Click here to switch to the map view.

The map label for this gene is rnr [H]

Identifier: 62391075

GI number: 62391075

Start: 2340786

End: 2342255

Strand: Reverse

Name: rnr [H]

Synonym: cg2453

Alternate gene names: 62391075

Gene position: 2342255-2340786 (Counterclockwise)

Preceding gene: 62391077

Following gene: 62391072

Centisome position: 71.35

GC content: 54.49

Gene sequence:

>1470_bases
GTGCCCAAGGAAACTCAACACCCCTGCATATACTTTTCCGCTGTGGAACAATGGGAGCGCATGAAGCTCTATGCAGCAGT
CCTCGACTTTGAACCAGTGGCACAAGAGTTCGGTGTGGAGCGAGGTTTTGACCCTCATATCCACGACGAAGCCGCGTCAA
GTGTCGATAGGTATGCGCAAGAGCGGGAAGATCTCCTGCACATGCCCTTTGTCACCATCGATCCCGTAGGTTCCAGAGAC
CTCGATCAAGCTGTGCTGATTGAGGAGATCGACAGCGGATTTCGGGTGCATTACGCGATTGCAGATGTCGCAGCCTTCGT
GGAGCCGGGCAGTGAATTGGAAAAGATTTCCCTTCACCGCGGGCAGACTATTTATCTGCCGGATTCCCCAGCGCGACTGC
ACCCTGAGGAATTATCCGAAGATGCGGCAAGCCTGCTGGAGGGACAAACGAGACCAGCGGTTGTGTGGTCGATTGATCTA
GATGAACGTGGCGAAGTCACAGCCACCAAGGTGCGTCGCGGGTTGGTGAAATCCCGGGCGCGTTTGGATTATGATCAGGC
TCAAATAGATGCCGAGAATGGTCGGTTGCATCCGTCGATAAGCTTATTGCCCAAGGTCGGGCAGCTGAGGCAGGAAAGCG
CGCTACGGCGCGAAGCCGTGAATCTTTCTATTCCCAGCCAGCGAGTGGTGAAAGTGCCCAATGATGACGCCGGTGAACAC
TATGAAATTGTCATCGAGCCACGCCCGCACATCATGGATTACAATTCCGAGATTTCCCTGCTCACAGGCATGGTAGCGGG
GGAGATGATGGTGAAAGCGGGGCACGGTTTGCTGCGTACACTCGCCCCGGCGACCAAAGAATCCGAAGCTACTTTCAGAT
CAGAGGCGCAAGCCCTTGGTTTTGAGATCGCGCCCGAACAACCCATCGGTGAGTTTCTTCAAAGTGTGGATCCCAATACG
CCCAAAGGGATGGCCATTCAGAGGGAAGCACAGAAACTCTTGCGGGGCTCCGGCTACGCCAGCGTGAAAAATGGGGACTC
GGAAGTGCATTCCGGTGTTGGTGGTTACTATGCTCACGTCACCGCACCGCTGCGCCGACTTATCGACCGTTTCGCCACCG
AACATTGCCTTGCGATTGCCTCCGGAACGGACGTTCCTGAATGGGTGACCAGGGTGGAAGAGCAAGTTCTCGACACCATG
AAATACTCCTCCATTTTGGCCAGCCAAGTGGATAATGCCTGCCTCGACCTCACAGAAGCCACCGTGTTGAAATACTGGGA
GGGCCAAAACTTCAACGCGGTGGTTGTAGCGAGCGAACCTGAAAAGAACTCTGCTCGACTTTTTGTGTACAAACCGCCAG
TGTTGGCAAAGTGTATTGGCGCCCCAGAACAGGGAACAAACCAAGATGTCACACTGGTGACTGCGAACTTGAAGAAGCGT
GAAGTTTTGTTTGCGTGGCCGGCTGACTAA

Upstream 100 bases:

>100_bases
GCCCCACCAGTCCCAAAATGGAACCCTCTCAGAATCGCTTTTAACGGGCTAAATGAGCTCGACCCATACCAAGACCTATC
TGGGGAACCTCGACCCTTCT

Downstream 100 bases:

>100_bases
GCATGCAGGCTGGTTAAGTAGGCGTGCTAGCCCTGTTCCGCGACGTCCCCGTGCCCGAGAGGAACCACCAACAAGCCATC
CTCGCTGAGATCCGCAGCAA

Product: exoribonuclease

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MPKETQHPCIYFSAVEQWERMKLYAAVLDFEPVAQEFGVERGFDPHIHDEAASSVDRYAQEREDLLHMPFVTIDPVGSRD
LDQAVLIEEIDSGFRVHYAIADVAAFVEPGSELEKISLHRGQTIYLPDSPARLHPEELSEDAASLLEGQTRPAVVWSIDL
DERGEVTATKVRRGLVKSRARLDYDQAQIDAENGRLHPSISLLPKVGQLRQESALRREAVNLSIPSQRVVKVPNDDAGEH
YEIVIEPRPHIMDYNSEISLLTGMVAGEMMVKAGHGLLRTLAPATKESEATFRSEAQALGFEIAPEQPIGEFLQSVDPNT
PKGMAIQREAQKLLRGSGYASVKNGDSEVHSGVGGYYAHVTAPLRRLIDRFATEHCLAIASGTDVPEWVTRVEEQVLDTM
KYSSILASQVDNACLDLTEATVLKYWEGQNFNAVVVASEPEKNSARLFVYKPPVLAKCIGAPEQGTNQDVTLVTANLKKR
EVLFAWPAD

Sequences:

>Translated_489_residues
MPKETQHPCIYFSAVEQWERMKLYAAVLDFEPVAQEFGVERGFDPHIHDEAASSVDRYAQEREDLLHMPFVTIDPVGSRD
LDQAVLIEEIDSGFRVHYAIADVAAFVEPGSELEKISLHRGQTIYLPDSPARLHPEELSEDAASLLEGQTRPAVVWSIDL
DERGEVTATKVRRGLVKSRARLDYDQAQIDAENGRLHPSISLLPKVGQLRQESALRREAVNLSIPSQRVVKVPNDDAGEH
YEIVIEPRPHIMDYNSEISLLTGMVAGEMMVKAGHGLLRTLAPATKESEATFRSEAQALGFEIAPEQPIGEFLQSVDPNT
PKGMAIQREAQKLLRGSGYASVKNGDSEVHSGVGGYYAHVTAPLRRLIDRFATEHCLAIASGTDVPEWVTRVEEQVLDTM
KYSSILASQVDNACLDLTEATVLKYWEGQNFNAVVVASEPEKNSARLFVYKPPVLAKCIGAPEQGTNQDVTLVTANLKKR
EVLFAWPAD
>Mature_488_residues
PKETQHPCIYFSAVEQWERMKLYAAVLDFEPVAQEFGVERGFDPHIHDEAASSVDRYAQEREDLLHMPFVTIDPVGSRDL
DQAVLIEEIDSGFRVHYAIADVAAFVEPGSELEKISLHRGQTIYLPDSPARLHPEELSEDAASLLEGQTRPAVVWSIDLD
ERGEVTATKVRRGLVKSRARLDYDQAQIDAENGRLHPSISLLPKVGQLRQESALRREAVNLSIPSQRVVKVPNDDAGEHY
EIVIEPRPHIMDYNSEISLLTGMVAGEMMVKAGHGLLRTLAPATKESEATFRSEAQALGFEIAPEQPIGEFLQSVDPNTP
KGMAIQREAQKLLRGSGYASVKNGDSEVHSGVGGYYAHVTAPLRRLIDRFATEHCLAIASGTDVPEWVTRVEEQVLDTMK
YSSILASQVDNACLDLTEATVLKYWEGQNFNAVVVASEPEKNSARLFVYKPPVLAKCIGAPEQGTNQDVTLVTANLKKRE
VLFAWPAD

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=349, Percent_Identity=26.3610315186246, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI190014623, Length=349, Percent_Identity=26.3610315186246, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI219521928, Length=348, Percent_Identity=27.0114942528736, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI19115966, Length=348, Percent_Identity=27.0114942528736, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI134288890, Length=131, Percent_Identity=32.824427480916, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87082383, Length=390, Percent_Identity=25.6410256410256, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1787542, Length=197, Percent_Identity=31.9796954314721, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI212645896, Length=341, Percent_Identity=26.3929618768328, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17553506, Length=378, Percent_Identity=23.2804232804233, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324552, Length=365, Percent_Identity=26.8493150684932, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24649634, Length=173, Percent_Identity=28.3236994219653, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24654592, Length=346, Percent_Identity=26.0115606936416, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19922976, Length=346, Percent_Identity=26.0115606936416, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24654597, Length=346, Percent_Identity=26.0115606936416, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 54173; Mature: 54041

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKETQHPCIYFSAVEQWERMKLYAAVLDFEPVAQEFGVERGFDPHIHDEAASSVDRYAQ
CCCCCCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
EREDLLHMPFVTIDPVGSRDLDQAVLIEEIDSGFRVHYAIADVAAFVEPGSELEKISLHR
HHHHHHHCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCHHHHHHHCC
GQTIYLPDSPARLHPEELSEDAASLLEGQTRPAVVWSIDLDERGEVTATKVRRGLVKSRA
CCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
RLDYDQAQIDAENGRLHPSISLLPKVGQLRQESALRREAVNLSIPSQRVVKVPNDDAGEH
HCCCHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCE
YEIVIEPRPHIMDYNSEISLLTGMVAGEMMVKAGHGLLRTLAPATKESEATFRSEAQALG
EEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHCC
FEIAPEQPIGEFLQSVDPNTPKGMAIQREAQKLLRGSGYASVKNGDSEVHSGVGGYYAHV
EECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCHHHHCCCCCHHHHH
TAPLRRLIDRFATEHCLAIASGTDVPEWVTRVEEQVLDTMKYSSILASQVDNACLDLTEA
HHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVLKYWEGQNFNAVVVASEPEKNSARLFVYKPPVLAKCIGAPEQGTNQDVTLVTANLKKR
HHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCHHHHHCCCCCCCCCCCEEEEEECCCCC
EVLFAWPAD
EEEEEECCC
>Mature Secondary Structure 
PKETQHPCIYFSAVEQWERMKLYAAVLDFEPVAQEFGVERGFDPHIHDEAASSVDRYAQ
CCCCCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
EREDLLHMPFVTIDPVGSRDLDQAVLIEEIDSGFRVHYAIADVAAFVEPGSELEKISLHR
HHHHHHHCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCHHHHHHHCC
GQTIYLPDSPARLHPEELSEDAASLLEGQTRPAVVWSIDLDERGEVTATKVRRGLVKSRA
CCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
RLDYDQAQIDAENGRLHPSISLLPKVGQLRQESALRREAVNLSIPSQRVVKVPNDDAGEH
HCCCHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCE
YEIVIEPRPHIMDYNSEISLLTGMVAGEMMVKAGHGLLRTLAPATKESEATFRSEAQALG
EEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHCC
FEIAPEQPIGEFLQSVDPNTPKGMAIQREAQKLLRGSGYASVKNGDSEVHSGVGGYYAHV
EECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCHHHHCCCCCHHHHH
TAPLRRLIDRFATEHCLAIASGTDVPEWVTRVEEQVLDTMKYSSILASQVDNACLDLTEA
HHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVLKYWEGQNFNAVVVASEPEKNSARLFVYKPPVLAKCIGAPEQGTNQDVTLVTANLKKR
HHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCHHHHHCCCCCCCCCCCEEEEEECCCCC
EVLFAWPAD
EEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]