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The map label for this gene is srp [H]

Identifier: 62390895

GI number: 62390895

Start: 2137991

End: 2139634

Strand: Reverse

Name: srp [H]

Synonym: cg2257

Alternate gene names: 62390895

Gene position: 2139634-2137991 (Counterclockwise)

Preceding gene: 62390896

Following gene: 62390894

Centisome position: 65.18

GC content: 57.42

Gene sequence:

>1644_bases
GTGTTTGAGTCACTGTCCGATCGGTTGAATAGCGCGCTTTCCGGCCTGCGCGGCAAAGGAAAGCTCACCGAGGCAGACAT
CAATGCAACCACACGCGAGATCCGTCTCGCGCTGCTGGAAGCTGACGTTTCATTAACGGTTGTTCGTGCCTTCATTAACC
GAATCAAGGAACGCGCCGTTGGTGCAGAAGTTTCTCAGGCACTCAACCCCGCGCAGCAAGTCATCAAGATCGTCAACGAG
GAACTGGTTCAGATCCTCGGTGGCGAAACCCGCCGACTGTCACTGGCCAAAAACCCACCGACCGTCATCATGCTGGCAGG
TCTGCAGGGTGCAGGTAAGACCACCCTCGCAGGTAAACTGTCCAAGCACCTGGTCAAGCAGGGTCACACTCCTATGCTTG
TTGCCTGTGACCTTCAGCGTCCAGGCGCAGTTCAGCAGCTGCAAATTGTGGGTGAACGCGCAGGCGTTACCACTTTCGCA
CCGGATCCAGGCACCAGCATCGACTCCCTCGAGCACGAAATGGGCACCTCCCACGGTGATCCAGTCGAGGTAGCGCGCGC
AGGTATCGAAGAAGCCAAGCGCACCCAGCACGACATCGTGATCGTGGATACCGCAGGTCGCCTCGGTATCGATGAAACCC
TGATGACTCAGGCACGCAACATCCGCGAAGCCATCAACCCTGATGAAGTGCTCTTTGTCATTGACTCCATGATTGGTCAA
GACGCCGTAGACACCGCCGAAGCATTCCGCGACGGCGTCGACTTCACCGGTGTTGTCCTGACCAAGCTTGATGGCGACGC
CCGCGGTGGTGCTGCACTATCCATCCGTGAAGTCACCGGCAAGCCCATCATGTTTGCCTCCACTGGTGAAAAACTCGACG
ACTTCGACGTCTTCCACCCAGAGCGCATGGCCAGCCGAATCCTGGGCATGGGTGACGTACTGTCACTCATCGAGCAGGCC
GAAGCAGTCATGGATCAGGAAAAGGCAGAGGTCGCTGCCCAGAAGTTGGGCTCCGGCGAGCTCACCCTGGAAGACTTCCT
TGACCAAATGCTGATGATCCGCCGCATGGGACCAATCGGCAACATCCTCAAGATGCTGCCTGGTGGCAAGCAGATGTCCC
AAATGGCGGACATGGTTGATGAGAAGCAACTCGACCGCATCCAGGCGATTATCCGCGGTATGACCCCGGCCGAGCGCGAT
AATCCAAAGATCCTCAACGCTTCCAGGCGCAAGCGCATCGCCAACGGTTCCGGTGTGACCGTGTCCGAAGTAAACAAACT
TGTTGAACGCTTCTTCGAGGCTCGCAAGATGATGGGTCAAATGGCTGGCCAGTTTGGCATGGGTCCTGGATCCCGCAGTG
CAACCAAGAAGCAAGCCAAGGGCCGCAAGGGTAAGAACGGCAAGCGTAAACCAGCCAAGAAGGGCCCAACCCAGCCAAAG
ATGCCAATGGGCGGTATGCCAGGAATGCCTGGGATGCCGGGTATGGGTGGAGCCGGAATGCCTGACCTTGCTGAACTACA
GAAGCAGCTTGGTGGAGCAGGTGGCGGTATGGGAGGCCTTGGTGGCGGACTCCCGGGCATGCCAAAGCCGCCTAAAGGCA
TGGAGAACATAGATCTCAACAACCTAGACTTCGGTAAGAAGTAA

Upstream 100 bases:

>100_bases
CAGGTCGTTGGCAGGTAGCTGACGTGACCTGAGCGGGGGCAACCGGCTAACATGTAGGGATTAGCAACCCCGCACTCTAG
AACCTACTGGGAGTTCATTC

Downstream 100 bases:

>100_bases
CTTTGCTTTAGTTGGTCGGCGCATCACTTTCCCTAAGCGATGCGCCGATTACTTGTTTTTGCTACAAATTTAACTATGTC
ACCCATCCTAAAAGTGCGGG

Product: Signal recognition particle GTPase

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MFESLSDRLNSALSGLRGKGKLTEADINATTREIRLALLEADVSLTVVRAFINRIKERAVGAEVSQALNPAQQVIKIVNE
ELVQILGGETRRLSLAKNPPTVIMLAGLQGAGKTTLAGKLSKHLVKQGHTPMLVACDLQRPGAVQQLQIVGERAGVTTFA
PDPGTSIDSLEHEMGTSHGDPVEVARAGIEEAKRTQHDIVIVDTAGRLGIDETLMTQARNIREAINPDEVLFVIDSMIGQ
DAVDTAEAFRDGVDFTGVVLTKLDGDARGGAALSIREVTGKPIMFASTGEKLDDFDVFHPERMASRILGMGDVLSLIEQA
EAVMDQEKAEVAAQKLGSGELTLEDFLDQMLMIRRMGPIGNILKMLPGGKQMSQMADMVDEKQLDRIQAIIRGMTPAERD
NPKILNASRRKRIANGSGVTVSEVNKLVERFFEARKMMGQMAGQFGMGPGSRSATKKQAKGRKGKNGKRKPAKKGPTQPK
MPMGGMPGMPGMPGMGGAGMPDLAELQKQLGGAGGGMGGLGGGLPGMPKPPKGMENIDLNNLDFGKK

Sequences:

>Translated_547_residues
MFESLSDRLNSALSGLRGKGKLTEADINATTREIRLALLEADVSLTVVRAFINRIKERAVGAEVSQALNPAQQVIKIVNE
ELVQILGGETRRLSLAKNPPTVIMLAGLQGAGKTTLAGKLSKHLVKQGHTPMLVACDLQRPGAVQQLQIVGERAGVTTFA
PDPGTSIDSLEHEMGTSHGDPVEVARAGIEEAKRTQHDIVIVDTAGRLGIDETLMTQARNIREAINPDEVLFVIDSMIGQ
DAVDTAEAFRDGVDFTGVVLTKLDGDARGGAALSIREVTGKPIMFASTGEKLDDFDVFHPERMASRILGMGDVLSLIEQA
EAVMDQEKAEVAAQKLGSGELTLEDFLDQMLMIRRMGPIGNILKMLPGGKQMSQMADMVDEKQLDRIQAIIRGMTPAERD
NPKILNASRRKRIANGSGVTVSEVNKLVERFFEARKMMGQMAGQFGMGPGSRSATKKQAKGRKGKNGKRKPAKKGPTQPK
MPMGGMPGMPGMPGMGGAGMPDLAELQKQLGGAGGGMGGLGGGLPGMPKPPKGMENIDLNNLDFGKK
>Mature_547_residues
MFESLSDRLNSALSGLRGKGKLTEADINATTREIRLALLEADVSLTVVRAFINRIKERAVGAEVSQALNPAQQVIKIVNE
ELVQILGGETRRLSLAKNPPTVIMLAGLQGAGKTTLAGKLSKHLVKQGHTPMLVACDLQRPGAVQQLQIVGERAGVTTFA
PDPGTSIDSLEHEMGTSHGDPVEVARAGIEEAKRTQHDIVIVDTAGRLGIDETLMTQARNIREAINPDEVLFVIDSMIGQ
DAVDTAEAFRDGVDFTGVVLTKLDGDARGGAALSIREVTGKPIMFASTGEKLDDFDVFHPERMASRILGMGDVLSLIEQA
EAVMDQEKAEVAAQKLGSGELTLEDFLDQMLMIRRMGPIGNILKMLPGGKQMSQMADMVDEKQLDRIQAIIRGMTPAERD
NPKILNASRRKRIANGSGVTVSEVNKLVERFFEARKMMGQMAGQFGMGPGSRSATKKQAKGRKGKNGKRKPAKKGPTQPK
MPMGGMPGMPGMPGMGGAGMPDLAELQKQLGGAGGGMGGLGGGLPGMPKPPKGMENIDLNNLDFGKK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=529, Percent_Identity=32.3251417769376, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI226371618, Length=471, Percent_Identity=32.484076433121, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI89061728, Length=159, Percent_Identity=41.5094339622642, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI295424842, Length=308, Percent_Identity=30.5194805194805, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI23308697, Length=308, Percent_Identity=30.5194805194805, Blast_Score=115, Evalue=2e-25,
Organism=Escherichia coli, GI1788963, Length=437, Percent_Identity=48.7414187643021, Blast_Score=404, Evalue=1e-113,
Organism=Escherichia coli, GI1789874, Length=278, Percent_Identity=33.0935251798561, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17539958, Length=523, Percent_Identity=29.2543021032505, Blast_Score=221, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI193206261, Length=304, Percent_Identity=31.9078947368421, Blast_Score=111, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6325345, Length=515, Percent_Identity=33.5922330097087, Blast_Score=250, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6320498, Length=307, Percent_Identity=24.4299674267101, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17647949, Length=464, Percent_Identity=31.4655172413793, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24641198, Length=307, Percent_Identity=29.6416938110749, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 58337; Mature: 58337

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFESLSDRLNSALSGLRGKGKLTEADINATTREIRLALLEADVSLTVVRAFINRIKERAV
CCCHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GAEVSQALNPAQQVIKIVNEELVQILGGETRRLSLAKNPPTVIMLAGLQGAGKTTLAGKL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHH
SKHLVKQGHTPMLVACDLQRPGAVQQLQIVGERAGVTTFAPDPGTSIDSLEHEMGTSHGD
HHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHCCCCCC
PVEVARAGIEEAKRTQHDIVIVDTAGRLGIDETLMTQARNIREAINPDEVLFVIDSMIGQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
DAVDTAEAFRDGVDFTGVVLTKLDGDARGGAALSIREVTGKPIMFASTGEKLDDFDVFHP
HHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCH
ERMASRILGMGDVLSLIEQAEAVMDQEKAEVAAQKLGSGELTLEDFLDQMLMIRRMGPIG
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCHH
NILKMLPGGKQMSQMADMVDEKQLDRIQAIIRGMTPAERDNPKILNASRRKRIANGSGVT
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCC
VSEVNKLVERFFEARKMMGQMAGQFGMGPGSRSATKKQAKGRKGKNGKRKPAKKGPTQPK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCC
MPMGGMPGMPGMPGMGGAGMPDLAELQKQLGGAGGGMGGLGGGLPGMPKPPKGMENIDLN
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NLDFGKK
CCCCCCC
>Mature Secondary Structure
MFESLSDRLNSALSGLRGKGKLTEADINATTREIRLALLEADVSLTVVRAFINRIKERAV
CCCHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GAEVSQALNPAQQVIKIVNEELVQILGGETRRLSLAKNPPTVIMLAGLQGAGKTTLAGKL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHH
SKHLVKQGHTPMLVACDLQRPGAVQQLQIVGERAGVTTFAPDPGTSIDSLEHEMGTSHGD
HHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHCCCCCC
PVEVARAGIEEAKRTQHDIVIVDTAGRLGIDETLMTQARNIREAINPDEVLFVIDSMIGQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
DAVDTAEAFRDGVDFTGVVLTKLDGDARGGAALSIREVTGKPIMFASTGEKLDDFDVFHP
HHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCH
ERMASRILGMGDVLSLIEQAEAVMDQEKAEVAAQKLGSGELTLEDFLDQMLMIRRMGPIG
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCHH
NILKMLPGGKQMSQMADMVDEKQLDRIQAIIRGMTPAERDNPKILNASRRKRIANGSGVT
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCC
VSEVNKLVERFFEARKMMGQMAGQFGMGPGSRSATKKQAKGRKGKNGKRKPAKKGPTQPK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCC
MPMGGMPGMPGMPGMGGAGMPDLAELQKQLGGAGGGMGGLGGGLPGMPKPPKGMENIDLN
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NLDFGKK
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]