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The map label for this gene is dctA [H]

Identifier: 62391433

GI number: 62391433

Start: 2731168

End: 2732508

Strand: Reverse

Name: dctA [H]

Synonym: cg2870

Alternate gene names: 62391433

Gene position: 2732508-2731168 (Counterclockwise)

Preceding gene: 62391434

Following gene: 62391432

Centisome position: 83.24

GC content: 51.45

Gene sequence:

>1341_bases
ATGGATTCAAACACAGAATCTTCAAGTGTTGAGGTCAAAAACGAACACATTAAAGTTCAAAAGCCGCCGAAGAAGGACCG
CACTCACTGGCTCTACATTGCGGTCATTATCGCATTGATTGGCGGTATTACCCTAGGCCTGATTTCACCGGAGTTGGGCA
AAGAATTCAAGATTTTGGGCACCATGTTTGTGTCCTTGATCAAGATGATTATCGCTCCAGTTATTTTCTGCACCATCGTC
ATCGGAATCGGTTCAGTCAAGGCAGCGGCAACAGTCGGACGCGCTGGTGGCATCGCCCTTGCGTACTTCATCACGATGTC
CACATTCGCACTCGCAGTTGGCCTGCTAGTCGGTAACTTCATCCAGCCAGGTAGCGGACTGAACATCTCAGTTGATGAAG
AATCTTCATTCGCATCCACAGAGAGCAGCCCTGAAGGACTCTTGGGATTCATCCACTCGATCATCCCTGAAACGTTCTTC
TCTGCATTTACTGATGGTTCGGTGCTGCAGGTACTGTTCATCGCCATCCTCGTGGGCTTTGCAGCTCAGTCGATGGGTGA
AAAGGGACAGCCCATCCTTGATTTCGTATCCCATCTGCAGAAGCTCATCTTCAAGATTTTGAACTGGATTCTGTGGCTCG
CCCCAGTCGGTGCATTCGGTGCAATGGCCGGCGTCGTTGGCGAAACAGGCTTTGATGCCGTTGTTCAGCTCGGTATTTTG
ATCCTCGCCTTTTACGTCACCTGCGTGATCTTCATCTTTGGCGTGCTGGGCGCCGTACTGAAGGTGTTCACCGGCGTGAA
TATCTTCAAGCTGGTCAAGTACCTTGCCAAGGAATTCCTGCTGATCTTTGCTACCTCATCCTCTGAATCTGCCTTGCCAA
ACCTCATGCGCAAGATGGAACACATCGGTGTGGCTAAACCAACCGTCGGAATCGTGGTCCCAACCGGCTATTCCTTCAAC
TTGGACGGCACCGCAATTTACCTCACCATGGCATCTATCTTCATTGCCGACGCGATGAATATGCCGATGAGCCTCGGCGA
GCAGGTCGGTCTGCTTGTCTTCATGATCATCGCATCCAAGGGCGCTGCTGGTGTCTCGGGTGCCGGTATTGCAACGTTGG
CTGCCGGATTGTCTTCACACCGCCCAGAACTTCTGCACGGCGTTGACGTGATTGTGGGCATCGATAAATTCATGTCTGAA
GCCCGCGCACTAACCAACTTCGCCGGAAACTCCGTGGCAACACTGCTGGTCGGCAAGTGGACTGGCACCGTGGACATGAA
CCAAGTCCATGACGTTTTGAATGGAAAATCTCCATTTGTGGAGTTAGAAGAAGACCACTAG

Upstream 100 bases:

>100_bases
TTTAAGCTTCGTCGGCAACGATCACACCACGTTAAATTTCGACCATCAATGACGGTGGCCGTTTTTTGGCGAATCCCCAA
AAAGGTCGAAGAGGAAGTTC

Downstream 100 bases:

>100_bases
TTTTCAACAGGACGACAACGGCCGGACATGCGACAATACAATGCATGTCCGGCCGTCTTCTTGTTTCAGTTTCTAGTATT
TTCGACCAGACCCGATCGGC

Product: Na+/H+-dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MDSNTESSSVEVKNEHIKVQKPPKKDRTHWLYIAVIIALIGGITLGLISPELGKEFKILGTMFVSLIKMIIAPVIFCTIV
IGIGSVKAAATVGRAGGIALAYFITMSTFALAVGLLVGNFIQPGSGLNISVDEESSFASTESSPEGLLGFIHSIIPETFF
SAFTDGSVLQVLFIAILVGFAAQSMGEKGQPILDFVSHLQKLIFKILNWILWLAPVGAFGAMAGVVGETGFDAVVQLGIL
ILAFYVTCVIFIFGVLGAVLKVFTGVNIFKLVKYLAKEFLLIFATSSSESALPNLMRKMEHIGVAKPTVGIVVPTGYSFN
LDGTAIYLTMASIFIADAMNMPMSLGEQVGLLVFMIIASKGAAGVSGAGIATLAAGLSSHRPELLHGVDVIVGIDKFMSE
ARALTNFAGNSVATLLVGKWTGTVDMNQVHDVLNGKSPFVELEEDH

Sequences:

>Translated_446_residues
MDSNTESSSVEVKNEHIKVQKPPKKDRTHWLYIAVIIALIGGITLGLISPELGKEFKILGTMFVSLIKMIIAPVIFCTIV
IGIGSVKAAATVGRAGGIALAYFITMSTFALAVGLLVGNFIQPGSGLNISVDEESSFASTESSPEGLLGFIHSIIPETFF
SAFTDGSVLQVLFIAILVGFAAQSMGEKGQPILDFVSHLQKLIFKILNWILWLAPVGAFGAMAGVVGETGFDAVVQLGIL
ILAFYVTCVIFIFGVLGAVLKVFTGVNIFKLVKYLAKEFLLIFATSSSESALPNLMRKMEHIGVAKPTVGIVVPTGYSFN
LDGTAIYLTMASIFIADAMNMPMSLGEQVGLLVFMIIASKGAAGVSGAGIATLAAGLSSHRPELLHGVDVIVGIDKFMSE
ARALTNFAGNSVATLLVGKWTGTVDMNQVHDVLNGKSPFVELEEDH
>Mature_446_residues
MDSNTESSSVEVKNEHIKVQKPPKKDRTHWLYIAVIIALIGGITLGLISPELGKEFKILGTMFVSLIKMIIAPVIFCTIV
IGIGSVKAAATVGRAGGIALAYFITMSTFALAVGLLVGNFIQPGSGLNISVDEESSFASTESSPEGLLGFIHSIIPETFF
SAFTDGSVLQVLFIAILVGFAAQSMGEKGQPILDFVSHLQKLIFKILNWILWLAPVGAFGAMAGVVGETGFDAVVQLGIL
ILAFYVTCVIFIFGVLGAVLKVFTGVNIFKLVKYLAKEFLLIFATSSSESALPNLMRKMEHIGVAKPTVGIVVPTGYSFN
LDGTAIYLTMASIFIADAMNMPMSLGEQVGLLVFMIIASKGAAGVSGAGIATLAAGLSSHRPELLHGVDVIVGIDKFMSE
ARALTNFAGNSVATLLVGKWTGTVDMNQVHDVLNGKSPFVELEEDH

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=379, Percent_Identity=28.4960422163588, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI169790839, Length=462, Percent_Identity=25.7575757575758, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI194239697, Length=458, Percent_Identity=24.235807860262, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI40254478, Length=477, Percent_Identity=23.4800838574423, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI4827012, Length=232, Percent_Identity=32.3275862068966, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI66773030, Length=491, Percent_Identity=23.6252545824847, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI5032093, Length=435, Percent_Identity=25.9770114942529, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI262359914, Length=442, Percent_Identity=24.8868778280543, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI223468566, Length=267, Percent_Identity=26.5917602996255, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI223468564, Length=267, Percent_Identity=26.5917602996255, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1789947, Length=414, Percent_Identity=49.0338164251208, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1790514, Length=377, Percent_Identity=33.42175066313, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1788024, Length=397, Percent_Identity=24.1813602015113, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789473, Length=329, Percent_Identity=24.6200607902736, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17537407, Length=442, Percent_Identity=25.3393665158371, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71996953, Length=467, Percent_Identity=25.4817987152034, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71983099, Length=450, Percent_Identity=24.2222222222222, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71983106, Length=450, Percent_Identity=24.2222222222222, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI193206505, Length=451, Percent_Identity=21.9512195121951, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI193206654, Length=431, Percent_Identity=22.0417633410673, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17541374, Length=402, Percent_Identity=21.6417910447761, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24583025, Length=411, Percent_Identity=25.3041362530414, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17137668, Length=411, Percent_Identity=25.3041362530414, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24583023, Length=411, Percent_Identity=25.3041362530414, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI281360481, Length=350, Percent_Identity=26.2857142857143, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI281360483, Length=350, Percent_Identity=26.2857142857143, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17137666, Length=350, Percent_Identity=26.2857142857143, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 47237; Mature: 47237

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSNTESSSVEVKNEHIKVQKPPKKDRTHWLYIAVIIALIGGITLGLISPELGKEFKILG
CCCCCCCCCEEEECCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHH
TMFVSLIKMIIAPVIFCTIVIGIGSVKAAATVGRAGGIALAYFITMSTFALAVGLLVGNF
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHC
IQPGSGLNISVDEESSFASTESSPEGLLGFIHSIIPETFFSAFTDGSVLQVLFIAILVGF
CCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AAQSMGEKGQPILDFVSHLQKLIFKILNWILWLAPVGAFGAMAGVVGETGFDAVVQLGIL
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ILAFYVTCVIFIFGVLGAVLKVFTGVNIFKLVKYLAKEFLLIFATSSSESALPNLMRKME
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHH
HIGVAKPTVGIVVPTGYSFNLDGTAIYLTMASIFIADAMNMPMSLGEQVGLLVFMIIASK
HCCCCCCCEEEEECCCEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
GAAGVSGAGIATLAAGLSSHRPELLHGVDVIVGIDKFMSEARALTNFAGNSVATLLVGKW
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
TGTVDMNQVHDVLNGKSPFVELEEDH
CCCCCHHHHHHHHCCCCCEEECCCCC
>Mature Secondary Structure
MDSNTESSSVEVKNEHIKVQKPPKKDRTHWLYIAVIIALIGGITLGLISPELGKEFKILG
CCCCCCCCCEEEECCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHH
TMFVSLIKMIIAPVIFCTIVIGIGSVKAAATVGRAGGIALAYFITMSTFALAVGLLVGNF
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHC
IQPGSGLNISVDEESSFASTESSPEGLLGFIHSIIPETFFSAFTDGSVLQVLFIAILVGF
CCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AAQSMGEKGQPILDFVSHLQKLIFKILNWILWLAPVGAFGAMAGVVGETGFDAVVQLGIL
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ILAFYVTCVIFIFGVLGAVLKVFTGVNIFKLVKYLAKEFLLIFATSSSESALPNLMRKME
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHH
HIGVAKPTVGIVVPTGYSFNLDGTAIYLTMASIFIADAMNMPMSLGEQVGLLVFMIIASK
HCCCCCCCEEEEECCCEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
GAAGVSGAGIATLAAGLSSHRPELLHGVDVIVGIDKFMSEARALTNFAGNSVATLLVGKW
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
TGTVDMNQVHDVLNGKSPFVELEEDH
CCCCCHHHHHHHHCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA