTGGATCTCAGCGTGTCACCACTCAGGATCCAGAGGGACAGTTCCAG
GCTTTGGAAAAGTACTCCACTGACCTGACCAAGCTTGCTCGTGAAGGCAAGATTGATCCTGTTATTGGCCGTGACCAGGA
AATTCGTCGCGTCGTTCAGGTGCTTAGCCGTCGTACCAAGAACAACCCTGTTCTGATCGGTGAGCCAGGTGTCGGTAAAA
CCGCCATCGTGGAAGGCCTTGCACGCCGCATCGTTGCTGGTGACGTTCCAGAATCCCTCAAGGGCAAAACTCTGATCAGT
CTTGATCTTGGTTCCATGGTTGCCGGCGCTAAGTATCGCGGTGAATTCGAGGAGCGACTGAAGGCTGTTCTGGATGAGAT
CAAGGGAGCTAACGGCGAAGTCGTTACCTTCATCGATGAGCTGCACACCATCGTCGGCGCTGGTGCTTCGGGTGAATCCG
CCATGGATGCCGGAAACATGATTAAGCCACTGCTTGCCCGCGGTGAGCTGCGCTTGGTTGGTGCCACCACGCTGAATGAG
TACCGCAAGTACATCGAAAAGGACGCTGCCCTGGAGCGTAGGTTCCAGCAGGTTTATGTCGGTGAGCCAACGGTAGAAGA
TGCCATCGGTATTCTTCGTGGATTGAAGGAACGCTACGAGGTCCATCACGGTGTCCGCATCCAGGACTCCGCACTGGTCG
CCGCAGCTGAACTCTCAAACCGCTATATCACCAGCCGTTTCCTTCCTGATAAGGCTATTGACTTAGTTGATGAGGCAGCA
TCACGCCTGCGCATGGAGATTGATTCTTCACCTCAGGAAATCGATGAGCTGGAGCGTATCGTCCGCCGCCTCGAGATCGA
AGAGATGGCGCTGTCCAAGGAATCCGATGCAGCTTCCAAGGAACGTCTAGAAAAGCTGCGCTCGGAACTTGCTGATGAAC
GCGAAAAGCTCTCTGAGTTGAAGGCTCGTTGGCAGAATGAGAAAACTGCTATTGACGATGTCCGTGAGATGAAGGAAGAG
CTGGAAGCGCTGCGTTCTGAGTCGGATATTGCAGAACGTGACGGCAATTATGGTCGTGTCGCAGAGCTGCGCTACGGCCG
AATCCCTGAGCTGGAAAAGCAGATCGAGGATGCAGAATCCAAGGTCGAGGTCAATGAAAATGCCATGCTCACTGAGGAGG
TCACGCCAGACACGATCGCCGATGTGGTTTCCGCATGGACGGGCATTCCTGCAGGCAAGATGATGCAGGGTGAGACCGAG
AAGCTGCTCAACATGGAGCGCGTCTTGGGCAACCGTGTGGTCGGTCAGCTAGAAGCGGTAACTGCAGTGTCTGACGCGGT
GCGTCGTTCACGCGCGGGTGTTGCCGATCCAAACCGTCCAACTGGTTCCTTCCTGTTCCTTGGACCTACCGGCGTCGGTA
AGACTGAGCTGGCCAAGGCTGTCGCGGAGTTCCTCTTCGATGATGATCGCGCCATGATCCGCATCGATATGTCCGAATAC
GGTGAGAAGCACTCGGTTGCTCGTCTGGTCGGTGCCCCTCCGGGATACGTCGGCTATGACCAGGGCGGTCAACTCACTGA
GGCAGTGCGCCGTCGTCCGTACACCGTCGTGCTTTTCGACGAGGTGGAGAAGGCTCACCCTGATGTCTTCGATATCCTCC
TGCAGGTTCTCGACGAGGGTCGCCTCACCGACGGCCAAGGCCGGACCGTGGATTTCCGCAACACCATCTTGATCCTCACC
TCTAACCTGGGCGCAGGCGGTACTCGCGAACAAATGATGGATGCTGTGAAGATGGCATTCAAGCCTGAGTTCGTGAACCG
TCTCGATGATGTTGTGATCTTCGATCGTTTGTCCCCTGAGCAGCTGACCAGCATCGTTGATATCCAGATCAAGCAGCTGA
CTGACCGTTTGGCTGGCCGCAGGCTTAACCTTCGAGTCAGCGACAGCGCGAAGGCTTGGCTGGCGGAGCGTGGCTACGAC
CCTGCTTATGGTGCTCGTCCGTTGCGCAGGCTGATCCAGCAGGCCATCGGTGATACTTTGGCTAAGGAACTGCTGGCAGG
CAACGTCCGTGATGGCGATGGTGTGCTTGTCGACGTCGCCGACGGCGGCCAGAAGCTCGACGTTTCCAGGGCGGTCTAA

Upstream 100 bases:

>100_bases
ATAGATATTAGAGAGTTAAATAATGGCGCTTGACCTGCAGGAAATTGAGATCAACACTGATTGTGTAGGTTGGCGCCCAA
CAAAGAAAGGGCGTTGAAAG

Downstream 100 bases:

>100_bases
CGGCTCGTGGGCAAGCAGGAAAAGCTGCGCATTCCTCTCGATGTTCCGGGAGTGGAATCAGAAGAGGTAGGTGTAGAACT
GCTTGCCGAAGGCTACTACC

Product: ATP-dependent protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 852; Mature: 851

Protein sequence:

>852_residues
MSSFNPTTKTNEAMQAALQQASSAGNPDIRPAHLLAAILEQTDGVAAPVLMATGVDPKEILAEAKKLVASYPKASGANMA
NPNFNRDALNAFTAAQELAGELGDEYVSTEVLLAGIARGKSDAADLLTNKGATYDAIKEAFPSVRGSQRVTTQDPEGQFQ
ALEKYSTDLTKLAREGKIDPVIGRDQEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLARRIVAGDVPESLKGKTLIS
LDLGSMVAGAKYRGEFEERLKAVLDEIKGANGEVVTFIDELHTIVGAGASGESAMDAGNMIKPLLARGELRLVGATTLNE
YRKYIEKDAALERRFQQVYVGEPTVEDAIGILRGLKERYEVHHGVRIQDSALVAAAELSNRYITSRFLPDKAIDLVDEAA
SRLRMEIDSSPQEIDELERIVRRLEIEEMALSKESDAASKERLEKLRSELADEREKLSELKARWQNEKTAIDDVREMKEE
LEALRSESDIAERDGNYGRVAELRYGRIPELEKQIEDAESKVEVNENAMLTEEVTPDTIADVVSAWTGIPAGKMMQGETE
KLLNMERVLGNRVVGQLEAVTAVSDAVRRSRAGVADPNRPTGSFLFLGPTGVGKTELAKAVAEFLFDDDRAMIRIDMSEY
GEKHSVARLVGAPPGYVGYDQGGQLTEAVRRRPYTVVLFDEVEKAHPDVFDILLQVLDEGRLTDGQGRTVDFRNTILILT
SNLGAGGTREQMMDAVKMAFKPEFVNRLDDVVIFDRLSPEQLTSIVDIQIKQLTDRLAGRRLNLRVSDSAKAWLAERGYD
PAYGARPLRRLIQQAIGDTLAKELLAGNVRDGDGVLVDVADGGQKLDVSRAV

Sequences:

>Translated_852_residues
MSSFNPTTKTNEAMQAALQQASSAGNPDIRPAHLLAAILEQTDGVAAPVLMATGVDPKEILAEAKKLVASYPKASGANMA
NPNFNRDALNAFTAAQELAGELGDEYVSTEVLLAGIARGKSDAADLLTNKGATYDAIKEAFPSVRGSQRVTTQDPEGQFQ
ALEKYSTDLTKLAREGKIDPVIGRDQEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLARRIVAGDVPESLKGKTLIS
LDLGSMVAGAKYRGEFEERLKAVLDEIKGANGEVVTFIDELHTIVGAGASGESAMDAGNMIKPLLARGELRLVGATTLNE
YRKYIEKDAALERRFQQVYVGEPTVEDAIGILRGLKERYEVHHGVRIQDSALVAAAELSNRYITSRFLPDKAIDLVDEAA
SRLRMEIDSSPQEIDELERIVRRLEIEEMALSKESDAASKERLEKLRSELADEREKLSELKARWQNEKTAIDDVREMKEE
LEALRSESDIAERDGNYGRVAELRYGRIPELEKQIEDAESKVEVNENAMLTEEVTPDTIADVVSAWTGIPAGKMMQGETE
KLLNMERVLGNRVVGQLEAVTAVSDAVRRSRAGVADPNRPTGSFLFLGPTGVGKTELAKAVAEFLFDDDRAMIRIDMSEY
GEKHSVARLVGAPPGYVGYDQGGQLTEAVRRRPYTVVLFDEVEKAHPDVFDILLQVLDEGRLTDGQGRTVDFRNTILILT
SNLGAGGTREQMMDAVKMAFKPEFVNRLDDVVIFDRLSPEQLTSIVDIQIKQLTDRLAGRRLNLRVSDSAKAWLAERGYD
PAYGARPLRRLIQQAIGDTLAKELLAGNVRDGDGVLVDVADGGQKLDVSRAV
>Mature_851_residues
SSFNPTTKTNEAMQAALQQASSAGNPDIRPAHLLAAILEQTDGVAAPVLMATGVDPKEILAEAKKLVASYPKASGANMAN
PNFNRDALNAFTAAQELAGELGDEYVSTEVLLAGIARGKSDAADLLTNKGATYDAIKEAFPSVRGSQRVTTQDPEGQFQA
LEKYSTDLTKLAREGKIDPVIGRDQEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLARRIVAGDVPESLKGKTLISL
DLGSMVAGAKYRGEFEERLKAVLDEIKGANGEVVTFIDELHTIVGAGASGESAMDAGNMIKPLLARGELRLVGATTLNEY
RKYIEKDAALERRFQQVYVGEPTVEDAIGILRGLKERYEVHHGVRIQDSALVAAAELSNRYITSRFLPDKAIDLVDEAAS
RLRMEIDSSPQEIDELERIVRRLEIEEMALSKESDAASKERLEKLRSELADEREKLSELKARWQNEKTAIDDVREMKEEL
EALRSESDIAERDGNYGRVAELRYGRIPELEKQIEDAESKVEVNENAMLTEEVTPDTIADVVSAWTGIPAGKMMQGETEK
LLNMERVLGNRVVGQLEAVTAVSDAVRRSRAGVADPNRPTGSFLFLGPTGVGKTELAKAVAEFLFDDDRAMIRIDMSEYG
EKHSVARLVGAPPGYVGYDQGGQLTEAVRRRPYTVVLFDEVEKAHPDVFDILLQVLDEGRLTDGQGRTVDFRNTILILTS
NLGAGGTREQMMDAVKMAFKPEFVNRLDDVVIFDRLSPEQLTSIVDIQIKQLTDRLAGRRLNLRVSDSAKAWLAERGYDP
AYGARPLRRLIQQAIGDTLAKELLAGNVRDGDGVLVDVADGGQKLDVSRAV

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=310, Percent_Identity=34.8387096774194, Blast_Score=189, Evalue=7e-48,
Organism=Escherichia coli, GI1788943, Length=845, Percent_Identity=55.0295857988166, Blast_Score=923, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=312, Percent_Identity=46.474358974359, Blast_Score=286, Evalue=5e-78,
Organism=Saccharomyces cerevisiae, GI6320464, Length=726, Percent_Identity=54.5454545454545, Blast_Score=792, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=851, Percent_Identity=42.8907168037603, Blast_Score=672, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 93233; Mature: 93102

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFNPTTKTNEAMQAALQQASSAGNPDIRPAHLLAAILEQTDGVAAPVLMATGVDPKEI
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCHHHH
LAEAKKLVASYPKASGANMANPNFNRDALNAFTAAQELAGELGDEYVSTEVLLAGIARGK
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SDAADLLTNKGATYDAIKEAFPSVRGSQRVTTQDPEGQFQALEKYSTDLTKLAREGKIDP
CHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
VIGRDQEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLARRIVAGDVPESLKGKTLIS
CCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHCCCEEEE
LDLGSMVAGAKYRGEFEERLKAVLDEIKGANGEVVTFIDELHTIVGAGASGESAMDAGNM
EEHHHHHHCCHHCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCCCCHHHHHHHH
IKPLLARGELRLVGATTLNEYRKYIEKDAALERRFQQVYVGEPTVEDAIGILRGLKERYE
HHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VHHGVRIQDSALVAAAELSNRYITSRFLPDKAIDLVDEAASRLRMEIDSSPQEIDELERI
HHCCCEECCHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VRRLEIEEMALSKESDAASKERLEKLRSELADEREKLSELKARWQNEKTAIDDVREMKEE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LEALRSESDIAERDGNYGRVAELRYGRIPELEKQIEDAESKVEVNENAMLTEEVTPDTIA
HHHHHHHHHHHHCCCCCCCEEHCCCCCCCHHHHHHHHHHHHEEECCCCEEECCCCHHHHH
DVVSAWTGIPAGKMMQGETEKLLNMERVLGNRVVGQLEAVTAVSDAVRRSRAGVADPNRP
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TGSFLFLGPTGVGKTELAKAVAEFLFDDDRAMIRIDMSEYGEKHSVARLVGAPPGYVGYD
CCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHCCCHHHHHHHHCCCCCCCCCC
QGGQLTEAVRRRPYTVVLFDEVEKAHPDVFDILLQVLDEGRLTDGQGRTVDFRNTILILT
CCCHHHHHHHHCCCEEEEECCHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEE
SNLGAGGTREQMMDAVKMAFKPEFVNRLDDVVIFDRLSPEQLTSIVDIQIKQLTDRLAGR
ECCCCCCCHHHHHHHHHHHHCHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHCCC
RLNLRVSDSAKAWLAERGYDPAYGARPLRRLIQQAIGDTLAKELLAGNVRDGDGVLVDVA
EEEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
DGGQKLDVSRAV
CCCCCCCHHCCC
>Mature Secondary Structure 
SSFNPTTKTNEAMQAALQQASSAGNPDIRPAHLLAAILEQTDGVAAPVLMATGVDPKEI
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCHHHH
LAEAKKLVASYPKASGANMANPNFNRDALNAFTAAQELAGELGDEYVSTEVLLAGIARGK
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SDAADLLTNKGATYDAIKEAFPSVRGSQRVTTQDPEGQFQALEKYSTDLTKLAREGKIDP
CHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
VIGRDQEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLARRIVAGDVPESLKGKTLIS
CCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHCCCEEEE
LDLGSMVAGAKYRGEFEERLKAVLDEIKGANGEVVTFIDELHTIVGAGASGESAMDAGNM
EEHHHHHHCCHHCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCCCCHHHHHHHH
IKPLLARGELRLVGATTLNEYRKYIEKDAALERRFQQVYVGEPTVEDAIGILRGLKERYE
HHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VHHGVRIQDSALVAAAELSNRYITSRFLPDKAIDLVDEAASRLRMEIDSSPQEIDELERI
HHCCCEECCHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VRRLEIEEMALSKESDAASKERLEKLRSELADEREKLSELKARWQNEKTAIDDVREMKEE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LEALRSESDIAERDGNYGRVAELRYGRIPELEKQIEDAESKVEVNENAMLTEEVTPDTIA
HHHHHHHHHHHHCCCCCCCEEHCCCCCCCHHHHHHHHHHHHEEECCCCEEECCCCHHHHH
DVVSAWTGIPAGKMMQGETEKLLNMERVLGNRVVGQLEAVTAVSDAVRRSRAGVADPNRP
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TGSFLFLGPTGVGKTELAKAVAEFLFDDDRAMIRIDMSEYGEKHSVARLVGAPPGYVGYD
CCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHCCCHHHHHHHHCCCCCCCCCC
QGGQLTEAVRRRPYTVVLFDEVEKAHPDVFDILLQVLDEGRLTDGQGRTVDFRNTILILT
CCCHHHHHHHHCCCEEEEECCHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEE
SNLGAGGTREQMMDAVKMAFKPEFVNRLDDVVIFDRLSPEQLTSIVDIQIKQLTDRLAGR
ECCCCCCCHHHHHHHHHHHHCHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHCCC
RLNLRVSDSAKAWLAERGYDPAYGARPLRRLIQQAIGDTLAKELLAGNVRDGDGVLVDVA
EEEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
DGGQKLDVSRAV
CCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]