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The map label for this gene is ydgK [H]

Identifier: 62391579

GI number: 62391579

Start: 2897259

End: 2898455

Strand: Reverse

Name: ydgK [H]

Synonym: cg3038

Alternate gene names: 62391579

Gene position: 2898455-2897259 (Counterclockwise)

Preceding gene: 62391581

Following gene: 62391574

Centisome position: 88.29

GC content: 52.05

Gene sequence:

>1197_bases
ATGCAGAAAAAACAACAGCTGAGCACCGCCCTGATTATGGGATTGGCATTATTGTCAGCCAGCTCCGCGCTAGCGACTGA
TATGTATTTGCCGGCAATGCCTGGTATTGCGGAAGATTTGGGGACAACTGCACCGATGGTGCAGTTAACTCTTTCTTCCT
TTATGGCTGGAATGGCGATTGGCCAATTGATCATTGGTCCTTTGTCGGATCAATTGGGAAGGAAAGGCCTGCTCGTTGCA
GGTGCGGTGGCTGCGCTGGTCGCTAGTGTGGTGTGCGCGCTGGCGCCGTCGATAAGCGTATTAGTGATCGCACGCCTGGT
GCAGGGGCTTGGCGGCGGTGCGTGCGTGGTGATTGCGCGCGCGATCGTGCCAGACCTTGAACGCGGACAAAAGGCTGCGC
ACGCCTTTGCACTGCTGATGATTATTCAGGGAATTGCTCCCGTGGTAGCTCCGCTCATTGGTGGTGTGCTGGTCGGGCCT
TTTGGCTGGCGGGGAATTTTCTGGGCACTTGCACTGGTGAATTTTGCGCAGCTGCTTGTTGCTTTGCTGCAGATTAAGGA
GTCGAAGCCAGTTGAAGAGCGTACCGCAGCAGGACTTGGCGGAATGCTGTCCAACTATGTCTTTGTGCTGAAGAATCCTC
AATTTTTGGCATATGTATTCACATTGGGGCTGTCTTTTGGGGCGATGTTCTCCTACATTTCGGCGTCGCCGTTCGTGCTG
CAGAATCAAATGGGCATTCCGGTACTGCTGTATTCCATTATTTTCGGAGTGAATGCTTTTGGTTTGATTGTGGGCGGAAT
GGTCAATAGGCGACTTCTGCAGCGGATTCATCCACACCGCATCATGCAAACTGTGCTGGCCAGTTTTACTGTGCTGTGTG
CGCTTTTGCTGATTGAAGTGCTGTTTATTAATTGGATACCGCTGTTCCTGTTGCTGCTGTTTCTTATCGTTTCCCATATT
CCGATGGTTATGGCTAACGCGACAGCTCTGGGAACTGAAGTGGTGCGAAGCAGGGCGGGATCGGGTTCTGCAATTTTGGG
TTTCGTGCAATTCACGATGGGTGCTTTGGTGAGTTCACTGGTCGGATTAGGCTCTGATAAGGCTTTGACTATGGGAATCG
CAATGACTGCTTGTGCACTGCTGGCGTGTGGGTGTGCGTACCTGGCAGGTCGAAAAGGTATTCCAGAAATGAAGTAG

Upstream 100 bases:

>100_bases
TTTTAAGTATTGGTGCTATCTTCCGGTGCTGATGGTACCTGAATGAAAATTTCTAATTAAAAATACCCCCAAATCTTCGA
TATAGATACACGAGACAGTG

Downstream 100 bases:

>100_bases
CTCTAGGTGGCGTTTTAAGGGCTTTGAGGTGCCGGATGGACGCATGGGTGGAAATGGTGATTCGAGGCCCTTAAACGGCA
ATCTAGGGGTGTGACTTTTG

Product: major facilitator superfamily permease

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MQKKQQLSTALIMGLALLSASSALATDMYLPAMPGIAEDLGTTAPMVQLTLSSFMAGMAIGQLIIGPLSDQLGRKGLLVA
GAVAALVASVVCALAPSISVLVIARLVQGLGGGACVVIARAIVPDLERGQKAAHAFALLMIIQGIAPVVAPLIGGVLVGP
FGWRGIFWALALVNFAQLLVALLQIKESKPVEERTAAGLGGMLSNYVFVLKNPQFLAYVFTLGLSFGAMFSYISASPFVL
QNQMGIPVLLYSIIFGVNAFGLIVGGMVNRRLLQRIHPHRIMQTVLASFTVLCALLLIEVLFINWIPLFLLLLFLIVSHI
PMVMANATALGTEVVRSRAGSGSAILGFVQFTMGALVSSLVGLGSDKALTMGIAMTACALLACGCAYLAGRKGIPEMK

Sequences:

>Translated_398_residues
MQKKQQLSTALIMGLALLSASSALATDMYLPAMPGIAEDLGTTAPMVQLTLSSFMAGMAIGQLIIGPLSDQLGRKGLLVA
GAVAALVASVVCALAPSISVLVIARLVQGLGGGACVVIARAIVPDLERGQKAAHAFALLMIIQGIAPVVAPLIGGVLVGP
FGWRGIFWALALVNFAQLLVALLQIKESKPVEERTAAGLGGMLSNYVFVLKNPQFLAYVFTLGLSFGAMFSYISASPFVL
QNQMGIPVLLYSIIFGVNAFGLIVGGMVNRRLLQRIHPHRIMQTVLASFTVLCALLLIEVLFINWIPLFLLLLFLIVSHI
PMVMANATALGTEVVRSRAGSGSAILGFVQFTMGALVSSLVGLGSDKALTMGIAMTACALLACGCAYLAGRKGIPEMK
>Mature_398_residues
MQKKQQLSTALIMGLALLSASSALATDMYLPAMPGIAEDLGTTAPMVQLTLSSFMAGMAIGQLIIGPLSDQLGRKGLLVA
GAVAALVASVVCALAPSISVLVIARLVQGLGGGACVVIARAIVPDLERGQKAAHAFALLMIIQGIAPVVAPLIGGVLVGP
FGWRGIFWALALVNFAQLLVALLQIKESKPVEERTAAGLGGMLSNYVFVLKNPQFLAYVFTLGLSFGAMFSYISASPFVL
QNQMGIPVLLYSIIFGVNAFGLIVGGMVNRRLLQRIHPHRIMQTVLASFTVLCALLLIEVLFINWIPLFLLLLFLIVSHI
PMVMANATALGTEVVRSRAGSGSAILGFVQFTMGALVSSLVGLGSDKALTMGIAMTACALLACGCAYLAGRKGIPEMK

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=386, Percent_Identity=31.3471502590674, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1790146, Length=237, Percent_Identity=32.0675105485232, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI48994889, Length=281, Percent_Identity=32.3843416370107, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI87082312, Length=368, Percent_Identity=26.9021739130435, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787065, Length=281, Percent_Identity=26.6903914590747, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790794, Length=232, Percent_Identity=26.7241379310345, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1789042, Length=171, Percent_Identity=26.9005847953216, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324264, Length=183, Percent_Identity=30.6010928961749, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319480, Length=271, Percent_Identity=23.9852398523985, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319657, Length=146, Percent_Identity=26.7123287671233, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41608; Mature: 41608

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKQQLSTALIMGLALLSASSALATDMYLPAMPGIAEDLGTTAPMVQLTLSSFMAGMAI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHH
GQLIIGPLSDQLGRKGLLVAGAVAALVASVVCALAPSISVLVIARLVQGLGGGACVVIAR
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHH
AIVPDLERGQKAAHAFALLMIIQGIAPVVAPLIGGVLVGPFGWRGIFWALALVNFAQLLV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
ALLQIKESKPVEERTAAGLGGMLSNYVFVLKNPQFLAYVFTLGLSFGAMFSYISASPFVL
HHHHHHCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHC
QNQMGIPVLLYSIIFGVNAFGLIVGGMVNRRLLQRIHPHRIMQTVLASFTVLCALLLIEV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
LFINWIPLFLLLLFLIVSHIPMVMANATALGTEVVRSRAGSGSAILGFVQFTMGALVSSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VGLGSDKALTMGIAMTACALLACGCAYLAGRKGIPEMK
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQKKQQLSTALIMGLALLSASSALATDMYLPAMPGIAEDLGTTAPMVQLTLSSFMAGMAI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHH
GQLIIGPLSDQLGRKGLLVAGAVAALVASVVCALAPSISVLVIARLVQGLGGGACVVIAR
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHH
AIVPDLERGQKAAHAFALLMIIQGIAPVVAPLIGGVLVGPFGWRGIFWALALVNFAQLLV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
ALLQIKESKPVEERTAAGLGGMLSNYVFVLKNPQFLAYVFTLGLSFGAMFSYISASPFVL
HHHHHHCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHC
QNQMGIPVLLYSIIFGVNAFGLIVGGMVNRRLLQRIHPHRIMQTVLASFTVLCALLLIEV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
LFINWIPLFLLLLFLIVSHIPMVMANATALGTEVVRSRAGSGSAILGFVQFTMGALVSSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VGLGSDKALTMGIAMTACALLACGCAYLAGRKGIPEMK
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]