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The map label for this gene is ftsI [H]

Identifier: 62391003

GI number: 62391003

Start: 2262881

End: 2264836

Strand: Reverse

Name: ftsI [H]

Synonym: cg2375

Alternate gene names: 62391003

Gene position: 2264836-2262881 (Counterclockwise)

Preceding gene: 62391004

Following gene: 62391002

Centisome position: 68.99

GC content: 53.73

Gene sequence:

>1956_bases
GTGACCTACCGGCCTAAATCTTCAACCCAGGGCGGCGCACGCAAGCGACGTGTGAACATGGTTACCGCTATCGCATTGGT
CATCGCTGGCGTACTGATCATTCGCCTCGGCTGGGTCCAAGTTGTCTGGGGACCAGAACTGTCCCTCAATGCTTCGGAAC
AGCGCACCCGCGTGTACGTAGATCCTGCACGTCGTGGAAGCATCGTGGACCGCGAAGGAAACCAGATGGCGTACACGATG
CAGGCACGTTCGCTGACGGTTTCTCCGAACATCATGCGTGAGGAATTAAAGACCGGAACTGATTTGGCCTTGCGTTTGGC
GGCTGAAGAAACCGATCCGGAAAACGTGGCCAGCTATGTGACCATCGAAGAAGGCAACGCGTATGTTTTTGCGTCTGAAG
AACAGCGCGAAACCATTCTGTCCGACAAGGTAGAAGAGCGCATTCAAAGCATTGCGGATCGGATCCCTGAGATCATCAAA
TCCCATGACCAAGATGTCACTGGAATTTCCTCTGAGGAGATCCTGGACAAGCTCAATGCTGATAGCCAGTATGAGGTGCT
CGTCCGCAATGTTGATCCCGATGTAGCGTCAGAAATCACCGATGAGATGCCCAGCGTCGCAGCTGATCATCAAGACATCC
GCCAATACCCAAACGGCGCGATTGGTGAAAACATCATCGGTCGAATCAGCATGGACGGCGAAGGCCAGTTCGGCTTTGAG
GCTTCCAACGATTCCCTGTTGGCAGGAAACAACGGTCGCTCAACCCAGGACATGTCCATTTTGGGACAAGCAATCCCGGG
CACGTTGAGGGATCAAATTCCAGCCATTGATGGTGCCAGCGTTGAACTCACCGTTGATCTGGATCTGCAAACCTATGTGC
AGCAGGCATTGGAGCAGGCGAAAGCTAACTCCGGTGCAGAAAACGCCTCCGCTGTGGTTCTTGATGCCAAGACCGCTGAG
GTTTTGGCGATGGCAAACACCGATACCATCAACCCCAACGAAGACACGGGAAAGCAGATTGAGCAGGGCAAGAGCTTTGA
CAATCCTTCTGTCACCCACCCCTTCGAGCCTGGTTCTGTAGCCAAGGTGATTACTGCAGCAGGCGTAATTCAAGAGGGCT
TGACTACTCCAGATGAAGTGTTGCAGGTACCGGGCAGTATTGAAATGGCCGGTGTTTCTGTCGGTGATGCGTGGGACCAC
GGTGTCGTTCCCTACACCACTGCAGGAATTTTTGGTAAGTCCTCGAATGTAGGCACTCTGATGCTTGCGCAGCGTCTTGG
TGAAGATAAATTTGCTGATTACCTGGAACGATTCGGTGTGGGACAGCCAACGGGTATTGAGCTTCCGAGCGAATCCCAAG
GCCTGCTGCCCGCACGTGAGCAGTGGTCTGGCGGTACTTTTGCTAACCTGCCCATCGGTCAGGGTATGTCGATCACCACG
TTGCAAATGGCTGGAATCTACCAAGCCTTGGCCAACGATGGTGAACGCATTCAACCGCGGATCATCAAGAGCGTGACTGA
TTCTGACGGAACAGTCCTAGAGCAGCCAGAACCCGATAAAATCCAGGTTGTCAGCGCTGAAGCTGCCCGCACCACGGTGG
ATATGTTTAGGTCTGTCACCCAGGTTGATCCAACTGGAGTGCAACAAGGTACCGCTCCAGACGCCTCCATTGAGGGTTAT
CAAATCTCAGGTAAGACAGGTACGGCGCAGAAAGTTGACCCCAACACGGGCGCGTACTCTAACTCGCAATACTGGATTAC
CTTCGCGGGTATTGCACCCGCTGATGATCCTCGATTTGTTGTAGCCATCATGCTTGATGAGCCAGAACGCGGAGTCCACG
GTGGTGGCGGCCAAACCGCAGCACCTTTGTTCAAAGACATCGCCACCTGGTTGCTCAACCGCGACAACATCCCACTGTCT
GCAGCCACCGAACCGATCATCCTTCAAGCTCAATAA

