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The map label for this gene is pcaB2 [H]

Identifier: 62390884

GI number: 62390884

Start: 2129334

End: 2130587

Strand: Reverse

Name: pcaB2 [H]

Synonym: cg2244

Alternate gene names: 62390884

Gene position: 2130587-2129334 (Counterclockwise)

Preceding gene: 62390885

Following gene: 62390883

Centisome position: 64.9

GC content: 53.99

Gene sequence:

>1254_bases
TTGGCTGCGGAGAGAGCACTCTCAACTGCTCAAGCCCGCCATGGTGTGATCACTGAAGACGATGCTGCACAGATCAACCA
GGCGGCAGTCCTTTCCAACATTGACCGCGAGAAGCTGTGGGAAGATGCCAAAAATGTCGGCTACCCCATCCTTGGCTTGG
TAAGACAAATCGCCAGTCACCTTCCAGAAGGCCCCAACGGGCGAGTCCACTACGGCGCCACGACCCAAGTCATCATGGAC
ACTGGACTGGTGTTGCAAATGACTGCCTCTTTGAACGCCCTTGATAAACAGATCGTGCGTCTGGGGAATGCACTGGCAGC
ACGGGCTGAAGAGCACAAAGACACCGTGATGCCGGGACGCACCCATGCTCAGCAGGCAATTCCCACTACATTTGGAGCAA
CCCTCGCTACCTTTTTGGATCAAATCCGCAGGCAGAGGGAACGACTTGAGGAAGCACTCGAGCGCGTGCGAGTCATTTCG
CTGTTTGGTGCTGGTGGAAACAACGCAGCACAAGGCGAACAAGCGGCAACGGTTCGTGCAGAGATGGCCCGCCTGTTGGA
TCTGAAGGACCCGGTGGTGTCATGGCATGTGGAACGCGATGTGCTTGGGGACTTCGGATGGGTGTGCTCAACGCTGTGTG
GATCGATGGCAAAATTTGGCCGAAACATCGTGGATCTTTCCCGAACTGAAATCGGAGAAGTTTTTGAGCCTTACAACTCC
CATCGGGGTGCATCTTCCATGATGCCTCAGAAAGTCAACCCGATTTCTTCCGAGCTCATGATTGGTATTTCAGTGGTGGC
GGGTGCCTTGACCTCGACTTTGCCACGGCTTCAGGAATCGGGACATGAACGAGCAGCAGGAGAGTGGCAGGGAGAATGGC
TTGTCATTCCAACGTTGGCCAATCTAGCTGGCGCTGCACTCGATGAAGCCATTGTGGTGGCTGAAGGAATGCGAGTGGAT
ACAGATCGTATGTCCTCGAACTTGGCTTTTGCTGGTGGATTGATCATGGCGGAAGCTCAGATGATTCAACTAGCTCCAGC
TCTGGGGCGTGAGAAAGCTCATGACTTGGTTTATGAAGCATCCACAAAGACTCGTGAAGAGCACACCACGCTGGCAGAAG
AACTGCCGATAATTGCAGTTCAACATGGGGTCGAAGACCTGTTGCCTAAGAATTTTGCGCAGCCTGCAGACTACGTCGGC
GAAGCACAATCCATGGTGAATGCAGCTGTCGCCGCCTGGAATGCCCAACTTTAA

Upstream 100 bases:

>100_bases
GTATCCCACTGACAAAGCCCCATTCTCCTAACTTTGGCAGTACGCAGGAAATGACACTCAACTAGAAATCTTTTCTTCAG
ATGCCACAATCGAAAGCTGG

Downstream 100 bases:

>100_bases
CAACCCAAAACTTTAACAACTCGAATCGTTCAGGAGTTTACGCACGATGAGTACACCGATCAAGAACCAATCCCAAGGTG
TTAATGCACCTGCCAGGTCC

Product: 3-carboxy-cis,cis-muconate cycloisomerase

Products: NA

Alternate protein names: 3-carboxymuconate lactonizing enzyme; CMLE [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MAAERALSTAQARHGVITEDDAAQINQAAVLSNIDREKLWEDAKNVGYPILGLVRQIASHLPEGPNGRVHYGATTQVIMD
TGLVLQMTASLNALDKQIVRLGNALAARAEEHKDTVMPGRTHAQQAIPTTFGATLATFLDQIRRQRERLEEALERVRVIS
LFGAGGNNAAQGEQAATVRAEMARLLDLKDPVVSWHVERDVLGDFGWVCSTLCGSMAKFGRNIVDLSRTEIGEVFEPYNS
HRGASSMMPQKVNPISSELMIGISVVAGALTSTLPRLQESGHERAAGEWQGEWLVIPTLANLAGAALDEAIVVAEGMRVD
TDRMSSNLAFAGGLIMAEAQMIQLAPALGREKAHDLVYEASTKTREEHTTLAEELPIIAVQHGVEDLLPKNFAQPADYVG
EAQSMVNAAVAAWNAQL

Sequences:

>Translated_417_residues
MAAERALSTAQARHGVITEDDAAQINQAAVLSNIDREKLWEDAKNVGYPILGLVRQIASHLPEGPNGRVHYGATTQVIMD
TGLVLQMTASLNALDKQIVRLGNALAARAEEHKDTVMPGRTHAQQAIPTTFGATLATFLDQIRRQRERLEEALERVRVIS
LFGAGGNNAAQGEQAATVRAEMARLLDLKDPVVSWHVERDVLGDFGWVCSTLCGSMAKFGRNIVDLSRTEIGEVFEPYNS
HRGASSMMPQKVNPISSELMIGISVVAGALTSTLPRLQESGHERAAGEWQGEWLVIPTLANLAGAALDEAIVVAEGMRVD
TDRMSSNLAFAGGLIMAEAQMIQLAPALGREKAHDLVYEASTKTREEHTTLAEELPIIAVQHGVEDLLPKNFAQPADYVG
EAQSMVNAAVAAWNAQL
>Mature_416_residues
AAERALSTAQARHGVITEDDAAQINQAAVLSNIDREKLWEDAKNVGYPILGLVRQIASHLPEGPNGRVHYGATTQVIMDT
GLVLQMTASLNALDKQIVRLGNALAARAEEHKDTVMPGRTHAQQAIPTTFGATLATFLDQIRRQRERLEEALERVRVISL
FGAGGNNAAQGEQAATVRAEMARLLDLKDPVVSWHVERDVLGDFGWVCSTLCGSMAKFGRNIVDLSRTEIGEVFEPYNSH
RGASSMMPQKVNPISSELMIGISVVAGALTSTLPRLQESGHERAAGEWQGEWLVIPTLANLAGAALDEAIVVAEGMRVDT
DRMSSNLAFAGGLIMAEAQMIQLAPALGREKAHDLVYEASTKTREEHTTLAEELPIIAVQHGVEDLLPKNFAQPADYVGE
AQSMVNAAVAAWNAQL

Specific function: Catalyzes an anti cycloisomerization [H]

COG id: COG0015

COG function: function code F; Adenylosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family [H]

Homologues:

Organism=Escherichia coli, GI1790398, Length=285, Percent_Identity=27.0175438596491, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17508577, Length=318, Percent_Identity=24.8427672955975, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17553882, Length=216, Percent_Identity=28.7037037037037, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32565146, Length=171, Percent_Identity=31.5789473684211, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24640179, Length=219, Percent_Identity=30.1369863013699, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24640177, Length=219, Percent_Identity=30.1369863013699, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI78710009, Length=360, Percent_Identity=26.1111111111111, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24662684, Length=220, Percent_Identity=28.1818181818182, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019468
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- InterPro:   IPR012789 [H]

Pfam domain/function: PF10397 ADSL_C; PF00206 Lyase_1 [H]

EC number: =5.5.1.2 [H]

Molecular weight: Translated: 45005; Mature: 44873

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAERALSTAQARHGVITEDDAAQINQAAVLSNIDREKLWEDAKNVGYPILGLVRQIASH
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHH
LPEGPNGRVHYGATTQVIMDTGLVLQMTASLNALDKQIVRLGNALAARAEEHKDTVMPGR
CCCCCCCCEEECCHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
THAQQAIPTTFGATLATFLDQIRRQRERLEEALERVRVISLFGAGGNNAAQGEQAATVRA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHH
EMARLLDLKDPVVSWHVERDVLGDFGWVCSTLCGSMAKFGRNIVDLSRTEIGEVFEPYNS
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHC
HRGASSMMPQKVNPISSELMIGISVVAGALTSTLPRLQESGHERAAGEWQGEWLVIPTLA
CCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHH
NLAGAALDEAIVVAEGMRVDTDRMSSNLAFAGGLIMAEAQMIQLAPALGREKAHDLVYEA
HHHHHHHHHHHHHHCCCEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHC
STKTREEHTTLAEELPIIAVQHGVEDLLPKNFAQPADYVGEAQSMVNAAVAAWNAQL
CCHHHHHHHHHHHHCCCHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AAERALSTAQARHGVITEDDAAQINQAAVLSNIDREKLWEDAKNVGYPILGLVRQIASH
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHH
LPEGPNGRVHYGATTQVIMDTGLVLQMTASLNALDKQIVRLGNALAARAEEHKDTVMPGR
CCCCCCCCEEECCHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
THAQQAIPTTFGATLATFLDQIRRQRERLEEALERVRVISLFGAGGNNAAQGEQAATVRA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHH
EMARLLDLKDPVVSWHVERDVLGDFGWVCSTLCGSMAKFGRNIVDLSRTEIGEVFEPYNS
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHC
HRGASSMMPQKVNPISSELMIGISVVAGALTSTLPRLQESGHERAAGEWQGEWLVIPTLA
CCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHH
NLAGAALDEAIVVAEGMRVDTDRMSSNLAFAGGLIMAEAQMIQLAPALGREKAHDLVYEA
HHHHHHHHHHHHHHCCCEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHC
STKTREEHTTLAEELPIIAVQHGVEDLLPKNFAQPADYVGEAQSMVNAAVAAWNAQL
CCHHHHHHHHHHHHCCCHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]