Click here to switch to the map view.

The map label for this gene is hpt [H]

Identifier: 62391534

GI number: 62391534

Start: 2843168

End: 2843770

Strand: Reverse

Name: hpt [H]

Synonym: cg2985

Alternate gene names: 62391534

Gene position: 2843770-2843168 (Counterclockwise)

Preceding gene: 62391535

Following gene: 62391533

Centisome position: 86.63

GC content: 53.9

Gene sequence:

>603_bases
ATGAGCAACAACGTAGAAATGGCCGACCACAAAGATCTCAATGTTCCAGCCAACCCATACGGCACCGACATTGAATCAGT
ATTGATCAGCGAAGAGAAGCTCAAGCAGCGCATCGCCGAAATGGCCAAGCGCGTCTCCGAAGAGTTCAAAGACGCCGAAG
AAGACCTCATCCTGGTGTGCGTGCTCAAGGGCGCGTTCTACTTCCTGGCAGATTTCTCCCGCATGCTCGACATCCCCACC
CAGTCCGAGTTCATGGCGGTGTCCTCTTACGGAAACTCCACCTCCTCTTCAGGCGTGGTGCGCATCCTCAAGGACCTGGA
CAAGGAAATTGAAGGCCGCGACGTTTTGATCGTGGAAGACATCATCGATTCCGGACTGACCCTGTCCTGGCTGATGCGCA
ACCTGAAAAACCGCAACCCTAAGTCCCTCAACGTGATCACCTTGCTGCGTAAGCCAGAGCGCCTGACCACCAACATCGAC
ATGTTCGACATTGGATTTGATATTCCAAATGAGTTTGTTGTGGGCTACGGACTTGATTTCGCAGAACGCTACCGCGACCT
GCCATATGTGGGCACCCTCGAGCCTCACGTGTACTCCGACTAG

Upstream 100 bases:

>100_bases
GGGTAAAAGCGATAATGGAAGGTTGGAAGTGGTGCGGCAAAGTGGCAAGCTTAAGATCACTGATTGACACCTGAATCTAC
AACACAAGGGGAACGCGACG

Downstream 100 bases:

>100_bases
TAATCAAAAGTGCGAAAGAGGGAACGTTTTGGCCCTCAACTTCGTTTGATTAGTTGTCTAGTAGATCCCTTTTATTCGAT
TCCGAGAAAGGCACGGGCAA

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MSNNVEMADHKDLNVPANPYGTDIESVLISEEKLKQRIAEMAKRVSEEFKDAEEDLILVCVLKGAFYFLADFSRMLDIPT
QSEFMAVSSYGNSTSSSGVVRILKDLDKEIEGRDVLIVEDIIDSGLTLSWLMRNLKNRNPKSLNVITLLRKPERLTTNID
MFDIGFDIPNEFVVGYGLDFAERYRDLPYVGTLEPHVYSD

Sequences:

>Translated_200_residues
MSNNVEMADHKDLNVPANPYGTDIESVLISEEKLKQRIAEMAKRVSEEFKDAEEDLILVCVLKGAFYFLADFSRMLDIPT
QSEFMAVSSYGNSTSSSGVVRILKDLDKEIEGRDVLIVEDIIDSGLTLSWLMRNLKNRNPKSLNVITLLRKPERLTTNID
MFDIGFDIPNEFVVGYGLDFAERYRDLPYVGTLEPHVYSD
>Mature_199_residues
SNNVEMADHKDLNVPANPYGTDIESVLISEEKLKQRIAEMAKRVSEEFKDAEEDLILVCVLKGAFYFLADFSRMLDIPTQ
SEFMAVSSYGNSTSSSGVVRILKDLDKEIEGRDVLIVEDIIDSGLTLSWLMRNLKNRNPKSLNVITLLRKPERLTTNIDM
FDIGFDIPNEFVVGYGLDFAERYRDLPYVGTLEPHVYSD

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=193, Percent_Identity=35.2331606217617, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI9910262, Length=197, Percent_Identity=32.994923857868, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI87081689, Length=167, Percent_Identity=51.497005988024, Blast_Score=179, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI17510817, Length=185, Percent_Identity=31.3513513513514, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 22722; Mature: 22591

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNVEMADHKDLNVPANPYGTDIESVLISEEKLKQRIAEMAKRVSEEFKDAEEDLILVC
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEEEEH
VLKGAFYFLADFSRMLDIPTQSEFMAVSSYGNSTSSSGVVRILKDLDKEIEGRDVLIVED
HHHHHHHHHHHHHHHHCCCCCHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHH
IIDSGLTLSWLMRNLKNRNPKSLNVITLLRKPERLTTNIDMFDIGFDIPNEFVVGYGLDF
HHCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCHHCCCCEEEEECCCCCCCEEEECCCCH
AERYRDLPYVGTLEPHVYSD
HHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SNNVEMADHKDLNVPANPYGTDIESVLISEEKLKQRIAEMAKRVSEEFKDAEEDLILVC
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEEEEH
VLKGAFYFLADFSRMLDIPTQSEFMAVSSYGNSTSSSGVVRILKDLDKEIEGRDVLIVED
HHHHHHHHHHHHHHHHCCCCCHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHH
IIDSGLTLSWLMRNLKNRNPKSLNVITLLRKPERLTTNIDMFDIGFDIPNEFVVGYGLDF
HHCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCHHCCCCEEEEECCCCCCCEEEECCCCH
AERYRDLPYVGTLEPHVYSD
HHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA