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The map label for this gene is galE

Identifier: 62390761

GI number: 62390761

Start: 1993007

End: 1993996

Strand: Direct

Name: galE

Synonym: cg2104

Alternate gene names: 62390761

Gene position: 1993007-1993996 (Clockwise)

Preceding gene: 62390760

Following gene: 62390763

Centisome position: 60.71

GC content: 54.14

Gene sequence:

>990_bases
ATGAAGCTTCTGGTTACCGGTGGCGCTGGCTATGTTGGCAGCGTTGCTGCCGCTGTTCTTCTAGAACATGGGCACGATGT
CACAATCATTGACAATTTCAGTACCGGCAACCGTGAAGCAGTCCCTGCTGACGCTCGCCTGATAGAAGGTGACGTCAACG
ATGTCGTTGAGGAAGTCCTTTCTGAAGGCGGATTCGAGGGTGTCGTCCACTTCGCTGCTCGCTCATTGGTAGGCGAATCA
GTGGAAAAGCCCAATGAATACTGGCACGACAATGTGGTCACGGCGCTCACCTTGCTCGATGCAATGCGTGCCCATGGGGT
GAACAACCTTGTGTTCTCCTCCACTGCTGCTACCTACGGTGAACCAGACGTTGTTCCCATCACCGAGGACATGCCCACCC
AGCCCACCAATGCTTATGGCGCAACGAAGCTGTCCATCGACTACGCAATTACGTCCTACGCTGCTGCCTTTGGTCTGGCT
GCAACCAGCTTGCGCTACTTCAACGTTGCTGGCGCATACGGAAACATCGGTGAAAATCGTGAAGTTGAAACTCACCTCAT
TCCACTAGTGCTGCAGGTAGCAACCGGTCACCGCGAGAAAACCTTCATGTTCGGCGATGACTGGCCAACTCCCGATGGAA
CCGCGGTCCGCGATTACATCCACATTCTTGATCTTGCCAAAGCACACGTGTTGGCTTTGGAATCCAACGAAGCCGGTAAG
CACCGCATTTTCAACCTTGGTTCCGGAGATGGCTACAGCGTGAAACAGGTTGTGGAGATGTGCCGTGAAGTAACCGGACA
TCCCATCCCGGCAGAGGTCGCACCCAGGCGTGCAGGAGATCCAGCAACACTAATTGCATCTTCTGAGAAGGCAAAGCAAG
AACTGGGTTGGACCCCTGAGCACACTGATCTGCGCACCATCGTTGAGGACGCTTGGGCGTTTACATCCGCACTGGGCGAT
CGTTCCCATGCTGCAAAGAAGAAAGCTTAA

Upstream 100 bases:

>100_bases
GCAGGGCCGGGTCGTGATCACCCACAACGGCTCCAGCGTAGAACTGATTGACGATCTTGCACATGCAGTCCGCGTAGAAA
AGGTTGAGGGCTAACACACG

Downstream 100 bases:

>100_bases
GCTTTCGGATCGGGGACGTGAAAGTCCCGCAATTGCTGGTTGCCGCGGAGGCAGGCGTCGATAAGCTTTGTTGTTTCGCC
GTTGAACAACCCTTCGCGCA

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MKLLVTGGAGYVGSVAAAVLLEHGHDVTIIDNFSTGNREAVPADARLIEGDVNDVVEEVLSEGGFEGVVHFAARSLVGES
VEKPNEYWHDNVVTALTLLDAMRAHGVNNLVFSSTAATYGEPDVVPITEDMPTQPTNAYGATKLSIDYAITSYAAAFGLA
ATSLRYFNVAGAYGNIGENREVETHLIPLVLQVATGHREKTFMFGDDWPTPDGTAVRDYIHILDLAKAHVLALESNEAGK
HRIFNLGSGDGYSVKQVVEMCREVTGHPIPAEVAPRRAGDPATLIASSEKAKQELGWTPEHTDLRTIVEDAWAFTSALGD
RSHAAKKKA

Sequences:

>Translated_329_residues
MKLLVTGGAGYVGSVAAAVLLEHGHDVTIIDNFSTGNREAVPADARLIEGDVNDVVEEVLSEGGFEGVVHFAARSLVGES
VEKPNEYWHDNVVTALTLLDAMRAHGVNNLVFSSTAATYGEPDVVPITEDMPTQPTNAYGATKLSIDYAITSYAAAFGLA
ATSLRYFNVAGAYGNIGENREVETHLIPLVLQVATGHREKTFMFGDDWPTPDGTAVRDYIHILDLAKAHVLALESNEAGK
HRIFNLGSGDGYSVKQVVEMCREVTGHPIPAEVAPRRAGDPATLIASSEKAKQELGWTPEHTDLRTIVEDAWAFTSALGD
RSHAAKKKA
>Mature_329_residues
MKLLVTGGAGYVGSVAAAVLLEHGHDVTIIDNFSTGNREAVPADARLIEGDVNDVVEEVLSEGGFEGVVHFAARSLVGES
VEKPNEYWHDNVVTALTLLDAMRAHGVNNLVFSSTAATYGEPDVVPITEDMPTQPTNAYGATKLSIDYAITSYAAAFGLA
ATSLRYFNVAGAYGNIGENREVETHLIPLVLQVATGHREKTFMFGDDWPTPDGTAVRDYIHILDLAKAHVLALESNEAGK
HRIFNLGSGDGYSVKQVVEMCREVTGHPIPAEVAPRRAGDPATLIASSEKAKQELGWTPEHTDLRTIVEDAWAFTSALGD
RSHAAKKKA

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family

Homologues:

Organism=Homo sapiens, GI56237023, Length=334, Percent_Identity=42.814371257485, Blast_Score=234, Evalue=7e-62,
Organism=Homo sapiens, GI56118217, Length=334, Percent_Identity=42.814371257485, Blast_Score=234, Evalue=7e-62,
Organism=Homo sapiens, GI189083684, Length=334, Percent_Identity=42.814371257485, Blast_Score=234, Evalue=7e-62,
Organism=Homo sapiens, GI42516563, Length=308, Percent_Identity=26.2987012987013, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI7657641, Length=276, Percent_Identity=25, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4504031, Length=335, Percent_Identity=26.865671641791, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786974, Length=332, Percent_Identity=41.566265060241, Blast_Score=244, Evalue=6e-66,
Organism=Escherichia coli, GI1788353, Length=340, Percent_Identity=26.4705882352941, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI48994969, Length=335, Percent_Identity=26.2686567164179, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788366, Length=358, Percent_Identity=27.3743016759777, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790049, Length=263, Percent_Identity=26.615969581749, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71982035, Length=340, Percent_Identity=39.4117647058824, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI71982038, Length=342, Percent_Identity=39.1812865497076, Blast_Score=210, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI115532424, Length=327, Percent_Identity=22.0183486238532, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319493, Length=342, Percent_Identity=39.4736842105263, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI19923002, Length=338, Percent_Identity=38.4615384615385, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI21356223, Length=309, Percent_Identity=23.3009708737864, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GALE_CORGL (Q45291)

Other databases:

- EMBL:   Z49823
- EMBL:   BA000036
- EMBL:   BX927153
- PIR:   JC5168
- RefSeq:   NP_601127.1
- RefSeq:   YP_226163.1
- ProteinModelPortal:   Q45291
- SMR:   Q45291
- GeneID:   1019878
- GeneID:   3343869
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg2104
- KEGG:   cgl:NCgl1846
- HOGENOM:   HBG755066
- OMA:   VREKIMI
- PhylomeDB:   Q45291
- ProtClustDB:   CLSK900066
- BioCyc:   CGLU196627:CG2104-MONOMER
- BRENDA:   5.1.3.2
- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10366:SF39
- TIGRFAMs:   TIGR01179

Pfam domain/function: PF01370 Epimerase

EC number: =5.1.3.2

Molecular weight: Translated: 35264; Mature: 35264

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: ACT_SITE 139-139 BINDING 115-115

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVTGGAGYVGSVAAAVLLEHGHDVTIIDNFSTGNREAVPADARLIEGDVNDVVEEVL
CEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEECCCHHHHHHHHH
SEGGFEGVVHFAARSLVGESVEKPNEYWHDNVVTALTLLDAMRAHGVNNLVFSSTAATYG
HCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
EPDVVPITEDMPTQPTNAYGATKLSIDYAITSYAAAFGLAATSLRYFNVAGAYGNIGENR
CCCEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCC
EVETHLIPLVLQVATGHREKTFMFGDDWPTPDGTAVRDYIHILDLAKAHVLALESNEAGK
CHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCC
HRIFNLGSGDGYSVKQVVEMCREVTGHPIPAEVAPRRAGDPATLIASSEKAKQELGWTPE
EEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCHHHHHHCCCCCC
HTDLRTIVEDAWAFTSALGDRSHAAKKKA
CHHHHHHHHHHHHHHHHHCCHHHHHCCCC
>Mature Secondary Structure
MKLLVTGGAGYVGSVAAAVLLEHGHDVTIIDNFSTGNREAVPADARLIEGDVNDVVEEVL
CEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEECCCHHHHHHHHH
SEGGFEGVVHFAARSLVGESVEKPNEYWHDNVVTALTLLDAMRAHGVNNLVFSSTAATYG
HCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
EPDVVPITEDMPTQPTNAYGATKLSIDYAITSYAAAFGLAATSLRYFNVAGAYGNIGENR
CCCEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCC
EVETHLIPLVLQVATGHREKTFMFGDDWPTPDGTAVRDYIHILDLAKAHVLALESNEAGK
CHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCC
HRIFNLGSGDGYSVKQVVEMCREVTGHPIPAEVAPRRAGDPATLIASSEKAKQELGWTPE
EEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCHHHHHHCCCCCC
HTDLRTIVEDAWAFTSALGDRSHAAKKKA
CHHHHHHHHHHHHHHHHHCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8921853; 12948626