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The map label for this gene is alsR [H]

Identifier: 62391455

GI number: 62391455

Start: 2758957

End: 2759664

Strand: Reverse

Name: alsR [H]

Synonym: cg2899

Alternate gene names: 62391455

Gene position: 2759664-2758957 (Counterclockwise)

Preceding gene: 62391456

Following gene: 62391454

Centisome position: 84.07

GC content: 54.1

Gene sequence:

>708_bases
GTGGAGATTCGTTGGTTGGAAGGCTTTATCGCGGTCGCGGAAGAATTGCACTTTAGTAATGCTGCGATTCGTTTGGGGAT
GCCGCAATCGCCGTTGAGTCAGTTGATCCGGCGGTTGGAGTCGGAGTTGGGGCAGAAGCTTTTTGATCGCAGTACCCGGT
CGGTGGAGTTAACTGCCGCGGGTCGGGCGTTTTTGCCACATGCCAGGGGGATTGTGGCGAGCGCTGCGGTGGCGAGGGAA
GCTGTGAATGCTGCCGAGGGGGAGATCGTTGGTGTTGTTCGCATTGGTTTTTCTGGTGTGCTGAACTATTCCACGCTGCC
GCTTTTGACCAGTGAGGTGCATAAACGGCTTCCTAATGTGGAGTTGGAGCTCGTTGGTCAGAAGTTGACGAGGGAAGCGG
TAAGTTTGCTGCGCTTGGGGGCGTTGGATATTACGTTGATGGGTTTGCCCATTGAGGATCCAGAGATTGAGACTCGGCTG
ATTAGTTTGGAAGAGTTTTGCGTGGTGTTGCCGAAGGATCATCGTCTTGCGGGGGAAGGAGTGGTGGATTTGGTGGATCT
GGCTAAAGATGGGTTTGTGACGACGCCGGAGTTTGCGGGGTCTGTGTTTAGGAATTCCACCTTTCAGTTGTGTGCTGAGG
CTGGTTTTGTGCCGAGGATCAGCCAGCAAGTTAATGATCCTTACATGGCGCTGTTGTTGGCGCGGTAG

Upstream 100 bases:

>100_bases
AACCTAGGCCGATACCCATGTGGAAATCTCGACGTCTTAAATGGACGATTGGAGCTAAAACCACGAACAGCTGGGATTTT
CCACGATAGGATTGGGTCTC

Downstream 100 bases:

>100_bases
TCAATCATGGGGGAGTATCCCACCGTATCCGCGTGAACAAGGGCGTGGTGCTGGCAGCAGGTGGATTCTCCCAGAATCCA
GAACTGCGCAAGAAGTACAT

Product: transcription regulator LysR

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MEIRWLEGFIAVAEELHFSNAAIRLGMPQSPLSQLIRRLESELGQKLFDRSTRSVELTAAGRAFLPHARGIVASAAVARE
AVNAAEGEIVGVVRIGFSGVLNYSTLPLLTSEVHKRLPNVELELVGQKLTREAVSLLRLGALDITLMGLPIEDPEIETRL
ISLEEFCVVLPKDHRLAGEGVVDLVDLAKDGFVTTPEFAGSVFRNSTFQLCAEAGFVPRISQQVNDPYMALLLAR

Sequences:

>Translated_235_residues
MEIRWLEGFIAVAEELHFSNAAIRLGMPQSPLSQLIRRLESELGQKLFDRSTRSVELTAAGRAFLPHARGIVASAAVARE
AVNAAEGEIVGVVRIGFSGVLNYSTLPLLTSEVHKRLPNVELELVGQKLTREAVSLLRLGALDITLMGLPIEDPEIETRL
ISLEEFCVVLPKDHRLAGEGVVDLVDLAKDGFVTTPEFAGSVFRNSTFQLCAEAGFVPRISQQVNDPYMALLLAR
>Mature_235_residues
MEIRWLEGFIAVAEELHFSNAAIRLGMPQSPLSQLIRRLESELGQKLFDRSTRSVELTAAGRAFLPHARGIVASAAVARE
AVNAAEGEIVGVVRIGFSGVLNYSTLPLLTSEVHKRLPNVELELVGQKLTREAVSLLRLGALDITLMGLPIEDPEIETRL
ISLEEFCVVLPKDHRLAGEGVVDLVDLAKDGFVTTPEFAGSVFRNSTFQLCAEAGFVPRISQQVNDPYMALLLAR

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=230, Percent_Identity=36.0869565217391, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI2367136, Length=236, Percent_Identity=33.0508474576271, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1788887, Length=203, Percent_Identity=36.9458128078818, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI157672245, Length=234, Percent_Identity=29.9145299145299, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790399, Length=217, Percent_Identity=30.4147465437788, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787601, Length=146, Percent_Identity=30.8219178082192, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1788748, Length=225, Percent_Identity=25.3333333333333, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789639, Length=224, Percent_Identity=29.4642857142857, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI145693105, Length=186, Percent_Identity=25.2688172043011, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790208, Length=150, Percent_Identity=30.6666666666667, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI87081904, Length=186, Percent_Identity=28.494623655914, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787589, Length=92, Percent_Identity=43.4782608695652, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 25672; Mature: 25672

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRWLEGFIAVAEELHFSNAAIRLGMPQSPLSQLIRRLESELGQKLFDRSTRSVELTAA
CCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
GRAFLPHARGIVASAAVAREAVNAAEGEIVGVVRIGFSGVLNYSTLPLLTSEVHKRLPNV
CCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHCCCCHHHHHHHHHHHHCCCC
ELELVGQKLTREAVSLLRLGALDITLMGLPIEDPEIETRLISLEEFCVVLPKDHRLAGEG
EEEHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHEEHHHHEEECCCCCCCCCCC
VVDLVDLAKDGFVTTPEFAGSVFRNSTFQLCAEAGFVPRISQQVNDPYMALLLAR
HHHHHHHHCCCCEECHHHHHHHHHCCHHHHHHHCCCCCHHHHHCCCCCCEEEECC
>Mature Secondary Structure
MEIRWLEGFIAVAEELHFSNAAIRLGMPQSPLSQLIRRLESELGQKLFDRSTRSVELTAA
CCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
GRAFLPHARGIVASAAVAREAVNAAEGEIVGVVRIGFSGVLNYSTLPLLTSEVHKRLPNV
CCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHCCCCHHHHHHHHHHHHCCCC
ELELVGQKLTREAVSLLRLGALDITLMGLPIEDPEIETRLISLEEFCVVLPKDHRLAGEG
EEEHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHEEHHHHEEECCCCCCCCCCC
VVDLVDLAKDGFVTTPEFAGSVFRNSTFQLCAEAGFVPRISQQVNDPYMALLLAR
HHHHHHHHCCCCEECHHHHHHHHHCCHHHHHHHCCCCCHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]