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The map label for this gene is ilvE [H]

Identifier: 62391043

GI number: 62391043

Start: 2307584

End: 2308723

Strand: Reverse

Name: ilvE [H]

Synonym: cg2418

Alternate gene names: 62391043

Gene position: 2308723-2307584 (Counterclockwise)

Preceding gene: 62391045

Following gene: 62391042

Centisome position: 70.33

GC content: 53.07

Gene sequence:

>1140_bases
GTGTATCTGTCAGGTAGCAGGTGTACCTTAAAATCCATGACGTCATTAGAGTTCACAGTAACCCGTACCGAAAATCCGAC
GTCACCCGATCGTCTGAAGGAAATTCTTGCCGCACCGAAGTTCGGTAAGTTCTTCACCGACCACATGGTGACCATTGACT
GGAACGAGTCGGAAGGCTGGCACAACGCCCAATTAGTGCCATACGCGCCGATTCCTATGGATCCTGCCACCACCGTATTC
CACTACGGACAGGCAATTTTTGAGGGAATTAAGGCCTACCGCCATTCGGACGAAACCATCAAGACTTTCCGTCCTGATGA
AAACGCCGAGCGTATGCAGCGTTCAGCAGCTCGAATGGCAATGCCACAGTTGCCAACCGAGGACTTTATTAAAGCACTTG
AACTGCTGGTAGACGCGGATCAGGATTGGGTTCCTGAGTACGGCGGAGAAGCTTCCCTCTACCTGCGCCCATTCATGATC
TCCACCGAAATTGGCTTGGGTGTCAGCCCAGCTGATGCCTACAAGTTCCTGGTCATCGCATCCCCAGTCGGCGCTTACTT
CACCGGTGGAATCAAGCCTGTTTCCGTCTGGCTGAGCGAAGATTACGTCCGCGCTGCACCCGGCGGAACTGGTGACGCCA
AATTTGCTGGCAACTACGCGGCTTCTTTGCTTGCCCAGTCCCAGGCTGCGGAAAAGGGCTGTGACCAGGTCGTATGGTTG
GATGCCATCGAGCACAAGTACATCGAAGAAATGGGTGGCATGAACCTTGGGTTCATCTACCGCAACGGCGACCAAGTCAA
GCTAGTCACCCCTGAACTTTCCGGCTCACTACTTCCAGGCATCACCCGCAAGTCACTTCTACAAGTAGCACGCGACTTGG
GATACGAAGTAGAAGAGCGAAAGATCACCACCACCGAGTGGGAAGAAGACGCAAAGTCTGGCGCCATGACCGAGGCATTT
GCTTGCGGTACTGCAGCTGTTATCACCCCTGTTGGCACCGTGAAATCAGCTCACGGCACCTTCGAAGTGAACAACAATGA
AGTCGGAGAAATCACGATGAAGCTTCGTGAAACCCTCACCGGAATTCAGCAAGGAAACGTTGAAGACCAAAACGGATGGC
TTTACCCACTGGTTGGCTAA

Upstream 100 bases:

>100_bases
GGGGGAGGCATCAAATTGAAACTAACTTTTAACAAGCCTAGCCATTCCTCAAAACCGTGAGACGAAATTGGCTATTCATC
CCATAAAATGGGGCTGACTA

Downstream 100 bases:

>100_bases
ATCAACCGGTTTTAAGACCCCGCTGCATTAAACCCTGATTTATTGCAGCGGGGTTTTTGCGTTGACAAGCTCTTATGAGA
CGTAGGGGGTGGAAGCAGGG

Product: branched-chain amino acid aminotransferase

Products: NA

Alternate protein names: BCAT [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MYLSGSRCTLKSMTSLEFTVTRTENPTSPDRLKEILAAPKFGKFFTDHMVTIDWNESEGWHNAQLVPYAPIPMDPATTVF
HYGQAIFEGIKAYRHSDETIKTFRPDENAERMQRSAARMAMPQLPTEDFIKALELLVDADQDWVPEYGGEASLYLRPFMI
STEIGLGVSPADAYKFLVIASPVGAYFTGGIKPVSVWLSEDYVRAAPGGTGDAKFAGNYAASLLAQSQAAEKGCDQVVWL
DAIEHKYIEEMGGMNLGFIYRNGDQVKLVTPELSGSLLPGITRKSLLQVARDLGYEVEERKITTTEWEEDAKSGAMTEAF
ACGTAAVITPVGTVKSAHGTFEVNNNEVGEITMKLRETLTGIQQGNVEDQNGWLYPLVG

Sequences:

>Translated_379_residues
MYLSGSRCTLKSMTSLEFTVTRTENPTSPDRLKEILAAPKFGKFFTDHMVTIDWNESEGWHNAQLVPYAPIPMDPATTVF
HYGQAIFEGIKAYRHSDETIKTFRPDENAERMQRSAARMAMPQLPTEDFIKALELLVDADQDWVPEYGGEASLYLRPFMI
STEIGLGVSPADAYKFLVIASPVGAYFTGGIKPVSVWLSEDYVRAAPGGTGDAKFAGNYAASLLAQSQAAEKGCDQVVWL
DAIEHKYIEEMGGMNLGFIYRNGDQVKLVTPELSGSLLPGITRKSLLQVARDLGYEVEERKITTTEWEEDAKSGAMTEAF
ACGTAAVITPVGTVKSAHGTFEVNNNEVGEITMKLRETLTGIQQGNVEDQNGWLYPLVG
>Mature_379_residues
MYLSGSRCTLKSMTSLEFTVTRTENPTSPDRLKEILAAPKFGKFFTDHMVTIDWNESEGWHNAQLVPYAPIPMDPATTVF
HYGQAIFEGIKAYRHSDETIKTFRPDENAERMQRSAARMAMPQLPTEDFIKALELLVDADQDWVPEYGGEASLYLRPFMI
STEIGLGVSPADAYKFLVIASPVGAYFTGGIKPVSVWLSEDYVRAAPGGTGDAKFAGNYAASLLAQSQAAEKGCDQVVWL
DAIEHKYIEEMGGMNLGFIYRNGDQVKLVTPELSGSLLPGITRKSLLQVARDLGYEVEERKITTTEWEEDAKSGAMTEAF
ACGTAAVITPVGTVKSAHGTFEVNNNEVGEITMKLRETLTGIQQGNVEDQNGWLYPLVG

Specific function: Catalyzes the reversible transfers of an amino group from glutamate to the alpha-ketoacid of the respective amino acid in the final step in the biosynthesis of branchedchain amino acids. The amino acids can be ranked in the following order with respect to

COG id: COG0115

COG function: function code EH; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI296010906, Length=332, Percent_Identity=40.0602409638554, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI38176287, Length=332, Percent_Identity=40.0602409638554, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI296010904, Length=332, Percent_Identity=40.0602409638554, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI50658084, Length=341, Percent_Identity=37.2434017595308, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI258614015, Length=296, Percent_Identity=37.1621621621622, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI296010902, Length=332, Percent_Identity=34.9397590361446, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI296010900, Length=332, Percent_Identity=34.9397590361446, Blast_Score=198, Evalue=7e-51,
Organism=Escherichia coli, GI48994963, Length=324, Percent_Identity=32.0987654320988, Blast_Score=129, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17568601, Length=361, Percent_Identity=37.6731301939058, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17565728, Length=377, Percent_Identity=33.9522546419098, Blast_Score=201, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6322002, Length=365, Percent_Identity=40.5479452054795, Blast_Score=257, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6322608, Length=372, Percent_Identity=36.8279569892473, Blast_Score=241, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24641779, Length=334, Percent_Identity=41.0179640718563, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: 2342 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 11,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001544
- InterPro:   IPR018300
- InterPro:   IPR005786 [H]

Pfam domain/function: PF01063 Aminotran_4 [H]

EC number: =2.6.1.42 [H]

Molecular weight: Translated: 41692; Mature: 41692

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLSGSRCTLKSMTSLEFTVTRTENPTSPDRLKEILAAPKFGKFFTDHMVTIDWNESEGW
CCCCCCCCCHHCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCHHCCCEEEEEECCCCCC
HNAQLVPYAPIPMDPATTVFHYGQAIFEGIKAYRHSDETIKTFRPDENAERMQRSAARMA
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHH
MPQLPTEDFIKALELLVDADQDWVPEYGGEASLYLRPFMISTEIGLGVSPADAYKFLVIA
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCCHHHEEEEEEE
SPVGAYFTGGIKPVSVWLSEDYVRAAPGGTGDAKFAGNYAASLLAQSQAAEKGCDQVVWL
CCCCHHHCCCCEEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEH
DAIEHKYIEEMGGMNLGFIYRNGDQVKLVTPELSGSLLPGITRKSLLQVARDLGYEVEER
HHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEECCC
KITTTEWEEDAKSGAMTEAFACGTAAVITPVGTVKSAHGTFEVNNNEVGEITMKLRETLT
EEECCCCHHHHHCCCCHHHHHCCCCCEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHH
GIQQGNVEDQNGWLYPLVG
HHHCCCCCCCCCEEEEECC
>Mature Secondary Structure
MYLSGSRCTLKSMTSLEFTVTRTENPTSPDRLKEILAAPKFGKFFTDHMVTIDWNESEGW
CCCCCCCCCHHCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCHHCCCEEEEEECCCCCC
HNAQLVPYAPIPMDPATTVFHYGQAIFEGIKAYRHSDETIKTFRPDENAERMQRSAARMA
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHH
MPQLPTEDFIKALELLVDADQDWVPEYGGEASLYLRPFMISTEIGLGVSPADAYKFLVIA
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCCHHHEEEEEEE
SPVGAYFTGGIKPVSVWLSEDYVRAAPGGTGDAKFAGNYAASLLAQSQAAEKGCDQVVWL
CCCCHHHCCCCEEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEH
DAIEHKYIEEMGGMNLGFIYRNGDQVKLVTPELSGSLLPGITRKSLLQVARDLGYEVEER
HHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEECCC
KITTTEWEEDAKSGAMTEAFACGTAAVITPVGTVKSAHGTFEVNNNEVGEITMKLRETLT
EEECCCCHHHHHCCCCHHHHHCCCCCEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHH
GIQQGNVEDQNGWLYPLVG
HHHCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA