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The map label for this gene is coaBC [C]

Identifier: 62390573

GI number: 62390573

Start: 1797096

End: 1797656

Strand: Direct

Name: coaBC [C]

Synonym: cg1907

Alternate gene names: 62390573

Gene position: 1797096-1797656 (Clockwise)

Preceding gene: 62390572

Following gene: 62390574

Centisome position: 54.74

GC content: 45.63

Gene sequence:

>561_bases
ATGACCAAAGTTACGAATGTGTCTTGGTTAGTAACAGGTTCAATGTCGGCCCTATCAATACCGGGTCTAATTTTCTCACT
TCGCTCATCACATCCTAACCTTAATTTCACTCCCTATCTAACACAAAGCGCAAGTCGAATCGTCACTATGACCAGTATGG
CCACGCTAAGTGGAGTGACTCCTAGAAATAGTGACTGGGGGTCAGAACCAGAGGCTACACCCAGCCACATTCAAATCGAA
TCAGAGTCAGATGCATATCTGATTGCCCCAGCGACCCTTGATTTTCTAGCTCGCTTTGCGCGTTATGATTGTTCGACCCC
TTTCTCCCTTGCTCTTCAATGTACGAAAAAGCCAATTCTCGTAGCACCGTCCTTGCCGCCTGGGGGGAAAGATTCAATAG
CATATAAGTCACTAAGCATGGACCTCTTAAAGTGGGAGAATTTACGGTTATTGAGTCCTATCGAAACTAAAAGTGCTTCT
TCCCCAAACGCATCGTCATCCGGCTTCGGATCTGCCACACGATTAATCGAATTCATGTTAGAAAACCTACAGGGTACTTA
G

Upstream 100 bases:

>100_bases
TTTGCGCCCAACTAATAATCGAAGAATTTTCAGGAAAATCCGTCACGATCGCAGAAAAACTATCCGAATGGGGTATTCCT
CAGAAGGAGGCCCACGCATA

Downstream 100 bases:

>100_bases
AGTGAAAAAAGTTTTTCAAAATGAAATGCGCACAATTTGGCAAAGAGATTCGGCCAATGATCAAGAACCGTGGTCCGAGA
TCCGTCGGTACTCTCCTGCA

Product: phosphopantothenoylcysteine synthetase/decarboxylase

Products: N-(R)-4-Phosphopantothenoyl)-L-cysteine; CMP; H+; Diphosphate [C]

Alternate protein names: Flavoprotein Domain-Containing Protein; Flavoprotein; Phosphopantothenoylcysteine Synthetase/Decarboxylase

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MTKVTNVSWLVTGSMSALSIPGLIFSLRSSHPNLNFTPYLTQSASRIVTMTSMATLSGVTPRNSDWGSEPEATPSHIQIE
SESDAYLIAPATLDFLARFARYDCSTPFSLALQCTKKPILVAPSLPPGGKDSIAYKSLSMDLLKWENLRLLSPIETKSAS
SPNASSSGFGSATRLIEFMLENLQGT

Sequences:

>Translated_186_residues
MTKVTNVSWLVTGSMSALSIPGLIFSLRSSHPNLNFTPYLTQSASRIVTMTSMATLSGVTPRNSDWGSEPEATPSHIQIE
SESDAYLIAPATLDFLARFARYDCSTPFSLALQCTKKPILVAPSLPPGGKDSIAYKSLSMDLLKWENLRLLSPIETKSAS
SPNASSSGFGSATRLIEFMLENLQGT
>Mature_185_residues
TKVTNVSWLVTGSMSALSIPGLIFSLRSSHPNLNFTPYLTQSASRIVTMTSMATLSGVTPRNSDWGSEPEATPSHIQIES
ESDAYLIAPATLDFLARFARYDCSTPFSLALQCTKKPILVAPSLPPGGKDSIAYKSLSMDLLKWENLRLLSPIETKSASS
PNASSSGFGSATRLIEFMLENLQGT

Specific function: Catalyzes Two Steps In The Biosynthesis Of Coenzyme A. In The First Step Cysteine Is Conjugated To 4'-Phosphopantothenate To Form 4-Phosphopantothenoylcysteine, In The Latter Compound Is Decarboxylated To Form 4'-Phosphopantotheine. [C]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.36; 6.3.2.5 [C]

Molecular weight: Translated: 20051; Mature: 19920

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVTNVSWLVTGSMSALSIPGLIFSLRSSHPNLNFTPYLTQSASRIVTMTSMATLSGVT
CCCCCCEEEEEECCCCHHHCCHHEEEHHCCCCCCCCCCHHCCCCCCEEEEHHHHHHCCCC
PRNSDWGSEPEATPSHIQIESESDAYLIAPATLDFLARFARYDCSTPFSLALQCTKKPIL
CCCCCCCCCCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHHCCCCCCHHHHEEECCCCEE
VAPSLPPGGKDSIAYKSLSMDLLKWENLRLLSPIETKSASSPNASSSGFGSATRLIEFML
EECCCCCCCCCCEEHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
ENLQGT
HHHCCC
>Mature Secondary Structure 
TKVTNVSWLVTGSMSALSIPGLIFSLRSSHPNLNFTPYLTQSASRIVTMTSMATLSGVT
CCCCCEEEEEECCCCHHHCCHHEEEHHCCCCCCCCCCHHCCCCCCEEEEHHHHHHCCCC
PRNSDWGSEPEATPSHIQIESESDAYLIAPATLDFLARFARYDCSTPFSLALQCTKKPIL
CCCCCCCCCCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHHCCCCCCHHHHEEECCCCEE
VAPSLPPGGKDSIAYKSLSMDLLKWENLRLLSPIETKSASSPNASSSGFGSATRLIEFML
EECCCCCCCCCCEEHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
ENLQGT
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-4'-Phosphopantothenate; CTP; L-Cysteine [C]

Specific reaction: D-4'-Phosphopantothenate + CTP + L-Cysteine --> N-((R)-4-Phosphopantothenoyl)-L-cysteine + CMP + H+ + Diphosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA