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The map label for this gene is cobA [H]

Identifier: 62390838

GI number: 62390838

Start: 2080481

End: 2081233

Strand: Reverse

Name: cobA [H]

Synonym: cg2189

Alternate gene names: 62390838

Gene position: 2081233-2080481 (Counterclockwise)

Preceding gene: 62390840

Following gene: 62390837

Centisome position: 63.4

GC content: 52.32

Gene sequence:

>753_bases
ATGACGATTTCCCAAGAAAACCAGCCAATAATCCAGCCAGTCTCCTTAATTGGTGGAGGTCCTGGTGCATGGGACTTAAT
TACGGTGCGTGGGATGAATCGCCTTCAGGAGGCTGATGTCATTTTGGCTGATCACTTGGGGCCCACTGATGAGTTGGAAA
AATTGTGCGACATCAGCTCGAAGACTGTTGTTGATGTGTCCAAGCTTCCGTATGGGCGGCAGGTCACTCAGGAGCGTACT
AATGAGATGCTTGTTGAATACGCACAGCAGGGACTAAAGGTGGTTCGCCTTAAAGGTGGTGACCCTTATGTCTTCGGTCG
GGGTTTTGAAGAGTTGGAGTTTTTGGGCGAGCATGGAATTGAATGCGAGGTCATTCCGGGTGTGACCAGTGCGGTGTCCG
TTCCAGCGGCGGCAGGTATTCCTATTACTAATCGGGGAGTGGTGCATTCCTTTACCGTGGTGTCTGGACATTTGCCTCCA
GGCCATCCGAAGTCACTGGTTGATTGGGCTGCGTTGGCCAAATCGGGTGGCACCTTGTCCATCATCATGGGTGTGAAAAA
TGCGGGTGCGATTGCCGAGGCGCTCATGGACGGCGGGCTTGATGCAGATACTCCAGCAGCTGTTATTCAGGAAGGCACTA
CTGATGCACAACGCTCAGTTCGGTGCACCTTGGGCACATTGGGTGCAGTCATGGTGGAGGAAGAGATTAAGCCTCCAGCT
GTGTATGTCATTGGACAAGTTGCTGGCCTCTAA

Upstream 100 bases:

>100_bases
GGGCTGATGCGAAGTCAGCTTCGAGTTTGAAAGGTGCAGTATTCATGGTTCAAGCCTAGTGTTCGGGTTCTGGCAATTGT
TGGGACTAGGATTAATGCCC

Downstream 100 bases:

>100_bases
GCAGATCGCCTAAGAATGGGGGTAGTTTCCTCCCTTTTATAGACACTTGTCCAGGGATTTGTTGTTGGTTTTGTGAAAAC
CTTAAGTTGGGTGGTTAAAC

Product: uroporphyrinogen III synthase/methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MTISQENQPIIQPVSLIGGGPGAWDLITVRGMNRLQEADVILADHLGPTDELEKLCDISSKTVVDVSKLPYGRQVTQERT
NEMLVEYAQQGLKVVRLKGGDPYVFGRGFEELEFLGEHGIECEVIPGVTSAVSVPAAAGIPITNRGVVHSFTVVSGHLPP
GHPKSLVDWAALAKSGGTLSIIMGVKNAGAIAEALMDGGLDADTPAAVIQEGTTDAQRSVRCTLGTLGAVMVEEEIKPPA
VYVIGQVAGL

Sequences:

>Translated_250_residues
MTISQENQPIIQPVSLIGGGPGAWDLITVRGMNRLQEADVILADHLGPTDELEKLCDISSKTVVDVSKLPYGRQVTQERT
NEMLVEYAQQGLKVVRLKGGDPYVFGRGFEELEFLGEHGIECEVIPGVTSAVSVPAAAGIPITNRGVVHSFTVVSGHLPP
GHPKSLVDWAALAKSGGTLSIIMGVKNAGAIAEALMDGGLDADTPAAVIQEGTTDAQRSVRCTLGTLGAVMVEEEIKPPA
VYVIGQVAGL
>Mature_249_residues
TISQENQPIIQPVSLIGGGPGAWDLITVRGMNRLQEADVILADHLGPTDELEKLCDISSKTVVDVSKLPYGRQVTQERTN
EMLVEYAQQGLKVVRLKGGDPYVFGRGFEELEFLGEHGIECEVIPGVTSAVSVPAAAGIPITNRGVVHSFTVVSGHLPPG
HPKSLVDWAALAKSGGTLSIIMGVKNAGAIAEALMDGGLDADTPAAVIQEGTTDAQRSVRCTLGTLGAVMVEEEIKPPAV
YVIGQVAGL

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=246, Percent_Identity=38.2113821138211, Blast_Score=160, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6322922, Length=233, Percent_Identity=33.4763948497854, Blast_Score=125, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 26228; Mature: 26097

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISQENQPIIQPVSLIGGGPGAWDLITVRGMNRLQEADVILADHLGPTDELEKLCDISS
CCCCCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHCEEEECCCCCHHHHHHHHCCCC
KTVVDVSKLPYGRQVTQERTNEMLVEYAQQGLKVVRLKGGDPYVFGRGFEELEFLGEHGI
CCEEEHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCHHHHHHHHCCCC
ECEVIPGVTSAVSVPAAAGIPITNRGVVHSFTVVSGHLPPGHPKSLVDWAALAKSGGTLS
EEEEECCCCHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEE
IIMGVKNAGAIAEALMDGGLDADTPAAVIQEGTTDAQRSVRCTLGTLGAVMVEEEIKPPA
EEEECCCCHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHEEEHHHHHHHHHHHHCCCCCE
VYVIGQVAGL
EEEEEECCCC
>Mature Secondary Structure 
TISQENQPIIQPVSLIGGGPGAWDLITVRGMNRLQEADVILADHLGPTDELEKLCDISS
CCCCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHCEEEECCCCCHHHHHHHHCCCC
KTVVDVSKLPYGRQVTQERTNEMLVEYAQQGLKVVRLKGGDPYVFGRGFEELEFLGEHGI
CCEEEHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCHHHHHHHHCCCC
ECEVIPGVTSAVSVPAAAGIPITNRGVVHSFTVVSGHLPPGHPKSLVDWAALAKSGGTLS
EEEEECCCCHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEE
IIMGVKNAGAIAEALMDGGLDADTPAAVIQEGTTDAQRSVRCTLGTLGAVMVEEEIKPPA
EEEECCCCHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHEEEHHHHHHHHHHHHCCCCCE
VYVIGQVAGL
EEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA