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The map label for this gene is lexA [H]

Identifier: 62390770

GI number: 62390770

Start: 2006798

End: 2007559

Strand: Direct

Name: lexA [H]

Synonym: cg2114

Alternate gene names: 62390770

Gene position: 2006798-2007559 (Clockwise)

Preceding gene: 62390767

Following gene: 62390771

Centisome position: 61.13

GC content: 54.33

Gene sequence:

>762_bases
ATGGCAATCGAAAAGAAGCCAGCAGGTGCACGAGGCAGTCGCGGTAGCCGCACAGTTAAGACCTTGCCCAACGGAAAACC
AGATCCAGCAAGTTTGTCAGATAGGCAGCGCAGGATTTTAGAGGTTATCCGAGATGCTGTGGTTTTGAGGGGTTATCCAC
CAAGCATTAGGGAAATTGGTGATGCTGCAGGACTTCAATCCACTTCTTCCGTTGCTTACCAGCTTAAAGAGCTAGAGAAG
AAGGGCTTCCTGCGCAGGGACCCTAATAAGCCTCGCGCGGTGGATGTTCGCCACCTTCCAGAAACTGAAAGCCGTTCCTC
CAAGGCTGCTACACAGGCAAAGAGCAAGGCCCCTCAGGCCGGGGTCCATGATCCTGAGTTAGCTGGCCAGACCTCATTTG
TCCCAGTGGTGGGCAAAATTGCCGCTGGTAGCCCGATCACCGCTGAGCAGAACATCGAAGAGTACTACCCACTCCCCGCA
GAAATCGTCGGAGACGGTGACTTGTTCATGCTCCAGGTTGTTGGCGAGTCCATGAGGGATGCTGGCATCCTCACCGGCGA
CTGGGTTGTTGTTCGTTCCCAGCCGGTCGCTGAGCAGGGCGAGTTCGTCGCGGCAATGATTGACGGTGAAGCCACCGTGA
AGGAATTCCACAAGGATTCATCTGGCATCTGGCTCCTGCCACACAACGATACGTTTGCCCCAATTCCTGCTGAGAATGCA
GAAATCATGGGCAAGGTTGTTTCCGTGATGCGCAAGCTTTAA

Upstream 100 bases:

>100_bases
AGAAGTTCACACTGGATGAACCCTCATCAAGAGTGAACATGGAAGCGAACAGAGTTTTTAGTGCTTTAACGGGCAAACAA
TGAGAGGAAGGGAACGGAAG

Downstream 100 bases:

>100_bases
GTCGCTTTTCAGGTTCCCGCCACAGTATGTGTTCTCACATATCGTGGCGGGTTTTGCTTTATATAGCCACATTCGGGGGT
AATCGGGCAAATAAGTTTTT

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MAIEKKPAGARGSRGSRTVKTLPNGKPDPASLSDRQRRILEVIRDAVVLRGYPPSIREIGDAAGLQSTSSVAYQLKELEK
KGFLRRDPNKPRAVDVRHLPETESRSSKAATQAKSKAPQAGVHDPELAGQTSFVPVVGKIAAGSPITAEQNIEEYYPLPA
EIVGDGDLFMLQVVGESMRDAGILTGDWVVVRSQPVAEQGEFVAAMIDGEATVKEFHKDSSGIWLLPHNDTFAPIPAENA
EIMGKVVSVMRKL

Sequences:

>Translated_253_residues
MAIEKKPAGARGSRGSRTVKTLPNGKPDPASLSDRQRRILEVIRDAVVLRGYPPSIREIGDAAGLQSTSSVAYQLKELEK
KGFLRRDPNKPRAVDVRHLPETESRSSKAATQAKSKAPQAGVHDPELAGQTSFVPVVGKIAAGSPITAEQNIEEYYPLPA
EIVGDGDLFMLQVVGESMRDAGILTGDWVVVRSQPVAEQGEFVAAMIDGEATVKEFHKDSSGIWLLPHNDTFAPIPAENA
EIMGKVVSVMRKL
>Mature_252_residues
AIEKKPAGARGSRGSRTVKTLPNGKPDPASLSDRQRRILEVIRDAVVLRGYPPSIREIGDAAGLQSTSSVAYQLKELEKK
GFLRRDPNKPRAVDVRHLPETESRSSKAATQAKSKAPQAGVHDPELAGQTSFVPVVGKIAAGSPITAEQNIEEYYPLPAE
IVGDGDLFMLQVVGESMRDAGILTGDWVVVRSQPVAEQGEFVAAMIDGEATVKEFHKDSSGIWLLPHNDTFAPIPAENAE
IMGKVVSVMRKL

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=226, Percent_Identity=30.5309734513274, Blast_Score=99, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 27300; Mature: 27169

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIEKKPAGARGSRGSRTVKTLPNGKPDPASLSDRQRRILEVIRDAVVLRGYPPSIREIG
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
DAAGLQSTSSVAYQLKELEKKGFLRRDPNKPRAVDVRHLPETESRSSKAATQAKSKAPQA
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCC
GVHDPELAGQTSFVPVVGKIAAGSPITAEQNIEEYYPLPAEIVGDGDLFMLQVVGESMRD
CCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCHHEECCCCEEEHHHHHHHHHH
AGILTGDWVVVRSQPVAEQGEFVAAMIDGEATVKEFHKDSSGIWLLPHNDTFAPIPAENA
CCCEECCEEEEECCCCCCCCCEEEEEECCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCH
EIMGKVVSVMRKL
HHHHHHHHHHHCC
>Mature Secondary Structure 
AIEKKPAGARGSRGSRTVKTLPNGKPDPASLSDRQRRILEVIRDAVVLRGYPPSIREIG
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
DAAGLQSTSSVAYQLKELEKKGFLRRDPNKPRAVDVRHLPETESRSSKAATQAKSKAPQA
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCC
GVHDPELAGQTSFVPVVGKIAAGSPITAEQNIEEYYPLPAEIVGDGDLFMLQVVGESMRD
CCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCHHEECCCCEEEHHHHHHHHHH
AGILTGDWVVVRSQPVAEQGEFVAAMIDGEATVKEFHKDSSGIWLLPHNDTFAPIPAENA
CCCEECCEEEEECCCCCCCCCEEEEEECCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCH
EIMGKVVSVMRKL
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA