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The map label for this gene is iunH2 [H]

Identifier: 62390817

GI number: 62390817

Start: 2055926

End: 2056876

Strand: Reverse

Name: iunH2 [H]

Synonym: cg2168

Alternate gene names: 62390817

Gene position: 2056876-2055926 (Counterclockwise)

Preceding gene: 62390818

Following gene: 62390816

Centisome position: 62.66

GC content: 56.47

Gene sequence:

>951_bases
ATGAGCAAAAAAGCCATCCTTGATATCGACACCGGCATCGATGATGCCCTCGCACTTGCCTACGCACTGGGCTCACCTGA
ACTAGAGCTCATTGGTGTCACCACCACCTACGGTAACGTGCTACTCGAAACCGGTGCAGTCAATGACCTGGCACTGCTTG
ATCTGTTCGGTGCACCAGAAGTACCTGTGTACTTGGGTGAGCCACACGCACAGACCAAGGATGGCTTTGAAGTTCTTGAG
ATCTCCGCGTTCATTCACGGACAAAACGGCATCGGCGAAGTCGAGCTGCCAGCAAGCGAGTCAAAGGCACTCCCCGGCGC
AGTGGATTTCCTCATTGATTCCGTCAACACCCACGGCGATGACCTGGTGATCATCGCAACTGGTCCCATGACCAACCTGT
CTGCGGCAATCGCAAAGGATCCAAGCTTTGCTTCCAAGGCTCACGTGGTCATCATGGGTGGCGCCTTGACTGTCCCAGGC
AACGTCAGCACATGGGCAGAAGCAAACATCAACCAGGACCCAGATGCAGCAAACGATCTGTTCCGTTCCGGTGCAGATGT
CACCATGATCGGTCTTGATGTCACCCTGCAGACCCTTCTTACCAAGAAGCACACTGCGCAGTGGCGCGAACTGGGCACTC
CAGCTGCTATCGCACTGGCCGACATGACTGATTACTACATCAAGGCATATGAGACCACCGCACCACACCTGGGCGGTTGC
GGCCTGCACGACCCACTGGCAGTAGGCGTTGCAGTGGACCCAAGCCTGGTCACTTTGCTCCCCATCAACCTCAAGGTAGA
CATTGAGGGCGAGACCCGTGGACGCACCATTGGCGATGAAGTCCGCCTCAACGATCCAGTGCGCACCTCCCGCGCAGCTG
TCGCCGTAGACGTGGATCGTTTCCTTTCTGAATTCATGACCCGCATCGGCCGAGTCGCAGCACAGCAGTAA

Upstream 100 bases:

>100_bases
CCAGCGCTTAAGGCCGGTCACCGGCCATCAAGCTTGTCACATCGGGTGCCTTATGATGGTGCCCGACCTTAAAAATAAAA
ACCTGAAAGGTTAAAAACGC

Downstream 100 bases:

>100_bases
AAGCAGCTCTGGTGAAGGTTTTTGGAGAAGTACCACCAAGCTGTTAAGCTTCCAAGGTGGTTTTGCGACTGCGGTCCGCA
GCAGTTGTGAAAAGTACACA

Product: nucleoside hydrolase protein

Products: uracil; ribose; cytosine [C]

Alternate protein names: Cytidine/uridine-specific hydrolase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MSKKAILDIDTGIDDALALAYALGSPELELIGVTTTYGNVLLETGAVNDLALLDLFGAPEVPVYLGEPHAQTKDGFEVLE
ISAFIHGQNGIGEVELPASESKALPGAVDFLIDSVNTHGDDLVIIATGPMTNLSAAIAKDPSFASKAHVVIMGGALTVPG
NVSTWAEANINQDPDAANDLFRSGADVTMIGLDVTLQTLLTKKHTAQWRELGTPAAIALADMTDYYIKAYETTAPHLGGC
GLHDPLAVGVAVDPSLVTLLPINLKVDIEGETRGRTIGDEVRLNDPVRTSRAAVAVDVDRFLSEFMTRIGRVAAQQ

Sequences:

>Translated_316_residues
MSKKAILDIDTGIDDALALAYALGSPELELIGVTTTYGNVLLETGAVNDLALLDLFGAPEVPVYLGEPHAQTKDGFEVLE
ISAFIHGQNGIGEVELPASESKALPGAVDFLIDSVNTHGDDLVIIATGPMTNLSAAIAKDPSFASKAHVVIMGGALTVPG
NVSTWAEANINQDPDAANDLFRSGADVTMIGLDVTLQTLLTKKHTAQWRELGTPAAIALADMTDYYIKAYETTAPHLGGC
GLHDPLAVGVAVDPSLVTLLPINLKVDIEGETRGRTIGDEVRLNDPVRTSRAAVAVDVDRFLSEFMTRIGRVAAQQ
>Mature_315_residues
SKKAILDIDTGIDDALALAYALGSPELELIGVTTTYGNVLLETGAVNDLALLDLFGAPEVPVYLGEPHAQTKDGFEVLEI
SAFIHGQNGIGEVELPASESKALPGAVDFLIDSVNTHGDDLVIIATGPMTNLSAAIAKDPSFASKAHVVIMGGALTVPGN
VSTWAEANINQDPDAANDLFRSGADVTMIGLDVTLQTLLTKKHTAQWRELGTPAAIALADMTDYYIKAYETTAPHLGGCG
LHDPLAVGVAVDPSLVTLLPINLKVDIEGETRGRTIGDEVRLNDPVRTSRAAVAVDVDRFLSEFMTRIGRVAAQQ

Specific function: Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively [H]

COG id: COG1957

COG function: function code F; Inosine-uridine nucleoside N-ribohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IUNH family. RihA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786871, Length=307, Percent_Identity=33.8762214983713, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788486, Length=304, Percent_Identity=30.9210526315789, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1786213, Length=283, Percent_Identity=33.2155477031802, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32565474, Length=288, Percent_Identity=29.5138888888889, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17565698, Length=297, Percent_Identity=27.6094276094276, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320608, Length=331, Percent_Identity=23.8670694864048, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24641839, Length=209, Percent_Identity=29.6650717703349, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641837, Length=338, Percent_Identity=28.4023668639053, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015910
- InterPro:   IPR023186
- InterPro:   IPR001910
- InterPro:   IPR022975 [H]

Pfam domain/function: PF01156 IU_nuc_hydro [H]

EC number: NA

Molecular weight: Translated: 33264; Mature: 33133

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKAILDIDTGIDDALALAYALGSPELELIGVTTTYGNVLLETGAVNDLALLDLFGAPE
CCCCEEEEECCCCCHHHHHHHHCCCCCEEEEEEEEECCCEEEECCCCCCEEEEEECCCCC
VPVYLGEPHAQTKDGFEVLEISAFIHGQNGIGEVELPASESKALPGAVDFLIDSVNTHGD
CCEEECCCCCCCCCCCEEEEEEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCC
DLVIIATGPMTNLSAAIAKDPSFASKAHVVIMGGALTVPGNVSTWAEANINQDPDAANDL
CEEEEEECCCCCCHHHHHCCCCCCCCEEEEEECCEEECCCCCCCEEECCCCCCCCHHHHH
FRSGADVTMIGLDVTLQTLLTKKHTAQWRELGTPAAIALADMTDYYIKAYETTAPHLGGC
HHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHCEEEEEEECCCCCCCCC
GLHDPLAVGVAVDPSLVTLLPINLKVDIEGETRGRTIGDEVRLNDPVRTSRAAVAVDVDR
CCCCCEEEEEEECCCEEEEEEEEEEEEECCCCCCCCCCCCEEECCCCCCCCEEEEEEHHH
FLSEFMTRIGRVAAQQ
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKKAILDIDTGIDDALALAYALGSPELELIGVTTTYGNVLLETGAVNDLALLDLFGAPE
CCCEEEEECCCCCHHHHHHHHCCCCCEEEEEEEEECCCEEEECCCCCCEEEEEECCCCC
VPVYLGEPHAQTKDGFEVLEISAFIHGQNGIGEVELPASESKALPGAVDFLIDSVNTHGD
CCEEECCCCCCCCCCCEEEEEEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCC
DLVIIATGPMTNLSAAIAKDPSFASKAHVVIMGGALTVPGNVSTWAEANINQDPDAANDL
CEEEEEECCCCCCHHHHHCCCCCCCCEEEEEECCEEECCCCCCCEEECCCCCCCCHHHHH
FRSGADVTMIGLDVTLQTLLTKKHTAQWRELGTPAAIALADMTDYYIKAYETTAPHLGGC
HHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHCEEEEEEECCCCCCCCC
GLHDPLAVGVAVDPSLVTLLPINLKVDIEGETRGRTIGDEVRLNDPVRTSRAAVAVDVDR
CCCCCEEEEEEECCCEEEEEEEEEEEEECCCCCCCCCCCCEEECCCCCCCCEEEEEEHHH
FLSEFMTRIGRVAAQQ
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine; H2O; cytidine [C]

Specific reaction: uridine + H2O = uracil + ribose cytidine + H2O = cytosine + ribose [C]

General reaction: Pyrimidine-specific nucleoside hydrolase [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA