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The map label for this gene is hisS

Identifier: 62390530

GI number: 62390530

Start: 1749456

End: 1750745

Strand: Reverse

Name: hisS

Synonym: cg1855

Alternate gene names: 62390530

Gene position: 1750745-1749456 (Counterclockwise)

Preceding gene: 62390531

Following gene: 62390529

Centisome position: 53.33

GC content: 54.5

Gene sequence:

>1290_bases
GTGAGTCAAAACAAGTCCAAGTCTGAAAAGCTTCAGTCATTTGCTGCACCCAAGGGTGTTCCTGATTACGCCCCACCAAA
ATCTGCAGCGTTTTTAGCAGTCCGTGATGCCTTTGTTAATCAAGCACATAAGGCCGGGTTTGAGCATATTGAGCTGCCGA
TCTTTGAAGACACCGGCTTGTTTGCGCGTGGTGTTGGTGAGTCCACTGACGTAGTGAGCAAGGAAATGTACACCTTCGCT
GATCGTGGCGAGCGCTCTGTCACGCTGCGCCCAGAAGGCACTGCAGGCGTGATGCGTGCAGTTATTGAACACAGCCTGGA
CCGTGGACAGCTTCCCGTAAAGCTGAACTACGCCGGACCATTCTTCCGTTATGAGCGTCCTCAGGCAGGGCGTTACCGTC
AGCTTCAGCAAGTAGGCGTAGAGGCAATTGGTGTGGATGATCCAGCGCTTGATGCGGAGATCATTGCGCTTGCTGATCGT
TCTTACCGCAGCTTGGGGCTGCAGGATTTCCGTCTGGAGCTCACCAGCTTGGGTGATCGTCACTGCCGTCCCGAGTATCG
TCAGAAGCTGCAGGATTTCTTGTTTGCACTTCCTTTGGATGAGGAAACCCGCAAGCGCGCAGAGATCAACCCACTTCGGG
TGTTGGATGATAAGCGTCCTGAAGTCCAAGAGATGACTGCGGATGCACCATTGATGCTGGATCACCTTGATGCAGAGTGC
CGTGAGCACTTTGAAACAGTGACTGGTTTGCTCGATGACATGGGTGTTCCATATGTGATTAACCCACGCATGGTTCGTGG
TTTGGATTACTACACCAAGACTTGTTTTGAGTTCGTTCACGATGGCCTGGGCGCACAGTCTGGCATTGGTGGCGGCGGAC
GCTACGACGGTCTGATGGCACAGCTTGGCGGACAGGATCTGTCTGGCATCGGCTATGGCCTGGGTGTGGATCGCACCATG
TTGGCTCTGGAAGCTGAAGGTGTGACTGTTGGTGCTGAGCGTCGCGTTGATGTGTACGGCGTTCCACTGGGCAAGGATGC
TAAGAAGGCTCTTGCTGGAATCGTGAACACGCTGCGCGCTGCGGGTATTTCCACCGATATGTCTTACGGCGACCGTGGCC
TGAAGGGTGCCATGAAGGGCGCTGACCGCTCCAACGCGTTGTACACCTTGGTGCTGGGCGAGCAGGAGCTGGAGAACAAC
ACCATCGCGGTGAAGGATATGCGTGCGCATGAGCAGCACGATGTCGCATTGGACGAGGTTGTGGCCTTTTTGCAGGGGAA
ACTTATTTAA

Upstream 100 bases:

>100_bases
AACCACCACCATGCGTGCAGAACGCACTGGTAACCCTTTCTTGCTGGCACTGTAGGGCTAAGTTCCGTACTACTTCTTCG
AATAGGTATCGTTAATAATC

Downstream 100 bases:

>100_bases
ATAATTCATAAGTAAAAAACCGTCAATTCACGATGTGGGTTGGCGGTTTTCCTATTAGGCTCACTTTTATGACGAGCGCA
CACTTTGAATCCCGCCGGAT

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSQNKSKSEKLQSFAAPKGVPDYAPPKSAAFLAVRDAFVNQAHKAGFEHIELPIFEDTGLFARGVGESTDVVSKEMYTFA
DRGERSVTLRPEGTAGVMRAVIEHSLDRGQLPVKLNYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEIIALADR
SYRSLGLQDFRLELTSLGDRHCRPEYRQKLQDFLFALPLDEETRKRAEINPLRVLDDKRPEVQEMTADAPLMLDHLDAEC
REHFETVTGLLDDMGVPYVINPRMVRGLDYYTKTCFEFVHDGLGAQSGIGGGGRYDGLMAQLGGQDLSGIGYGLGVDRTM
LALEAEGVTVGAERRVDVYGVPLGKDAKKALAGIVNTLRAAGISTDMSYGDRGLKGAMKGADRSNALYTLVLGEQELENN
TIAVKDMRAHEQHDVALDEVVAFLQGKLI

Sequences:

>Translated_429_residues
MSQNKSKSEKLQSFAAPKGVPDYAPPKSAAFLAVRDAFVNQAHKAGFEHIELPIFEDTGLFARGVGESTDVVSKEMYTFA
DRGERSVTLRPEGTAGVMRAVIEHSLDRGQLPVKLNYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEIIALADR
SYRSLGLQDFRLELTSLGDRHCRPEYRQKLQDFLFALPLDEETRKRAEINPLRVLDDKRPEVQEMTADAPLMLDHLDAEC
REHFETVTGLLDDMGVPYVINPRMVRGLDYYTKTCFEFVHDGLGAQSGIGGGGRYDGLMAQLGGQDLSGIGYGLGVDRTM
LALEAEGVTVGAERRVDVYGVPLGKDAKKALAGIVNTLRAAGISTDMSYGDRGLKGAMKGADRSNALYTLVLGEQELENN
TIAVKDMRAHEQHDVALDEVVAFLQGKLI
>Mature_428_residues
SQNKSKSEKLQSFAAPKGVPDYAPPKSAAFLAVRDAFVNQAHKAGFEHIELPIFEDTGLFARGVGESTDVVSKEMYTFAD
RGERSVTLRPEGTAGVMRAVIEHSLDRGQLPVKLNYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEIIALADRS
YRSLGLQDFRLELTSLGDRHCRPEYRQKLQDFLFALPLDEETRKRAEINPLRVLDDKRPEVQEMTADAPLMLDHLDAECR
EHFETVTGLLDDMGVPYVINPRMVRGLDYYTKTCFEFVHDGLGAQSGIGGGGRYDGLMAQLGGQDLSGIGYGLGVDRTML
ALEAEGVTVGAERRVDVYGVPLGKDAKKALAGIVNTLRAAGISTDMSYGDRGLKGAMKGADRSNALYTLVLGEQELENNT
IAVKDMRAHEQHDVALDEVVAFLQGKLI

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Escherichia coli, GI1788861, Length=422, Percent_Identity=44.3127962085308, Blast_Score=340, Evalue=7e-95,
Organism=Caenorhabditis elegans, GI71993693, Length=460, Percent_Identity=23.4782608695652, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71993686, Length=460, Percent_Identity=23.4782608695652, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_CORGL (Q8NQ07)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927153
- RefSeq:   NP_600861.1
- RefSeq:   YP_225932.1
- ProteinModelPortal:   Q8NQ07
- SMR:   Q8NQ07
- World-2DPAGE:   0001:Q8NQ07
- PRIDE:   Q8NQ07
- GeneID:   1019616
- GeneID:   3343445
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1855
- KEGG:   cgl:NCgl1585
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- PhylomeDB:   Q8NQ07
- ProtClustDB:   PRK00037
- BioCyc:   CGLU196627:CG1855-MONOMER
- BRENDA:   6.1.1.21
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 47127; Mature: 46996

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQNKSKSEKLQSFAAPKGVPDYAPPKSAAFLAVRDAFVNQAHKAGFEHIELPIFEDTGL
CCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
FARGVGESTDVVSKEMYTFADRGERSVTLRPEGTAGVMRAVIEHSLDRGQLPVKLNYAGP
CCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEECCCC
FFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEIIALADRSYRSLGLQDFRLELTSLGDR
CCCCCCCCCHHHHHHHHHCCEEECCCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHCCCC
HCRPEYRQKLQDFLFALPLDEETRKRAEINPLRVLDDKRPEVQEMTADAPLMLDHLDAEC
CCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEECCCCCCHHHHHCCCCCHHHHHCCHHH
REHFETVTGLLDDMGVPYVINPRMVRGLDYYTKTCFEFVHDGLGAQSGIGGGGRYDGLMA
HHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
QLGGQDLSGIGYGLGVDRTMLALEAEGVTVGAERRVDVYGVPLGKDAKKALAGIVNTLRA
HHCCCCCCCCCCCCCCCCEEEEEEECCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHH
AGISTDMSYGDRGLKGAMKGADRSNALYTLVLGEQELENNTIAVKDMRAHEQHDVALDEV
HCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCHHHCCCEEEEEECHHHHHHCHHHHHH
VAFLQGKLI
HHHHHCCCC
>Mature Secondary Structure 
SQNKSKSEKLQSFAAPKGVPDYAPPKSAAFLAVRDAFVNQAHKAGFEHIELPIFEDTGL
CCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
FARGVGESTDVVSKEMYTFADRGERSVTLRPEGTAGVMRAVIEHSLDRGQLPVKLNYAGP
CCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEECCCC
FFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEIIALADRSYRSLGLQDFRLELTSLGDR
CCCCCCCCCHHHHHHHHHCCEEECCCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHCCCC
HCRPEYRQKLQDFLFALPLDEETRKRAEINPLRVLDDKRPEVQEMTADAPLMLDHLDAEC
CCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEECCCCCCHHHHHCCCCCHHHHHCCHHH
REHFETVTGLLDDMGVPYVINPRMVRGLDYYTKTCFEFVHDGLGAQSGIGGGGRYDGLMA
HHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
QLGGQDLSGIGYGLGVDRTMLALEAEGVTVGAERRVDVYGVPLGKDAKKALAGIVNTLRA
HHCCCCCCCCCCCCCCCCEEEEEEECCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHH
AGISTDMSYGDRGLKGAMKGADRSNALYTLVLGEQELENNTIAVKDMRAHEQHDVALDEV
HCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCHHHCCCEEEEEECHHHHHHCHHHHHH
VAFLQGKLI
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626