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The map label for this gene is metB [H]

Identifier: 62391286

GI number: 62391286

Start: 2561985

End: 2563145

Strand: Reverse

Name: metB [H]

Synonym: cg2687

Alternate gene names: 62391286

Gene position: 2563145-2561985 (Counterclockwise)

Preceding gene: 62391287

Following gene: 62391284

Centisome position: 78.08

GC content: 57.62

Gene sequence:

>1161_bases
TTGTCTTTTGACCCAAACACCCAGGGTTTCTCCACTGCATCGATTCACGCTGGGTATGAGCCAGACGACTACTACGGTTC
GATTAACACCCCAATCTATGCCTCCACCACCTTCGCGCAGAACGCTCCAAACGAACTGCGCAAAGGCTACGAGTACACCC
GTGTGGGCAACCCCACCATCGTGGCATTAGAGCAGACCGTCGCAGCACTCGAAGGCGCAAAGTATGGCCGCGCATTCTCC
TCCGGCATGGCTGCAACCGACATCCTGTTCCGCATCATCCTCAAGCCGGGCGATCACATCGTCCTCGGCAACGATGCTTA
CGGCGGAACCTACCGCCTGATCGACACCGTATTCACCGCATGGGGCGTCGAATACACCGTTGTTGATACCTCCGTCGTGG
AAGAGGTCAAGGCAGCGATCAAGGACAACACCAAGCTGATCTGGGTGGAAACCCCAACCAACCCAGCACTTGGCATCACC
GACATCGAAGCAGTAGCAAAGCTCACCGAAGGCACCAACGCCAAGCTGGTTGTTGACAACACCTTCGCATCCCCATACCT
GCAGCAGCCACTAAAACTCGGCGCACACGCAGTCCTGCACTCCACCACCAAGTACATCGGAGGACACTCCGACGTTGTTG
GCGGCCTTGTGGTTACCAACGACCAGGAAATGGACGAAGAACTGCTGTTCATGCAGGGCGGCATCGGACCGATCCCATCA
GTTTTCGATGCATACCTGACCGCCCGTGGCCTCAAGACCCTTGCAGTGCGCATGGATCGCCACTGCGACAACGCAGAAAA
GATCGCGGAATTCCTGGACTCCCGCCCAGAGGTCTCCACCGTGCTCTACCCAGGTCTGAAGAACCACCCAGGCCACGAAG
TCGCAGCGAAGCAGATGAAGCGCTTCGGCGGCATGATCTCCGTCCGTTTCGCAGGCGGCGAAGAAGCAGCTAAGAAGTTC
TGTACCTCCACCAAACTGATCTGTCTGGCCGAGTCCCTCGGTGGCGTGGAATCCCTCCTGGAGCACCCAGCAACCATGAC
CCACCAGTCAGCTGCCGGCTCTCAGCTCGAGGTTCCCCGCGACCTCGTGCGCATCTCCATTGGTATTGAAGACATTGAAG
ACCTGCTCGCAGATGTCGAGCAGGCCCTCAATAACCTTTAG

Upstream 100 bases:

>100_bases
AGGGGCTAGTTTTACACAAAAGTGGACAGCTTGGTCTATCATTGCCAGAAGACCGGTCCTTTTAGGGCCATAGAATTCTG
ATTACAGGAGTTGATCTACC

Downstream 100 bases:

>100_bases
AAACTATTTGGCGGCAAGCAGCTTTTCAATATAAGCAATGCGAGCCTCCACCATGTAGCCGAAGAGTTCGTCAGAAGTTG
AGACGGACTCTTCGACTGCT

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: CGS; O-succinylhomoserine (thiol)-lyase [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MSFDPNTQGFSTASIHAGYEPDDYYGSINTPIYASTTFAQNAPNELRKGYEYTRVGNPTIVALEQTVAALEGAKYGRAFS
SGMAATDILFRIILKPGDHIVLGNDAYGGTYRLIDTVFTAWGVEYTVVDTSVVEEVKAAIKDNTKLIWVETPTNPALGIT
DIEAVAKLTEGTNAKLVVDNTFASPYLQQPLKLGAHAVLHSTTKYIGGHSDVVGGLVVTNDQEMDEELLFMQGGIGPIPS
VFDAYLTARGLKTLAVRMDRHCDNAEKIAEFLDSRPEVSTVLYPGLKNHPGHEVAAKQMKRFGGMISVRFAGGEEAAKKF
CTSTKLICLAESLGGVESLLEHPATMTHQSAAGSQLEVPRDLVRISIGIEDIEDLLADVEQALNNL

Sequences:

>Translated_386_residues
MSFDPNTQGFSTASIHAGYEPDDYYGSINTPIYASTTFAQNAPNELRKGYEYTRVGNPTIVALEQTVAALEGAKYGRAFS
SGMAATDILFRIILKPGDHIVLGNDAYGGTYRLIDTVFTAWGVEYTVVDTSVVEEVKAAIKDNTKLIWVETPTNPALGIT
DIEAVAKLTEGTNAKLVVDNTFASPYLQQPLKLGAHAVLHSTTKYIGGHSDVVGGLVVTNDQEMDEELLFMQGGIGPIPS
VFDAYLTARGLKTLAVRMDRHCDNAEKIAEFLDSRPEVSTVLYPGLKNHPGHEVAAKQMKRFGGMISVRFAGGEEAAKKF
CTSTKLICLAESLGGVESLLEHPATMTHQSAAGSQLEVPRDLVRISIGIEDIEDLLADVEQALNNL
>Mature_385_residues
SFDPNTQGFSTASIHAGYEPDDYYGSINTPIYASTTFAQNAPNELRKGYEYTRVGNPTIVALEQTVAALEGAKYGRAFSS
GMAATDILFRIILKPGDHIVLGNDAYGGTYRLIDTVFTAWGVEYTVVDTSVVEEVKAAIKDNTKLIWVETPTNPALGITD
IEAVAKLTEGTNAKLVVDNTFASPYLQQPLKLGAHAVLHSTTKYIGGHSDVVGGLVVTNDQEMDEELLFMQGGIGPIPSV
FDAYLTARGLKTLAVRMDRHCDNAEKIAEFLDSRPEVSTVLYPGLKNHPGHEVAAKQMKRFGGMISVRFAGGEEAAKKFC
TSTKLICLAESLGGVESLLEHPATMTHQSAAGSQLEVPRDLVRISIGIEDIEDLLADVEQALNNL

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=387, Percent_Identity=46.7700258397933, Blast_Score=322, Evalue=3e-88,
Organism=Homo sapiens, GI299473759, Length=387, Percent_Identity=42.6356589147287, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI25453487, Length=386, Percent_Identity=40.9326424870466, Blast_Score=256, Evalue=4e-68,
Organism=Escherichia coli, GI1790375, Length=385, Percent_Identity=41.2987012987013, Blast_Score=291, Evalue=7e-80,
Organism=Escherichia coli, GI1789383, Length=389, Percent_Identity=27.5064267352185, Blast_Score=151, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17538055, Length=381, Percent_Identity=47.244094488189, Blast_Score=329, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17560056, Length=381, Percent_Identity=46.7191601049869, Blast_Score=325, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI71980708, Length=368, Percent_Identity=39.945652173913, Blast_Score=259, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6319307, Length=384, Percent_Identity=52.34375, Blast_Score=350, Evalue=3e-97,
Organism=Saccharomyces cerevisiae, GI6321254, Length=403, Percent_Identity=32.0099255583127, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6323333, Length=436, Percent_Identity=31.4220183486239, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6321170, Length=331, Percent_Identity=30.2114803625378, Blast_Score=152, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6321904, Length=394, Percent_Identity=28.4263959390863, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI19922554, Length=389, Percent_Identity=46.2724935732648, Blast_Score=347, Evalue=6e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =2.5.1.48 [H]

Molecular weight: Translated: 41659; Mature: 41527

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDPNTQGFSTASIHAGYEPDDYYGSINTPIYASTTFAQNAPNELRKGYEYTRVGNPTI
CCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCHHHHCCCCEEECCCCEE
VALEQTVAALEGAKYGRAFSSGMAATDILFRIILKPGDHIVLGNDAYGGTYRLIDTVFTA
EEHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHH
WGVEYTVVDTSVVEEVKAAIKDNTKLIWVETPTNPALGITDIEAVAKLTEGTNAKLVVDN
HCCEEEEECHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEC
TFASPYLQQPLKLGAHAVLHSTTKYIGGHSDVVGGLVVTNDQEMDEELLFMQGGIGPIPS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEECCHHHHHHHHHHCCCCCCCHH
VFDAYLTARGLKTLAVRMDRHCDNAEKIAEFLDSRPEVSTVLYPGLKNHPGHEVAAKQMK
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHH
RFGGMISVRFAGGEEAAKKFCTSTKLICLAESLGGVESLLEHPATMTHQSAAGSQLEVPR
HHCCEEEEEECCCHHHHHHHHCCCHHEEEHHHHCHHHHHHHCCCHHHHCCCCCCCCCCCH
DLVRISIGIEDIEDLLADVEQALNNL
HHHEEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SFDPNTQGFSTASIHAGYEPDDYYGSINTPIYASTTFAQNAPNELRKGYEYTRVGNPTI
CCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCHHHHCCCCEEECCCCEE
VALEQTVAALEGAKYGRAFSSGMAATDILFRIILKPGDHIVLGNDAYGGTYRLIDTVFTA
EEHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHH
WGVEYTVVDTSVVEEVKAAIKDNTKLIWVETPTNPALGITDIEAVAKLTEGTNAKLVVDN
HCCEEEEECHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEC
TFASPYLQQPLKLGAHAVLHSTTKYIGGHSDVVGGLVVTNDQEMDEELLFMQGGIGPIPS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEECCHHHHHHHHHHCCCCCCCHH
VFDAYLTARGLKTLAVRMDRHCDNAEKIAEFLDSRPEVSTVLYPGLKNHPGHEVAAKQMK
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHH
RFGGMISVRFAGGEEAAKKFCTSTKLICLAESLGGVESLLEHPATMTHQSAAGSQLEVPR
HHCCEEEEEECCCHHHHHHHHCCCHHEEEHHHHCHHHHHHHCCCHHHHCCCCCCCCCCCH
DLVRISIGIEDIEDLLADVEQALNNL
HHHEEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]