Click here to switch to the map view.

The map label for this gene is hisI [H]

Identifier: 62390928

GI number: 62390928

Start: 2179948

End: 2180304

Strand: Reverse

Name: hisI [H]

Synonym: cg2296

Alternate gene names: 62390928

Gene position: 2180304-2179948 (Counterclockwise)

Preceding gene: 62390929

Following gene: 62390927

Centisome position: 66.42

GC content: 56.3

Gene sequence:

>357_bases
ATGAGTGACAATCCACAAGAGTATGAGCTGGATTGGGACGTCGAAAAGCGATTAAAGCTTAACGACGCCGGCCTGGTGCC
GGCAATCGTCCAGGCCGACGGGACCAACGAGGTCCTCATGATGGCCTGGATGGATACCCACGCGCTAGCCTATACTTTGG
CGACCCGCCGTGGAACCTATTTTTCTAGGTCCCGCAACGAGTACTGGATCAAGGGCCTGACCTCTGGAAACGTCCAAGAA
GTCACCGGACTTGCCCTCGACTGCGACGGCGACACCGTCCTTCTGACCGTGAAACAAACCGGCGGTGCGTGCCACACTGG
TGCCCACACATGTTTCGACAATGACGTTTTGCTGTAA

Upstream 100 bases:

>100_bases
GCGCCAACGCAGTGCTTGCCGCGACCATTTTCCACTTCCGCGAAGTAACCATCGCCGAAGTAAAGGGAGCCATTAAAGAT
GCAGGATTTGAGGTGCGGAA

Downstream 100 bases:

>100_bases
AAGCAACAACGATTAAGGAAGAAATCTTATGAAGCCACGCGTGCTGTCAGCATTAGGCATTGGAGCTGGCGCCCTGGTTG
TCTGGATCAGCTCACGCATG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 118; Mature: 117

Protein sequence:

>118_residues
MSDNPQEYELDWDVEKRLKLNDAGLVPAIVQADGTNEVLMMAWMDTHALAYTLATRRGTYFSRSRNEYWIKGLTSGNVQE
VTGLALDCDGDTVLLTVKQTGGACHTGAHTCFDNDVLL

Sequences:

>Translated_118_residues
MSDNPQEYELDWDVEKRLKLNDAGLVPAIVQADGTNEVLMMAWMDTHALAYTLATRRGTYFSRSRNEYWIKGLTSGNVQE
VTGLALDCDGDTVLLTVKQTGGACHTGAHTCFDNDVLL
>Mature_117_residues
SDNPQEYELDWDVEKRLKLNDAGLVPAIVQADGTNEVLMMAWMDTHALAYTLATRRGTYFSRSRNEYWIKGLTSGNVQEV
TGLALDCDGDTVLLTVKQTGGACHTGAHTCFDNDVLL

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=112, Percent_Identity=41.0714285714286, Blast_Score=91, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319819, Length=90, Percent_Identity=38.8888888888889, Blast_Score=67, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 13041; Mature: 12910

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNPQEYELDWDVEKRLKLNDAGLVPAIVQADGTNEVLMMAWMDTHALAYTLATRRGTY
CCCCCCCEEECCCCCCEEEECCCCCCEEEEECCCCCCEEEEEEECCCEEEEEEECCCCCE
FSRSRNEYWIKGLTSGNVQEVTGLALDCDGDTVLLTVKQTGGACHTGAHTCFDNDVLL
EECCCCCEEEEECCCCCCEEEEEEEEECCCCEEEEEEECCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SDNPQEYELDWDVEKRLKLNDAGLVPAIVQADGTNEVLMMAWMDTHALAYTLATRRGTY
CCCCCCEEECCCCCCEEEECCCCCCEEEEECCCCCCEEEEEEECCCEEEEEEECCCCCE
FSRSRNEYWIKGLTSGNVQEVTGLALDCDGDTVLLTVKQTGGACHTGAHTCFDNDVLL
EECCCCCEEEEECCCCCCEEEEEEEEECCCCEEEEEEECCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA