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The map label for this gene is fda

Identifier: 62391605

GI number: 62391605

Start: 2927544

End: 2928578

Strand: Reverse

Name: fda

Synonym: cg3068

Alternate gene names: 62391605

Gene position: 2928578-2927544 (Counterclockwise)

Preceding gene: 62391606

Following gene: 62391604

Centisome position: 89.21

GC content: 56.43

Gene sequence:

>1035_bases
ATGCCTATCGCAACTCCCGAGGTCTATAACGAGATGCTCGATCGTGCTAAGGAAGGCGGATTCGCCTTCCCAGCCATCAA
CTGCACCTCCTCGGAAACCATCAACGCAGCTCTCAAGGGCTTCGCAGAGGCTGAATCTGACGGAATCATCCAGTTCTCCA
CCGGTGGTGCAGAGTTCGGTTCCGGCCTGGCAGTAAAGAACAAGGTCAAGGGCGCAGTTGCGCTTGCAGCCTTCGCCCAC
GAGGCAGCAAAGAGCTACGGCATCAACGTTGCTCTGCACACTGACCACTGCCAGAAGGAAGTCCTGGACGAGTACGTCCG
CCCACTGCTGGCTATCTCCCAGGAGCGCGTCGACCGCGGCGAGCTTCCACTGTTCCAGTCCCACATGTGGGATGGTTCCG
CTGTCCCAATCGACGAGAACCTCGAAATCGCACAGGAGCTGCTGGCTAAGGCCAAGGCAGCGAACATCATCTTGGAAGTT
GAGATCGGTGTTGTCGGTGGCGAAGAAGACGGCGTTGAGGCTAAGGCTGGCGCAAACCTCTACACCTCCCCAGAAGACTT
TGAGAAGACCATCGATGCAATCGGCACCGGTGAGAAGGGCCGCTACCTGCTAGCAGCTACCTTCGGTAACGTCCACGGCG
TTTACAAGCCAGGCAACGTCAAGCTGCGCCCAGAGGTCCTCCTTGAGGGCCAGCAGGTTGCACGCAAGAAGCTTGGACTT
GCAGACGACGCACTTCCATTCGACTTCGTCTTCCACGGTGGCTCAGGCTCCGAGAAGGAAAAGATCGAAGAGGCGCTGAC
CTACGGCGTCATCAAGATGAACGTTGATACTGACACCCAGTACGCATTCACCCGCCCAATCGTCTCCCACATGTTTGAGA
ACTACAACGGCGTTCTCAAGATCGACGGCGAGGTCGGAAACAAGAAGGCTTACGACCCACGCTCTTACATGAAGAAGGCT
GAGCAGAGCATGTCTGAGCGCATTATCGAGTCTTGCCAGGACCTCAAGTCTGTTGGAAAGACCACCTCTAAGTAA

Upstream 100 bases:

>100_bases
ATTGTGAATGTGGGATTATCGGTTCGCGCTTCACCATGTTTCTGCATGATGAAATTACATACATAGTTCAGTGACAGTCA
CCTTTTGGAGGAGACACCTT

Downstream 100 bases:

>100_bases
TCTCAGCAGTTAAAAAGGGCAGTTCCGCATCAGGGGGACTGCCCTTTTTCGTGTCTTCTCATGCTCTTGTGAATATGCAT
AGCTAATCTTGAGGCCATGG

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MPIATPEVYNEMLDRAKEGGFAFPAINCTSSETINAALKGFAEAESDGIIQFSTGGAEFGSGLAVKNKVKGAVALAAFAH
EAAKSYGINVALHTDHCQKEVLDEYVRPLLAISQERVDRGELPLFQSHMWDGSAVPIDENLEIAQELLAKAKAANIILEV
EIGVVGGEEDGVEAKAGANLYTSPEDFEKTIDAIGTGEKGRYLLAATFGNVHGVYKPGNVKLRPEVLLEGQQVARKKLGL
ADDALPFDFVFHGGSGSEKEKIEEALTYGVIKMNVDTDTQYAFTRPIVSHMFENYNGVLKIDGEVGNKKAYDPRSYMKKA
EQSMSERIIESCQDLKSVGKTTSK

Sequences:

>Translated_344_residues
MPIATPEVYNEMLDRAKEGGFAFPAINCTSSETINAALKGFAEAESDGIIQFSTGGAEFGSGLAVKNKVKGAVALAAFAH
EAAKSYGINVALHTDHCQKEVLDEYVRPLLAISQERVDRGELPLFQSHMWDGSAVPIDENLEIAQELLAKAKAANIILEV
EIGVVGGEEDGVEAKAGANLYTSPEDFEKTIDAIGTGEKGRYLLAATFGNVHGVYKPGNVKLRPEVLLEGQQVARKKLGL
ADDALPFDFVFHGGSGSEKEKIEEALTYGVIKMNVDTDTQYAFTRPIVSHMFENYNGVLKIDGEVGNKKAYDPRSYMKKA
EQSMSERIIESCQDLKSVGKTTSK
>Mature_343_residues
PIATPEVYNEMLDRAKEGGFAFPAINCTSSETINAALKGFAEAESDGIIQFSTGGAEFGSGLAVKNKVKGAVALAAFAHE
AAKSYGINVALHTDHCQKEVLDEYVRPLLAISQERVDRGELPLFQSHMWDGSAVPIDENLEIAQELLAKAKAANIILEVE
IGVVGGEEDGVEAKAGANLYTSPEDFEKTIDAIGTGEKGRYLLAATFGNVHGVYKPGNVKLRPEVLLEGQQVARKKLGLA
DDALPFDFVFHGGSGSEKEKIEEALTYGVIKMNVDTDTQYAFTRPIVSHMFENYNGVLKIDGEVGNKKAYDPRSYMKKAE
QSMSERIIESCQDLKSVGKTTSK

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family

Homologues:

Organism=Escherichia coli, GI1789293, Length=339, Percent_Identity=39.8230088495575, Blast_Score=242, Evalue=2e-65,
Organism=Escherichia coli, GI87082041, Length=325, Percent_Identity=25.2307692307692, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1789526, Length=317, Percent_Identity=24.9211356466877, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788072, Length=261, Percent_Identity=26.0536398467433, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322790, Length=348, Percent_Identity=37.0689655172414, Blast_Score=206, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALF_CORGL (P19537)

Other databases:

- EMBL:   X17313
- EMBL:   BA000036
- EMBL:   BX927156
- PIR:   S09283
- RefSeq:   NP_601964.1
- RefSeq:   YP_227007.1
- ProteinModelPortal:   P19537
- SMR:   P19537
- World-2DPAGE:   0001:P19537
- PRIDE:   P19537
- GeneID:   1020714
- GeneID:   3345516
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg3068
- KEGG:   cgl:NCgl2673
- HOGENOM:   HBG327581
- OMA:   QAYCAEK
- PhylomeDB:   P19537
- ProtClustDB:   PRK09197
- BioCyc:   CGLU196627:CG3068-MONOMER
- BRENDA:   4.1.2.13
- GO:   GO:0006096
- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF001359
- TIGRFAMs:   TIGR00167
- TIGRFAMs:   TIGR01520

Pfam domain/function: PF01116 F_bP_aldolase

EC number: =4.1.2.13

Molecular weight: Translated: 37214; Mature: 37083

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00602 ALDOLASE_CLASS_II_1; PS00806 ALDOLASE_CLASS_II_2

Important sites: ACT_SITE 95-95 BINDING 53-53 BINDING 213-213

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIATPEVYNEMLDRAKEGGFAFPAINCTSSETINAALKGFAEAESDGIIQFSTGGAEFG
CCCCCHHHHHHHHHHHHCCCEECCEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCC
SGLAVKNKVKGAVALAAFAHEAAKSYGINVALHTDHCQKEVLDEYVRPLLAISQERVDRG
CCCEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
ELPLFQSHMWDGSAVPIDENLEIAQELLAKAKAANIILEVEIGVVGGEEDGVEAKAGANL
CCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCCCCC
YTSPEDFEKTIDAIGTGEKGRYLLAATFGNVHGVYKPGNVKLRPEVLLEGQQVARKKLGL
CCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECCCCEEECHHHHHCCHHHHHHHCCC
ADDALPFDFVFHGGSGSEKEKIEEALTYGVIKMNVDTDTQYAFTRPIVSHMFENYNGVLK
CCCCCCEEEEEECCCCCHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEE
IDGEVGNKKAYDPRSYMKKAEQSMSERIIESCQDLKSVGKTTSK
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PIATPEVYNEMLDRAKEGGFAFPAINCTSSETINAALKGFAEAESDGIIQFSTGGAEFG
CCCCHHHHHHHHHHHHCCCEECCEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCC
SGLAVKNKVKGAVALAAFAHEAAKSYGINVALHTDHCQKEVLDEYVRPLLAISQERVDRG
CCCEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
ELPLFQSHMWDGSAVPIDENLEIAQELLAKAKAANIILEVEIGVVGGEEDGVEAKAGANL
CCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCCCCC
YTSPEDFEKTIDAIGTGEKGRYLLAATFGNVHGVYKPGNVKLRPEVLLEGQQVARKKLGL
CCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECCCCEEECHHHHHCCHHHHHHHCCC
ADDALPFDFVFHGGSGSEKEKIEEALTYGVIKMNVDTDTQYAFTRPIVSHMFENYNGVLK
CCCCCCEEEEEECCCCCHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEE
IDGEVGNKKAYDPRSYMKKAEQSMSERIIESCQDLKSVGKTTSK
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2615658; 12948626