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The map label for this gene is thrC

Identifier: 62391059

GI number: 62391059

Start: 2325269

End: 2326714

Strand: Reverse

Name: thrC

Synonym: cg2437

Alternate gene names: 62391059

Gene position: 2326714-2325269 (Counterclockwise)

Preceding gene: 62391060

Following gene: 62391056

Centisome position: 70.88

GC content: 56.15

Gene sequence:

>1446_bases
GTGGACTACATTTCGACGCGTGATGCCAGCCGTACCCCTGCCCGCTTCAGTGATATTTTGCTGGGCGGTCTAGCACCAGA
CGGCGGCCTGTACCTGCCTGCAACCTACCCTCAACTAGATGATGCCCAGCTGAGTAAATGGCGTGAGGTATTAGCCAACG
AAGGATACGCAGCTTTGGCTGCTGAAGTTATCTCCCTGTTTGTTGATGACATCCCAGTAGAAGACATCAAGGCGATCACC
GCACGCGCCTACACCTACCCGAAGTTCAACAGCGAAGACATCGTTCCTGTCACCGAACTCGAGGACAACATTTACCTGGG
CCACCTTTCCGAAGGCCCAACCGCTGCATTCAAAGACATGGCCATGCAGCTGCTCGGCGAACTTTTCGAATACGAGCTTC
GCCGCCGCAACGAAACCATCAACATCCTGGGCGCTACCTCTGGCGATACCGGCTCCTCTGCGGAATACGCCATGCGCGGC
CGCGAGGGAATCCGCGTATTCATGCTGACCCCAGCTGGCCGCATGACCCCATTCCAGCAAGCACAGATGTTTGGCCTTGA
CGATCCAAACATCTTCAACATCGCCCTCGACGGCGTTTTCGACGATTGCCAAGACGTAGTCAAGGCTGTCTCCGCCGACG
CAGAATTCAAAAAAGACAACCGCATCGGTGCCGTGAACTCCATCAACTGGGCACGCCTTATGGCACAGGTTGTGTACTAC
GTTTCCTCATGGATCCGCACCACAACCAGCAATGACCAAAAGGTCAGCTTCTCCGTACCAACCGGCAACTTCGGTGACAT
TTGCGCAGGCCACATCGCCCGCCAAATGGGACTTCCCATCGATCGCCTCATCGTGGCCACCAACGAAAACGATGTGCTCG
ACGAGTTCTTCCGTACCGGCGACTACCGAGTCCGCAGCTCCGCAGACACCCACGAGACCTCCTCACCTTCGATGGATATC
TCCCGCGCCTCCAACTTCGAGCGTTTCATCTTCGACCTGCTCGGCCGCGACGCCACCCGCGTCAACGATCTATTTGGTAC
CCAGGTTCGCCAAGGCGGATTCTCACTGGCTGATGACGCCAACTTTGAGAAGGCTGCAGCAGAATACGGTTTCGCCTCCG
GACGATCCACCCATGCTGACCGTGTGGCAACCATCGCTGACGTGCATTCCCGCCTCGACGTACTAATCGATCCCCACACC
GCCGACGGCGTTCACGTGGCACGCCAGTGGAGGGACGAGGTCAACACCCCAATCATCGTCCTAGAAACTGCACTCCCAGT
GAAATTTGCCGACACCATCGTCGAAGCAATTGGTGAAGCACCTCAAACTCCAGAGCGTTTCGCCGCGATCATGGATGCTC
CATTCAAGGTTTCCGACCTACCAAACGACACCGATGCAGTTAAGCAGTACATAGTCGATGCGATTGCAAACACTTCCGTG
AAGTAA

Upstream 100 bases:

>100_bases
GCAACACTTTAGGGTATCGCGTGGGCGAAGTCACCTTTTTCAACATATTTGAGACGGTGTGGGGGAGTATTGTGTCACCC
CTTGGGATAGGGTTATATCC

Downstream 100 bases:

>100_bases
CTTGCTTTACGCCAAGGCCTGATTCCTCTCTTTATGGGATGGAACCAGGCCTTTCGCATTGAGTGGCGTTTTAAGGCCTC
CAATTCTTAGAACGGGTGTT

Product: threonine synthase

Products: NA

Alternate protein names: TS

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MDYISTRDASRTPARFSDILLGGLAPDGGLYLPATYPQLDDAQLSKWREVLANEGYAALAAEVISLFVDDIPVEDIKAIT
ARAYTYPKFNSEDIVPVTELEDNIYLGHLSEGPTAAFKDMAMQLLGELFEYELRRRNETINILGATSGDTGSSAEYAMRG
REGIRVFMLTPAGRMTPFQQAQMFGLDDPNIFNIALDGVFDDCQDVVKAVSADAEFKKDNRIGAVNSINWARLMAQVVYY
VSSWIRTTTSNDQKVSFSVPTGNFGDICAGHIARQMGLPIDRLIVATNENDVLDEFFRTGDYRVRSSADTHETSSPSMDI
SRASNFERFIFDLLGRDATRVNDLFGTQVRQGGFSLADDANFEKAAAEYGFASGRSTHADRVATIADVHSRLDVLIDPHT
ADGVHVARQWRDEVNTPIIVLETALPVKFADTIVEAIGEAPQTPERFAAIMDAPFKVSDLPNDTDAVKQYIVDAIANTSV
K

Sequences:

>Translated_481_residues
MDYISTRDASRTPARFSDILLGGLAPDGGLYLPATYPQLDDAQLSKWREVLANEGYAALAAEVISLFVDDIPVEDIKAIT
ARAYTYPKFNSEDIVPVTELEDNIYLGHLSEGPTAAFKDMAMQLLGELFEYELRRRNETINILGATSGDTGSSAEYAMRG
REGIRVFMLTPAGRMTPFQQAQMFGLDDPNIFNIALDGVFDDCQDVVKAVSADAEFKKDNRIGAVNSINWARLMAQVVYY
VSSWIRTTTSNDQKVSFSVPTGNFGDICAGHIARQMGLPIDRLIVATNENDVLDEFFRTGDYRVRSSADTHETSSPSMDI
SRASNFERFIFDLLGRDATRVNDLFGTQVRQGGFSLADDANFEKAAAEYGFASGRSTHADRVATIADVHSRLDVLIDPHT
ADGVHVARQWRDEVNTPIIVLETALPVKFADTIVEAIGEAPQTPERFAAIMDAPFKVSDLPNDTDAVKQYIVDAIANTSV
K
>Mature_481_residues
MDYISTRDASRTPARFSDILLGGLAPDGGLYLPATYPQLDDAQLSKWREVLANEGYAALAAEVISLFVDDIPVEDIKAIT
ARAYTYPKFNSEDIVPVTELEDNIYLGHLSEGPTAAFKDMAMQLLGELFEYELRRRNETINILGATSGDTGSSAEYAMRG
REGIRVFMLTPAGRMTPFQQAQMFGLDDPNIFNIALDGVFDDCQDVVKAVSADAEFKKDNRIGAVNSINWARLMAQVVYY
VSSWIRTTTSNDQKVSFSVPTGNFGDICAGHIARQMGLPIDRLIVATNENDVLDEFFRTGDYRVRSSADTHETSSPSMDI
SRASNFERFIFDLLGRDATRVNDLFGTQVRQGGFSLADDANFEKAAAEYGFASGRSTHADRVATIADVHSRLDVLIDPHT
ADGVHVARQWRDEVNTPIIVLETALPVKFADTIVEAIGEAPQTPERFAAIMDAPFKVSDLPNDTDAVKQYIVDAIANTSV
K

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family

Homologues:

Organism=Homo sapiens, GI149193323, Length=458, Percent_Identity=29.4759825327511, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI153792148, Length=460, Percent_Identity=31.5217391304348, Blast_Score=207, Evalue=2e-53,
Organism=Escherichia coli, GI1786185, Length=464, Percent_Identity=28.8793103448276, Blast_Score=183, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6319901, Length=467, Percent_Identity=39.6145610278373, Blast_Score=317, Evalue=4e-87,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): THRC_CORGL (P23669)

Other databases:

- EMBL:   X56037
- EMBL:   Z29563
- EMBL:   BA000036
- EMBL:   BX927154
- PIR:   S11979
- RefSeq:   NP_601423.1
- RefSeq:   YP_226461.1
- ProteinModelPortal:   P23669
- SMR:   P23669
- GeneID:   1020172
- GeneID:   3342939
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg2437
- KEGG:   cgl:NCgl2139
- HOGENOM:   HBG521025
- OMA:   FGRIAFQ
- PhylomeDB:   P23669
- ProtClustDB:   PRK09225
- BioCyc:   CGLU196627:CG2437-MONOMER
- BRENDA:   4.2.3.1
- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450
- TIGRFAMs:   TIGR00260

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.3.1

Molecular weight: Translated: 52932; Mature: 52932

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYISTRDASRTPARFSDILLGGLAPDGGLYLPATYPQLDDAQLSKWREVLANEGYAALA
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCCHHHHH
AEVISLFVDDIPVEDIKAITARAYTYPKFNSEDIVPVTELEDNIYLGHLSEGPTAAFKDM
HHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCCCCCCEECCCCEEEEECCCCCHHHHHHH
AMQLLGELFEYELRRRNETINILGATSGDTGSSAEYAMRGREGIRVFMLTPAGRMTPFQQ
HHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHCCCCCCEEEEECCCCCCCCHHH
AQMFGLDDPNIFNIALDGVFDDCQDVVKAVSADAEFKKDNRIGAVNSINWARLMAQVVYY
HHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCHHHHHHHHHHHH
VSSWIRTTTSNDQKVSFSVPTGNFGDICAGHIARQMGLPIDRLIVATNENDVLDEFFRTG
HHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHCC
DYRVRSSADTHETSSPSMDISRASNFERFIFDLLGRDATRVNDLFGTQVRQGGFSLADDA
CEEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCC
NFEKAAAEYGFASGRSTHADRVATIADVHSRLDVLIDPHTADGVHVARQWRDEVNTPIIV
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCEEECCCCCCHHHHHHHHHHHCCCCEEE
LETALPVKFADTIVEAIGEAPQTPERFAAIMDAPFKVSDLPNDTDAVKQYIVDAIANTSV
EECCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHCCCC
K
C
>Mature Secondary Structure
MDYISTRDASRTPARFSDILLGGLAPDGGLYLPATYPQLDDAQLSKWREVLANEGYAALA
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCCHHHHH
AEVISLFVDDIPVEDIKAITARAYTYPKFNSEDIVPVTELEDNIYLGHLSEGPTAAFKDM
HHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCCCCCCEECCCCEEEEECCCCCHHHHHHH
AMQLLGELFEYELRRRNETINILGATSGDTGSSAEYAMRGREGIRVFMLTPAGRMTPFQQ
HHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHCCCCCCEEEEECCCCCCCCHHH
AQMFGLDDPNIFNIALDGVFDDCQDVVKAVSADAEFKKDNRIGAVNSINWARLMAQVVYY
HHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCHHHHHHHHHHHH
VSSWIRTTTSNDQKVSFSVPTGNFGDICAGHIARQMGLPIDRLIVATNENDVLDEFFRTG
HHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHCC
DYRVRSSADTHETSSPSMDISRASNFERFIFDLLGRDATRVNDLFGTQVRQGGFSLADDA
CEEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCC
NFEKAAAEYGFASGRSTHADRVATIADVHSRLDVLIDPHTADGVHVARQWRDEVNTPIIV
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCEEECCCCCCHHHHHHHHHHHCCCCEEE
LETALPVKFADTIVEAIGEAPQTPERFAAIMDAPFKVSDLPNDTDAVKQYIVDAIANTSV
EECCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2127631; 12948626