Click here to switch to the map view.

The map label for this gene is ruvC

Identifier: 62390543

GI number: 62390543

Start: 1764646

End: 1765287

Strand: Reverse

Name: ruvC

Synonym: cg1871

Alternate gene names: 62390543

Gene position: 1765287-1764646 (Counterclockwise)

Preceding gene: 62390544

Following gene: 62390542

Centisome position: 53.78

GC content: 54.36

Gene sequence:

>642_bases
ATGGGCATTGACCCAGGTCTTACCCGTTGTGGCTTATCTGTGGTTCAAGCAGGTCGTGGTCGTACCGTGTATCCAGTGTC
GGTGGGCGTGGTGCGCACCCCACCAGATGCGGAGTTGGCGGAGCGGTTGCTTCGGCTCAGCAAAGCAGTGGGTGAGTGGA
TGGATGAGTACACCCCAGATGTCATTGCTATTGAGCGTGTCTTTGAGCGCGGAAATGTTTCCACCGTGATGAACACTGCG
CATGCGGTGGGTGTGTTGATCTTGGCTGCTGCTGAACGCGGATTGCCAGTTCACATGTACACCCCCAGTGAGGTGAAAAA
GGCTATCTCCGGTAATGGTCGCGCTGATAAGAAACAGATGACGGTCATGATCACTCGAATTCTGGGCCTTGGTGAGCCAC
CCAAACCTGCTGACGCCGCTGATGCTTTATCGTTGGCGGTGTGTCACTGCTGGCGGGCGCCAATGCTTATGCGGGCGCAA
TCGCAGTACTCCGAGCAAGAGTTGGAAAAGCGACGGCGTGTGCAGCAAGGAAAATTGGGTAAAGCGAAATCAACTTACAA
TGCGGAACAAGCTCAATCCCATGCATCCGATCCTGCTAAAGCGGCTCATCCCAGTCAGTTTCAACGAACTGACACCAATT
AG

Upstream 100 bases:

>100_bases
AATTGTGTGCTAAAAATGAGTATGGAATAGCAACTGCACAGCGACGAATCAGCGACGAATCAGTGAGGACACGAATATGA
ACCACGAAGGGCTTCGGGTA

Downstream 100 bases:

>100_bases
TTTTTAAAAAGTTCTAGTACATTTTTCAGGAGTGTCTTCATGATTGCCTCACTTCGTGGCACTGTTATCAACATTGGTCT
GAGCTCTGCTGTCATTGAAT

Product: Holliday junction resolvase

Products: NA

Alternate protein names: Holliday junction nuclease ruvC; Holliday junction resolvase ruvC

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MGIDPGLTRCGLSVVQAGRGRTVYPVSVGVVRTPPDAELAERLLRLSKAVGEWMDEYTPDVIAIERVFERGNVSTVMNTA
HAVGVLILAAAERGLPVHMYTPSEVKKAISGNGRADKKQMTVMITRILGLGEPPKPADAADALSLAVCHCWRAPMLMRAQ
SQYSEQELEKRRRVQQGKLGKAKSTYNAEQAQSHASDPAKAAHPSQFQRTDTN

Sequences:

>Translated_213_residues
MGIDPGLTRCGLSVVQAGRGRTVYPVSVGVVRTPPDAELAERLLRLSKAVGEWMDEYTPDVIAIERVFERGNVSTVMNTA
HAVGVLILAAAERGLPVHMYTPSEVKKAISGNGRADKKQMTVMITRILGLGEPPKPADAADALSLAVCHCWRAPMLMRAQ
SQYSEQELEKRRRVQQGKLGKAKSTYNAEQAQSHASDPAKAAHPSQFQRTDTN
>Mature_212_residues
GIDPGLTRCGLSVVQAGRGRTVYPVSVGVVRTPPDAELAERLLRLSKAVGEWMDEYTPDVIAIERVFERGNVSTVMNTAH
AVGVLILAAAERGLPVHMYTPSEVKKAISGNGRADKKQMTVMITRILGLGEPPKPADAADALSLAVCHCWRAPMLMRAQS
QYSEQELEKRRRVQQGKLGKAKSTYNAEQAQSHASDPAKAAHPSQFQRTDTN

Specific function: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leav

COG id: COG0817

COG function: function code L; Holliday junction resolvasome, endonuclease subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvC family

Homologues:

Organism=Escherichia coli, GI1788170, Length=158, Percent_Identity=32.9113924050633, Blast_Score=76, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVC_CORGL (Q9AE11)

Other databases:

- EMBL:   AF038651
- EMBL:   BA000036
- EMBL:   BX927153
- RefSeq:   NP_600874.2
- RefSeq:   YP_225945.1
- ProteinModelPortal:   Q9AE11
- SMR:   Q9AE11
- GeneID:   1019629
- GeneID:   3343449
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1871
- KEGG:   cgl:NCgl1598
- HOGENOM:   HBG437552
- OMA:   RTGWGVI
- PhylomeDB:   Q9AE11
- ProtClustDB:   PRK00039
- BioCyc:   CGLU196627:CG1871-MONOMER
- BRENDA:   3.1.22.4
- HAMAP:   MF_00034
- InterPro:   IPR012337
- InterPro:   IPR020563
- InterPro:   IPR002176
- PRINTS:   PR00696
- TIGRFAMs:   TIGR00228

Pfam domain/function: PF02075 RuvC; SSF53098 RNaseH_fold

EC number: =3.1.22.4

Molecular weight: Translated: 23160; Mature: 23029

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS01321 RUVC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIDPGLTRCGLSVVQAGRGRTVYPVSVGVVRTPPDAELAERLLRLSKAVGEWMDEYTPD
CCCCCCHHHHHHHHHHCCCCCEEEEEEECEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC
VIAIERVFERGNVSTVMNTAHAVGVLILAAAERGLPVHMYTPSEVKKAISGNGRADKKQM
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHCCCCCCHHHHH
TVMITRILGLGEPPKPADAADALSLAVCHCWRAPMLMRAQSQYSEQELEKRRRVQQGKLG
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCC
KAKSTYNAEQAQSHASDPAKAAHPSQFQRTDTN
CCCCCCCHHHHHHHCCCCCCCCCCCHHHCCCCC
>Mature Secondary Structure 
GIDPGLTRCGLSVVQAGRGRTVYPVSVGVVRTPPDAELAERLLRLSKAVGEWMDEYTPD
CCCCCHHHHHHHHHHCCCCCEEEEEEECEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC
VIAIERVFERGNVSTVMNTAHAVGVLILAAAERGLPVHMYTPSEVKKAISGNGRADKKQM
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHCCCCCCHHHHH
TVMITRILGLGEPPKPADAADALSLAVCHCWRAPMLMRAQSQYSEQELEKRRRVQQGKLG
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCC
KAKSTYNAEQAQSHASDPAKAAHPSQFQRTDTN
CCCCCCCHHHHHHHCCCCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626