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The map label for this gene is pyrE [H]

Identifier: 62391608

GI number: 62391608

Start: 2930788

End: 2931342

Strand: Reverse

Name: pyrE [H]

Synonym: cg3071

Alternate gene names: 62391608

Gene position: 2931342-2930788 (Counterclockwise)

Preceding gene: 62391609

Following gene: 62391607

Centisome position: 89.3

GC content: 59.1

Gene sequence:

>555_bases
ATGTCATCTAATTCCATTAACGCAGAAGCGCGCGCTGAGCTTGCTGAACTGATCAAAGAGCTAGCTGTCGTCCACGGTGA
AGTCACCTTGTCTTCGGGCAAGAAGGCTGATTACTACATCGATGTCCGTCGTGCCACCTTGCACGCGCGCGCATCTCGCC
TGATCGGTCAGCTGCTGCGCGAAGCCACCGCTGACTGGGACTATGACGCAGTTGGCGGCCTGACCTTGGGCGCTGACCCG
GTTGCCACCGCCATCATGCACGCCGACGGCCGCGATATCAACGCGTTTGTGGTGCGCAAGGAGGCCAAGAAGCACGGCAT
GCAGCGTCGCATTGAGGGCCCTGACCTGACGGGCAAGAAGGTGCTCGTGGTGGAAGATACCACCACCACCGGAAATTCCC
CTCTGACAGCTGTTGCCGCGTTGCGTGAAGCTGGCATTGAGGTTGTGGGCGTTGCCACCGTGGTCGATCGCGCAACCGGT
GCAGATGAGGTTATCGCAGCGGAAGGCCTTCCTTACCGCAGCTTGCTGGGACTTTCTGATCTTGGACTCAACTAA

Upstream 100 bases:

>100_bases
GAAAACTGGTGTTTTTCGGCCGTGTCCACCCCAGGTTCTATGCTGTAACAAACGCGGGTTTAAACCTCAATCATCAAATT
AGGGAAGGGCTGGGAAATCC

Downstream 100 bases:

>100_bases
CACCCCCGGCCCCACGGAGTGGGGCGAGTCCCGCGTGGGCAAAGGTCCATGGGAAGAGGAAAACCCCGGCGTACCTCGGC
CTACAAGCCCGCTTTTCGAC

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MSSNSINAEARAELAELIKELAVVHGEVTLSSGKKADYYIDVRRATLHARASRLIGQLLREATADWDYDAVGGLTLGADP
VATAIMHADGRDINAFVVRKEAKKHGMQRRIEGPDLTGKKVLVVEDTTTTGNSPLTAVAALREAGIEVVGVATVVDRATG
ADEVIAAEGLPYRSLLGLSDLGLN

Sequences:

>Translated_184_residues
MSSNSINAEARAELAELIKELAVVHGEVTLSSGKKADYYIDVRRATLHARASRLIGQLLREATADWDYDAVGGLTLGADP
VATAIMHADGRDINAFVVRKEAKKHGMQRRIEGPDLTGKKVLVVEDTTTTGNSPLTAVAALREAGIEVVGVATVVDRATG
ADEVIAAEGLPYRSLLGLSDLGLN
>Mature_183_residues
SSNSINAEARAELAELIKELAVVHGEVTLSSGKKADYYIDVRRATLHARASRLIGQLLREATADWDYDAVGGLTLGADPV
ATAIMHADGRDINAFVVRKEAKKHGMQRRIEGPDLTGKKVLVVEDTTTTGNSPLTAVAALREAGIEVVGVATVVDRATGA
DEVIAAEGLPYRSLLGLSDLGLN

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=180, Percent_Identity=31.1111111111111, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508631, Length=158, Percent_Identity=32.9113924050633, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17554964, Length=173, Percent_Identity=28.9017341040462, Blast_Score=66, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 19445; Mature: 19314

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNSINAEARAELAELIKELAVVHGEVTLSSGKKADYYIDVRRATLHARASRLIGQLLR
CCCCCCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
EATADWDYDAVGGLTLGADPVATAIMHADGRDINAFVVRKEAKKHGMQRRIEGPDLTGKK
HHCCCCCCCCCCCEEECCCHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCE
VLVVEDTTTTGNSPLTAVAALREAGIEVVGVATVVDRATGADEVIAAEGLPYRSLLGLSD
EEEEECCCCCCCCCHHHHHHHHHCCCEEEEHHHHHHCCCCCCCEEECCCCCHHHHHCCCC
LGLN
CCCC
>Mature Secondary Structure 
SSNSINAEARAELAELIKELAVVHGEVTLSSGKKADYYIDVRRATLHARASRLIGQLLR
CCCCCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
EATADWDYDAVGGLTLGADPVATAIMHADGRDINAFVVRKEAKKHGMQRRIEGPDLTGKK
HHCCCCCCCCCCCEEECCCHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCE
VLVVEDTTTTGNSPLTAVAALREAGIEVVGVATVVDRATGADEVIAAEGLPYRSLLGLSD
EEEEECCCCCCCCCHHHHHHHHHCCCEEEEHHHHHHCCCCCCCEEECCCCCHHHHHCCCC
LGLN
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA