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The map label for this gene is gltT [H]

Identifier: 62391390

GI number: 62391390

Start: 2669865

End: 2671262

Strand: Reverse

Name: gltT [H]

Synonym: cg2810

Alternate gene names: 62391390

Gene position: 2671262-2669865 (Counterclockwise)

Preceding gene: 62391391

Following gene: 62391389

Centisome position: 81.37

GC content: 54.72

Gene sequence:

>1398_bases
GTGCTACCCATGGCTAACGCCACCGCACAGAAGGGCCGTTTCGGCCTTCCCGGCTGGATGACTGGCTTTGGTGCCCAGGT
TATCGCCGGCCTCATTCTTGGTCTTATTCTCGGCCTTGTCGCCCGAGGCATGGACAGCGGCGCTGCAGACGGTGAAGCAA
GCTGGCTTACCGGTCTTCTTAGCGGCGTCGGTTCTGCTTATGTTTCTCTACTTAAAGTTATGGTTCCACCACTGGTGTTC
GCTGCAGTGGTTACCAGTGTGGCAAAGTTGCGCGAGGTAGCTAACGCTGCTCGCCTGGCTGTTTCCACCTTGGTGTGGTT
CGCCATTACTGCATTCTTCTCTGTGCTCGCGGGTATCGCCGTAGCGCTGATTATGCAGCCTGGTGTTGGATCCACTGTCG
ACGCATCTAATGCTGCTGATCCTTCTCGCGTGGGCAGCTGGCTGGGCTTTATCCAGTCCGTTATTCCATCAAACATTCTG
GGACTTTCCGGTTCTTACAGTGAGAACTCTGGTGTGAACCTGTCCTTCAACGTGCTGCAGATCCTGGTTATCTCCATTGC
GATTGGTGTTGCAGCTCTGAAGGCTGGCAAGTCCGCCGAGCCTTTCTTGAAGTTCACCGAGTCCTTCCTCAAGATCATCC
AGATCGTGTTGTGGTGGATTATTCGCCTGGCTCCAATTGGTTCCGCTGCGCTGATCGGTAATGCTGTTGCTACCTACGGT
TGGTCTGCACTTGGATCCCTGGGCAAGTTTGTTCTTGCGATCTACGTTGGTCTGGCAATCGTCATGTTCGTTATCTACCC
AGTCGTGCTGAAGCTCAATGGAATTCCTGTTCTTGGATTCTTCAAGCGCGTTTGGCCTGTCACAAGCCTTGGCTTTGTTA
CCCGTTCCTCCATGGGCGTTATGCCAGTTACCCAGCGCGTTACTGAGCAGTCCTTGGGTGTTCCATCTGCGTACGCTTCC
TTTGCTATCCCACTGGGTGCGACCAGCAAGATGGACGGCTGCGCTGCTGTCTACCCAGCTGTTGCCGCTATCTTCGTGGC
ACAGTTCTACGGCATTGACTTGAGCATCATGGATTACGTACTGATCATGATCGTCTCTGTCCTGGGCTCTGCTGCAACTG
CAGGCACCACTGGCGCAACCGTCATGCTGACCCTGACCCTATCCACCTTGGGTCTGCCACTTGCTGGTGTTGGTCTGCTG
CTGGCTATCGAGCCAATCATCGACATGGGACGTACCGCAACCAACGTCACCGGTCAGGCACTGGTTCCTGCGATCGTTGC
TAAGCGCGAGGGCATTCTGGATCAGGATGTGTGGGATGCTGCTGAAAAGGGTGGCGCTGCTATTGAAATGGCAACCGTCT
CTGAGAAAGAAACTGAGCCTGCAGAGGTTCGCTCCTAA

Upstream 100 bases:

>100_bases
CTTTATAGACAGCTTCGGTTAATTTGGTCACACTAATGCAATAAATTCCTGTCTACAGCGTTACAGTTAATGAATTCAAT
TCAACCGCTAAACGCAAGGA

Downstream 100 bases:

>100_bases
GCTCTCTTGAGTACCTGAGACCTTCTCAGCAAAACACAAAGTGCCTTCACCCAACCTGGGGTGGAGGCACTTTCTCATTG
CTAAGGTGTGCATCGTGAAC

Product: Na(+)/H(+)-dicarboxylate symporter family protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MLPMANATAQKGRFGLPGWMTGFGAQVIAGLILGLILGLVARGMDSGAADGEASWLTGLLSGVGSAYVSLLKVMVPPLVF
AAVVTSVAKLREVANAARLAVSTLVWFAITAFFSVLAGIAVALIMQPGVGSTVDASNAADPSRVGSWLGFIQSVIPSNIL
GLSGSYSENSGVNLSFNVLQILVISIAIGVAALKAGKSAEPFLKFTESFLKIIQIVLWWIIRLAPIGSAALIGNAVATYG
WSALGSLGKFVLAIYVGLAIVMFVIYPVVLKLNGIPVLGFFKRVWPVTSLGFVTRSSMGVMPVTQRVTEQSLGVPSAYAS
FAIPLGATSKMDGCAAVYPAVAAIFVAQFYGIDLSIMDYVLIMIVSVLGSAATAGTTGATVMLTLTLSTLGLPLAGVGLL
LAIEPIIDMGRTATNVTGQALVPAIVAKREGILDQDVWDAAEKGGAAIEMATVSEKETEPAEVRS

Sequences:

>Translated_465_residues
MLPMANATAQKGRFGLPGWMTGFGAQVIAGLILGLILGLVARGMDSGAADGEASWLTGLLSGVGSAYVSLLKVMVPPLVF
AAVVTSVAKLREVANAARLAVSTLVWFAITAFFSVLAGIAVALIMQPGVGSTVDASNAADPSRVGSWLGFIQSVIPSNIL
GLSGSYSENSGVNLSFNVLQILVISIAIGVAALKAGKSAEPFLKFTESFLKIIQIVLWWIIRLAPIGSAALIGNAVATYG
WSALGSLGKFVLAIYVGLAIVMFVIYPVVLKLNGIPVLGFFKRVWPVTSLGFVTRSSMGVMPVTQRVTEQSLGVPSAYAS
FAIPLGATSKMDGCAAVYPAVAAIFVAQFYGIDLSIMDYVLIMIVSVLGSAATAGTTGATVMLTLTLSTLGLPLAGVGLL
LAIEPIIDMGRTATNVTGQALVPAIVAKREGILDQDVWDAAEKGGAAIEMATVSEKETEPAEVRS
>Mature_465_residues
MLPMANATAQKGRFGLPGWMTGFGAQVIAGLILGLILGLVARGMDSGAADGEASWLTGLLSGVGSAYVSLLKVMVPPLVF
AAVVTSVAKLREVANAARLAVSTLVWFAITAFFSVLAGIAVALIMQPGVGSTVDASNAADPSRVGSWLGFIQSVIPSNIL
GLSGSYSENSGVNLSFNVLQILVISIAIGVAALKAGKSAEPFLKFTESFLKIIQIVLWWIIRLAPIGSAALIGNAVATYG
WSALGSLGKFVLAIYVGLAIVMFVIYPVVLKLNGIPVLGFFKRVWPVTSLGFVTRSSMGVMPVTQRVTEQSLGVPSAYAS
FAIPLGATSKMDGCAAVYPAVAAIFVAQFYGIDLSIMDYVLIMIVSVLGSAATAGTTGATVMLTLTLSTLGLPLAGVGLL
LAIEPIIDMGRTATNVTGQALVPAIVAKREGILDQDVWDAAEKGGAAIEMATVSEKETEPAEVRS

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI5032093, Length=341, Percent_Identity=29.0322580645161, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI21314632, Length=439, Percent_Identity=25.9681093394077, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI4827012, Length=446, Percent_Identity=26.6816143497758, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI40254478, Length=481, Percent_Identity=27.027027027027, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI194239697, Length=434, Percent_Identity=26.2672811059908, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI169790839, Length=490, Percent_Identity=25.5102040816327, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI66773030, Length=402, Percent_Identity=26.3681592039801, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI223468564, Length=250, Percent_Identity=30.4, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI223468566, Length=250, Percent_Identity=30.4, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI301601644, Length=165, Percent_Identity=30.9090909090909, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI262359914, Length=415, Percent_Identity=24.3373493975904, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1790514, Length=437, Percent_Identity=30.8924485125858, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1788024, Length=425, Percent_Identity=31.2941176470588, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1789947, Length=387, Percent_Identity=27.6485788113695, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17537407, Length=472, Percent_Identity=30.2966101694915, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71996953, Length=468, Percent_Identity=25.2136752136752, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI193206505, Length=442, Percent_Identity=25.5656108597285, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71983099, Length=483, Percent_Identity=26.0869565217391, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71983106, Length=483, Percent_Identity=26.0869565217391, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17541374, Length=443, Percent_Identity=24.8306997742664, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI193206654, Length=455, Percent_Identity=24.3956043956044, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24583025, Length=392, Percent_Identity=24.7448979591837, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17137668, Length=392, Percent_Identity=24.7448979591837, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24583023, Length=392, Percent_Identity=24.7448979591837, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281360481, Length=458, Percent_Identity=26.4192139737991, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281360483, Length=458, Percent_Identity=26.4192139737991, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17137666, Length=458, Percent_Identity=26.4192139737991, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 47986; Mature: 47986

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]