Upstream 100 bases:

>100_bases
CCGCCGTTCGGCGTATCAGGACGAAAGCAGAAGAGCCGCTAGAGAGCGCGAACTTACGCGACGCAGCGGTAAAGCTAAAG
GCGTAAACCAAGAAGAAGGA

Downstream 100 bases:

>100_bases
CTCAAACAGAAGTGTCTTTTGTAGAATTTCATAATCTGAACTTTTGTTTGAACTCTTTTCGGCATCACCCACGTGCCGCG
TCCGAATTATTAACACCTAG

Product: penicillin-binding protein 2X

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 651; Mature: 650

Protein sequence:

>651_residues
MTYRPKSSTQGGARKRRVNMVTAIALVIAGVLIIRLGWVQVVWGPELSLNASEQRTRVYVDPARRGSIVDREGNQMAYTM
QARSLTVSPNIMREELKTGTDLALRLAAEETDPENVASYVTIEEGNAYVFASEEQRETILSDKVEERIQSIADRIPEIIK
SHDQDVTGISSEEILDKLNADSQYEVLVRNVDPDVASEITDEMPSVAADHQDIRQYPNGAIGENIIGRISMDGEGQFGFE
ASNDSLLAGNNGRSTQDMSILGQAIPGTLRDQIPAIDGASVELTVDLDLQTYVQQALEQAKANSGAENASAVVLDAKTAE
VLAMANTDTINPNEDTGKQIEQGKSFDNPSVTHPFEPGSVAKVITAAGVIQEGLTTPDEVLQVPGSIEMAGVSVGDAWDH
GVVPYTTAGIFGKSSNVGTLMLAQRLGEDKFADYLERFGVGQPTGIELPSESQGLLPAREQWSGGTFANLPIGQGMSITT
LQMAGIYQALANDGERIQPRIIKSVTDSDGTVLEQPEPDKIQVVSAEAARTTVDMFRSVTQVDPTGVQQGTAPDASIEGY
QISGKTGTAQKVDPNTGAYSNSQYWITFAGIAPADDPRFVVAIMLDEPERGVHGGGGQTAAPLFKDIATWLLNRDNIPLS
AATEPIILQAQ

Sequences:

>Translated_651_residues
MTYRPKSSTQGGARKRRVNMVTAIALVIAGVLIIRLGWVQVVWGPELSLNASEQRTRVYVDPARRGSIVDREGNQMAYTM
QARSLTVSPNIMREELKTGTDLALRLAAEETDPENVASYVTIEEGNAYVFASEEQRETILSDKVEERIQSIADRIPEIIK
SHDQDVTGISSEEILDKLNADSQYEVLVRNVDPDVASEITDEMPSVAADHQDIRQYPNGAIGENIIGRISMDGEGQFGFE
ASNDSLLAGNNGRSTQDMSILGQAIPGTLRDQIPAIDGASVELTVDLDLQTYVQQALEQAKANSGAENASAVVLDAKTAE
VLAMANTDTINPNEDTGKQIEQGKSFDNPSVTHPFEPGSVAKVITAAGVIQEGLTTPDEVLQVPGSIEMAGVSVGDAWDH
GVVPYTTAGIFGKSSNVGTLMLAQRLGEDKFADYLERFGVGQPTGIELPSESQGLLPAREQWSGGTFANLPIGQGMSITT
LQMAGIYQALANDGERIQPRIIKSVTDSDGTVLEQPEPDKIQVVSAEAARTTVDMFRSVTQVDPTGVQQGTAPDASIEGY
QISGKTGTAQKVDPNTGAYSNSQYWITFAGIAPADDPRFVVAIMLDEPERGVHGGGGQTAAPLFKDIATWLLNRDNIPLS
AATEPIILQAQ
>Mature_650_residues
TYRPKSSTQGGARKRRVNMVTAIALVIAGVLIIRLGWVQVVWGPELSLNASEQRTRVYVDPARRGSIVDREGNQMAYTMQ
ARSLTVSPNIMREELKTGTDLALRLAAEETDPENVASYVTIEEGNAYVFASEEQRETILSDKVEERIQSIADRIPEIIKS
HDQDVTGISSEEILDKLNADSQYEVLVRNVDPDVASEITDEMPSVAADHQDIRQYPNGAIGENIIGRISMDGEGQFGFEA
SNDSLLAGNNGRSTQDMSILGQAIPGTLRDQIPAIDGASVELTVDLDLQTYVQQALEQAKANSGAENASAVVLDAKTAEV
LAMANTDTINPNEDTGKQIEQGKSFDNPSVTHPFEPGSVAKVITAAGVIQEGLTTPDEVLQVPGSIEMAGVSVGDAWDHG
VVPYTTAGIFGKSSNVGTLMLAQRLGEDKFADYLERFGVGQPTGIELPSESQGLLPAREQWSGGTFANLPIGQGMSITTL
QMAGIYQALANDGERIQPRIIKSVTDSDGTVLEQPEPDKIQVVSAEAARTTVDMFRSVTQVDPTGVQQGTAPDASIEGYQ
ISGKTGTAQKVDPNTGAYSNSQYWITFAGIAPADDPRFVVAIMLDEPERGVHGGGGQTAAPLFKDIATWLLNRDNIPLSA
ATEPIILQAQ

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=633, Percent_Identity=28.5939968404423, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1786854, Length=502, Percent_Identity=24.3027888446215, Blast_Score=102, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 69771; Mature: 69639

Theoretical pI: Translated: 4.17; Mature: 4.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYRPKSSTQGGARKRRVNMVTAIALVIAGVLIIRLGWVQVVWGPELSLNASEQRTRVYV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEE
DPARRGSIVDREGNQMAYTMQARSLTVSPNIMREELKTGTDLALRLAAEETDPENVASYV
CCCCCCCEECCCCCEEEEEEEECEEEECHHHHHHHHCCCCCEEEEEECCCCCCCHHEEEE
TIEEGNAYVFASEEQRETILSDKVEERIQSIADRIPEIIKSHDQDVTGISSEEILDKLNA
EEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
DSQYEVLVRNVDPDVASEITDEMPSVAADHQDIRQYPNGAIGENIIGRISMDGEGQFGFE
CCEEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCEEEEEECCCCCCCEE
ASNDSLLAGNNGRSTQDMSILGQAIPGTLRDQIPAIDGASVELTVDLDLQTYVQQALEQA
CCCCCEEECCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHH
KANSGAENASAVVLDAKTAEVLAMANTDTINPNEDTGKQIEQGKSFDNPSVTHPFEPGSV
HCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCHH
AKVITAAGVIQEGLTTPDEVLQVPGSIEMAGVSVGDAWDHGVVPYTTAGIFGKSSNVGTL
HHHHHHHHHHHHCCCCHHHHHCCCCCEEEEEEEECCCCCCCCCCEEECCCCCCCCCCHHH
MLAQRLGEDKFADYLERFGVGQPTGIELPSESQGLLPAREQWSGGTFANLPIGQGMSITT
HHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCEEECCCCCCCEEEE
LQMAGIYQALANDGERIQPRIIKSVTDSDGTVLEQPEPDKIQVVSAEAARTTVDMFRSVT
HHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEECCCCCCCEEEEECHHHHHHHHHHHHHH
QVDPTGVQQGTAPDASIEGYQISGKTGTAQKVDPNTGAYSNSQYWITFAGIAPADDPRFV
HCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEE
VAIMLDEPERGVHGGGGQTAAPLFKDIATWLLNRDNIPLSAATEPIILQAQ
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
TYRPKSSTQGGARKRRVNMVTAIALVIAGVLIIRLGWVQVVWGPELSLNASEQRTRVYV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEE
DPARRGSIVDREGNQMAYTMQARSLTVSPNIMREELKTGTDLALRLAAEETDPENVASYV
CCCCCCCEECCCCCEEEEEEEECEEEECHHHHHHHHCCCCCEEEEEECCCCCCCHHEEEE
TIEEGNAYVFASEEQRETILSDKVEERIQSIADRIPEIIKSHDQDVTGISSEEILDKLNA
EEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
DSQYEVLVRNVDPDVASEITDEMPSVAADHQDIRQYPNGAIGENIIGRISMDGEGQFGFE
CCEEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCEEEEEECCCCCCCEE
ASNDSLLAGNNGRSTQDMSILGQAIPGTLRDQIPAIDGASVELTVDLDLQTYVQQALEQA
CCCCCEEECCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHH
KANSGAENASAVVLDAKTAEVLAMANTDTINPNEDTGKQIEQGKSFDNPSVTHPFEPGSV
HCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCHH
AKVITAAGVIQEGLTTPDEVLQVPGSIEMAGVSVGDAWDHGVVPYTTAGIFGKSSNVGTL
HHHHHHHHHHHHCCCCHHHHHCCCCCEEEEEEEECCCCCCCCCCEEECCCCCCCCCCHHH
MLAQRLGEDKFADYLERFGVGQPTGIELPSESQGLLPAREQWSGGTFANLPIGQGMSITT
HHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCEEECCCCCCCEEEE
LQMAGIYQALANDGERIQPRIIKSVTDSDGTVLEQPEPDKIQVVSAEAARTTVDMFRSVT
HHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEECCCCCCCEEEEECHHHHHHHHHHHHHH
QVDPTGVQQGTAPDASIEGYQISGKTGTAQKVDPNTGAYSNSQYWITFAGIAPADDPRFV
HCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEE
VAIMLDEPERGVHGGGGQTAAPLFKDIATWLLNRDNIPLSAATEPIILQAQ
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]