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The map label for this gene is hemN [H]

Identifier: 62391133

GI number: 62391133

Start: 2396637

End: 2397779

Strand: Reverse

Name: hemN [H]

Synonym: cg2517

Alternate gene names: 62391133

Gene position: 2397779-2396637 (Counterclockwise)

Preceding gene: 62391135

Following gene: 62391132

Centisome position: 73.04

GC content: 58.97

Gene sequence:

>1143_bases
ATGTCAGTTTTTGGTGTGTATATTCATGTGCCGTTTTGTTCAACTCGGTGCGGTTATTGCGATTTCAACACCTATACTGC
TGGGGAATTAGGTAGTACTGCAGGCCCGGACACCTATCTTGACTCGTTGGAAGTTGAGTTGGAGATGGCTGTGGCTTCGC
TGGATAATCCTCGGCAGGCGGAAACTATCTTTATTGGCGGGGGTACCCCGTCGTTGATTGGTGCGGACGGTTTGGCCAGG
GTTTTGGGGGCTGTGCGCAATACTTTTGGCATTGCGGATGGTGCGGAAGTCACCACGGAGTCCAATCCGGAGTCTACCTC
GCCTGAGTTTTTCGATGGCCTGCGTGAGGCGGGCTACAACAGGATTTCGTTAGGGATGCAGTCGGCGTCGTCAAGCGTTT
TGAAGGTGCTGGACCGCACGCACACCCCAGGGCGCCCGGTGGCGGCGGCCAAGGAGGCACGTGAGGCGGGGTTTGAGCAT
GTCAATTTGGACATGATTTATGGCACGCCGACAGAGACCGATGATGATGTCCGCAAGACGCTGGATGCGGTGCTCGAAGC
GAACGTGGATCACGTGTCTGCCTATTCCTTGATCGTGGAAGATGGCACGGCGATGGCGCGCAAGGTGCGCAAGGGCGAGC
TGCCAGCGCCGGACGAGGATGTCTACGCTGATCGTTTTGAGCTTATCGACGCTCGCCTGCGCTCAGCTGGTTTCGATTGG
TACGAGGTGTCCAACTGGGCGAAACCCGGCGGAGAATGCAAGCACAACATGGGCTATTGGGTCGACGGCGACTGGTGGGG
CGCGGGCCCGGGCGCGCACTCGCACATCGGCGACCGCCGCTTCTACAACATCAAGCACCCAGCGCGTTACTCCGCGCAGA
TTGCGGCCGGCGAGCTGCCCATTAAGGAAACAGAGCGGCTGACGGCGGAAGATCACCACACCGAGCGCGTCATGCTTGGT
TTGCGCCTGAAACAAGGCGTGCCGCTGAACCTTTTCGCACCCGCAGCGCGCCCGGTCATCGACCGTCATATCGCAGGGGG
CCTGCTGCACGTCAATGCGCTGGGCAACCTGGCGGTGACCGATGCGGGACGTTTGCTTGCCGACGGCATCATCGCCGACA
TTTTGCTTAGTGAAGAAGACTAA

Upstream 100 bases:

>100_bases
CATCTTCCGTTTCATACCCTGCACTCTACCCTGTTCTTAGGAATTCGCTATGTTTAACATCAATTAATCATGTATAGGGG
GCAGGCACTAGGCTTGGGGC

Downstream 100 bases:

>100_bases
ATATTTAGTAGGGTTACAGACATGGTGAGTGCAACAGAGAAACGTAGATACGAAGTGTTGCGGGCCATCGTCGCTGATTA
CATTGCGTCTCAGGAACCTG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MSVFGVYIHVPFCSTRCGYCDFNTYTAGELGSTAGPDTYLDSLEVELEMAVASLDNPRQAETIFIGGGTPSLIGADGLAR
VLGAVRNTFGIADGAEVTTESNPESTSPEFFDGLREAGYNRISLGMQSASSSVLKVLDRTHTPGRPVAAAKEAREAGFEH
VNLDMIYGTPTETDDDVRKTLDAVLEANVDHVSAYSLIVEDGTAMARKVRKGELPAPDEDVYADRFELIDARLRSAGFDW
YEVSNWAKPGGECKHNMGYWVDGDWWGAGPGAHSHIGDRRFYNIKHPARYSAQIAAGELPIKETERLTAEDHHTERVMLG
LRLKQGVPLNLFAPAARPVIDRHIAGGLLHVNALGNLAVTDAGRLLADGIIADILLSEED

Sequences:

>Translated_380_residues
MSVFGVYIHVPFCSTRCGYCDFNTYTAGELGSTAGPDTYLDSLEVELEMAVASLDNPRQAETIFIGGGTPSLIGADGLAR
VLGAVRNTFGIADGAEVTTESNPESTSPEFFDGLREAGYNRISLGMQSASSSVLKVLDRTHTPGRPVAAAKEAREAGFEH
VNLDMIYGTPTETDDDVRKTLDAVLEANVDHVSAYSLIVEDGTAMARKVRKGELPAPDEDVYADRFELIDARLRSAGFDW
YEVSNWAKPGGECKHNMGYWVDGDWWGAGPGAHSHIGDRRFYNIKHPARYSAQIAAGELPIKETERLTAEDHHTERVMLG
LRLKQGVPLNLFAPAARPVIDRHIAGGLLHVNALGNLAVTDAGRLLADGIIADILLSEED
>Mature_379_residues
SVFGVYIHVPFCSTRCGYCDFNTYTAGELGSTAGPDTYLDSLEVELEMAVASLDNPRQAETIFIGGGTPSLIGADGLARV
LGAVRNTFGIADGAEVTTESNPESTSPEFFDGLREAGYNRISLGMQSASSSVLKVLDRTHTPGRPVAAAKEAREAGFEHV
NLDMIYGTPTETDDDVRKTLDAVLEANVDHVSAYSLIVEDGTAMARKVRKGELPAPDEDVYADRFELIDARLRSAGFDWY
EVSNWAKPGGECKHNMGYWVDGDWWGAGPGAHSHIGDRRFYNIKHPARYSAQIAAGELPIKETERLTAEDHHTERVMLGL
RLKQGVPLNLFAPAARPVIDRHIAGGLLHVNALGNLAVTDAGRLLADGIIADILLSEED

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=323, Percent_Identity=33.4365325077399, Blast_Score=176, Evalue=3e-44,
Organism=Escherichia coli, GI1789325, Length=386, Percent_Identity=33.6787564766839, Blast_Score=191, Evalue=8e-50,
Organism=Escherichia coli, GI87082341, Length=304, Percent_Identity=29.2763157894737, Blast_Score=141, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 41116; Mature: 40985

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVFGVYIHVPFCSTRCGYCDFNTYTAGELGSTAGPDTYLDSLEVELEMAVASLDNPRQA
CCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEHHHHCCCCCCC
ETIFIGGGTPSLIGADGLARVLGAVRNTFGIADGAEVTTESNPESTSPEFFDGLREAGYN
CEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCC
RISLGMQSASSSVLKVLDRTHTPGRPVAAAKEAREAGFEHVNLDMIYGTPTETDDDVRKT
EEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHH
LDAVLEANVDHVSAYSLIVEDGTAMARKVRKGELPAPDEDVYADRFELIDARLRSAGFDW
HHHHHHCCCCCEEEEEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
YEVSNWAKPGGECKHNMGYWVDGDWWGAGPGAHSHIGDRRFYNIKHPARYSAQIAAGELP
EECCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEECCCCC
IKETERLTAEDHHTERVMLGLRLKQGVPLNLFAPAARPVIDRHIAGGLLHVNALGNLAVT
HHHHHHCCCCCCCHHHEEEEEECCCCCCCEEECCCHHHHHHHHHCCCEEEEECCCCEEEE
DAGRLLADGIIADILLSEED
CCHHHHHHHHHHHHEECCCC
>Mature Secondary Structure 
SVFGVYIHVPFCSTRCGYCDFNTYTAGELGSTAGPDTYLDSLEVELEMAVASLDNPRQA
CEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEHHHHCCCCCCC
ETIFIGGGTPSLIGADGLARVLGAVRNTFGIADGAEVTTESNPESTSPEFFDGLREAGYN
CEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCC
RISLGMQSASSSVLKVLDRTHTPGRPVAAAKEAREAGFEHVNLDMIYGTPTETDDDVRKT
EEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHH
LDAVLEANVDHVSAYSLIVEDGTAMARKVRKGELPAPDEDVYADRFELIDARLRSAGFDW
HHHHHHCCCCCEEEEEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
YEVSNWAKPGGECKHNMGYWVDGDWWGAGPGAHSHIGDRRFYNIKHPARYSAQIAAGELP
EECCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEECCCCC
IKETERLTAEDHHTERVMLGLRLKQGVPLNLFAPAARPVIDRHIAGGLLHVNALGNLAVT
HHHHHHCCCCCCCHHHEEEEEECCCCCCCEEECCCHHHHHHHHHCCCEEEEECCCCEEEE
DAGRLLADGIIADILLSEED
CCHHHHHHHHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]