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The map label for this gene is murC [H]

Identifier: 62390996

GI number: 62390996

Start: 2252835

End: 2254295

Strand: Reverse

Name: murC [H]

Synonym: cg2368

Alternate gene names: 62390996

Gene position: 2254295-2252835 (Counterclockwise)

Preceding gene: 62390997

Following gene: 62390995

Centisome position: 68.67

GC content: 56.13

Gene sequence:

>1461_bases
GTGACCACTCCACACTTGGATTCTGCACAAGATATTGATCTGTCCCGCGTCCACCTCATCGGTATTGGCGGAGCCGGAAT
GTCTGGCGTTGCCCGAATCCTGCTTGCCCGCGGTAAGACAGTCACTGGTTCCGATGCCAAAGATTCCCGCACCTTGCTTC
CACTCCGCGCCGTGGGAGCCACCATCGCAGTGGGACACGCTGCGGAAAACCTTGAGCTTTCCGGCGAACTTCCCACCGTC
GTGGTGACCTCTTTTGCCGCCATTCCGCAAGACAACCCGGAACTTGTTCGTGCACGTGAAGAAGGCATTCCGGTTATTCG
TCGCTCCGATCTGTTGGGCGAATTGCTGGAAGGCTCCACCCAGGTCTTGATCGCGGGTACCCACGGTAAGACCTCCACCA
CCTCTATGTCTGTGGTAGCTATGCAGGCAGCGGGCATGGATCCAAGCTTTGCTATCGGCGGACAGCTCAACAAGGCTGGC
ACCAATGCGCACCATGGAACTGGTGAGGTCTTTATCGCTGAAGCAGATGAATCTGACGCATCGCTGCTGCGCTACAAGCC
AAATGTTGCAGTGGTCACCAATGTGGAACCAGACCACCTGGACTTCTTTAAAACCCCTGAAGCCTACTTCCAAGTGTTCG
ACGATTTCGCAGGACGCATCACCCCGAACGGCAAGCTGGTTGTGTGCCTGAACGATCCTCACGCAGCGGAGCTGGGGGAG
AGGTCTGTCCGCAAGGGTATCAAGACTGTTGGTTACGGTACCGCTGACGCCGTACAGGCACACCCTGAGGTTCCAGCGAT
GGCTACCATCGTGGATTCCCAAGTTGTCGCAGAAGGCACCCGCGCCACCATCAACATCGATGGACAGGAAGTATCTGTGA
TTCTTCAAATCCCTGGTGATCACATGGTACTCAACGGTGCAGCCGCCCTGCTGGCCGGATACCTGGTGGGTGGGGACGTC
GACAAGCTTGTTGAAGGCTTGTCGGATTTTTCCGGCGTGCGACGCCGCTTTGAGTTCCACGGTGCTATCGAGGGCGGCAA
ATTTAATGGCGCTGCTATTTATGATGATTACGCACACCACCCAACGGAAGTAACTGCAGTGCTCAGCGCTGCGCGCACCC
GGGTGAAGGCCGCTGGAAAGGGCCGTGTCATCGTCGCGTTCCAACCACATTTATACTCACGCACCATAGAATTCCAAAAG
GAGTTCGCGGGGGCACTGTCACTGGCAGACGCTGCCGTGGTGCTTGAGATTTACGGAGCGCGCGAACAACCGGTGGATGG
CGTGTCCTCGGAAATCATCACCGATGCGATGACCATTCCAGTGGTGTACGAACCTAATTTCTCTGCAGTCCCAGAACGCA
TTGCAGAAATCGCAGGACCTAATGACATCGTGCTCACCATGGGTGCAGGTTCCGTGACCATGCTTGCTCCAGAAATCCTG
GATCAGCTGCAAAACAATTAG

Upstream 100 bases:

>100_bases
GCAGGTAACGCCTCCACGGTGATTGCAGACATGATTGCTGCAACTATCAATAGCCAACACAACTAAAACGACCAGCTCAA
CGCAAAGGAATAGTTTAAAG

Downstream 100 bases:

>100_bases
GACGTAAGTGAACAAGGCAGGACTAGCGTGAACAAAAAAGTCATCGCCATTGTTGTGGGTGTGGTTGTTGTCCTCGTGGC
AATCCTGGGCGTTGTTGCCT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTTPHLDSAQDIDLSRVHLIGIGGAGMSGVARILLARGKTVTGSDAKDSRTLLPLRAVGATIAVGHAAENLELSGELPTV
VVTSFAAIPQDNPELVRAREEGIPVIRRSDLLGELLEGSTQVLIAGTHGKTSTTSMSVVAMQAAGMDPSFAIGGQLNKAG
TNAHHGTGEVFIAEADESDASLLRYKPNVAVVTNVEPDHLDFFKTPEAYFQVFDDFAGRITPNGKLVVCLNDPHAAELGE
RSVRKGIKTVGYGTADAVQAHPEVPAMATIVDSQVVAEGTRATINIDGQEVSVILQIPGDHMVLNGAAALLAGYLVGGDV
DKLVEGLSDFSGVRRRFEFHGAIEGGKFNGAAIYDDYAHHPTEVTAVLSAARTRVKAAGKGRVIVAFQPHLYSRTIEFQK
EFAGALSLADAAVVLEIYGAREQPVDGVSSEIITDAMTIPVVYEPNFSAVPERIAEIAGPNDIVLTMGAGSVTMLAPEIL
DQLQNN

Sequences:

>Translated_486_residues
MTTPHLDSAQDIDLSRVHLIGIGGAGMSGVARILLARGKTVTGSDAKDSRTLLPLRAVGATIAVGHAAENLELSGELPTV
VVTSFAAIPQDNPELVRAREEGIPVIRRSDLLGELLEGSTQVLIAGTHGKTSTTSMSVVAMQAAGMDPSFAIGGQLNKAG
TNAHHGTGEVFIAEADESDASLLRYKPNVAVVTNVEPDHLDFFKTPEAYFQVFDDFAGRITPNGKLVVCLNDPHAAELGE
RSVRKGIKTVGYGTADAVQAHPEVPAMATIVDSQVVAEGTRATINIDGQEVSVILQIPGDHMVLNGAAALLAGYLVGGDV
DKLVEGLSDFSGVRRRFEFHGAIEGGKFNGAAIYDDYAHHPTEVTAVLSAARTRVKAAGKGRVIVAFQPHLYSRTIEFQK
EFAGALSLADAAVVLEIYGAREQPVDGVSSEIITDAMTIPVVYEPNFSAVPERIAEIAGPNDIVLTMGAGSVTMLAPEIL
DQLQNN
>Mature_485_residues
TTPHLDSAQDIDLSRVHLIGIGGAGMSGVARILLARGKTVTGSDAKDSRTLLPLRAVGATIAVGHAAENLELSGELPTVV
VTSFAAIPQDNPELVRAREEGIPVIRRSDLLGELLEGSTQVLIAGTHGKTSTTSMSVVAMQAAGMDPSFAIGGQLNKAGT
NAHHGTGEVFIAEADESDASLLRYKPNVAVVTNVEPDHLDFFKTPEAYFQVFDDFAGRITPNGKLVVCLNDPHAAELGER
SVRKGIKTVGYGTADAVQAHPEVPAMATIVDSQVVAEGTRATINIDGQEVSVILQIPGDHMVLNGAAALLAGYLVGGDVD
KLVEGLSDFSGVRRRFEFHGAIEGGKFNGAAIYDDYAHHPTEVTAVLSAARTRVKAAGKGRVIVAFQPHLYSRTIEFQKE
FAGALSLADAAVVLEIYGAREQPVDGVSSEIITDAMTIPVVYEPNFSAVPERIAEIAGPNDIVLTMGAGSVTMLAPEILD
QLQNN

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=470, Percent_Identity=37.2340425531915, Blast_Score=234, Evalue=8e-63,
Organism=Escherichia coli, GI1790680, Length=484, Percent_Identity=28.099173553719, Blast_Score=155, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 51109; Mature: 50978

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPHLDSAQDIDLSRVHLIGIGGAGMSGVARILLARGKTVTGSDAKDSRTLLPLRAVGA
CCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCEEEEHHHCCC
TIAVGHAAENLELSGELPTVVVTSFAAIPQDNPELVRAREEGIPVIRRSDLLGELLEGST
EEEECCCCCCCEECCCCCCCEEEHHHHCCCCCHHHHHHHHCCCCEEEHHHHHHHHHCCCC
QVLIAGTHGKTSTTSMSVVAMQAAGMDPSFAIGGQLNKAGTNAHHGTGEVFIAEADESDA
EEEEEECCCCCCCCEEEEEEEEECCCCCCEEECCCCCCCCCCCCCCCCEEEEEECCCCCC
SLLRYKPNVAVVTNVEPDHLDFFKTPEAYFQVFDDFAGRITPNGKLVVCLNDPHAAELGE
EEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCEECCCCEEEEEECCCCHHHHHH
RSVRKGIKTVGYGTADAVQAHPEVPAMATIVDSQVVAEGTRATINIDGQEVSVILQIPGD
HHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHCCHHHCCCCEEEEEECCCEEEEEEEECCC
HMVLNGAAALLAGYLVGGDVDKLVEGLSDFSGVRRRFEFHGAIEGGKFNGAAIYDDYAHH
EEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEECCCCCC
PTEVTAVLSAARTRVKAAGKGRVIVAFQPHLYSRTIEFQKEFAGALSLADAAVVLEIYGA
CHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECC
REQPVDGVSSEIITDAMTIPVVYEPNFSAVPERIAEIAGPNDIVLTMGAGSVTMLAPEIL
CCCCCCCCHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCEEEECHHHH
DQLQNN
HHHHCC
>Mature Secondary Structure 
TTPHLDSAQDIDLSRVHLIGIGGAGMSGVARILLARGKTVTGSDAKDSRTLLPLRAVGA
CCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCEEEEHHHCCC
TIAVGHAAENLELSGELPTVVVTSFAAIPQDNPELVRAREEGIPVIRRSDLLGELLEGST
EEEECCCCCCCEECCCCCCCEEEHHHHCCCCCHHHHHHHHCCCCEEEHHHHHHHHHCCCC
QVLIAGTHGKTSTTSMSVVAMQAAGMDPSFAIGGQLNKAGTNAHHGTGEVFIAEADESDA
EEEEEECCCCCCCCEEEEEEEEECCCCCCEEECCCCCCCCCCCCCCCCEEEEEECCCCCC
SLLRYKPNVAVVTNVEPDHLDFFKTPEAYFQVFDDFAGRITPNGKLVVCLNDPHAAELGE
EEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCEECCCCEEEEEECCCCHHHHHH
RSVRKGIKTVGYGTADAVQAHPEVPAMATIVDSQVVAEGTRATINIDGQEVSVILQIPGD
HHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHCCHHHCCCCEEEEEECCCEEEEEEEECCC
HMVLNGAAALLAGYLVGGDVDKLVEGLSDFSGVRRRFEFHGAIEGGKFNGAAIYDDYAHH
EEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEECCCCCC
PTEVTAVLSAARTRVKAAGKGRVIVAFQPHLYSRTIEFQKEFAGALSLADAAVVLEIYGA
CHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECC
REQPVDGVSSEIITDAMTIPVVYEPNFSAVPERIAEIAGPNDIVLTMGAGSVTMLAPEIL
CCCCCCCCHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCEEEECHHHH
DQLQNN
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA